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Conserved domains on  [gi|972776807|ref|NP_001305466|]
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protein sprouty homolog 2 [Homo sapiens]

Protein Classification

sprouty family protein( domain architecture ID 10525175)

sprouty family protein may be an inhibitor of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 183-284 1.73e-31

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


:

Pssm-ID: 461589  Cd Length: 101  Bit Score: 113.58  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972776807  183 KCKCKEC----TYPRPLPSDwicdkqclCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCS-CSQSHCCTRWSAMG 257
Cdd:pfam05210   1 RCRCVYCqelfTEPRNLPGS--------CSAESCIDYVSCMCCAKGLFYHCMSDAEGDDSCDPCScCSPHRCCKRWLALA 72

                          90       100
                  ....*....|....*....|....*..
gi 972776807  258 VMSLFLPCLWCYLPAKGCLKLCQGCYD 284
Cdd:pfam05210  73 LLSLLLPCLCCYPPLRACHKCCVACGC 99
 
Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 183-284 1.73e-31

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


Pssm-ID: 461589  Cd Length: 101  Bit Score: 113.58  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972776807  183 KCKCKEC----TYPRPLPSDwicdkqclCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCS-CSQSHCCTRWSAMG 257
Cdd:pfam05210   1 RCRCVYCqelfTEPRNLPGS--------CSAESCIDYVSCMCCAKGLFYHCMSDAEGDDSCDPCScCSPHRCCKRWLALA 72

                          90       100
                  ....*....|....*....|....*..
gi 972776807  258 VMSLFLPCLWCYLPAKGCLKLCQGCYD 284
Cdd:pfam05210  73 LLSLLLPCLCCYPPLRACHKCCVACGC 99
 
Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 183-284 1.73e-31

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


Pssm-ID: 461589  Cd Length: 101  Bit Score: 113.58  E-value: 1.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972776807  183 KCKCKEC----TYPRPLPSDwicdkqclCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCS-CSQSHCCTRWSAMG 257
Cdd:pfam05210   1 RCRCVYCqelfTEPRNLPGS--------CSAESCIDYVSCMCCAKGLFYHCMSDAEGDDSCDPCScCSPHRCCKRWLALA 72

                          90       100
                  ....*....|....*....|....*..
gi 972776807  258 VMSLFLPCLWCYLPAKGCLKLCQGCYD 284
Cdd:pfam05210  73 LLSLLLPCLCCYPPLRACHKCCVACGC 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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