|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
5-1016 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 1486.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 5 KGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKgKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCC 84
Cdd:PLN02959 7 KSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPGE-KFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 85 LFPFGLHCTGMPI---------------------------------------------------KSKAAAKAGSSKYQWG 113
Cdd:PLN02959 86 LLPFAFHCTGMPIkasadklareiqqygnppvfpeededeaaavaaakaeaeaaaappdkfkgkKSKAVAKSGTQKYQWE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 114 IMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTI 193
Cdd:PLN02959 166 IMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKKGKIVKDKRYTI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 194 YSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETV 273
Cdd:PLN02959 246 YSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLPPFPGKLKALEGKKVFLAAATLRPETMYGQTNCWVLPDGKYGAYEIN 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 274 NGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDD 353
Cdd:PLN02959 326 DTEVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTILTDKGTGVVTSVPSDSPDD 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 354 IAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLV 433
Cdd:PLN02959 406 YMALSDLKAKPALRAKYGVKDEWVLPFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKLAEAKRLTYLKGFTDGTMLV 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 434 DGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRR 513
Cdd:PLN02959 486 GEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWKKKAEKCLSKMNLYSDETRH 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 514 NFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPlgIRPQQMTKEVWDYVF 593
Cdd:PLN02959 566 GFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGGDMYGKDKSS--IKPEQMTDEVWDFVF 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 594 FKeAPFPKT-QIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsDKWPTAVRANGHLLLNSEKMS 672
Cdd:PLN02959 644 CG-GPLPKSsDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAE--EHWPRGFRCNGHLMLNSEKMS 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 673 KSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFA 752
Cdd:PLN02959 721 KSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAAESSLRTGPPSTYADRVFE 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 753 SELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYR-ELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIW-TLLGK 830
Cdd:PLN02959 801 NEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRlSCGSGGMNRDLVWRFMDVQTRLITPICPHYAEHVWrEILKK 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 831 PDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCT---IYVAKNYPPWQHTTLS 907
Cdd:PLN02959 881 EGFAVTAGWPVAGEPDLTLKRANKYLQDSIVSFRKLLQKQLAGSKKAKKGGAPVTLPEKKLaglIYVAEKYDGWKEECLR 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 908 VLRKHFEANNGKL-PDNKVIA----SELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLT 982
Cdd:PLN02959 961 ILQSKFDSQSRTFaPDAEILEalkeSSVGQEANFKQVQKLCMPFVKFKKDEAIAVGPQALDLKLPFDEIEVLQENLELIK 1040
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....
gi 964751093 983 NSLELEHIEVKFASEAEDKIR----------EDCCPGKPLNVFR 1016
Cdd:PLN02959 1041 RQLGLEEVEILSASDPDAVAKagahasllkqNPPSPGNPVAIFV 1084
|
|
| leuS_arch |
TIGR00395 |
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ... |
14-1011 |
0e+00 |
|
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273056 [Multi-domain] Cd Length: 938 Bit Score: 862.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 14 KKIEKEIQQKWDTERVFEVNASNLEKqtskgkYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCT 93
Cdd:TIGR00395 1 IAIEKKWQKRWEEAHIFEADPDDREK------FFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKNVLFPLGFHVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 94 GMPIKSKAAA-KAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFV 172
Cdd:TIGR00395 75 GTPILGLAELiKRRDELTIKNYTEVHAIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 173 RWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEpypsklsglkgKNIFLVAATLRPET 252
Cdd:TIGR00395 153 EWQMNKLKELGLIVKGEHPVRYCPKDGNPVEDHDLLSGEGVTIVEYILIKFELED-----------GAFYFVAATLRPET 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 253 MFGQTNCWVRPDMKYIGFEtVNGDIFICTQKAARNMSYQGFTkdngvVPVVKELMGEEILGASLSAPLTsYKVIYVLPML 332
Cdd:TIGR00395 222 VYGVTNCWVNPTITYVIAE-VGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNPVV-GPEVPILPAE 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 333 TIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALrakYGIRDdMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDRE 412
Cdd:TIGR00395 295 FVDTTKGTGVVMSVPAHAPDDYIALEDLLHDPEY---LGIKP-VVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKN 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 413 KLAEAKEKIYLKGFYEGIML--VDGFKGQKVQDVKKTIQKKMIDAGDALIYMEP-EKQVMSRSSDECVVALC-DQWYLDY 488
Cdd:TIGR00395 371 LLEEATKILYKEEYHTGVMIynIPPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKVVeDQWFVKY 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 489 GEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGN 568
Cdd:TIGR00395 451 SDESWKELAHECLEGMRIIPEEVKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDY 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 569 lhgqaesplgIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWP 648
Cdd:TIGR00395 531 ----------YGNEQMTDEFFDYIFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFP 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 649 EqsDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWV 728
Cdd:TIGR00395 601 E--KFWPRGIVVNGYVMLEGKKMSKSKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFA 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 729 KEmVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRElAVEGMHRELVFRFIEV 808
Cdd:TIGR00395 679 EE-ITKESNLETGEETSFIDRWLESRMNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRR-RGGVNHKDVLARYLET 756
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 809 QTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAG--PVNEVLIHSSQYLMEVTHDLRlrlknymmpaKGKKTDKqplQK 886
Cdd:TIGR00395 757 WIKLLAPFAPHFAEEMWEEVGNEGFVSLAKFPEASepAVDKEVEAAEEYLRNLVRDIQ----------EIAKIDA---SK 823
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 887 PSHCTIYVAknyPPWQHTTLSVLRKHFEANNGKlpDNKVIASElgsmPELKKYMKKVMPFVAMIKENLEKmgprilDLQL 966
Cdd:TIGR00395 824 PKRVYLYTS---EDWKSQCLKIVAELFGEDTGE--DMKKVMEE----PEERKRGKEVISLVKQIIKDEKK------EDEL 888
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*.
gi 964751093 967 EFDEKAVLMENIVYLTNSLELEHI-EVKFASEAEDKiREDCCPGKP 1011
Cdd:TIGR00395 889 QISEIEVLKAAARFIKKEVGALVIiEFSADSFPENK-KRNAVPGKP 933
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
59-1011 |
0e+00 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 760.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 59 LHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKSKAAA-KAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDY 137
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAERiARGDPETIELYKSLYGIPEEELEKFKDPEYIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 138 FPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQE 217
Cdd:PRK12300 81 FSEEAKEDMKRIGYSIDWRREFTTTD--PEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPEIVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 218 YTLLKLKvlepypsklsglKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFEtVNGDIFICTQKAARNMSYQGFTkdn 297
Cdd:PRK12300 159 YTLIKFE------------ESEDLILPAATLRPETIFGVTNLWVNPDATYVKAE-VDGEKWIVSKEAAEKLSFQDRD--- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 298 gvVPVVKELMGEEILGASLSAPLTSYKVIyVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKygirddmv 377
Cdd:PRK12300 223 --VEIIEEIKGSELIGKKVKNPVTGKEVP-ILPADFVDPDNGTGVVMSVPAHAPYDYVALRDLKKNKELLDV-------- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 378 lpFEPVPVIEIPGFGNLSAVTICDELKIQSQNDReKLAEAKEKIYLKGFYEGIMLVD--GFKGQKVQDVKKTIQKKMIDA 455
Cdd:PRK12300 292 --IEPIPLIEVEGYGEFPAKEVVEKLGIKSQEDP-ELEEATKEVYRAEFHKGVLKENtgEYAGKPVREAREKITKDLIEK 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 456 GDALIYME-PEKQVMSRSSDECVVA-LCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGL 533
Cdd:PRK12300 369 GIADIMYEfSNRPVYCRCGTECVVKvVKDQWFIDYSDPEWKELAHKALDNMEIIPEEYRKEFENTIDWLKDRACARRRGL 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 534 GTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGnlhgqaesplGIRPQQMTKEVWDYVF----FKEAPFPKTQIAKEKL 609
Cdd:PRK12300 449 GTRLPWDEEWIIESLSDSTIYMAYYTIAHKIREY----------GIKPEQLTPEFFDYVFlgkgDPEEVSKKTGIPKEIL 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 610 DQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFS 689
Cdd:PRK12300 519 EEMREEFLYWYPVDWRHSGKDLIPNHLTFFIFNHVAIFPE--EKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYG 596
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 690 ADGMRLALADAGDTVEDANFVEAMADAGILRLytwvEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKM 769
Cdd:PRK12300 597 ADVVRLYLTSSAELLQDADWREKEVESVRRQL----ERFYELAKELIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESF 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 770 MFKEALKTGFFEFQAAKDKYRELaVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGP--VNE 847
Cdd:PRK12300 673 QTRDAVQEAFYELLNDLRWYLRR-VGEANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDEskIDE 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 848 VLIHSSQYLMEVTHDLRlRLKNYmmpAKGkktdkqplqKPSHCTIYVAknyPPWQHTTLSVLRkhfeanngKLPDNKVIA 927
Cdd:PRK12300 752 EAELAEEYVKRLIEDIR-EILKV---AKI---------KPKKVYIYVA---PDWKYEVLEIAA--------ENGDVKEAI 807
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 928 SELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDL-QLEFDEKAVLMENIVYLTNSLELEhIEVKFASEAE-DKIRED 1005
Cdd:PRK12300 808 KELMKDEELRKHGKEVAKLAQKIVKEVLKLDKEVRKLiLKNIDEEEVLEEAKDFLEKELGVE-VEIYGADDPGkKKKKKK 886
|
....*.
gi 964751093 1006 CCPGKP 1011
Cdd:PRK12300 887 ALPLKP 892
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
479-711 |
1.59e-72 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 243.69 E-value: 1.59e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 479 ALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGwlqehaCSRTYGLGTHLPWdeQWLIESLSDSTIYMAFY 558
Cdd:cd00812 127 KLLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARY 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 559 TVAHLLQggnlhgqaesplgirpqqmtkevwdyvffkeapfpktQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSY 638
Cdd:cd00812 199 TDAHNLE-------------------------------------QPYEGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLY 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 964751093 639 YLYNHVAMWPEQ--SDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDtvEDANFVE 711
Cdd:cd00812 242 SRFNHKALFDEGlvTDEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
709-828 |
3.18e-51 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 175.86 E-value: 3.18e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 709 FVEAMADAGILRLYTWVEWVKEMVANWDSLrsgPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDK 788
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGEL---EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDW 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 964751093 789 YRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLL 828
Cdd:cd07959 78 YRERGGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
45-183 |
9.91e-32 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 126.59 E-value: 9.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 45 KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKSKAaakagsskyqwgimkslglsdEE 124
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAA---------------------IK 59
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 964751093 125 IVKfsEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERN 183
Cdd:cd00812 60 IGR--DPEDWTEYNIKKMKEQLKRMGFSYDWRREFTTCD--PEYYKFTQWLFLKLYEKG 114
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
14-1006 |
6.10e-30 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 128.25 E-value: 6.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 14 KKIEKEIQQKWDTERVFEVNASnlekqTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCT 93
Cdd:TIGR00422 8 HEVEKKWYKKWEKSGFFKPDGN-----SNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 94 GMPIKSKAAAKA---GSSKYQWGimkslglsDEEIVKfsEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDS 170
Cdd:TIGR00422 83 GIATQVKVEKKLgaeGKTKHDLG--------REEFRE--KIWEWKEESGGTIKNQIKRLGASLDWSRERFTMD--EGLSK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 171 FVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKvlepypsklsglKGKNIFLVAATLRP 250
Cdd:TIGR00422 151 AVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLA------------NGSKDYLVVATTRP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 251 ETMFGQTNCWVRP-DMKYigfetvngdifictqkaarnmsyqgftkdngvvpvvKELMGEEILgaslsAPLTSYKViyvl 329
Cdd:TIGR00422 219 ETMFGDTAVAVHPeDERY------------------------------------KHLIGKKVI-----LPLTGRKI---- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 330 PMLT---IKEDKGTGVVTSVPSDSPDDIAalrdLKKKQALrakygirddmvlpfEPVPVIEIPGFGNLSAvticdeLKIQ 406
Cdd:TIGR00422 254 PIIAdeyVDMEFGTGAVKVTPAHDFNDYE----WGKRHNL--------------EFINILDEDGLLNENA------GKYQ 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 407 SQndreKLAEAKEKIylkgfyegimlvdgfkgqkVQDVKKtiQKKmidagdaLIYMEPEKQ---VMSRSSDECVVALCDQ 483
Cdd:TIGR00422 310 GL----TRFEARKKI-------------------VEDLKE--EGL-------LVKIEPHTHnvgTCWRSGTVVEPLLSKQ 357
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 484 WYLDYgeENWKKQTSQCLKNLE-TFCEEtrrNFEATL-GWLQEHA--C-SRTYGLGTHLPwdeqwlieslsdstiymAFY 558
Cdd:TIGR00422 358 WFVKV--EKLADKALEAAEEGEiKFVPK---RMEKRYlNWLRNIKdwCiSRQLIWGHRIP-----------------VWY 415
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 559 TVahllQGGNLHGQAESPLGIRPQQMT--------KEVWDyVFFKEA--PFPKTQIAKEKLDqlkqeFEFWYPVDLRVSG 628
Cdd:TIGR00422 416 CK----ECGEVYVAKEEPLPDDKTNTGpsveleqdTDVLD-TWFSSSlwPFSTLGWPDETKD-----LKKFYPTDLLVTG 485
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 629 KDLVPNHLSYYLYNHVAMwpEQSDKWPTA-----VR-ANGHlllnseKMSKSTGNFLTLTQAIDKFSADGMRLALADAGD 702
Cdd:TIGR00422 486 YDIIFFWVARMIFRSLAL--TGQVPFKEVyihglVRdEQGR------KMSKSLGNVIDPLDVIEKYGADALRFTLASLVT 557
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 703 TVEDANFVEAMADAG---ILRLYTWVEWVKEMVANWDSLrSGPASTFN--DRVFASELNAGIIKTDQNYEKMMFKEALKt 777
Cdd:TIGR00422 558 PGDDINFDWKRVESArnfLNKLWNASRFVLMNLSDDLEL-SGGEEKLSlaDRWILSKLNRTIKEVRKALDKYRFAEAAK- 635
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 778 GFFEF----------QAAK--DKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIW-TLLGKPDSIMNASWPVAGP 844
Cdd:TIGR00422 636 ALYEFiwndfcdwyiELVKyrLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWqHFKEGADSIMLQSYPVVDA 715
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 845 --VNEVLIHSSQYLMEVTHDLRLRLKNYMMPAkgkktdKQPLQKpshCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLpd 922
Cdd:TIGR00422 716 efVDEEAEKAFELLKEIIVSIRNLKAESNIPP------NAPLKV---LLIYTEAETAERLKLNAVDIKGAINFSEVEV-- 784
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 923 nkviaseLGSMPELKKYMKKVMPFVAMI--KENLEKMGPRILDLQLEFDEKavLMENIVyLTNSLELEHIEVKFASEAED 1000
Cdd:TIGR00422 785 -------VIEKPEVTEAVVELVPGFEIIipVKGLINKAKELARLQKQLDKE--KKEVIR-IEGKLENEGFVKKAPKEVIE 854
|
....*.
gi 964751093 1001 KIREDC 1006
Cdd:TIGR00422 855 KEKEKL 860
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
20-709 |
3.32e-28 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 121.36 E-value: 3.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 20 IQQKWDTERVFEvnaSNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKS 99
Cdd:pfam00133 2 IYEFWDEQGYFK---PELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 100 KAAAKAGSSKYQwgIMKSLGLsdEEIVkfSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTL 179
Cdd:pfam00133 79 VVEKKLGIKEKK--TRHKYGR--EEFR--EKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 180 RERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVlepypsklsglkGKNIFLVAATLRPETMFGQTNC 259
Cdd:pfam00133 151 HDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLAD------------DEGASLVIWTTTPWTLPGNTAV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 260 WVRPDMKYIgfetVNGDIFICTQKAARNMSYQGFTKDngvvpVVKELMGEEILGASLSAPLTSYKViyvlPMLT---IKE 336
Cdd:pfam00133 219 AVNPEFDYV----ITGEGYILAEALLKSLYKKGTDKK-----ILEDFRGKELEGKEAIHPFVNREI----PIITddyVDM 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 337 DKGTGVVTSVPSDSPDDIAALRdlkkkqalraKYGIrdDMVLPFEPVPVIeipgfgnlsavticdelkiqsqndREKLAE 416
Cdd:pfam00133 286 EFGTGAVHIAPAHGENDYEVGQ----------RHNL--EVINPVDDDGTF------------------------TEEAPD 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 417 akekiylkgfyegimlvdgFKGQKVQDVKKTIQKKMIDAGdalIYMEPEKQVMS-----RSSDECVVALCDQWYLdygee 491
Cdd:pfam00133 330 -------------------FQGVYRFDARKKIVELLTEKG---LLLKIEPFTHSypfcwRSGTPIIPRATPQWFV----- 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 492 NWKKQTSQCLKNLE--TFCEETRRN-FEATLGWLQEHACSRTYGLGTHLPWdeqWLIESLSDstIYMA---FYTVAHLLQ 565
Cdd:pfam00133 383 RMDELADQALEAVEkvQFVPKSGEKrYFNWLANIQDWCISRQRWWGHPIPA---WVSKDTEE--VVCRgelFELVAGRFE 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 566 GG----NLHGQAESPLGIRPQQMTK--EVWDyVFFKEAPFPKTQIakEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYY 639
Cdd:pfam00133 458 EEgsikWLHREAKDKLGYGKGTLEQdeDVLD-TWFSSGSWPFSTL--GWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRM 534
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 964751093 640 LYNHVAMWPEQSDKwptAVRANGhLLLNSE--KMSKSTGNFLTLTQAIDKFSADGMRLALADAgDTVEDANF 709
Cdd:pfam00133 535 IMLSTALTGSVPFK---NVLVHG-LVRDEQgrKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINL 601
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
450-698 |
2.29e-20 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 93.25 E-value: 2.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 450 KKMIDAGdaLIYmepekqvmsrsSDECVVALCDQWYLDYGEenWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSR 529
Cdd:cd00668 121 SRLYEKG--LIY-----------RGTHPVRITEQWFFDMPK--FKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISR 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 530 TYGLGTHLPwdeQWLIESLSDSTIYMAFYTvahllqgGNLHGqaesplgirpqqmtkevwdyvffkeapfpktqiakekl 609
Cdd:cd00668 186 QRYWGTPLP---EDVFDVWFDSGIGPLGSL-------GYPEE-------------------------------------- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 610 dqlKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEqsdKWPTAVRANGHLLLN-SEKMSKSTGNFLTLTQAIDKF 688
Cdd:cd00668 218 ---KEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGE---IPPKNLLVHGFVLDEgGQKMSKSKGNVIDPSDVVEKY 291
|
250
....*....|
gi 964751093 689 SADGMRLALA 698
Cdd:cd00668 292 GADALRYYLT 301
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
45-196 |
1.24e-19 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 90.94 E-value: 1.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 45 KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKSKAAAKAGSSKyqwgimkslglSDEE 124
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKK-----------KTIW 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 964751093 125 IVKFSEA-EHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSP 196
Cdd:cd00668 70 IEEFREDpKEFVEEMSGEHKEDFRRLGISYDWSDEYITTE--PEYSKAVELIFSRLYEKGLIYRGTHPVRITE 140
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
748-864 |
4.19e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 78.98 E-value: 4.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 748 DRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQ---------AAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCP 818
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWndlsdwyleLIKDRLYGEEPDSRAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 964751093 819 HLCEHIWtllgKPDSIMNASWPVAGPVNEVLIHSS-QYLMEVTHDLR 864
Cdd:pfam08264 81 FITEELW----QKESIHLAPWPEDAELEEAELEEAfELRQEIVQAIR 123
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
628-842 |
1.70e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 84.01 E-value: 1.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 628 GKDLVpnhlsyylYNHVAMWP---EQSD-KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDT 703
Cdd:COG0143 289 GKDII--------RFHAIIWPamlMAAGlPLPKKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPF 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 704 VEDANFveamadagilrlyTWVEWV----KEMVANWDSL--RS--------------GPASTFNDRVFASELNAGIIKTD 763
Cdd:COG0143 361 GQDGDF-------------SWEDFVarvnSDLANDLGNLasRTlsmihkyfdgkvpePGELTEADEELLAEAEAALEEVA 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 764 QNYEKMMFKEALKT---------GFFEFQA----AKDKYRELAVEGMHREL-VFRFIevqTLLLAPFCPHLCEHIWTLLG 829
Cdd:COG0143 428 EAMEAFEFRKALEEimalaraanKYIDETApwklAKDEDPERLATVLYTLLeALRIL---AILLKPFLPETAEKILEQLG 504
|
250
....*....|....*.
gi 964751093 830 KPDSIMN---ASWPVA 842
Cdd:COG0143 505 LEGDELTwedAGWPLP 520
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
13-199 |
2.49e-13 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 74.46 E-value: 2.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 13 LKKIEKEIQQKWDTERVFEVNASNLEKQtskgkYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHC 92
Cdd:PRK13208 12 PEELEEKWQKIWEEEGTYKFDPDERKPV-----YSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 93 TGMPIKSKAAAKAGSSKYQWG----IMKSLGLSDEEIVKFSEAehwldyfpplaiqdLKRMGLKVDWRRSFITTDvnPYY 168
Cdd:PRK13208 87 NGLPTERKVEKYYGIRKDDISreefIELCRELTDEDEKKFREL--------------WRRLGLSVDWSLEYQTIS--PEY 150
|
170 180 190
....*....|....*....|....*....|.
gi 964751093 169 DSFVRWQFLTLRERNKIKFGKRYTIYSPKDG 199
Cdd:PRK13208 151 RRISQKSFLDLYKKGLIYRAEAPVLWCPRCE 181
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
656-842 |
1.94e-12 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 71.62 E-value: 1.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 656 TAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL------------ADAGdtVEDAN-FVEamadagilRLY 722
Cdd:COG0495 575 LEVGKDGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEmfagpperdlewSDSG--VEGAYrFLN--------RVW 644
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 723 TwvewvkeMVANWDSLRSGPASTFN--DRVFASELNAGIIKTDQNYEKMMFKEA------LKTGFFEFQAAKDKYRELAV 794
Cdd:COG0495 645 R-------LVVDEAEALKLDVADLSeaDKELRRALHKTIKKVTEDIERLRFNTAiaalmeLVNALYKAKDSGEADRAVLR 717
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 964751093 795 EGMhrelvfrfiEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVA 842
Cdd:COG0495 718 EAL---------ETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEA 756
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
44-199 |
5.23e-12 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 68.81 E-value: 5.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 44 GKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKS---KAAAKAGSSKYQWG----IMK 116
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvveKKLGIEGKTRHDLGreefLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 117 SLGLSDEEIVKFSEAehwldyfpplaiqdLKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSP 196
Cdd:cd00817 81 CWEWKEESGGKIREQ--------------LKRLGASVDWSREYFTMD--PGLSRAVQEAFVRLYEKGLIYRDNRLVNWCP 144
|
...
gi 964751093 197 KDG 199
Cdd:cd00817 145 KLR 147
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
17-1003 |
1.41e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 68.81 E-value: 1.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 17 EKEIQQKWDTERVFEVNAsnlekqTSKGKYFV-TFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGM 95
Cdd:PLN02943 66 EERIYNWWESQGYFKPNF------DRGGDPFViPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 96 PIK---SKAAAKAGsskyqwgiMKSLGLSDEEIVKfsEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNpyYDSFV 172
Cdd:PLN02943 140 ATQlvvEKMLASEG--------IKRTDLGRDEFTK--RVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQ--LSRAV 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 173 RWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGpqeyTLLKLKvlepYPskLSGlkGKNIFLVAATLRPET 252
Cdd:PLN02943 208 VEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPG----TLYYIK----YR--VAG--GSEDFLTIATTRPET 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 253 MFGQTNCWVRPDMKyigfetvngdifictqkaarnmSYQGFTKDNGVVPVVkelMGEEIlgaslsaPLTSYKviYVLPml 332
Cdd:PLN02943 276 LFGDVAIAVNPEDD----------------------RYSKYIGKMAIVPMT---YGRHV-------PIIADR--YVDK-- 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 333 tikeDKGTGVVTSVPSDSPDDIAALRDLKkkqalrakygirddmvLPFepVPVIEIPGfgnlsavTICDELKIQSQNDRE 412
Cdd:PLN02943 320 ----DFGTGVLKISPGHDHNDYLLARKLG----------------LPI--LNVMNKDG-------TLNEVAGLYWFEARE 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 413 KLAEAKEKIYL--KGFYEGIMLVDGFKGQKVqdVKKTIQKKMidagdaLIYMEP--EKQVMSRSSDECVVAlcdqwyldy 488
Cdd:PLN02943 371 KLWSDLEETGLavKKEPHTLRVPRSQRGGEV--IEPLVSKQW------FVTMEPlaEKALKAVENGELTII--------- 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 489 gEENWKKQTSQCLKNLETFCeetrrnfeatlgwlqehaCSRTYGLGTHLPwdeQWLIESLSDSTIYMAFYTVAHLLQggn 568
Cdd:PLN02943 434 -PERFEKIYNHWLSNIKDWC------------------ISRQLWWGHRIP---VWYIVGKDCEEDYIVARSAEEALE--- 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 569 lhgQAESPLGiRPQQMTKE--VWDyVFFKEAPFPKTQIAKEklDQLKQEFEFWYPVDLRVSGKDLvpnhLSYYLYNHVAM 646
Cdd:PLN02943 489 ---KAREKYG-KDVEIYQDpdVLD-TWFSSALWPFSTLGWP--DVSAEDFKKFYPTTVLETGHDI----LFFWVARMVMM 557
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 647 WPEQSDKWP-TAVRANGhLLLNSE--KMSKSTGNFLTLTQAIDKFSADGMRLALAdAGDTVEDAN-----------FVEA 712
Cdd:PLN02943 558 GIEFTGTVPfSYVYLHG-LIRDSQgrKMSKTLGNVIDPLDTIKEFGTDALRFTLA-LGTAGQDLNlsterltsnkaFTNK 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 713 MADAGILRLYTWVEwvKEMVANWDSLRSGPAST--------FNDRVFASELNAGIIKTDQNYEKMMFKEALKTGF-FEFQ 783
Cdd:PLN02943 636 LWNAGKFVLQNLPS--QSDTSAWEHILACKFDKeesllslpLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYdFFWS 713
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 784 AAKDKYRELAVEGM-HRELVFRFIEVQTLL----------LAPFCPHLCEHIWTLLGKP-DSIMNASWPVAG-PVNEVLI 850
Cdd:PLN02943 714 DFADWYIEASKTRLyHSGDNSALSRAQAVLlyvfenilklLHPFMPFVTEELWQALPYRkEALIVSPWPQTSlPKDLKSI 793
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 851 HSSQYLMEVTHDLRLRLKNYMMpakgkktdkQPLQKPSHCTIYVAKN--YPPWQHTTLSVLRK------HFEANNgklPD 922
Cdd:PLN02943 794 KRFENLQSLTRAIRNARAEYSV---------EPAKRISASIVASAEVieYISKEKEVLALLSRldlqnvHFTDSP---PG 861
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 923 NKVIASELGSMPELKKYmkkvMPFVAM--IKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLE--LEHIEVKfASEA 998
Cdd:PLN02943 862 DANQSVHLVASEGLEAY----LPLADMvdISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEdvVRGVREK-AAEA 936
|
....*
gi 964751093 999 EDKIR 1003
Cdd:PLN02943 937 EEKIK 941
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
628-832 |
1.33e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 65.56 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 628 GKDLVpnhlsyylYNHVAMWP---EQSD-KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALA-DAGD 702
Cdd:PRK00133 291 GKDII--------YFHTLFWPamlEGAGyRLPTNVFAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAaKLPE 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 703 TVEDANFveamadagilrlyTWVEWVK----EMVANWDSL--RS----------GPASTFNDRVFASELNAGIIKTDQNY 766
Cdd:PRK00133 363 TIDDLDF-------------NWEDFQQrvnsELVGKVVNFasRTagfinkrfdgKLPDALADPELLEEFEAAAEKIAEAY 429
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 767 EKMMFKEALKT---------GFFEFQA----AKDKYRELAvEGMHREL-VFRFIevqTLLLAPFCPHLCEHIWTLLGKPD 832
Cdd:PRK00133 430 EAREFRKALREimaladfanKYVDDNEpwklAKQDGERLQ-AVCSVGLnLFRAL---AIYLKPVLPELAERAEAFLNLEE 505
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
13-161 |
2.95e-10 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 64.72 E-value: 2.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 13 LKKIEKEIQQKWDTERVFEvnasNLEKQTSKGKYFVtF---PyPYMNGRLHLGHTfsLSKC--EFAVGYQRLKGKCCLFP 87
Cdd:COG0060 18 LPKREPEILKFWEENDIYE----KSREARAGRPKFV-LhdgP-PYANGDIHIGHA--LNKIlkDIIVRYKTMRGFDVPYV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 88 FGLHCTGMPIkskaaakagsskyQWGIMKSLGLSDEEIVKFSEAE----------HWLDyfpplaIQ--DLKRMGLKVDW 155
Cdd:COG0060 90 PGWDCHGLPI-------------ELKVEKELGIKKKDIEKVGIAEfrekcreyalKYVD------EQreDFKRLGVWGDW 150
|
....*.
gi 964751093 156 RRSFIT 161
Cdd:COG0060 151 DNPYLT 156
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
670-878 |
3.81e-10 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 64.36 E-value: 3.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 670 KMSKSTGNF---LTLtqaIDKFSADGMRLALAdagdtvedanfveAMADAGI-LRL-YTWVE---------W-----VKE 730
Cdd:PRK05729 520 KMSKSKGNVidpLDL---IDKYGADALRFTLA-------------ALASPGRdIRFdEERVEgyrnfanklWnasrfVLM 583
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 731 MVANWDSLRSGPASTFN--DRVFASELNAGIIKTDQNYEKMMFKEALKT--GFF--EF-----QAAKDKYRELAVEGMHR 799
Cdd:PRK05729 584 NLEGADVGELPDPEELSlaDRWILSRLNRTVAEVTEALDKYRFDEAARAlyEFIwnEFcdwylELAKPVLQEAAKRATRA 663
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 800 ELVfRFIEvQTL-LLAPFCPHLCEHIWTLL---GKPDSIMNASWPVAGPV-NEVLIHSSQYLMEVTHDLRlRLKNYMMPA 874
Cdd:PRK05729 664 TLA-YVLE-QILrLLHPFMPFITEELWQKLaplGIEESIMLAPWPEADEAiDEAAEAEFEWLKELITAIR-NIRAEMNIP 740
|
....
gi 964751093 875 KGKK 878
Cdd:PRK05729 741 PSKK 744
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
589-844 |
3.93e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 64.46 E-value: 3.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 589 WDYVFFKEAPFPKTQIAKEKLdqlkqefEFWYPVDLRVSGKDLVPNHLSY------YLYN--------------HVAM-- 646
Cdd:PLN02563 591 WYYLRFMDPKNSNALVDKEKE-------KYWMPVDLYVGGAEHAVLHLLYarfwhkVLYDigvvstkepfqclvNQGMil 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 647 -------WPEQSDKWPTAVRANGHLLLNSE-----------------------------KMSKSTGNFLTLTQAIDKFSA 690
Cdd:PLN02563 664 geveytaFKDSDGEYVSADTADRLGELQQEkipeekviksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGA 743
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 691 DGMRLaladagdtvedanFVEAMadaGILR-LYTW----VEWVKEMVAN-WDSLRSGPAS--TFNDRVFASE-------- 754
Cdd:PLN02563 744 DSLRL-------------YEMFM---GPLRdSKTWstsgVEGVHRFLGRtWRLVVGAPLPdgSFRDGTVVTDeepsleql 807
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 755 --LNAGIIKTDQNYEKMMFKEALkTGFFEFQAAKDKYRELAVEgmhrelvfrFIEVQTLLLAPFCPHLCEHIWTLLGKPD 832
Cdd:PLN02563 808 rlLHKCIAKVTEEIESTRFNTAI-SAMMEFTNAAYKWDKVPRE---------AIEPFVLLLSPYAPHLAEELWFRLGHSN 877
|
330
....*....|..
gi 964751093 833 SIMNASWPVAGP 844
Cdd:PLN02563 878 SLAYEPWPEANP 889
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
670-864 |
8.36e-10 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 63.15 E-value: 8.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 670 KMSKSTGNF---LTLtqaIDKFSADGMRLALAdagdtvedanfveAMADAGI-LRLYT-WVE------------------ 726
Cdd:COG0525 522 KMSKSKGNVidpLDL---IDKYGADALRFTLA-------------ALASPGRdIKFDEeRVEgyrnfanklwnasrfvlm 585
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 727 WVKEMVANWDSLRSgpASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKT--GFF--EFQaakDKYRELA-------VE 795
Cdd:COG0525 586 NLEGFDPGLDPDPE--ELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQAlyDFVwnEFC---DWYLELAkprlyggDE 660
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 964751093 796 GMHRELVFRFIEV--QTL-LLAPFCPHLCEHIWTLLGKP---DSIMNASWPVAGP--VNEVLIHSSQYLMEVTHDLR 864
Cdd:COG0525 661 AAKRETRATLVYVleQILrLLHPFMPFITEEIWQKLPPRkegESIMLAPWPEADEelIDEEAEAEFEWLKEVISAIR 737
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
591-709 |
1.42e-09 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 61.54 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 591 YVFFkEAPFPKTQIAKEkLDQLKQEFEFWYPVDLRVS-----GKDLVpnhlsyylYNHVAMWP----EQSDKWPTAVRAN 661
Cdd:pfam09334 246 YVWL-DAPIGYISATKE-LSGNEEKWKEWWPNDPDTElvhfiGKDII--------YFHTIFWPamllGAGYRLPTTVFAH 315
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 964751093 662 GHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANF 709
Cdd:pfam09334 316 GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDF 363
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
618-834 |
2.10e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.44 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 618 FWyPVDLRVSGKDLVPNHLSYylynhvamWPEQ--SD--KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGM 693
Cdd:PRK11893 252 YW-PADVHLIGKDILRFHAVY--------WPAFlmAAglPLPKRVFAHGFLTLDGEKMSKSLGNVIDPFDLVDEYGVDAV 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 694 RLALA-------DaGDTVED----------ANFVEAMADAgilrlytwvewVKEMVANW--DSLRSGPASTFNDRVFASE 754
Cdd:PRK11893 323 RYFLLreipfgqD-GDFSREafinrinadlANDLGNLAQR-----------TLSMIAKNfdGKVPEPGALTEADEALLEA 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 755 LNAGIIKTDQNYEKMMFKEALK---------TGFFEFQA----AKDKYRELAVEGMHRELVFRFIevqTLLLAPFCPHLC 821
Cdd:PRK11893 391 AAALLERVRAAMDNLAFDKALEailalvraaNKYIDEQApwslAKTDPERLATVLYTLLEVLRGI---AVLLQPVMPELA 467
|
250
....*....|...
gi 964751093 822 EHIWTLLGKPDSI 834
Cdd:PRK11893 468 AKILDQLGVEEDE 480
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
647-847 |
6.57e-09 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 60.39 E-value: 6.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 647 WPEQSDK----WPTAVRANGHLLL--------------------------------NSEKMSKSTGNFLTLTQAIDKFSA 690
Cdd:PRK14900 479 WPEQTDTlrtfYPTSVMETGHDIIffwvarmmmmglhfmgevpfrtvylhpmvrdeKGQKMSKTKGNVIDPLVITEQYGA 558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 691 DGMRLALAD----------AGDTVEDAN-FVEAMADAGILRLYTWVEWVKEMVanwDSLRSgpASTFNDRVFASELNAGI 759
Cdd:PRK14900 559 DALRFTLAAltaqgrdiklAKERIEGYRaFANKLWNASRFALMNLSGYQERGE---DPARL--ARTPADRWILARLQRAV 633
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 760 IKTDQNYEKMMFKEALKTGF-FEFQAAKDKYRELAVEGMH----------RELVFRFIEVQTLLLAPFCPHLCEHIWTLL 828
Cdd:PRK14900 634 NETVEALEAFRFNDAANAVYaFVWHELCDWYIELAKEALAsedpearrsvQAVLVHCLQTSYRLLHPFMPFITEELWHVL 713
|
250 260
....*....|....*....|....*.
gi 964751093 829 -------GKPDSIMNASWPVAGPVNE 847
Cdd:PRK14900 714 raqvgasAWADSVLAAEYPRKGEADE 739
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
591-709 |
1.11e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 57.93 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 591 YVFFkEAPFPKTQIAKEKLDQLKQEFEFWY--PVDLRVSGKDLVPNHlsyylynhVAMWP---EQSDKW-PTAVRANGHL 664
Cdd:cd00814 204 YVWF-DALIGYISATGYYNEEWGNSWWWKDgwPELVHFIGKDIIRFH--------AIYWPamlLGAGLPlPTRIVAHGYL 274
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 964751093 665 LLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANF 709
Cdd:cd00814 275 TVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
661-697 |
2.01e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 58.19 E-value: 2.01e-08
10 20 30
....*....|....*....|....*....|....*..
gi 964751093 661 NGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 697
Cdd:COG0215 256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFL 292
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
661-697 |
1.74e-07 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 52.97 E-value: 1.74e-07
10 20 30
....*....|....*....|....*....|....*..
gi 964751093 661 NGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 697
Cdd:cd00672 165 TGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
53-190 |
8.28e-07 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 52.23 E-value: 8.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 53 PYMNGRLHLGHTfsLSKC--EFAVGYQRLKGKCCLFPFGLHCTGMPIKSKAAAKAGSSKYQwgIMKSLGLSD-----EEI 125
Cdd:cd00818 10 PYANGLPHYGHA--LNKIlkDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKK--DIEKMGIAEfnakcREF 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 964751093 126 VkFSEAEHWLDYFpplaiqdlKRMGLKVDWRRSFITTDvnPYYDSFVRWQFLTLRERNKIKFGKR 190
Cdd:cd00818 86 A-LRYVDEQEEQF--------QRLGVWVDWENPYKTMD--PEYMESVWWVFKQLHEKGLLYRGYK 139
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
620-700 |
1.13e-05 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 48.52 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 620 YPVDLRVSGKDLV-PNHlsyylYNHVAMWPEQSDK-WPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 697
Cdd:pfam01406 206 DQIDIHGGGIDLAfPHH-----ENEIAQSEAAFDKqLANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFL 280
|
...
gi 964751093 698 ADA 700
Cdd:pfam01406 281 LSV 283
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
611-709 |
1.43e-05 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 48.78 E-value: 1.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 611 QLKQEFEFWYPVDLRVSGKDLvpnhLSYYLYNHVAMWPEQSDKWP-TAVRANGhLLLNSE--KMSKSTGNFLTLTQAIDK 687
Cdd:cd00817 286 EETKDLKKFYPTSLLVTGHDI----IFFWVARMIMRGLKLTGKLPfKEVYLHG-LVRDEDgrKMSKSLGNVIDPLDVIDG 360
|
90 100
....*....|....*....|..
gi 964751093 688 FSADGMRLALADAGDTVEDANF 709
Cdd:cd00817 361 YGADALRFTLASAATQGRDINL 382
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
46-200 |
1.91e-05 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 48.44 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 46 YFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKSKAaakagsskyqwgimKSLGLSDEEI 125
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKA--------------EKEGITPEEL 66
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 964751093 126 VKFSEAEHwldyfpplaIQDLKRMGLKVDwrrSFITTDvNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQ 200
Cdd:pfam09334 67 VDRYHEIH---------REDFKKFNISFD---DYGRTT-SERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDER 128
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
662-695 |
2.16e-05 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 48.49 E-value: 2.16e-05
10 20 30
....*....|....*....|....*....|....
gi 964751093 662 GHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRL 695
Cdd:PTZ00399 307 GHLHIKGLKMSKSLKNFITIRQALSKYTARQIRL 340
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
17-100 |
4.25e-05 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 47.84 E-value: 4.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 17 EKEIQQKWDTERVFEVNASNlekqtSKGKYFVTF--PyPYMNGRLHLGHtfSLSKC--EFAVGYQRLKGKCCLFPFGLHC 92
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDR-----NNGESFTLHdgP-PYANGDLHIGH--ALNKIlkDFINRYQLLQGKKVHYVPGWDC 80
|
....*...
gi 964751093 93 TGMPIKSK 100
Cdd:PLN02843 81 HGLPIELK 88
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
18-163 |
1.43e-04 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 46.15 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 18 KEIQQKWDT---ERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTG 94
Cdd:PTZ00419 31 KEVESGWYEwweKSGFFKPAEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAG 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 964751093 95 MPIKS----KAAAKAGSSKYQWGimkslglsDEEIVKfsEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTD 163
Cdd:PTZ00419 111 IATQVvvekKLMKEENKTRHDLG--------REEFLK--KVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMD 173
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
16-264 |
2.41e-04 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 45.28 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 16 IEKEIQQKWDTERVFEVNASnlekqTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGM 95
Cdd:PLN02381 105 VEKSWYAWWEKSGYFGADAK-----SSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGI 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 96 PIKSKAAAKagsskyqwgIMKSLGLSDEEIVK---FSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTD---VNPYYD 169
Cdd:PLN02381 180 ATQVVVEKK---------LMRERHLTRHDIGReefVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDeqrSKAVTE 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 170 SFVR---------------WQfLTLR------ERNKIKFGKRYTIYSPKDGQPcmdhdrqtgegvgpqeytlLKLKVLEP 228
Cdd:PLN02381 251 AFVRlykegliyrdirlvnWD-CTLRtaisdvEVDYIDIKERTLLKVPGYDKP-------------------VEFGVLTS 310
|
250 260 270
....*....|....*....|....*....|....*.
gi 964751093 229 YPSKLSGLKGKnifLVAATLRPETMFGQTNCWVRPD 264
Cdd:PLN02381 311 FAYPLEGGLGE---IVVATTRIETMLGDTAIAIHPD 343
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
789-828 |
3.72e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 41.44 E-value: 3.72e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 964751093 789 YRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLL 828
Cdd:cd07958 78 YKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
45-199 |
3.99e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 44.49 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 45 KYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLF-----PFGLHctgmpIKSKAAAKagsskyqwgimkslG 119
Cdd:PRK11893 2 KFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFltgtdEHGQK-----IQRKAEEA--------------G 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 120 LSDEEIV-KFSEaehwldyfpplAIQDL-KRMGLKVDwrrSFI-TTDvnPYYDSFVRWQFLTLRERNKIKFGKRYTIYSP 196
Cdd:PRK11893 63 ISPQELAdRNSA-----------AFKRLwEALNISYD---DFIrTTD--PRHKEAVQEIFQRLLANGDIYLGKYEGWYCV 126
|
...
gi 964751093 197 KDG 199
Cdd:PRK11893 127 RCE 129
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
620-697 |
5.32e-04 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 44.15 E-value: 5.32e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 964751093 620 YPVDLRVSGKDLV-PNHLSYYLYNHVAMWPEQSDKWPtavrANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLAL 697
Cdd:PLN02946 276 HSFDIHGGGMDLVfPHHENEIAQSCAACCDSNISYWI----HNGFVTVDSEKMSKSLGNFFTIRQVIDLYHPLALRLFL 350
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
670-844 |
1.38e-03 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 42.84 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 670 KMSKSTGNFLTLTQAID---------KFSADGMRLALAD---AGDTVEDANFVEAMADA-----GILR--LYTWVEWVKE 730
Cdd:PLN02843 611 KMSKSLGNVVDPRLVIEggknqkqepAYGADVLRLWVASvdyTGDVLIGPQILKQMSDIyrklrGTLRylLGNLHDWKPD 690
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 731 MVANWDSLrsgPAStfnDRVFASELNAGIIKTDQNYEKMMFKEALKT---------GFFEFQAAKDKyreLAVEGMHRel 801
Cdd:PLN02843 691 NAVPYEDL---PSI---DKYALFQLENVVNEIEESYDNYQFFKIFQIlqrftivdlSNFYLDVAKDR---LYVGGTTS-- 759
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 964751093 802 vFRFIEVQTLL----------LAPFCPHLCEHIWTLL------GKPDSIMNASWPVAGP 844
Cdd:PLN02843 760 -FTRRSCQTVLaahllsllraIAPILPHLAEDAWQNLpfqedgSAAESVFEAGWPTPNE 817
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
608-706 |
1.52e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 42.78 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964751093 608 KLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYlynhVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDK 687
Cdd:PLN02224 308 KQQNLETAVSFGWPASLHLIGKDILRFHAVYW----PAMLMSAGLELPKMVFGHGFLTKDGMKMGKSLGNTLEPFELVQK 383
|
90 100
....*....|....*....|....*
gi 964751093 688 FSADGMR------LALADAGDTVED 706
Cdd:PLN02224 384 FGPDAVRyfflreVEFGNDGDYSED 408
|
|
| |
