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Conserved domains on  [gi|999809067|ref|NP_001307302|]
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von Willebrand factor A domain-containing protein 5B2 isoform 2 [Homo sapiens]

Protein Classification

vWA domain-containing protein( domain architecture ID 10618672)

vWA (von Willebrand factor type A) domain-containing protein may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation, and immune defenses

CATH:  3.40.50.410
PubMed:  10830113|12579041|12388743
SCOP:  3000832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWA_3 pfam13768
von Willebrand factor type A domain;
135-282 3.18e-46

von Willebrand factor type A domain;


:

Pssm-ID: 372716 [Multi-domain]  Cd Length: 155  Bit Score: 162.95  E-value: 3.18e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067   135 ELLFLLDSSSVAH------KDAIVLAVKSLPPQTLINLAVFGTLVQPLFPESRPCSDDAVQLICESIETLQVPSGPPDVL 208
Cdd:pfam13768    2 DVVIVVDVSSSMSgepklqKDALSVALRQLPTGDKFAVLGFGTLPRPLFPGWRVVSPRSLQEAFQFIKTLQPPLGGSDLL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999809067   209 AALDWAVGQPQHRAYPRQLFLLTAASPMaATTHRTLELMRWHRGTARCFSFGLGPT-CHQLLQGLSALSRGQAYF 282
Cdd:pfam13768   82 GALKEAVRAPASPGYIRHVLLLTDGSPM-QGETRVSDLISRAPGKIRFFAYGLGASiSAPMLQLLAEASNGTYEF 155
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 346-890 8.92e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  346 DGFRSRPPGGQEPGwqsSGGSVFPSPEEAPSAASPGT---EPTGTSEPLGTGTVS---AELSS-------PWAARDSEQT 412
Cdd:PHA03247 2486 ARFPFAAGAAPDPG---GGGPPDPDAPPAPSRLAPAIlpdEPVGEPVHPRMLTWIrglEELASddagdppPPLPPAAPPA 2562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  413 GTDAlTDPVTDPGPNPSDTAIWRRIFQSSYIREqyvlthcSASPEPGPGSTGSSESPGSQGPGSPEGSAPLEPPSQQGCR 492
Cdd:PHA03247 2563 APDR-SVPPPRPAPRPSEPAVTSRARRPDAPPQ-------SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA 2634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  493 SLAWGEPAGSRSCPLPAPTPAPfkvgALSTEVLGRQHRAALAGRSLSSPPGRANQVPGRPRKPSLGAILDGPSPEPGQQL 572
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDP----APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEP 2710

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  573 GQGLDDSGNLLSPAPMDWDMLMEPPFLFTAVPPSGELAPPAVPPQAPRCHVVIRGLCGEQPmcwevgvgletlwgPGDGS 652
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP--------------PAAPA 2776

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  653 QPPSPPVREAAWDQALHRLTAASVVRDNEQLALRGGAETTADRGHARRCWLRALQTSKVSSAPSCFTCPVAVDATTR-EV 731
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgSV 2856

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  732 LPGAlQVCSSEPAEPPGTPPASHSHLDAAPLPtvvySKGLQRGSPAGAWDSDQngnskralgdPATPTEGPRRPPPRPPC 811
Cdd:PHA03247 2857 APGG-DVRRRPPSRSPAAKPAAPARPPVRRLA----RPAVSRSTESFALPPDQ----------PERPPQPQAPPPPQPQP 2921

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 999809067  812 RLSMGRRHKLCSPDPGQANNSEGSDHDYLPLVRLQEAPGSFRLDAPFCAAVRISQERLCRASPFAVHRASLSPTSASLP 890
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000
 
Name Accession Description Interval E-value
VWA_3 pfam13768
von Willebrand factor type A domain;
135-282 3.18e-46

von Willebrand factor type A domain;


Pssm-ID: 372716 [Multi-domain]  Cd Length: 155  Bit Score: 162.95  E-value: 3.18e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067   135 ELLFLLDSSSVAH------KDAIVLAVKSLPPQTLINLAVFGTLVQPLFPESRPCSDDAVQLICESIETLQVPSGPPDVL 208
Cdd:pfam13768    2 DVVIVVDVSSSMSgepklqKDALSVALRQLPTGDKFAVLGFGTLPRPLFPGWRVVSPRSLQEAFQFIKTLQPPLGGSDLL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999809067   209 AALDWAVGQPQHRAYPRQLFLLTAASPMaATTHRTLELMRWHRGTARCFSFGLGPT-CHQLLQGLSALSRGQAYF 282
Cdd:pfam13768   82 GALKEAVRAPASPGYIRHVLLLTDGSPM-QGETRVSDLISRAPGKIRFFAYGLGASiSAPMLQLLAEASNGTYEF 155
vWA_interalpha_trypsin_inhibitor cd01461
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- ...
 134-295 2.47e-20

vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix.


Pssm-ID: 238738 [Multi-domain]  Cd Length: 171  Bit Score: 89.20  E-value: 2.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  134 RELLFLLDSSS-------VAHKDAIVLAVKSLPPQTLINLAVFGTLVQPLFPESRPCSDDAVQLICESIETLQvPSGPPD 206
Cdd:cd01461     3 KEVVFVIDTSGsmsgtkiEQTKEALLTALKDLPPGDYFNIIGFSDTVEEFSPSSVSATAENVAAAIEYVNRLQ-ALGGTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  207 VLAALDWAVGQPQHRA-YPRQLFLLTAASpmAATTHRTLELMRWH-RGTARCFSFGLGPTC-HQLLQGLSALSRGQAYFL 283
Cdd:cd01461    82 MNDALEAALELLNSSPgSVPQIILLTDGE--VTNESQILKNVREAlSGRIRLFTFGIGSDVnTYLLERLAREGRGIARRI 159

                         170
                  ....*....|..
gi 999809067  284 RPGQRLQPMLVQ 295
Cdd:cd01461   160 YETDDIESQLLR 171
PHA03247 PHA03247
large tegument protein UL36; Provisional
 346-890 8.92e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  346 DGFRSRPPGGQEPGwqsSGGSVFPSPEEAPSAASPGT---EPTGTSEPLGTGTVS---AELSS-------PWAARDSEQT 412
Cdd:PHA03247 2486 ARFPFAAGAAPDPG---GGGPPDPDAPPAPSRLAPAIlpdEPVGEPVHPRMLTWIrglEELASddagdppPPLPPAAPPA 2562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  413 GTDAlTDPVTDPGPNPSDTAIWRRIFQSSYIREqyvlthcSASPEPGPGSTGSSESPGSQGPGSPEGSAPLEPPSQQGCR 492
Cdd:PHA03247 2563 APDR-SVPPPRPAPRPSEPAVTSRARRPDAPPQ-------SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA 2634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  493 SLAWGEPAGSRSCPLPAPTPAPfkvgALSTEVLGRQHRAALAGRSLSSPPGRANQVPGRPRKPSLGAILDGPSPEPGQQL 572
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDP----APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEP 2710

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  573 GQGLDDSGNLLSPAPMDWDMLMEPPFLFTAVPPSGELAPPAVPPQAPRCHVVIRGLCGEQPmcwevgvgletlwgPGDGS 652
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP--------------PAAPA 2776

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  653 QPPSPPVREAAWDQALHRLTAASVVRDNEQLALRGGAETTADRGHARRCWLRALQTSKVSSAPSCFTCPVAVDATTR-EV 731
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgSV 2856

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  732 LPGAlQVCSSEPAEPPGTPPASHSHLDAAPLPtvvySKGLQRGSPAGAWDSDQngnskralgdPATPTEGPRRPPPRPPC 811
Cdd:PHA03247 2857 APGG-DVRRRPPSRSPAAKPAAPARPPVRRLA----RPAVSRSTESFALPPDQ----------PERPPQPQAPPPPQPQP 2921

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 999809067  812 RLSMGRRHKLCSPDPGQANNSEGSDHDYLPLVRLQEAPGSFRLDAPFCAAVRISQERLCRASPFAVHRASLSPTSASLP 890
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000
 
Name Accession Description Interval E-value
VWA_3 pfam13768
von Willebrand factor type A domain;
135-282 3.18e-46

von Willebrand factor type A domain;


Pssm-ID: 372716 [Multi-domain]  Cd Length: 155  Bit Score: 162.95  E-value: 3.18e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067   135 ELLFLLDSSSVAH------KDAIVLAVKSLPPQTLINLAVFGTLVQPLFPESRPCSDDAVQLICESIETLQVPSGPPDVL 208
Cdd:pfam13768    2 DVVIVVDVSSSMSgepklqKDALSVALRQLPTGDKFAVLGFGTLPRPLFPGWRVVSPRSLQEAFQFIKTLQPPLGGSDLL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 999809067   209 AALDWAVGQPQHRAYPRQLFLLTAASPMaATTHRTLELMRWHRGTARCFSFGLGPT-CHQLLQGLSALSRGQAYF 282
Cdd:pfam13768   82 GALKEAVRAPASPGYIRHVLLLTDGSPM-QGETRVSDLISRAPGKIRFFAYGLGASiSAPMLQLLAEASNGTYEF 155
vWA_interalpha_trypsin_inhibitor cd01461
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- ...
 134-295 2.47e-20

vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix.


Pssm-ID: 238738 [Multi-domain]  Cd Length: 171  Bit Score: 89.20  E-value: 2.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  134 RELLFLLDSSS-------VAHKDAIVLAVKSLPPQTLINLAVFGTLVQPLFPESRPCSDDAVQLICESIETLQvPSGPPD 206
Cdd:cd01461     3 KEVVFVIDTSGsmsgtkiEQTKEALLTALKDLPPGDYFNIIGFSDTVEEFSPSSVSATAENVAAAIEYVNRLQ-ALGGTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  207 VLAALDWAVGQPQHRA-YPRQLFLLTAASpmAATTHRTLELMRWH-RGTARCFSFGLGPTC-HQLLQGLSALSRGQAYFL 283
Cdd:cd01461    82 MNDALEAALELLNSSPgSVPQIILLTDGE--VTNESQILKNVREAlSGRIRLFTFGIGSDVnTYLLERLAREGRGIARRI 159

                         170
                  ....*....|..
gi 999809067  284 RPGQRLQPMLVQ 295
Cdd:cd01461   160 YETDDIESQLLR 171
PHA03247 PHA03247
large tegument protein UL36; Provisional
 346-890 8.92e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 8.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  346 DGFRSRPPGGQEPGwqsSGGSVFPSPEEAPSAASPGT---EPTGTSEPLGTGTVS---AELSS-------PWAARDSEQT 412
Cdd:PHA03247 2486 ARFPFAAGAAPDPG---GGGPPDPDAPPAPSRLAPAIlpdEPVGEPVHPRMLTWIrglEELASddagdppPPLPPAAPPA 2562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  413 GTDAlTDPVTDPGPNPSDTAIWRRIFQSSYIREqyvlthcSASPEPGPGSTGSSESPGSQGPGSPEGSAPLEPPSQQGCR 492
Cdd:PHA03247 2563 APDR-SVPPPRPAPRPSEPAVTSRARRPDAPPQ-------SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA 2634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  493 SLAWGEPAGSRSCPLPAPTPAPfkvgALSTEVLGRQHRAALAGRSLSSPPGRANQVPGRPRKPSLGAILDGPSPEPGQQL 572
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDP----APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEP 2710

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  573 GQGLDDSGNLLSPAPMDWDMLMEPPFLFTAVPPSGELAPPAVPPQAPRCHVVIRGLCGEQPmcwevgvgletlwgPGDGS 652
Cdd:PHA03247 2711 APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP--------------PAAPA 2776

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  653 QPPSPPVREAAWDQALHRLTAASVVRDNEQLALRGGAETTADRGHARRCWLRALQTSKVSSAPSCFTCPVAVDATTR-EV 731
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgSV 2856

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  732 LPGAlQVCSSEPAEPPGTPPASHSHLDAAPLPtvvySKGLQRGSPAGAWDSDQngnskralgdPATPTEGPRRPPPRPPC 811
Cdd:PHA03247 2857 APGG-DVRRRPPSRSPAAKPAAPARPPVRRLA----RPAVSRSTESFALPPDQ----------PERPPQPQAPPPPQPQP 2921

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 999809067  812 RLSMGRRHKLCSPDPGQANNSEGSDHDYLPLVRLQEAPGSFRLDAPFCAAVRISQERLCRASPFAVHRASLSPTSASLP 890
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS 3000
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 361-490 6.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.48  E-value: 6.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 999809067  361 QSSGGSVFPSPEEAPSAASPGTEPTGTSEPLGTGTVSAE----LSSPWAARDSEQTGTDALtDPVTDPGPNPSDTaiwRR 436
Cdd:PRK14949  569 DDEQHSANVQSAQSAAEAQPSSQSLSPISAVTTAAASLAdddiLDAVLAARDSLLSDLDAL-SPKEGDGKKSSAD---RK 644

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 999809067  437 IFQSSYIREQYVLTHCSASPEPGPGSTgSSESPGSQGPGSPEGSAPLEPPSQQG 490
Cdd:PRK14949  645 PKTPPSRAPPASLSKPASSPDASQTSA-SFDLDPDFELATHQSVPEAALASGSA 697
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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