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Conserved domains on  [gi|974141096|ref|NP_001305800|]
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proline-rich transmembrane protein 3 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 31-392 1.55e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096   31 PRPLENSEIPMIPGAHPkgsvgsEPQAFDVFPENPRADSHR--NSDVRHAPAEEMPEKPVASPLGPALyGPKAAQGAQRE 108
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVP------PPERPRDDPAPGRVSRPRraRRLGRAAQASSPPQRPRRRAARPTV-GSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  109 RLPVTDDLQMAQGPSSHGWTGPLDSQELLQQEAVAPHPVGHPHLTFIPTTPRRQLRVATVppslqhEGQEGQWPPRDEGL 188
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT------AGPPAPAPPAAPAA 2777

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  189 KAKTKSRVPPTSPSDHQGPPHTLVSHSGTVKRPVLEGQGGFEEHLQEAAQGPHFTQQDPAAPDVGSvPPVEVVYSQEPGA 268
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-GPPPPSLPLGGSV 2856

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  269 QPDLALARSLPPAEELPV-ETPKRAGAEvswevSSPGPPPKQADLPDAKDSPGPQPTDPPASEAPDRPSKPERAAMNGAD 347
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKpAAPARPPVR-----RLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 974141096  348 PISPQRVRGAVEAPGTPKSLIPGPSDPGPAvnrteSPMGALQPGE 392
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ-----PWLGALVPGR 2971
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-392 1.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096   31 PRPLENSEIPMIPGAHPkgsvgsEPQAFDVFPENPRADSHR--NSDVRHAPAEEMPEKPVASPLGPALyGPKAAQGAQRE 108
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVP------PPERPRDDPAPGRVSRPRraRRLGRAAQASSPPQRPRRRAARPTV-GSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  109 RLPVTDDLQMAQGPSSHGWTGPLDSQELLQQEAVAPHPVGHPHLTFIPTTPRRQLRVATVppslqhEGQEGQWPPRDEGL 188
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT------AGPPAPAPPAAPAA 2777

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  189 KAKTKSRVPPTSPSDHQGPPHTLVSHSGTVKRPVLEGQGGFEEHLQEAAQGPHFTQQDPAAPDVGSvPPVEVVYSQEPGA 268
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-GPPPPSLPLGGSV 2856

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  269 QPDLALARSLPPAEELPV-ETPKRAGAEvswevSSPGPPPKQADLPDAKDSPGPQPTDPPASEAPDRPSKPERAAMNGAD 347
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKpAAPARPPVR-----RLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 974141096  348 PISPQRVRGAVEAPGTPKSLIPGPSDPGPAvnrteSPMGALQPGE 392
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ-----PWLGALVPGR 2971
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 31-392 1.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096   31 PRPLENSEIPMIPGAHPkgsvgsEPQAFDVFPENPRADSHR--NSDVRHAPAEEMPEKPVASPLGPALyGPKAAQGAQRE 108
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVP------PPERPRDDPAPGRVSRPRraRRLGRAAQASSPPQRPRRRAARPTV-GSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  109 RLPVTDDLQMAQGPSSHGWTGPLDSQELLQQEAVAPHPVGHPHLTFIPTTPRRQLRVATVppslqhEGQEGQWPPRDEGL 188
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT------AGPPAPAPPAAPAA 2777

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  189 KAKTKSRVPPTSPSDHQGPPHTLVSHSGTVKRPVLEGQGGFEEHLQEAAQGPHFTQQDPAAPDVGSvPPVEVVYSQEPGA 268
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-GPPPPSLPLGGSV 2856

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  269 QPDLALARSLPPAEELPV-ETPKRAGAEvswevSSPGPPPKQADLPDAKDSPGPQPTDPPASEAPDRPSKPERAAMNGAD 347
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKpAAPARPPVR-----RLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 974141096  348 PISPQRVRGAVEAPGTPKSLIPGPSDPGPAvnrteSPMGALQPGE 392
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ-----PWLGALVPGR 2971
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
247-383 4.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 4.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 247 PAAPDVGSVPPVEVVYSQEPGAQPDLALARSLPPAEELPVETPKRAGAEVSwevsSPGPPPKQADLPDAKDSPGPQPTDP 326
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG----APAPAPAPAAAPAAAARPAAAGPRP 471

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 974141096 327 PASEAPDRPSKPERAAMNGAdpiSPQRVRGAVEAPGTPKSLIPGPSDPGPAVNRTES 383
Cdd:PRK12323 472 VAAAAAAAPARAAPAAAPAP---ADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES 525
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 252-371 6.12e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 6.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 252 VGSVPPVEVVYSQEPGAQPDLALARSLPPAEELPVETPKRAGAEVSWEVSSPGPPPKQADLPDAKDS---PGPQPTDPPA 328
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAapaAAPAAVALAP 449

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 974141096 329 SEAPDRPSKPERAAMNGADPISPQRVRGAVEAPGTPKSLIPGP 371
Cdd:PRK14951 450 APPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTE 492
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 225-376 6.44e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 6.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 225 GQGGFEEHLQEAAQGPHFTQQDPAAPDVGSVPPVEVVYSQEPGAQPDLALARSLPPAEELPVETPKRAGAEVS---WEVS 301
Cdd:PRK07764 593 GAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdgWPAK 672

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 974141096 302 SPGPPPKQADLPDAKDSPGPQPTDPPASEAPDRPSKPERAAMNGADPISPQRVRGAVEAPGTPKSLIPGPSDPGP 376
Cdd:PRK07764 673 AGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDD 747
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 164-375 7.79e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 7.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 164 RVATVPPSLQHEGQEGQWPPRDEGLKAKTKSRVPPTSPSDHQGPPHTlvSHSGTVKRPVLEGQGGFEEHLQEAAQGPHFT 243
Cdd:PRK07764 587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAA--AAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 244 QQDPAAPDVGSVPPVEVVYSQEPGAQPDLALARSLPPAEELPVETPKRAGAEVSweVSSPGPPPKQADLPDAKDSPGPQP 323
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPA--AQPPQAAQGASAPSPAADDPVPLP 742

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 974141096 324 TDPPASEAPDRP---SKPERAAMNGADPISPQRVRGAVEAPGTPKSLIPGPSDPG 375
Cdd:PRK07764 743 PEPDDPPDPAGApaqPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDED 797
PHA03247 PHA03247
large tegument protein UL36; Provisional
 79-377 1.00e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096   79 PAEEMPEKPVASPLGPALYGPKAAQGAQRERLPVTddLQMAQGPSSHGWTGPLDSQELLQQEAVAPHPVGHPHLTFIPTT 158
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALP--AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  159 PRRQLRVATVPPSLQHEGQEGQWPPRDE--GLKAKTKSRVPPTSPSDHQGPPHTLVSHSGTVKRPVLEGQ--------GG 228
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPpaAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvaPG 2859

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  229 FEEHLQEAAQGPHFTQQDPAAPDVGSVPPVEVVYSQEPGAQPDLALARSLPPAeelpvetpkragaevswevssPGPPPK 308
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ---------------------APPPPQ 2918

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 974141096  309 QADLPDAKDSPGPQPTDPPASEAPDRPSkPERAAMNGADPISPQRVRGAVeAPG---TPKSLIPGPSDPGPA 377
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPT-TDPAGAGEPSGAVPQPWLGAL-VPGrvaVPRFRVPQPAPSREA 2988
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 188-374 1.42e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.21  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 188 LKAKTKSRVPPTSPSD---HQGPPHTLVSHSGTVKRPvleGQGGFEEHLQEAAQGP-----HFTQQDPAAPDVGSVP-PV 258
Cdd:PTZ00449 488 LIKKSKKKLAPIEEEDsdkHDEPPEGPEASGLPPKAP---GDKEGEEGEHEDSKESdepkeGGKPGETKEGEVGKKPgPA 564

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 259 EvvySQEPGAQPDLALARSLPPAEELP--VETPKRAGAEVSWEVSSPGPPPKQADLPDAKDSPG--PQPTDPPASEAPDR 334
Cdd:PTZ00449 565 K---EHKPSKIPTLSKKPEFPKDPKHPkdPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKrpESPKSPKRPPPPQR 641

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 974141096 335 PSKPERaamngadPISPQrvrgAVEAPGTPKSLIPgPSDP 374
Cdd:PTZ00449 642 PSSPER-------PEGPK----IIKSPKPPKSPKP-PFDP 669
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 236-345 2.01e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 236 AAQGPHFTQQDPAAPDVGSVPPVEVVYSQEPGAQPDLALARSLPPAEELPVETPKRAGAEVSWEVSSPGPPPKQADLPDA 315
Cdd:PRK14951 385 EAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPV 464

                         90       100       110
                 ....*....|....*....|....*....|
gi 974141096 316 KDSPGPQPTDPPASEAPDRPSKPERAAMNG 345
Cdd:PRK14951 465 RVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 261-368 4.21e-03

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 39.59  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096 261 VYSQEPGAQPDLALArslPPAEELPVETPKRAGAE----VSWEVSSPGPPPKQADLP-----DAKDSPGPQPTDPPASEA 331
Cdd:PLN02328  18 VVSEASSPETDLSLS---PSQSEQNIENDGQNSPEtqspLTELQPSPLPPNTTLDAPvsdsqGDESSSEQQPQNPNSTEP 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974141096 332 PDRPSKPER-----AAMNGADPISPQRVRGAVEAPGTPKSLI 368
Cdd:PLN02328  95 APPPKKRRRrkrffTEINANPAFRRHRVRGGLGKEVDVEALI 136
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 262-357 7.24e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 38.72  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141096  262 YSQEPGAQPDLALARSLPPAEELPVETPKRAGAEvswevssPGPPPKQADLPDAKDSPGPQPTDPPASEAPDRPSKPERA 341
Cdd:PRK12270   36 YGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAA-------PAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAP 108

                          90
                  ....*....|....*.
gi 974141096  342 AMNGADPISpQRVRGA 357
Cdd:PRK12270  109 AAAAVEDEV-TPLRGA 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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