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Conserved domains on  [gi|1000232090|ref|NP_001307346|]
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MIT domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

BREX system Lon protease-like protein BrxL( domain architecture ID 10219180)

BREX system Lon protease-like protein BrxL is part of the phage resistance system BREX (BacteRiophage EXclusion) that employs a defense strategy involving DNA methylation of the host cell and blocking phage DNA replication

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 29-177 8.90e-87

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


:

Pssm-ID: 239148  Cd Length: 148  Bit Score: 251.39  E-value: 8.90e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232090  29 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQvQQSRGLQEIEES 108
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000232090 109 LRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKH 177
Cdd:cd02685    80 LASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT super family cl00299
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 1-18 9.90e-05

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


The actual alignment was detected with superfamily member cd02683:

Pssm-ID: 469712  Cd Length: 77  Bit Score: 39.33  E-value: 9.90e-05
                          10
                  ....*....|....*...
gi 1000232090   1 MDRAENIKKYLDQEKEDG 18
Cdd:cd02683    60 MDRAEAIKKRLDQEKEDG 77
 
Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 29-177 8.90e-87

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 251.39  E-value: 8.90e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232090  29 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQvQQSRGLQEIEES 108
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000232090 109 LRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKH 177
Cdd:cd02685    80 LASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 32-169 8.84e-86

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 248.21  E-value: 8.84e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232090  32 GFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGiEQVQQSRGLQEIEESLRS 111
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLTGEDEE-NLDQQLDNLEELKDSLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1000232090 112 HGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETT 169
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKFSLGYCDQDLRKCKETT 137
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 1-18 9.90e-05

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 39.33  E-value: 9.90e-05
                          10
                  ....*....|....*...
gi 1000232090   1 MDRAENIKKYLDQEKEDG 18
Cdd:cd02683    60 MDRAEAIKKRLDQEKEDG 77
 
Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 29-177 8.90e-87

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 251.39  E-value: 8.90e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232090  29 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQvQQSRGLQEIEES 108
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQIRNFLRFCELVVKPPCELKYIHLVTGEDEDNGK-QQIEALEEIKQS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000232090 109 LRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKH 177
Cdd:cd02685    80 LASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 32-169 8.84e-86

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 248.21  E-value: 8.84e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232090  32 GFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGiEQVQQSRGLQEIEESLRS 111
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRNLVRFCELLVKKCGNLKKIHLLTGEDEE-NLDQQLDNLEELKDSLAS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1000232090 112 HGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETT 169
Cdd:pfam16565  80 RGVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKFSLGYCDQDLRKCKETT 137
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 1-18 9.90e-05

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 39.33  E-value: 9.90e-05
                          10
                  ....*....|....*...
gi 1000232090   1 MDRAENIKKYLDQEKEDG 18
Cdd:cd02683    60 MDRAEAIKKRLDQEKEDG 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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