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Conserved domains on  [gi|968121907|ref|NP_001304984|]
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zinc finger protein 426 isoform 3 [Homo sapiens]

Protein Classification

COG5048 and zf-H2C2_2 domain-containing protein( domain architecture ID 11986989)

protein containing domains zf-C2H2, COG5048, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-375 3.03e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 223 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 294
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 295 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 365
Cdd:COG5048  368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 968121907 366 ECKQCGKAFS 375
Cdd:COG5048  448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-208 9.74e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 9.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 968121907  183 YLSIHMRTHTGEKPYECKECGKAFNY 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 5.98e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 968121907  379 SFQIHERTHTGEKPYECKECGKAFTC 404
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-135 2.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.36e-03
                          10        20
                  ....*....|....*....|...
gi 968121907  113 FECSHCGKSFINESYLQAHMRTH 135
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-375 3.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 223 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 294
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 295 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 365
Cdd:COG5048  368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 968121907 366 ECKQCGKAFS 375
Cdd:COG5048  448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 3.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.03e-05
                          10        20
                  ....*....|....*....|....*.
gi 968121907  351 HLKIHMRIHTGEKPYECKQCGKAFSH 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-208 9.74e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 9.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 968121907  183 YLSIHMRTHTGEKPYECKECGKAFNY 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 5.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 968121907  379 SFQIHERTHTGEKPYECKECGKAFTC 404
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-135 2.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.36e-03
                          10        20
                  ....*....|....*....|...
gi 968121907  113 FECSHCGKSFINESYLQAHMRTH 135
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-375 3.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 223 KPYVCKECGKAFTQYSGLSMHVRS--HSG--DKPYECKE--CGKSFLTSSRLIQHIRTHTGEKPFVCV--ECGKAFAVSS 294
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 295 NLSGHLRTH-------TEEKACECKICGKVFGYPSCLNNHMRTHSAQKPYTCK--ECGKAFNYSTHLKIHMRIHTGEKPY 365
Cdd:COG5048  368 NNEPPQSLQqykdlknDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|
gi 968121907 366 ECKQCGKAFS 375
Cdd:COG5048  448 LCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 3.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.03e-05
                          10        20
                  ....*....|....*....|....*.
gi 968121907  351 HLKIHMRIHTGEKPYECKQCGKAFSH 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
37-428 3.11e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907  37 CEQCGEVFSEHSCLKTHVRTQSTGNTHDCNQYGKDflTLCEKTSTGEKLSEFNQSEKIFSLTPNIVYQR--TSTQEKSFE 114
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCD--KSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 115 CSHCGKSFINESYLQAHMR----THNGEKLYEWRNYG-PGFIdsTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMR 189
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSrdpqLPDLLSISNLRNNPlPGNN--SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 190 THTGEKPYECKECGKAFN-YSNSFQIHGRTHTgEKPYVCKECGKAFTQYSGLSMHVRSHSGDKPYECKECGKSFLTSSRL 268
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYsIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 269 IQHIRTHTGE-------KPFVCVECGKAFAVSSNLSGHLRT--HTEEKA----CECKICGKVFGYPSCLNNHMRTHSAQK 335
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpfsCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 336 PYTCKEC------GKAFNYSTHLKIHMR-IHTGEKPYEC--KQCGKAFSHSSSFQIHERTHTGEKPYECK--ECGKAFTC 404
Cdd:COG5048  351 PAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 968121907 405 SSSFRIHEKTHTEEKPYKCQQCGK 428
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
183-208 9.74e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 9.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 968121907  183 YLSIHMRTHTGEKPYECKECGKAFNY 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-443 1.28e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 152 DSTSLSVLIETLNAKKPYKCKECGKGYRYPAYLSIHMRTHTGEKPYECKECGKAFNYSN--SFQIHGRTHTGEKPYVCKE 229
Cdd:COG5048   17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 230 CGKAFTQYSGLSMHVRSHSGDkPYECKECGKSFLTSSRLIQHI----RTHTGEKPF---------------------VCV 284
Cdd:COG5048   97 SLPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLpgnnsssvntpqsnslhpplpANS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 285 ECGKAFAVSSNLSGHLRTHTEEKACECKICGKVFGYPSCLNNHMRTHS-----AQKPYTCKECGKAFNYSTHLKIHMRIH 359
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSssslpLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 360 TGEKPYECKQCGKAFSHSSSFQIHERTHTG-EKPYECKECGKAFTCSSSFRIHEKT--HTEE--KPYKC--QQCGKAYSH 432
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                        330
                 ....*....|.
gi 968121907 433 PRSLRRHEQIH 443
Cdd:COG5048  336 NDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 5.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 968121907  379 SFQIHERTHTGEKPYECKECGKAFTC 404
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-348 1.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.41e-03
                          10        20
                  ....*....|....*....|....*
gi 968121907  324 LNNHMRTHSAQKPYTCKECGKAFNY 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 113-135 2.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.36e-03
                          10        20
                  ....*....|....*....|...
gi 968121907  113 FECSHCGKSFINESYLQAHMRTH 135
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 2.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|....*
gi 968121907  240 LSMHVRSHSGDKPYECKECGKSFLT 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 167-250 2.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121907 167 KPYKCK--ECGKGYRYPAYLSIHMRT-HTGEKPYECKECGKafnySNSFQIHgrthtgEKPYVCKECGKAFTQYSGLSMH 243
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----MNIFSAK------DKPYRCEVCDKRYKNLNGLKYH 417


                 ....*..
gi 968121907 244 vRSHSGD 250
Cdd:COG5189  418 -RKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-359 6.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.41e-03
                          10        20
                  ....*....|....*....|...
gi 968121907  337 YTCKECGKAFNYSTHLKIHMRIH 359
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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