NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|960513900|ref|NP_001304697|]
View 

protein ripply3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ripply super family cl20876
Transcription Regulator; The precise function of this family is not clear, but it is thought ...
1-33 1.14e-14

Transcription Regulator; The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.


The actual alignment was detected with superfamily member pfam14998:

Pssm-ID: 464433  Cd Length: 85  Bit Score: 63.44  E-value: 1.14e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 960513900    1 MSKRQEYLRSSGEQVLASFPVQATIDFYDDEST 33
Cdd:pfam14998  49 KSKSYDYLYSAGEKLLRNFPVQATIHFYEDSDS 81
 
Name Accession Description Interval E-value
Ripply pfam14998
Transcription Regulator; The precise function of this family is not clear, but it is thought ...
1-33 1.14e-14

Transcription Regulator; The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.


Pssm-ID: 464433  Cd Length: 85  Bit Score: 63.44  E-value: 1.14e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 960513900    1 MSKRQEYLRSSGEQVLASFPVQATIDFYDDEST 33
Cdd:pfam14998  49 KSKSYDYLYSAGEKLLRNFPVQATIHFYEDSDS 81
 
Name Accession Description Interval E-value
Ripply pfam14998
Transcription Regulator; The precise function of this family is not clear, but it is thought ...
1-33 1.14e-14

Transcription Regulator; The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.


Pssm-ID: 464433  Cd Length: 85  Bit Score: 63.44  E-value: 1.14e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 960513900    1 MSKRQEYLRSSGEQVLASFPVQATIDFYDDEST 33
Cdd:pfam14998  49 KSKSYDYLYSAGEKLLRNFPVQATIHFYEDSDS 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH