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Conserved domains on  [gi|953768350|ref|NP_001304114|]
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cadherin-1 isoform 3 [Homo sapiens]

Protein Classification

Cadherin_repeat and Cadherin_C domain-containing protein( domain architecture ID 10182671)

Cadherin_repeat and Cadherin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 302-361 3.21e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 96.45  E-value: 3.21e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768350  302 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 361
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3-75 4.96e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 4.96e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 953768350   3 QKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDN 75
Cdd:cd11304   30 GEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
82-170 9.54e-10

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 9.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768350   82 RTIFFCE---RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTqesiiLKPKMAL---EVGDYKINLKLMD 155
Cdd:pfam00028   1 YSASVPEnapVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 953768350  156 N--QNKDQVTTLEVSVC 170
Cdd:pfam00028  76 SggPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 302-361 3.21e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 96.45  E-value: 3.21e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768350  302 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 361
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3-75 4.96e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 4.96e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 953768350   3 QKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDN 75
Cdd:cd11304   30 GEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 4-77 7.20e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 7.20e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 953768350     4 KITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP 77
Cdd:smart00112  12 KVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3-65 6.51e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 6.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 953768350    3 QKITYRIWRD-TANWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTL 65
Cdd:pfam00028  29 GRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSGGPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
82-170 9.54e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 9.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768350   82 RTIFFCE---RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTqesiiLKPKMAL---EVGDYKINLKLMD 155
Cdd:pfam00028   1 YSASVPEnapVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 953768350  156 N--QNKDQVTTLEVSVC 170
Cdd:pfam00028  76 SggPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 302-361 3.21e-25

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 96.45  E-value: 3.21e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768350  302 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 361
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3-75 4.96e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 4.96e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 953768350   3 QKITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDN 75
Cdd:cd11304   30 GEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 4-77 7.20e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 7.20e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 953768350     4 KITYRIWRDTA-NWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAP 77
Cdd:smart00112  12 KVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3-65 6.51e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 6.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 953768350    3 QKITYRIWRD-TANWLEINPDTGAISTRAELDREdfehvKNSTYTALIIATDNGSPVATGTGTL 65
Cdd:pfam00028  29 GRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSGGPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
82-170 9.54e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 9.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 953768350   82 RTIFFCE---RNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTqesiiLKPKMAL---EVGDYKINLKLMD 155
Cdd:pfam00028   1 YSASVPEnapVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGD-----ISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 953768350  156 N--QNKDQVTTLEVSVC 170
Cdd:pfam00028  76 SggPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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