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Conserved domains on  [gi|985567539|ref|NP_001306603|]
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glucocorticoid modulatory element-binding protein 1 isoform 2 [Homo sapiens]

Protein Classification

SAND domain-containing protein( domain architecture ID 10474440)

SAND domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 80-155 3.21e-29

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


:

Pssm-ID: 460167  Cd Length: 76  Bit Score: 110.36  E-value: 3.21e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985567539   80 DMEIAYPITCGESKAILlWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQI 155
Cdd:pfam01342   2 FDSPVLPVTCGAAKGLL-HKKKFKQGISGKCIQNEDSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
 
Name Accession Description Interval E-value
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 80-155 3.21e-29

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 110.36  E-value: 3.21e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985567539   80 DMEIAYPITCGESKAILlWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQI 155
Cdd:pfam01342   2 FDSPVLPVTCGAAKGLL-HKKKFKQGISGKCIQNEDSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
85-156 3.66e-28

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 107.05  E-value: 3.66e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985567539    85 YPITCGESKAILLWKKFVCpGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQID 156
Cdd:smart00258   3 LPVTCGTVKGILYKKKFKC-GISVKCIQYEDKWFTPKEFEIEGGKGKSKDWKRSIRCGGSSLRTLMENGTLD 73
 
Name Accession Description Interval E-value
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 80-155 3.21e-29

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 110.36  E-value: 3.21e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985567539   80 DMEIAYPITCGESKAILlWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQI 155
Cdd:pfam01342   2 FDSPVLPVTCGAAKGLL-HKKKFKQGISGKCIQNEDSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
85-156 3.66e-28

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 107.05  E-value: 3.66e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985567539    85 YPITCGESKAILLWKKFVCpGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQID 156
Cdd:smart00258   3 LPVTCGTVKGILYKKKFKC-GISVKCIQYEDKWFTPKEFEIEGGKGKSKDWKRSIRCGGSSLRTLMENGTLD 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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