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Conserved domains on  [gi|974987447|ref|NP_001305897|]
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translation initiation factor eIF2B subunit delta isoform 7 [Homo sapiens]

Protein Classification

translation initiation factor eIF-2B subunit( domain architecture ID 12013350)

translation initiation factor eIF-2B subunit, belonging to the eIF-2B alpha/beta/delta subunits family, is part of the complex that catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IF-2B pfam01008
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
24-314 1.86e-110

Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.


:

Pssm-ID: 395798 [Multi-domain]  Cd Length: 281  Bit Score: 322.32  E-value: 1.86e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447   24 VSGSNARCIALLRALQQVIQDYTTPPNEELsrdlVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 103
Cdd:pfam01008   2 VRGSPAIAIAALEGLLLVIQDARTPTVAEL----KEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLALHSSSDVEEAKE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  104 ELRAAIDRYVQEkIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVH 183
Cdd:pfam01008  78 SLIEAADEFIDE-IEEARRKIGAIAAELIKDGDTILTHCNSGTVLGVLRAAHKEGKRFRVIVTESRPRLQGRLTAKELVQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  184 AGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELD 263
Cdd:pfam01008 157 AGIPVTLITDSAVGYVMQEVDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDEDIFIEER 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 974987447  264 DPDDLQCKRGEHVALANwqnhasLRLLNLVYDVTPPELVDLVITELGMIPC 314
Cdd:pfam01008 237 DPEEVLYRTGVRIAPPN------LKVRNPAFDYTPPELITLIITEVGVLPP 281
 
Name Accession Description Interval E-value
IF-2B pfam01008
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
24-314 1.86e-110

Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.


Pssm-ID: 395798 [Multi-domain]  Cd Length: 281  Bit Score: 322.32  E-value: 1.86e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447   24 VSGSNARCIALLRALQQVIQDYTTPPNEELsrdlVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 103
Cdd:pfam01008   2 VRGSPAIAIAALEGLLLVIQDARTPTVAEL----KEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLALHSSSDVEEAKE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  104 ELRAAIDRYVQEkIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVH 183
Cdd:pfam01008  78 SLIEAADEFIDE-IEEARRKIGAIAAELIKDGDTILTHCNSGTVLGVLRAAHKEGKRFRVIVTESRPRLQGRLTAKELVQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  184 AGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELD 263
Cdd:pfam01008 157 AGIPVTLITDSAVGYVMQEVDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDEDIFIEER 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 974987447  264 DPDDLQCKRGEHVALANwqnhasLRLLNLVYDVTPPELVDLVITELGMIPC 314
Cdd:pfam01008 237 DPEEVLYRTGVRIAPPN------LKVRNPAFDYTPPELITLIITEVGVLPP 281
GCD2 COG1184
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ...
32-322 2.35e-58

Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440797 [Multi-domain]  Cd Length: 304  Bit Score: 190.06  E-value: 2.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  32 IALLRALQQVIQDYTTPPNEELSRDLvnklKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSkreEEAKSELRAAIDR 111
Cdd:COG1184   24 RAAAEALRDLAERSRAADPEEFRREL----EAAARALRRARPSAASLPNAVRRVLARVADGETV---EEAREAVLEAADE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 112 yVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASyl 191
Cdd:COG1184   97 -FIERAEEAKERAAEIAAKRIRDGDTILTHSNSSTVLAAIEAAVPQGKDIRVYVTESRPRYQGRITARELAEAGVPVT-- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 192 LIP--AASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERvqTDAFVSNELDDPDDlq 269
Cdd:COG1184  174 LIVdsAARHFLKEVDRVVVGADTITADGAVVNKIGTSPLALAAREAGVPVTVAAETYKFSPE--TFELVEIEERDPSE-- 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 974987447 270 ckrgehVALANWQNhasLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLR 322
Cdd:COG1184  250 ------VYDEEPEG---VTVRNPAFDVTPPDLIDAIITERGVLPPEAIYTVIR 293
PRK08535 PRK08535
ribose 1,5-bisphosphate isomerase;
56-322 4.34e-49

ribose 1,5-bisphosphate isomerase;


Pssm-ID: 236282 [Multi-domain]  Cd Length: 310  Bit Score: 166.23  E-value: 4.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  56 DLVNKLKPYMSFLTQCRPLSASMHNAIKFlnkeITSVGSSKREEEAKSELRAAIDRYVQEkivlAAQAISR---FAYQKI 132
Cdd:PRK08535  47 EFKAEMRAAANILISTRPTAVSLPNAVRY----VMRYYSGETVEEARESVIERAEEFIES----SENAVEKigeIGAKRI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 133 SNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHA 212
Cdd:PRK08535 119 RDGDVIMTHCNSSAALSVIKTAHEQGKDIEVIATETRPRNQGHITAKELAEYGIPVTLIVDSAVRYFMKDVDKVVVGADA 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 213 LLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKrgehVALANWQNhasLRLLNL 292
Cdd:PRK08535 199 ITANGAVINKIGTSQIALAAHEARVPFMVAAETYKFSPKTLLGELVEIEERDPTEVLPE----EILAKLPG---VKVRNP 271
                        250       260       270
                 ....*....|....*....|....*....|
gi 974987447 293 VYDVTPPELVDLVITELGMIPCSSVPVVLR 322
Cdd:PRK08535 272 AFDVTPPEYIDAIITEIGAIPPEMAYTIIK 301
eIF-2B_rel TIGR00524
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes ...
55-313 5.38e-35

eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins. [Unknown function, General]


Pssm-ID: 273119 [Multi-domain]  Cd Length: 303  Bit Score: 129.10  E-value: 5.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447   55 RDLVNKLKPYMSFLTQCRPLSASMHNAIKFLnkeITSVGSSKREEEAK-SELRAAIDryVQEKIVLAAQAISRFAYQKIS 133
Cdd:TIGR00524  43 EEFKEDLEKAADFLLSTRPTAVNLFWALDRV---LNSLKSGESVEEFKeSLLREAIE--IINEDLETNRKIGENGAKLIK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  134 NGDVILVYgCSS---LVSR------ILQEAWTEGRRFRVVVVDSRPWLEGRH-TLRSLVHAGVPASYLLIPAASYVL--P 201
Cdd:TIGR00524 118 DGDTVLTH-CNAgalATSGygtalgVIRSAWEDGKRIRVIADETRPRNQGSRlTAWELVQDGIPVTLITDSAAAYFMqtG 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  202 EVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANw 281
Cdd:TIGR00524 197 EIDAVIVGADRIARNGDVANKIGTYQLAVLAKEFRIPFFVAAPLSTFDPKTSTGEDIIIEERDPEEVAQVGGVRIAPLG- 275
                         250       260       270
                  ....*....|....*....|....*....|..
gi 974987447  282 qnhasLRLLNLVYDVTPPELVDLVITELGMIP 313
Cdd:TIGR00524 276 -----VKVYNPAFDITPHDLIDAIITEKGIIT 302
 
Name Accession Description Interval E-value
IF-2B pfam01008
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
24-314 1.86e-110

Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.


Pssm-ID: 395798 [Multi-domain]  Cd Length: 281  Bit Score: 322.32  E-value: 1.86e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447   24 VSGSNARCIALLRALQQVIQDYTTPPNEELsrdlVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKS 103
Cdd:pfam01008   2 VRGSPAIAIAALEGLLLVIQDARTPTVAEL----KEQLRSAIEFLISARPTAVSLGNAIDRLLRIVLALHSSSDVEEAKE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  104 ELRAAIDRYVQEkIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVH 183
Cdd:pfam01008  78 SLIEAADEFIDE-IEEARRKIGAIAAELIKDGDTILTHCNSGTVLGVLRAAHKEGKRFRVIVTESRPRLQGRLTAKELVQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  184 AGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELD 263
Cdd:pfam01008 157 AGIPVTLITDSAVGYVMQEVDKVIVGADRILANGGIANKIGTYQLALLAKAHNVPFYVVAETYKFDPRFPLDEDIFIEER 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 974987447  264 DPDDLQCKRGEHVALANwqnhasLRLLNLVYDVTPPELVDLVITELGMIPC 314
Cdd:pfam01008 237 DPEEVLYRTGVRIAPPN------LKVRNPAFDYTPPELITLIITEVGVLPP 281
GCD2 COG1184
Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ...
32-322 2.35e-58

Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440797 [Multi-domain]  Cd Length: 304  Bit Score: 190.06  E-value: 2.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  32 IALLRALQQVIQDYTTPPNEELSRDLvnklKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSkreEEAKSELRAAIDR 111
Cdd:COG1184   24 RAAAEALRDLAERSRAADPEEFRREL----EAAARALRRARPSAASLPNAVRRVLARVADGETV---EEAREAVLEAADE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 112 yVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASyl 191
Cdd:COG1184   97 -FIERAEEAKERAAEIAAKRIRDGDTILTHSNSSTVLAAIEAAVPQGKDIRVYVTESRPRYQGRITARELAEAGVPVT-- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 192 LIP--AASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERvqTDAFVSNELDDPDDlq 269
Cdd:COG1184  174 LIVdsAARHFLKEVDRVVVGADTITADGAVVNKIGTSPLALAAREAGVPVTVAAETYKFSPE--TFELVEIEERDPSE-- 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 974987447 270 ckrgehVALANWQNhasLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLR 322
Cdd:COG1184  250 ------VYDEEPEG---VTVRNPAFDVTPPDLIDAIITERGVLPPEAIYTVIR 293
PRK08535 PRK08535
ribose 1,5-bisphosphate isomerase;
56-322 4.34e-49

ribose 1,5-bisphosphate isomerase;


Pssm-ID: 236282 [Multi-domain]  Cd Length: 310  Bit Score: 166.23  E-value: 4.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  56 DLVNKLKPYMSFLTQCRPLSASMHNAIKFlnkeITSVGSSKREEEAKSELRAAIDRYVQEkivlAAQAISR---FAYQKI 132
Cdd:PRK08535  47 EFKAEMRAAANILISTRPTAVSLPNAVRY----VMRYYSGETVEEARESVIERAEEFIES----SENAVEKigeIGAKRI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 133 SNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHA 212
Cdd:PRK08535 119 RDGDVIMTHCNSSAALSVIKTAHEQGKDIEVIATETRPRNQGHITAKELAEYGIPVTLIVDSAVRYFMKDVDKVVVGADA 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 213 LLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKrgehVALANWQNhasLRLLNL 292
Cdd:PRK08535 199 ITANGAVINKIGTSQIALAAHEARVPFMVAAETYKFSPKTLLGELVEIEERDPTEVLPE----EILAKLPG---VKVRNP 271
                        250       260       270
                 ....*....|....*....|....*....|
gi 974987447 293 VYDVTPPELVDLVITELGMIPCSSVPVVLR 322
Cdd:PRK08535 272 AFDVTPPEYIDAIITEIGAIPPEMAYTIIK 301
eIF-2B_rel TIGR00524
eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes ...
55-313 5.38e-35

eIF-2B alpha/beta/delta-related uncharacterized proteins; This model, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins. [Unknown function, General]


Pssm-ID: 273119 [Multi-domain]  Cd Length: 303  Bit Score: 129.10  E-value: 5.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447   55 RDLVNKLKPYMSFLTQCRPLSASMHNAIKFLnkeITSVGSSKREEEAK-SELRAAIDryVQEKIVLAAQAISRFAYQKIS 133
Cdd:TIGR00524  43 EEFKEDLEKAADFLLSTRPTAVNLFWALDRV---LNSLKSGESVEEFKeSLLREAIE--IINEDLETNRKIGENGAKLIK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  134 NGDVILVYgCSS---LVSR------ILQEAWTEGRRFRVVVVDSRPWLEGRH-TLRSLVHAGVPASYLLIPAASYVL--P 201
Cdd:TIGR00524 118 DGDTVLTH-CNAgalATSGygtalgVIRSAWEDGKRIRVIADETRPRNQGSRlTAWELVQDGIPVTLITDSAAAYFMqtG 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  202 EVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANw 281
Cdd:TIGR00524 197 EIDAVIVGADRIARNGDVANKIGTYQLAVLAKEFRIPFFVAAPLSTFDPKTSTGEDIIIEERDPEEVAQVGGVRIAPLG- 275
                         250       260       270
                  ....*....|....*....|....*....|..
gi 974987447  282 qnhasLRLLNLVYDVTPPELVDLVITELGMIP 313
Cdd:TIGR00524 276 -----VKVYNPAFDITPHDLIDAIITEKGIIT 302
PRK08335 PRK08335
translation initiation factor IF-2B subunit alpha; Validated
51-312 8.03e-21

translation initiation factor IF-2B subunit alpha; Validated


Pssm-ID: 169387  Cd Length: 275  Bit Score: 90.22  E-value: 8.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  51 EELSRD-LVNKLKPYMSFLTQCRPLSASMHNAIKFL----NKEITSVGSS---KREEEAKSElraaidryvqekivlaaq 122
Cdd:PRK08335  37 EELDGEeLENALKELREEIPEVNPTMASLYNLARFIpitnNPELVKSRAEeflRLMEEAKRE------------------ 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 123 aISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPasYLLIPAASYVL-- 200
Cdd:PRK08335  99 -IGNIGSELIDDGDVIITHSFSSAVLEILKTAKRKGKRFKVILTESAPDYEGLALANELEFLGIE--FEVITDAQLGLfa 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 201 PEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDdpddlqCKRGEHvalan 280
Cdd:PRK08335 176 KEATLALVGADNVTRDGYVVNKAGTYLLALACHDNGVPFYVAAETFKFHPELKSEEVELVERP------YARQGH----- 244
                        250       260       270
                 ....*....|....*....|....*....|..
gi 974987447 281 wqnhaslRLLNLVYDVTPPELVDLVITELGMI 312
Cdd:PRK08335 245 -------RVRNVLFDVTPWKYVRGIITELGIL 269
mtnA PRK05720
methylthioribose-1-phosphate isomerase; Reviewed
151-312 2.07e-18

methylthioribose-1-phosphate isomerase; Reviewed


Pssm-ID: 235578  Cd Length: 344  Bit Score: 84.48  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 151 LQEAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASylLIP--AASYVLPE--VSKVLLGAHALLANGSVMSRVGT 225
Cdd:PRK05720 171 IYAAKEKGIDIHVYADETRPRLQGaRLTAWELYQAGIDVT--VITdnMAAHLMQTgkIDAVIVGADRIAANGDVANKIGT 248
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 226 AQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANwqnhasLRLLNLVYDVTPPELVDLV 305
Cdd:PRK05720 249 YQLAIAAKYHGVPFYVAAPSSTIDLTLADGKEIPIEERDPEEVTEVGGVRIAPEG------VKVYNPAFDVTPAELITGI 322

                 ....*..
gi 974987447 306 ITELGMI 312
Cdd:PRK05720 323 ITEKGIV 329
PRK05772 PRK05772
S-methyl-5-thioribose-1-phosphate isomerase;
68-312 1.42e-17

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 168237  Cd Length: 363  Bit Score: 82.50  E-value: 1.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  68 LTQCRPLSASMHNAI-KFLNK--EITSVGSSKREEEAKSELRAAIDRYVQEKIVlAAQAISRFAYQKISNGDVILVY--- 141
Cdd:PRK05772  98 LDSARPTAVNLVWATsRMLNKakNTVESGNAKSVNELIELLKVEAKKIFEEEYD-AEIQMGLYGLEKLNDGDTVLTQcna 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 142 -------GCSSLVSRIlQEAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASYLLIPAASYVLPE--VSKVLLGAH 211
Cdd:PRK05772 177 gglatgtGLGTALAPV-KLAKALGMSVSVIAPETRPWLQGsRLTVYELMEEGIKVTLITDTAVGLVMYKdmVNNVMVGAD 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 212 ALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAfVSNELDDPDDLQCKRGEHVALANwqnhasLRLLN 291
Cdd:PRK05772 256 RILRDGHVFNKIGTFKEAVIAHELGIPFYALAPTSTFDLKSDVND-VKIEERDPNEVRTIRGVPITPED------VNVYN 328
                        250       260
                 ....*....|....*....|.
gi 974987447 292 LVYDVTPPELVDLVITELGMI 312
Cdd:PRK05772 329 PVFDVTPPKYITGIITEKGII 349
MtnA COG0182
5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a ...
153-312 1.06e-14

5-methylthioribose/5-deoxyribulose 1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism];


Pssm-ID: 439952  Cd Length: 343  Bit Score: 73.54  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 153 EAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASylLIP--AASYVLP--EVSKVLLGAHALLANGSVMSRVGTAQ 227
Cdd:COG0182  174 AAHEAGKLIHVYADETRPLLQGaRLTAWELMQDGIPVT--LITdnAAGHLMQrgKVDAVIVGADRIAANGDVANKIGTYG 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 228 LALVARAHNVPVLVCCETYKFcervqtDAFVSN------ELDDPDDLQCKRGEHVALANwqnhasLRLLNLVYDVTPPEL 301
Cdd:COG0182  252 LAVLAKHHGIPFYVAAPTSTI------DLSLPDgedipiEERDPDEVTHVGGRRIAPEG------VPVYNPAFDVTPAEL 319
                        170
                 ....*....|.
gi 974987447 302 VDLVITELGMI 312
Cdd:COG0182  320 ITAIITEKGVI 330
PRK06371 PRK06371
S-methyl-5-thioribose-1-phosphate isomerase;
72-311 6.12e-13

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 180547  Cd Length: 329  Bit Score: 68.39  E-value: 6.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  72 RPLSASMHNAIKFLNKEITSVGSSKReeeakselraaidrYVQEkIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRI- 150
Cdd:PRK06371  89 RPTAYDLFKAIRYMNSNEFDMNAARR--------------YAME-IIGRSKKIGEYGNELIKNGARILTHCNAGALAVVd 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 151 -------LQEAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASYLLIPAASYVL--PEVSKVLLGAHALLANGSVM 220
Cdd:PRK06371 154 wgtalapIRIAHRNGKNIFVFVDETRPRLQGaRLTAWELAQEGIDHAIIADNAAGYFMrkKEIDLVIVGADRIASNGDFA 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 221 SRVGTAQLALVARAHNVPVLVCC--ETYKFCERvQTDAFVSNELDDPDDLQCkRGEHVALAnwQNHASlrllNLVYDVTP 298
Cdd:PRK06371 234 NKIGTYEKAVLAKVNGIPFYVAApgSTFDFSIK-SGDEIPIEERDENEVLEI-NGCRIGPQ--ESHAR----NPAFDVTP 305
                        250
                 ....*....|...
gi 974987447 299 PELVDLVITELGM 311
Cdd:PRK06371 306 NEYVTGFITEYGI 318
PRK06036 PRK06036
S-methyl-5-thioribose-1-phosphate isomerase;
56-321 1.38e-11

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 180362  Cd Length: 339  Bit Score: 64.36  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  56 DLVNKLKPYMSFLTQCRP----LSASMHNAIKflnkeITSVGSSkREEEAKSELRAAIDryVQEKIVLAAQAISRFAYQK 131
Cdd:PRK06036  73 ELLKDLKVAAETLKSTRPtavnLSWGVDRVLK-----AALDAED-VEEIRDIALREAER--IAEEDVARNKLIGKHGAKL 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 132 ISNGDVILVYgCSSlvSR-----------ILQEAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASYLLIPAASYV 199
Cdd:PRK06036 145 LEDGDTVLTH-CNA--GRlacvdwgtalgVIRSAVEQGKEIKVIACETRPLNQGsRLTTWELMQDNIPVTLITDSMAGIV 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 200 LPE--VSKVLLGAHALLANgSVMSRVGTAQLALVARAHNVPVLVCC--ETYKFcERVQTDafVSNELDDPDDLQCKRGEH 275
Cdd:PRK06036 222 MRQgmVDKVIVGADRITRD-AVFNKIGTYTHSVLAKEHEIPFYVAAplSTFDF-EGWEGS--VKIEERDPDELRYCGKTQ 297
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 974987447 276 VALANwqnhasLRLLNLVYDVTPPELVDLVITELGMI-PCSSVPVVL 321
Cdd:PRK06036 298 IAPKD------VPVYNPAFDATPMENVTAIITEKGVFyPPFLLDEVL 338
PRK06372 PRK06372
translation initiation factor IF-2B subunit delta; Provisional
80-319 4.21e-11

translation initiation factor IF-2B subunit delta; Provisional


Pssm-ID: 235788 [Multi-domain]  Cd Length: 253  Bit Score: 62.23  E-value: 4.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447  80 NAIKFLNKEITSVG------SSKREEEAKS--ELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSlvsril 151
Cdd:PRK06372  33 NIIKDLKNYFFGMGlvrnvcDSIISGPNLRpkNLKLGIEKHEKMAIEHAKPLFNDSVIGTISSSQVLKAFISSS------ 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 152 qEAWTegrrfRVVVVDSRPWLEGRHTLRSLVHAGVPAsYLLIPAASYVLPE-VSKVLLGAHALLANGSVMSRVGTAQLAL 230
Cdd:PRK06372 107 -EKIK-----SVYILESRPMLEGIDMAKLLVKSGIDV-VLLTDASMCEAVLnVDAVIVGSDSVLYDGGLIHKNGTFPLAL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 231 VARAHNVPVLVCCETYKFCERVQTDAFvsnelddpddlqckrgehvalANWQNHASLRL------LNLVYDVTPPELVDL 304
Cdd:PRK06372 180 CARYLKKPFYSLTISMKIERNFLYSTY---------------------PNFKNHPCSEWnidipcINRYFDKTPPDLIDY 238
                        250
                 ....*....|....*
gi 974987447 305 VITELGMIPCSSVPV 319
Cdd:PRK06372 239 YINENGFVKPSDVNI 253
PRK08334 PRK08334
S-methyl-5-thioribose-1-phosphate isomerase;
167-312 1.07e-05

S-methyl-5-thioribose-1-phosphate isomerase;


Pssm-ID: 169386  Cd Length: 356  Bit Score: 46.50  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974987447 167 DSRPWLEG-RHTLRSLVHAGVPASYLLIPAASYVLPE--VSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCC 243
Cdd:PRK08334 200 ETRPVLQGaRLSAWEYHYDGIPLKLISDNMAGFVMQQgkVDAIIVGADRIVANGDFANKIGTYTLAVLAKEHGIPFFTVA 279
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974987447 244 ETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVAlanwqnhASLRLLNLVYDVTPPELVDLVITELGMI 312
Cdd:PRK08334 280 PLSTIDMSLKSGKEIPIEERSPEEVLTCGGCRIA-------PDVDVYNPAFDVTPHKYLTGIITDRGVV 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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