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Conserved domains on  [gi|952977822|ref|NP_001304031|]
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dnaJ homolog subfamily B member 4 isoform c [Homo sapiens]

Protein Classification

J domain-containing protein( domain architecture ID 10180526)

J domain-containing protein similar to the N-terminal conserved domain (called J domain) of DnaJ-like proteins, which is involved in regulating the ATPase activity of heat shock protein 70 (Hsp70) by ATP hydrolysis

Gene Ontology:  GO:0006457
PubMed:  9585179|23894646|15170475

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 43-207 3.27e-53

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


:

Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 168.37  E-value: 3.27e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  43 PPVIHELRVSLEEIYSGCTKRMKISRKRLnadgrsYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIK 121
Cdd:cd10747    1 ADLRYDLELTLEEAYFGKEKEIKIPRKVT------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNGGPPgDLYVVIR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 122 DKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGrNIPMSVNDIVKPGMRRRIIGYGLPFPkNPDQRGDLLIEFEV 201
Cdd:cd10747   75 VKPHPVFRRDGNDLYCEVPISLTEALLGGEIEVPTLGG-KVKLKIPPGTQPGTVLRLKGKGMPRL-RGGGRGDLYVEVKV 152


                 ....*.
gi 952977822 202 SFPDTI 207
Cdd:cd10747  153 EFPKKL 158
 
Name Accession Description Interval E-value
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 43-207 3.27e-53

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 168.37  E-value: 3.27e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  43 PPVIHELRVSLEEIYSGCTKRMKISRKRLnadgrsYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIK 121
Cdd:cd10747    1 ADLRYDLELTLEEAYFGKEKEIKIPRKVT------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNGGPPgDLYVVIR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 122 DKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGrNIPMSVNDIVKPGMRRRIIGYGLPFPkNPDQRGDLLIEFEV 201
Cdd:cd10747   75 VKPHPVFRRDGNDLYCEVPISLTEALLGGEIEVPTLGG-KVKLKIPPGTQPGTVLRLKGKGMPRL-RGGGRGDLYVEVKV 152


                 ....*.
gi 952977822 202 SFPDTI 207
Cdd:cd10747  153 EFPKKL 158
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 45-204 2.41e-46

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 152.41  E-value: 2.41e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822   45 VIHELRVSLEEIYSGCTKRMKISRKRLNAD-------------------------------------------------- 74
Cdd:pfam01556   1 LEYELELTLEEAYFGCTKKIKITRNVICDTcggsgakpgtspktcpccggggqvrrqfgffstctccpccggggkiidkc 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822   75 ----GRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNS-IPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCG 149
Cdd:pfam01556  81 ckccGGGGVVEKKTLEVKIPAGVDDGQRIRLRGEGDAGENGgPPGDLYVVIRVKPHPVFRRDGDDLYCTVPISLTEALLG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 952977822  150 CSINVPTLDGRnIPMSVNDIVKPGMRRRIIGYGLPFPKnPDQRGDLLIEFEVSFP 204
Cdd:pfam01556 161 GTIEVPTLDGK-VKLKIPAGTQPGTVLRLKGKGMPRLK-GGGRGDLYVTVKVEVP 213
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 39-221 1.28e-34

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 127.24  E-value: 1.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  39 LKQDPPVIHELRVSLeeiySGCTKRMKI---SRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPAD 115
Cdd:PTZ00037 181 IRQMGSMIHQTQSTC----NSCNGQGKIipeSKKCKNCSGKGVKKTRKILEVNIDKGVPNQHKITFHGEADEKPNEIPGN 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 116 IVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRNIPMSVN--DIVKPGMRRRIIGYGLPFPKNPDQRG 193
Cdd:PTZ00037 257 VVFILNEKPHDTFKREGGDLFITKKISLYEALTGFVFYITHLDGRKLLVNTPpgEVVKPGDIKVINNEGMPTYKSPFKKG 336

                        170       180       190
                 ....*....|....*....|....*....|
gi 952977822 194 DLLIEFEVSFP--DTISSSSKEVLRKHLPA 221
Cdd:PTZ00037 337 NLYVTFEVIFPvdRKFTNEEKEILKSLFPQ 366
 
Name Accession Description Interval E-value
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 43-207 3.27e-53

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 168.37  E-value: 3.27e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  43 PPVIHELRVSLEEIYSGCTKRMKISRKRLnadgrsYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIK 121
Cdd:cd10747    1 ADLRYDLELTLEEAYFGKEKEIKIPRKVT------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNGGPPgDLYVVIR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 122 DKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGrNIPMSVNDIVKPGMRRRIIGYGLPFPkNPDQRGDLLIEFEV 201
Cdd:cd10747   75 VKPHPVFRRDGNDLYCEVPISLTEALLGGEIEVPTLGG-KVKLKIPPGTQPGTVLRLKGKGMPRL-RGGGRGDLYVEVKV 152


                 ....*.
gi 952977822 202 SFPDTI 207
Cdd:cd10747  153 EFPKKL 158
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 45-204 2.41e-46

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 152.41  E-value: 2.41e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822   45 VIHELRVSLEEIYSGCTKRMKISRKRLNAD-------------------------------------------------- 74
Cdd:pfam01556   1 LEYELELTLEEAYFGCTKKIKITRNVICDTcggsgakpgtspktcpccggggqvrrqfgffstctccpccggggkiidkc 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822   75 ----GRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNS-IPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCG 149
Cdd:pfam01556  81 ckccGGGGVVEKKTLEVKIPAGVDDGQRIRLRGEGDAGENGgPPGDLYVVIRVKPHPVFRRDGDDLYCTVPISLTEALLG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 952977822  150 CSINVPTLDGRnIPMSVNDIVKPGMRRRIIGYGLPFPKnPDQRGDLLIEFEVSFP 204
Cdd:pfam01556 161 GTIEVPTLDGK-VKLKIPAGTQPGTVLRLKGKGMPRLK-GGGRGDLYVTVKVEVP 213
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 39-221 1.28e-34

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 127.24  E-value: 1.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  39 LKQDPPVIHELRVSLeeiySGCTKRMKI---SRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPAD 115
Cdd:PTZ00037 181 IRQMGSMIHQTQSTC----NSCNGQGKIipeSKKCKNCSGKGVKKTRKILEVNIDKGVPNQHKITFHGEADEKPNEIPGN 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 116 IVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRNIPMSVN--DIVKPGMRRRIIGYGLPFPKNPDQRG 193
Cdd:PTZ00037 257 VVFILNEKPHDTFKREGGDLFITKKISLYEALTGFVFYITHLDGRKLLVNTPpgEVVKPGDIKVINNEGMPTYKSPFKKG 336

                        170       180       190
                 ....*....|....*....|....*....|
gi 952977822 194 DLLIEFEVSFP--DTISSSSKEVLRKHLPA 221
Cdd:PTZ00037 337 NLYVTFEVIFPvdRKFTNEEKEILKSLFPQ 366
PRK14289 PRK14289
molecular chaperone DnaJ;
82-217 7.52e-20

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 86.42  E-value: 7.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  82 DKILTIEIKKGWKEGTKITFPREGDETP-NSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGR 160
Cdd:PRK14289 226 EEVITVKIPAGVAEGMQLSMNGKGNAGKhGGVNGDLLVVIEEEPHPELIRDENDLIYNLLLSVPTAALGGAVEVPTIDGK 305

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 952977822 161 nIPMSVNDIVKPGMRRRIIGYGLPfPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14289 306 -AKVKIEAGTQPGKVLRLRNKGLP-SVNGYGTGDLLVNVSVYIPETLSKEEKQTLEK 360
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 75-215 1.77e-18

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 82.63  E-value: 1.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  75 GRSYRSEDkiLTIEIKKGWKEGTKITFPREGDETPNSiPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINV 154
Cdd:PRK14292 207 GRTLKAET--VKVKLPRGIDEGYRIRVAGMGNEGPGG-NGDLYVHIEMEPHPELRREQEHLIYEARIGFAKAALGGQITV 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952977822 155 PTLDGRNIpMSVNDIVKPGMRRRIIGYGLPFPKNPDQrGDLLIEFEVSFPDTISSSSKEVL 215
Cdd:PRK14292 284 PTLDGPQV-IEVKPGTQHGDLHRLRGQGMPRLQGAGT-GDLIVEYEIAVPKQLSPEAREAL 342
PRK14293 PRK14293
molecular chaperone DnaJ;
66-217 6.70e-18

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 80.80  E-value: 6.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  66 ISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLR 144
Cdd:PRK14293 199 IEDPCDACGGQGVKQVTKKLKINIPAGVDTGTRLRVSGEGDAGLRGGPPgDLYVYLFVKNDPEFRRDGINILSEIKISYL 278

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 952977822 145 EALCGCSINVPTLDGrnipmSVNDIVKPGMRRRII----GYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14293 279 QAILGDTLEVDTVDG-----PVELTIPAGTQPNTVltleNKGVPRLGNPVARGDHLITVKVKIPTRISDEERELLEK 350
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 75-217 2.07e-17

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 79.65  E-value: 2.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  75 GRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIP-ADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSIN 153
Cdd:PRK14286 211 GQGLQEKRRTINIKIPPGVETGSRLKVSGEGEAGPNGGPhGDLYVVTHIKKHELFERQGNDLILVRKISLAQAILGAEIE 290

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 952977822 154 VPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFpKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14286 291 VPTIDGKKAKMKIPEGTESGQVFRLKGHGMPY-LGAYGKGDQHVIVKIEIPKKITRRQRELIEE 353
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 75-217 3.66e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 75.93  E-value: 3.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  75 GRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSIN 153
Cdd:PRK14301 205 GSGIVQQTRELKVRIPAGVDTGSRLRLRGEGEPGVHGGPPgDLYVVITVEDDKIFQRQGQDLVVTQEISFVQAALGDRIE 284

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 952977822 154 VPTLDGrNIPMSVNDIVKPGMRRRIIGYGLPFPKNpDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14301 285 VPTLDD-PVTLDIPKGTQSGEVFRLRGKGLPYLGS-SQKGDLLVEVSVVTPTKLTKRQEELLRE 346
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 15-217 9.01e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 74.86  E-value: 9.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  15 DPFSAFG------FSMNGYPRDRNSvGPSRlKQDppVIHELRVSLEEIYSGCTKRMKISRKRL----------------- 71
Cdd:PRK14283  90 DIFQGFGfgigniFDMFGFGGGSRH-GPQR-GAD--IYTEVEITLEEAASGVEKDIKVRHTKKcpvcngsraepgsevkt 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  72 ------------------------------------------NADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDE-T 108
Cdd:PRK14283 166 cptcggtgqvkqvrntilgqmmnvttcpdcqgegkivekpcsNCHGKGVVRETKTISVKIPAGVETGSRLRVSGEGEMgD 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 109 PNSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGR---NIPMSvndiVKPGMRRRIIGYGLPf 185
Cdd:PRK14283 246 RGGEPGDLYVVIKVKPHKIFRREGANLYYEKPISFVQAALGDTVDVPTIDGPvelKIPAG----TQSGTTFRLKGHGMP- 320

                        250       260       270
                 ....*....|....*....|....*....|..
gi 952977822 186 PKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14283 321 SLRWSGKGNLYVKVKVVVPKKLSPKQKELLRE 352
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 72-204 2.39e-15

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 73.65  E-value: 2.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  72 NADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNS-IPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGC 150
Cdd:PRK14291 213 KCNGRGLVIKKETIKVRIPPGVDNGSKLRVPGKGHAGRFGgPPGDLYIIVKVKPHPLFERRGDNLYLDVNITVAEAVLGT 292

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 952977822 151 SINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNpDQRGDLLIEFEVSFP 204
Cdd:PRK14291 293 ELEVPLLDGKKEKVKIPPGTKEGDKIRVPGKGMPRLKG-SGYGDLVVRVHIDVP 345
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 79-217 2.40e-15

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 73.68  E-value: 2.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  79 RSEDKIlTIEIKKGWKEGTKITFPREGDETPNSIP-ADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTL 157
Cdd:PRK14277 225 RRRRKI-KVNIPAGIDDGQMITLRGEGEPGIKGGPnGDLYIVIKVKPHPLFKREGYNVYLEMPITFTDAALGGEIEIPTL 303

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 158 DGRNIpMSVNDIVKPGMRRRIIGYGLPFpKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14277 304 DGKVK-FTIPEGTQTGTKFRLRGKGIPH-LRGRGRGDQIVKVYIEVPKKLTEKQKELLRE 361
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 87-216 6.20e-15

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 72.53  E-value: 6.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  87 IEIKKGWKEGTKITFPREGDETP-NSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRnIPMS 165
Cdd:PRK14281 239 VTVPAGVQDGNYLTLRGQGNAGPrGGAPGDLIVVIEEKPHELFVRNGDDVIYNLAVSYPDLVLGTKVEVPTLDGA-VKLT 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 952977822 166 VNDIVKPGMRRRIIGYGLPFPKNPDqRGDLLIEFEVSFPDTISSSSKEVLR 216
Cdd:PRK14281 318 IPAGTQPETMLRIPGKGIGHLRGSG-RGDQYVRVNVFVPKEVSHQDKELLK 367
PRK14279 PRK14279
molecular chaperone DnaJ;
72-221 1.77e-13

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 68.61  E-value: 1.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  72 NADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGC 150
Cdd:PRK14279 231 ECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPSgDLYVTVHVRPDKVFGRDGDDLTVTVPVSFTELALGS 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 952977822 151 SINVPTLDGR---NIPMSVNDivkpGMRRRIIGYGLpfPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPA 221
Cdd:PRK14279 311 TLSVPTLDGPvgvKVPAGTAD----GRILRVRGRGV--PKRSGGAGDLLVTVKVAVPPNLDGAAAEALEAYAEA 378
PRK14295 PRK14295
molecular chaperone DnaJ;
72-222 2.00e-13

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 68.34  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  72 NADGRSYRSedKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGC 150
Cdd:PRK14295 226 KGSGRAKSS--RTMQVRIPAGVSDGQRIRLRGKGAPGERGGPAgDLYVVVHVDPHPVFGRSGDNLTVTVPVTFPEAALGA 303

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 952977822 151 SINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLpfPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS 222
Cdd:PRK14295 304 EVRVPTLGGPPVTVKLPPGTPNGRVLRVRGKGA--VRKDGTRGDLLVTVEVAVPKDLSGKAREALEAFREAT 373
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 81-217 4.46e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 67.09  E-value: 4.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  81 EDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DI-VFIIKdKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLD 158
Cdd:PRK10767 209 KEKTLSVKIPAGVDTGDRIRLSGEGEAGERGGPAgDLyVQIHV-KEHPIFERDGNDLYCEVPISFTTAALGGEIEVPTLD 287

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 952977822 159 GRnIPMSVNDIVKPGMRRRIIGYGLPfPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK10767 288 GR-VKLKIPEGTQTGKLFRLRGKGVK-SVRSGARGDLYCQVVVETPVNLTKRQKELLEE 344
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 37-217 2.76e-12

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 64.57  E-value: 2.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  37 SRLKQDppVIHELRVSLEEIYSGCTKRMKISRKRLnadgrsyrsedkilTIEIKKGWKEGTKITFPREGDETpnsipADI 116
Cdd:PRK14299 126 ARKGRD--LEAELPLTLEEAYRGGEKVVEVAGERL--------------SVRIPPGVREGQVIRLAGKGRQG-----GDL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 117 VFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGrNIPMSVNDIVKPGMRRRIIGYGlpFPKNPDQRGDLL 196
Cdd:PRK14299 185 YLVVRLLPHPVFRLEGDDLYATVDVPAPIAVVGGKVRVMTLDG-PVEVTIPPRTQAGRKLRLKGKG--WPRGPAGRGDQY 261

                        170       180
                 ....*....|....*....|.
gi 952977822 197 IEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14299 262 AEVRITIPTRPTPEEERLYKQ 282
PRK14297 PRK14297
molecular chaperone DnaJ;
79-222 6.49e-12

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 63.65  E-value: 6.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  79 RSEDKIlTIEIKKGWKEGTKITFPREGDETPNSIPADIVFI-IKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTL 157
Cdd:PRK14297 218 RKNRKI-KVNVPAGVDTGNVIPLRGQGEHGKNGGPTGDLYInIRVAPHKTFKRKGFDIYIDKHISFAKAALGTEIKVPTV 296

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 952977822 158 DGrNIPMSVNDIVKPGMRRRIIGYGLPFpKNPDQRGDLLIEFEVSFPDTISSSSKEVLRKHLPAS 222
Cdd:PRK14297 297 DG-EVKYEVPAGTQPGTVFRLKGKGVPR-VNSTGRGNQYVTVIVDIPKKLNSKQKEALTMFMEAS 359
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 69-215 1.15e-11

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 63.24  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  69 KRLNADGRSYRSedKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLREAL 147
Cdd:PRK14294 201 KTCHGQGRVRVS--KTVQVKIPAGVDTGSRLRLRGEGEAGVRGGPPgDLYVFLTVEPHEFFERDGNDVHCKVPISFVQAA 278

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 952977822 148 CGCSINVPTLDGRNiPMSVNDIVKPGMRRRIIGYGLPFPKNpDQRGDLLIEFEVSFPDTISSSSKEVL 215
Cdd:PRK14294 279 LGAQIEVPTLEGER-ELKIPKGTQPGDIFRFKGKGIPSLRG-GGRGDQIIEVEVKVPTRLTKKQEELL 344
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 83-217 1.42e-11

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 62.94  E-value: 1.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  83 KILTIEIKKGWKEGTKITFPREGDE-TPNSIPADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRn 161
Cdd:PRK14298 214 RKITVNVPAGADSGLRLKLSGEGEAgSPGAPSGDLYIVLHVKEHDYFERVGDDIISEIPISFTQAALGADIMVPTLYGK- 292

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 162 ipmsVNDIVKPGMRR----RIIGYGLPFpKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14298 293 ----VKMNIPPGTQThsvfRLKDKGMPR-LHGHGKGDQLVKVIVKTPTKLTQEQKELLRE 347
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 66-217 1.36e-10

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 59.96  E-value: 1.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  66 ISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDET-PNSIPADIVFIIKDKDHPKFKRDGSN-IIYTAKISL 143
Cdd:PRK14296 205 IKNKCKNCKGKGKYLERKKIEVNIPKGIRPNQQIKLSQKGHASlNNGVNGDLIIDIYLKESKVFEIINNNdILMTYNISY 284

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 952977822 144 REALCGCSINVPTLDGR---NIPMSVNDivkpGMRRRIIGYGLPFPKNPDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14296 285 LDAILGNEIIIKTLDGDikyKLPKSINS----NELIIINNKGLYKSINKDKRGDLIIKVNIVVPKNLSKKEKELIEQ 357
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 74-217 1.22e-09

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 56.98  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  74 DGRsYRSEDKIlTIEIKKGWKEGTKITFPREGDETPNSIPADIVFI-IKDKDHPKFKRDGSNIIYTAKISLREALCGCSI 152
Cdd:PRK14278 205 DGR-VRARREI-TVKIPAGVGDGMRIRLAAQGEVGPGGGPAGDLYVeVHEQPHDVFVRDGDDLHCTVSVPMVDAALGTTV 282

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 952977822 153 NVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNpDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14278 283 TVEAILDGPSEITIPPGTQPGSVITLRGRGMPHLRS-GGRGDLHAHVEVVVPTRLDHEDIELLRE 346
PRK10266 PRK10266
curved DNA-binding protein;
15-204 1.63e-09

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 56.37  E-value: 1.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  15 DPFSAFGFSMNGYPRDRnsvgPSRLKQDPPVihELRVSLEEIYSGCTKRMKISRKRLNADGRSYRSEDKILTIEIKKGWK 94
Cdd:PRK10266  96 DIFSSIFGQHARQSRQR----PAARGHDIEI--EVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVG 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  95 EGTKITFPREGDETPNSIP-ADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTLDGRnIPMSVNDIVKPG 173
Cdd:PRK10266 170 NGQRIRLKGQGTPGENGGPnGDLWLVIHIAPHPLFDIVGQDLEIVVPLAPWEAALGAKVTVPTLKES-ILLTIPPGSQAG 248

                        170       180       190
                 ....*....|....*....|....*....|.
gi 952977822 174 MRRRIIGYGLPFPKnpdQRGDLLIEFEVSFP 204
Cdd:PRK10266 249 QRLRVKGKGLVSKK---QTGDLYAVLKIVMP 276
PRK14280 PRK14280
molecular chaperone DnaJ;
81-217 2.61e-09

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 56.27  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  81 EDKILTIEIK--KGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTL 157
Cdd:PRK14280 212 VRKRKKINVKipAGVDNGQQIRVSGEGEPGVNGGPAgDLYVVFRVRPHEFFERDGDDIYCEMPLTFAQAALGDEIEVPTL 291

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 158 DGrNIPMSVNDIVKPGMRRRIIGYGLPFPKNPDQrGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14280 292 HG-KVKLKIPAGTQTGTQFRLKGKGVPNVRGYGQ-GDQYVVVRVVTPTKLTDRQKELLRE 349
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 81-222 5.47e-09

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 55.09  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  81 EDKILTIEIK--KGWKEGTKITFPREGDETPNSIP-ADIVFIIKDKDHPKFKRDGSNIIYTAKISLREALCGCSINVPTL 157
Cdd:PRK14276 215 EKQAHTVSVKipAGVETGQQIRLQGQGEAGFNGGPyGDLYVVFRVEPSKKFERDGSTIYYTLPISFVQAALGDTVEVPTV 294

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 952977822 158 DGrNIPMSVNDIVKPGMRRRIIGYGLPFPKNPDQrGDLLIEFEVSFPDTISSSSKEVLRKHLPAS 222
Cdd:PRK14276 295 HG-DVELKIPAGTQTGKKFRLRGKGAPKLRGGGN-GDQHVTVNIVTPTKLNDAQKEALKAFAKAS 357
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 69-217 7.56e-09

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 54.64  E-value: 7.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  69 KRLNADGRSYRSEDkiLTIEIKKGWKEGTKITFPREGD---ETPNSipADIVFIIKDKDHPKFKRDGSNIIYTAKISLRE 145
Cdd:PRK14300 202 KKCHGMGRYHKQRN--LSVNIPAGVENGTRIRHTGEGEagiRGGNS--GDLYVDIAIKPHDIYKVDGANLHCKLPISFVN 277

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 952977822 146 ALCGCSINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNpDQRGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14300 278 AALGGEIEVPVIEGGKVNLTIPAGTQNGDQLRLRSKGMSKMRS-TIRGDMLTHIHVEVPKNLSKRQRELLEE 348
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 66-217 2.88e-08

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 53.09  E-value: 2.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  66 ISRKRLNADGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPA-DIVFIIKDKDHPKFKRDGSNIIYTAKISLR 144
Cdd:PRK14287 194 IKQKCATCGGKGKVRKRKKINVKVPAGIDHGQQLRVSGQGEAGVNGGPPgDLYVVFNVKPHEFFERDGDDIYCEMPLTFP 273

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 952977822 145 EALCGCSINVPTLDGRnIPMSVNDIVKPGMRRRIIGYGLPFPKNPDQrGDLLIEFEVSFPDTISSSSKEVLRK 217
Cdd:PRK14287 274 QVALGDEIEVPTLNGK-VKLKIPAGTQTGTSFRLRGKGVPNVHGRGQ-GDQHVQVRVVTPKNLTEKEKELMRE 344
PRK14288 PRK14288
molecular chaperone DnaJ;
51-217 1.39e-06

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 48.15  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822  51 VSLEEIYSGCTKRMKISRKRLNA-DGRSYRSEDKILTIEIKKGWKEGTKITFPREGDETPNSIPADIVFIIKDKDHPKFK 129
Cdd:PRK14288 175 MSFAQTCGACQGKGKIIKTPCQAcKGKTYILKDEEIDAIIPEGIDDQNRMVLKNKGNEYEKGKRGDLYLEARVKEDEHFK 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977822 130 RDGSNIIYTAKISLREALCGCSINVPTLDGRNIPMSVNDIVKPGMRRRIIGYGLPFPKNpDQRGDLLIEFEVSFPDTISS 209
Cdd:PRK14288 255 REGCDLFIEAPVFFTTIALGHTIKVPSLKGDELELKIPRNARDRQTFAFRNEGVKHPES-SYRGSLIVELQVIYPKSLNK 333


                 ....*...
gi 952977822 210 SSKEVLRK 217
Cdd:PRK14288 334 EQQELLEK 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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