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Conserved domains on  [gi|961658101|ref|NP_001304859|]
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ran GTPase-activating protein 1 [Homo sapiens]

Protein Classification

Ran GTPase-activating protein 1( domain architecture ID 10061473)

Ran GTPase-activating protein 1 (RanGAP1) converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export

Gene Symbol:  RANGAP1
PubMed:  8146159|16428860

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
21-358 1.75e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 320.46  E-value: 1.75e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  21 GQLSFKGKSLKlntAEDAKDVIKEIEDfdsLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRlrteIPPAL 100
Cdd:cd00116    1 LQLSLKGELLK---TERATELLPKLLC---LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGR----IPRGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 101 ISLGEGLITaGAQLVELDLSDNAFGPDGVQGFEALLKSSacfTLQELKLNNCGMGIGGGKILAAALTEChrkssaqgkPL 180
Cdd:cd00116   71 QSLLQGLTK-GCGLQELDLSDNALGPDGCGVLESLLRSS---SLQELKLNNNGLGDRGLRLLAKGLKDL---------PP 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 181 ALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETL 260
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 261 KTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQ 340
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297
                        330
                 ....*....|....*....
gi 961658101 341 LQEVLEGF-NMAKVLASLS 358
Cdd:cd00116  298 LAESLLEPgNELESLWVKD 316
RanGAP1_C pfam07834
RanGAP1 C-terminal domain; Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for ...
409-585 1.04e-96

RanGAP1 C-terminal domain; Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localization at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1). This domain is composed almost entirely of helical substructures that are organized into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation.


:

Pssm-ID: 462282  Cd Length: 177  Bit Score: 292.40  E-value: 1.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  409 TPSRKILDPNTGEPApvlSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRM 488
Cdd:pfam07834   4 EPEKKINGNKVSTPP---SAPRPPDVSSFLAFPSPEKLLRLGPKRSQLIQQQVDVSDAEKVVEAFLKISSVYKEETEVKT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  489 AVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNS 568
Cdd:pfam07834  81 AVLETIDALLRKAFSSPSFQSYLFISSLLVHMGLLKSEDKIKPVPVVPGHLLALEHAVQQDYFPKELAPVLLAFMSRPNR 160
                         170
                  ....*....|....*..
gi 961658101  569 ALESCSFARHSLLQTLY 585
Cdd:pfam07834 161 VLESCSSARHALLQTLH 177
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
21-358 1.75e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 320.46  E-value: 1.75e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  21 GQLSFKGKSLKlntAEDAKDVIKEIEDfdsLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRlrteIPPAL 100
Cdd:cd00116    1 LQLSLKGELLK---TERATELLPKLLC---LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGR----IPRGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 101 ISLGEGLITaGAQLVELDLSDNAFGPDGVQGFEALLKSSacfTLQELKLNNCGMGIGGGKILAAALTEChrkssaqgkPL 180
Cdd:cd00116   71 QSLLQGLTK-GCGLQELDLSDNALGPDGCGVLESLLRSS---SLQELKLNNNGLGDRGLRLLAKGLKDL---------PP 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 181 ALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETL 260
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 261 KTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQ 340
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297
                        330
                 ....*....|....*....
gi 961658101 341 LQEVLEGF-NMAKVLASLS 358
Cdd:cd00116  298 LAESLLEPgNELESLWVKD 316
RanGAP1_C pfam07834
RanGAP1 C-terminal domain; Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for ...
409-585 1.04e-96

RanGAP1 C-terminal domain; Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localization at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1). This domain is composed almost entirely of helical substructures that are organized into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation.


Pssm-ID: 462282  Cd Length: 177  Bit Score: 292.40  E-value: 1.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  409 TPSRKILDPNTGEPApvlSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRM 488
Cdd:pfam07834   4 EPEKKINGNKVSTPP---SAPRPPDVSSFLAFPSPEKLLRLGPKRSQLIQQQVDVSDAEKVVEAFLKISSVYKEETEVKT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  489 AVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNS 568
Cdd:pfam07834  81 AVLETIDALLRKAFSSPSFQSYLFISSLLVHMGLLKSEDKIKPVPVVPGHLLALEHAVQQDYFPKELAPVLLAFMSRPNR 160
                         170
                  ....*....|....*..
gi 961658101  569 ALESCSFARHSLLQTLY 585
Cdd:pfam07834 161 VLESCSSARHALLQTLH 177
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
99-353 3.94e-23

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 102.18  E-value: 3.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  99 ALISLGEGLitAGAQLVELDLSDNAFGPDGVQGFEALLKSSAcfTLQELKLNNCGMGIGGGKILAAALTECHRKSSaqgk 178
Cdd:COG5238  169 AAISMAKAL--QNNSVETVYLGCNQIGDEGIEELAEALTQNT--TVTTLWLKRNPIGDEGAEILAEALKGNKSLTT---- 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 179 pLALkvfvaGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAE 258
Cdd:COG5238  241 -LDL-----SNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAE 314
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 259 TLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGlPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGC 338
Cdd:COG5238  315 GLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
                        250
                 ....*....|....*
gi 961658101 339 EQLQEVLEGFNMAKV 353
Cdd:COG5238  394 EALIDALQTNRLHTL 408
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
323-346 1.63e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.93  E-value: 1.63e-04
                           10        20
                   ....*....|....*....|....
gi 961658101   323 LEKLDLNGNTLGEEGCEQLQEVLE 346
Cdd:smart00368   4 LRELDLSNNKLGDEGARALAEALK 27
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
21-358 1.75e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 320.46  E-value: 1.75e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  21 GQLSFKGKSLKlntAEDAKDVIKEIEDfdsLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRlrteIPPAL 100
Cdd:cd00116    1 LQLSLKGELLK---TERATELLPKLLC---LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGR----IPRGL 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 101 ISLGEGLITaGAQLVELDLSDNAFGPDGVQGFEALLKSSacfTLQELKLNNCGMGIGGGKILAAALTEChrkssaqgkPL 180
Cdd:cd00116   71 QSLLQGLTK-GCGLQELDLSDNALGPDGCGVLESLLRSS---SLQELKLNNNGLGDRGLRLLAKGLKDL---------PP 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 181 ALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETL 260
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 261 KTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQ 340
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297
                        330
                 ....*....|....*....
gi 961658101 341 LQEVLEGF-NMAKVLASLS 358
Cdd:cd00116  298 LAESLLEPgNELESLWVKD 316
RanGAP1_C pfam07834
RanGAP1 C-terminal domain; Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for ...
409-585 1.04e-96

RanGAP1 C-terminal domain; Ran-GTPase activating protein 1 (RanGAP1) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localization at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1). This domain is composed almost entirely of helical substructures that are organized into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation.


Pssm-ID: 462282  Cd Length: 177  Bit Score: 292.40  E-value: 1.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  409 TPSRKILDPNTGEPApvlSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRM 488
Cdd:pfam07834   4 EPEKKINGNKVSTPP---SAPRPPDVSSFLAFPSPEKLLRLGPKRSQLIQQQVDVSDAEKVVEAFLKISSVYKEETEVKT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  489 AVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNS 568
Cdd:pfam07834  81 AVLETIDALLRKAFSSPSFQSYLFISSLLVHMGLLKSEDKIKPVPVVPGHLLALEHAVQQDYFPKELAPVLLAFMSRPNR 160
                         170
                  ....*....|....*..
gi 961658101  569 ALESCSFARHSLLQTLY 585
Cdd:pfam07834 161 VLESCSSARHALLQTLH 177
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
99-353 3.94e-23

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 102.18  E-value: 3.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  99 ALISLGEGLitAGAQLVELDLSDNAFGPDGVQGFEALLKSSAcfTLQELKLNNCGMGIGGGKILAAALTECHRKSSaqgk 178
Cdd:COG5238  169 AAISMAKAL--QNNSVETVYLGCNQIGDEGIEELAEALTQNT--TVTTLWLKRNPIGDEGAEILAEALKGNKSLTT---- 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 179 pLALkvfvaGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAE 258
Cdd:COG5238  241 -LDL-----SNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAE 314
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 259 TLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGlPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGC 338
Cdd:COG5238  315 GLQGNKTLHTLNLAYNGIGAQGAIALAKALQEN-TTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
                        250
                 ....*....|....*
gi 961658101 339 EQLQEVLEGFNMAKV 353
Cdd:COG5238  394 EALIDALQTNRLHTL 408
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
50-346 1.87e-22

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 100.25  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  50 SLEALRLEGNTVGVEAARVIAKALekkselkrchwsdmftgrlrteippalislgegliTAGAQLVELDLSDNAFGPDGV 129
Cdd:COG5238  181 SVETVYLGCNQIGDEGIEELAEAL-----------------------------------TQNTTVTTLWLKRNPIGDEGA 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 130 QGFEALLKSSAcfTLQELKLNNCGMGIGGGKILAAALTECHRKSSaqgkpLALkvfvaGRNRLENDGATALAEAFRVIGT 209
Cdd:COG5238  226 EILAEALKGNK--SLTTLDLSNNQIGDEGVIALAEALKNNTTVET-----LYL-----SGNQIGAEGAIALAKALQGNTT 293
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 210 LEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIR 289
Cdd:COG5238  294 LTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 961658101 290 GGlPKLKELNLSFCEIKrDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLE 346
Cdd:COG5238  374 GN-TTLRELNLGKNNIG-KQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
96-358 1.16e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 63.66  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  96 IPPALISLGEGLITAGAQLVELDLSDNAfgpdgvQGFEALLKSSACFTLQELKLNNCGMGIGggkILAAALTECHRKSSA 175
Cdd:COG5238   74 NPVALEKAAEAFPTQLLVVDWEGAEEVS------PVALAETATAVATPPPDLRRIMAKTLED---SLILYLALPRRINLI 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 176 QGKPLaLKVFVAGRNRLENDGATALA----EAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEK 251
Cdd:COG5238  145 QVLKD-PLGGNAVHLLGLAARLGLLAaismAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDE 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 252 GAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGlPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN 331
Cdd:COG5238  224 GAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVN 302
                        250       260
                 ....*....|....*....|....*..
gi 961658101 332 TLGEEGCEQLQEVLEGfnmAKVLASLS 358
Cdd:COG5238  303 RIGDEGAIALAEGLQG---NKTLHTLN 326
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
49-288 4.03e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 4.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101  49 DSLEALRLEGNTVGVEAARVIAKALEKKSELKrchwsdmftgrlrteippalislgeglitagaqlvELDLSDNAFGPDG 128
Cdd:COG5238  264 TTVETLYLSGNQIGAEGAIALAKALQGNTTLT-----------------------------------SLDLSVNRIGDEG 308
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 129 VQGFEALLKSSAcfTLQELKLNNCGMGigggkilaaaltechrkssaqgkplalkvfvagrnrleNDGATALAEAFRVIG 208
Cdd:COG5238  309 AIALAEGLQGNK--TLHTLNLAYNGIG--------------------------------------AQGAIALAKALQENT 348
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 209 TLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTlRQVEVINFGDCLVRSKGAVAIADAI 288
Cdd:COG5238  349 TLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
323-346 1.63e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.93  E-value: 1.63e-04
                           10        20
                   ....*....|....*....|....
gi 961658101   323 LEKLDLNGNTLGEEGCEQLQEVLE 346
Cdd:smart00368   4 LRELDLSNNKLGDEGARALAEALK 27
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
235-261 3.75e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 3.75e-04
                           10        20
                   ....*....|....*....|....*..
gi 961658101   235 NPLLRVINLNDNTFTEKGAVAMAETLK 261
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-349 1.71e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 108 ITAGAQLVELDLSDNAFG--PDGVQGFEALlkssacftlQELKLNNCGMgigggKILAAALTECHrkssaqgkplALKVF 185
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTdlPEELANLTNL---------KELDLSNNQL-----TDLPEPLGNLT----------NLKSL 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 186 VAGRNRLENdgataLAEAFRVIGTLEEVHMPQNGInhpgiTALAQAFAVNPLLRVINLNDNTFTEkgavaMAETLKTLRQ 265
Cdd:COG4886  165 DLSNNQLTD-----LPEELGNLTNLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTN 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961658101 266 VEVINFGDCLVRSKGAVaiadairGGLPKLKELNLSFCEIKRdaalavAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345
Cdd:COG4886  230 LETLDLSNNQLTDLPEL-------GNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLL 296

                 ....
gi 961658101 346 EGFN 349
Cdd:COG4886  297 GLNS 300
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
143-168 4.25e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 4.25e-03
                           10        20
                   ....*....|....*....|....*.
gi 961658101   143 TLQELKLNNCGMGIGGGKILAAALTE 168
Cdd:smart00368   3 SLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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