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Conserved domains on  [gi|951233315|ref|NP_001303992|]
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methylosome protein WDR77 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-317 1.15e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 1.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200    9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 237
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASlSEDCSLAVLDSSLSELSQ---AHRDFVRDATWSPlNHSLLTTV 314
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGtlrGHENGVNSVAFSP-DGYLLASG 237


                 ...
gi 951233315 315 GWD 317
Cdd:cd00200  238 SED 240
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-317 1.15e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 1.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200    9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 237
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASlSEDCSLAVLDSSLSELSQ---AHRDFVRDATWSPlNHSLLTTV 314
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGtlrGHENGVNSVAFSP-DGYLLASG 237


                 ...
gi 951233315 315 GWD 317
Cdd:cd00200  238 SED 240
WD40 COG2319
WD40 repeat [General function prediction only];
94-320 2.84e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 174 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253
Cdd:COG2319  253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 254 HSQCVTGLVFSPHSvPFLASLSEDCSLAVLDSSLSELS---QAHRDFVRDATWSPlNHSLLTTVGWDHQV 320
Cdd:COG2319  329 HTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLrtlTGHTGAVTSVAFSP-DGRTLASGSADGTV 396
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-196 7.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 951233315   159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
160-196 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 951233315  160 LSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-317 1.15e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 1.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200    9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 237
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASlSEDCSLAVLDSSLSELSQ---AHRDFVRDATWSPlNHSLLTTV 314
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGtlrGHENGVNSVAFSP-DGYLLASG 237


                 ...
gi 951233315 315 GWD 317
Cdd:cd00200  238 SED 240
WD40 COG2319
WD40 repeat [General function prediction only];
94-320 2.84e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.84e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 174 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253
Cdd:COG2319  253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 254 HSQCVTGLVFSPHSvPFLASLSEDCSLAVLDSSLSELS---QAHRDFVRDATWSPlNHSLLTTVGWDHQV 320
Cdd:COG2319  329 HTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLrtlTGHTGAVTSVAFSP-DGRTLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-282 1.33e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 1.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  80 EAGVADLTWVGERGILVAS-DSGAVELWELDENETLIVSKFckyeHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200   93 TSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 159 VLSSYRAHAAQVTCVAASPhKDSVFLSCSEDNRILLWDTRCPKP-ASQIGCSAPgylPTSLAWHPQqSEVFVFGDENGTV 237
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENG---VNSVAFSPD-GYLLASGSEDGTI 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 951233315 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLAV 282
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
46-320 9.40e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 9.40e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  46 ASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCkyEHD 125
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL--GHT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPhkDSVFL-SCSEDNRILLWDTRCPKPAS 204
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--DGKTLaSGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 205 QIgcSAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLAVLD 284
Cdd:COG2319  157 TL--TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWD 232

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 951233315 285 SSLSELSQ---AHRDFVRDATWSPlNHSLLTTVGWDHQV 320
Cdd:COG2319  233 LATGKLLRtltGHSGSVRSVAFSP-DGRLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-324 5.04e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 5.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFlSCSEDNRILLWDTRCPK 201
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 202 PASQIGCSAPGylPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLA 281
Cdd:cd00200   85 CVRTLTGHTSY--VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 951233315 282 VLDSSLSELSQ---AHRDFVRDATWSPLNHSLLTTVG------WDHQVVHHV 324
Cdd:cd00200  161 LWDLRTGKCVAtltGHTGEVNSVAFSPDGEKLLSSSSdgtiklWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-196 1.62e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  91 ERGILVASDSGAVELWELDenetlivSKFCKYE---HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLS-------TGKCLGTlrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261

                         90       100
                 ....*....|....*....|....*....
gi 951233315 168 AQVTCVAASPHKdSVFLSCSEDNRILLWD 196
Cdd:cd00200  262 NSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
94-198 5.18e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 5.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                         90       100
                 ....*....|....*....|....*
gi 951233315 174 AASPHkDSVFLSCSEDNRILLWDTR 198
Cdd:COG2319  379 AFSPD-GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-320 1.07e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 163 YRAHAAQVTCVAASPHKDsVFLSCSEDNRILLWDT-RCPKPASQIGCSAPGylpTSLAWHPqQSEVFVFGDENGTVSLVD 241
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLeTGELLRTLKGHTGPV---RDVAASA-DGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 242 TKSTSCVLSSAVHSQCVTGLVFSPHSvPFLASLSEDCSLAVLDSSLSELSQA---HRDFVRDATWSPlNHSLLTTVGWDH 318
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTlrgHTDWVNSVAFSP-DGTFVASSSQDG 157


                 ..
gi 951233315 319 QV 320
Cdd:cd00200  158 TI 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-196 7.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 951233315   159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
158-265 2.38e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 2.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIgcsAPGYLPTSLAWHPQQSEVFVFGDENGTV 237
Cdd:COG3391   58 AGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATI---PVGGGPRGLAVDPDGGRLYVADSGNGRV 134

                         90       100
                 ....*....|....*....|....*...
gi 951233315 238 SLVDTKSTSCVLSSAVHSQcVTGLVFSP 265
Cdd:COG3391  135 SVIDTATGKVVATIPVGAG-PHGIAVDP 161
WD40 pfam00400
WD domain, G-beta repeat;
160-196 3.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 951233315  160 LSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
75-265 6.31e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 6.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315  75 AGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154
Cdd:COG3391   18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233315 155 AQQVVLSSYRAhAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIgcsAPGYLPTSLAWHPQQSEVFVFGDEN 234
Cdd:COG3391   98 ATGKVVATIPV-GGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI---PVGAGPHGIAVDPDGKRLYVANSGS 173

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 951233315 235 GTVSLV----DTKSTScVLSSAVHSQCVTGLVFSP 265
Cdd:COG3391  174 NTVSVIvsviDTATGK-VVATIPVGGGPVGVAVSP 207
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 88-154 4.92e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.36  E-value: 4.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951233315  88 WVG----ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154
Cdd:cd22857   85 FVGlhlfSGTLLTCTSKGSLRSTKLPDDSTASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDL 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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