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Conserved domains on  [gi|970259835|ref|NP_001305032|]
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galactosylceramide sulfotransferase isoform 1 [Homo sapiens]

Protein Classification

sulfotransferase family protein( domain architecture ID 10536973)

sulfotransferase family protein may catalyze the transfer of sulfate from a donor such as 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor substrate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gal-3-0_sulfotr pfam06990
Galactose-3-O-sulfotransferase; This family consists of several mammalian ...
1-408 0e+00

Galactose-3-O-sulfotransferase; This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.


:

Pssm-ID: 254007  Cd Length: 400  Bit Score: 653.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835    1 MLP----PQKKPWESMAKGLVLGAL-FTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPAlepeavirangsagECQPR 75
Cdd:pfam06990   1 MLPilqrLQKKPWESMAKGLVLGALgFTSFLLLVYSYAVPPLHAGLASTTPEFAASCSPPA--------------ECPPR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835   76 RNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNG-RNDFDYPTFFARSLVQDYRpgACFNIICNHMRFHYDEVRGLVP 154
Cdd:pfam06990  67 RNIVFLKTHKTASSTVLNILFRFAEKHNLKVALPNGcRNDFDYPTFFAASLVQDYR--ACFNIICNHLRFHYDEVRGLMP 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  155 TNAIFITVLRDPARLFESSFHYFGPVVPLTWKLSAGDkLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQ 234
Cdd:pfam06990 145 TNTIYITILRDPARLFESSFHYYGPYVPAFRKLPAGD-LTAFLQDPDRYYDPNGHNAHYARNLLFFDLGYDNSLDPSSPQ 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  235 --VQEHILEVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAWNMLDSHLYRHFN 312
Cdd:pfam06990 224 ayVQEHILEVERRFHLVLIAEYFDESLVLLRRLLCWELDDVLYFKLNARRASPVPRLSGELYGRARAWNALDSHLYRHFN 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  313 ASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHA-VDAAAIQDEAMQPWQPLGTKSILGYNLKKSIGQRHAQLCR 391
Cdd:pfam06990 304 ATFWRKVAAFGRERMAREVAALRHARERLRTICIDDGHAlVDAAQIRDEALQPWQPSGKKDILGYNLKKGIGQRHAQLCR 383
                         410
                  ....*....|....*..
gi 970259835  392 RMLTPEIQYLMDLGANL 408
Cdd:pfam06990 384 RLLMPEIQYLMDLGANQ 400
 
Name Accession Description Interval E-value
Gal-3-0_sulfotr pfam06990
Galactose-3-O-sulfotransferase; This family consists of several mammalian ...
1-408 0e+00

Galactose-3-O-sulfotransferase; This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.


Pssm-ID: 254007  Cd Length: 400  Bit Score: 653.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835    1 MLP----PQKKPWESMAKGLVLGAL-FTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPAlepeavirangsagECQPR 75
Cdd:pfam06990   1 MLPilqrLQKKPWESMAKGLVLGALgFTSFLLLVYSYAVPPLHAGLASTTPEFAASCSPPA--------------ECPPR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835   76 RNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNG-RNDFDYPTFFARSLVQDYRpgACFNIICNHMRFHYDEVRGLVP 154
Cdd:pfam06990  67 RNIVFLKTHKTASSTVLNILFRFAEKHNLKVALPNGcRNDFDYPTFFAASLVQDYR--ACFNIICNHLRFHYDEVRGLMP 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  155 TNAIFITVLRDPARLFESSFHYFGPVVPLTWKLSAGDkLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQ 234
Cdd:pfam06990 145 TNTIYITILRDPARLFESSFHYYGPYVPAFRKLPAGD-LTAFLQDPDRYYDPNGHNAHYARNLLFFDLGYDNSLDPSSPQ 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  235 --VQEHILEVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAWNMLDSHLYRHFN 312
Cdd:pfam06990 224 ayVQEHILEVERRFHLVLIAEYFDESLVLLRRLLCWELDDVLYFKLNARRASPVPRLSGELYGRARAWNALDSHLYRHFN 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  313 ASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHA-VDAAAIQDEAMQPWQPLGTKSILGYNLKKSIGQRHAQLCR 391
Cdd:pfam06990 304 ATFWRKVAAFGRERMAREVAALRHARERLRTICIDDGHAlVDAAQIRDEALQPWQPSGKKDILGYNLKKGIGQRHAQLCR 383
                         410
                  ....*....|....*..
gi 970259835  392 RMLTPEIQYLMDLGANL 408
Cdd:pfam06990 384 RLLMPEIQYLMDLGANQ 400
 
Name Accession Description Interval E-value
Gal-3-0_sulfotr pfam06990
Galactose-3-O-sulfotransferase; This family consists of several mammalian ...
1-408 0e+00

Galactose-3-O-sulfotransferase; This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans.


Pssm-ID: 254007  Cd Length: 400  Bit Score: 653.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835    1 MLP----PQKKPWESMAKGLVLGAL-FTSFLLLVYSYAVPPLHAGLASTTPEAAASCSPPAlepeavirangsagECQPR 75
Cdd:pfam06990   1 MLPilqrLQKKPWESMAKGLVLGALgFTSFLLLVYSYAVPPLHAGLASTTPEFAASCSPPA--------------ECPPR 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835   76 RNIVFLKTHKTASSTLLNILFRFGQKHRLKFAFPNG-RNDFDYPTFFARSLVQDYRpgACFNIICNHMRFHYDEVRGLVP 154
Cdd:pfam06990  67 RNIVFLKTHKTASSTVLNILFRFAEKHNLKVALPNGcRNDFDYPTFFAASLVQDYR--ACFNIICNHLRFHYDEVRGLMP 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  155 TNAIFITVLRDPARLFESSFHYFGPVVPLTWKLSAGDkLTEFLQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQ 234
Cdd:pfam06990 145 TNTIYITILRDPARLFESSFHYYGPYVPAFRKLPAGD-LTAFLQDPDRYYDPNGHNAHYARNLLFFDLGYDNSLDPSSPQ 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  235 --VQEHILEVERRFHLVLLQEYFDESLVLLKDLLCWELEDVLYFKLNARRDSPVPRLSGELYGRATAWNMLDSHLYRHFN 312
Cdd:pfam06990 224 ayVQEHILEVERRFHLVLIAEYFDESLVLLRRLLCWELDDVLYFKLNARRASPVPRLSGELYGRARAWNALDSHLYRHFN 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259835  313 ASFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHA-VDAAAIQDEAMQPWQPLGTKSILGYNLKKSIGQRHAQLCR 391
Cdd:pfam06990 304 ATFWRKVAAFGRERMAREVAALRHARERLRTICIDDGHAlVDAAQIRDEALQPWQPSGKKDILGYNLKKGIGQRHAQLCR 383
                         410
                  ....*....|....*..
gi 970259835  392 RMLTPEIQYLMDLGANL 408
Cdd:pfam06990 384 RLLMPEIQYLMDLGANQ 400
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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