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Conserved domains on  [gi|1000232094|ref|NP_001307348|]
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MIT domain-containing protein 1 isoform 4 [Homo sapiens]

Protein Classification

BREX system Lon protease-like protein BrxL( domain architecture ID 10119420)

BREX system Lon protease-like protein BrxL is part of the phage resistance system BREX (BacteRiophage EXclusion) that employs a defense strategy involving DNA methylation of the host cell and blocking phage DNA replication

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIT_C super family cl02780
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-216 4.84e-63

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


The actual alignment was detected with superfamily member cd02685:

Pssm-ID: 470673  Cd Length: 148  Bit Score: 192.84  E-value: 4.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232094  97 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQ------GIEQV----------------------QQSRGLQEIEESL 148
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQirnflrFCELVvkppcelkyihlvtgededngkQQIEALEEIKQSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1000232094 149 RSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKH 216
Cdd:cd02685    81 ASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 7.01e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


:

Pssm-ID: 239146  Cd Length: 77  Bit Score: 136.79  E-value: 7.01e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1000232094  10 PQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683     1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
 
Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-216 4.84e-63

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 192.84  E-value: 4.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232094  97 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQ------GIEQV----------------------QQSRGLQEIEESL 148
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQirnflrFCELVvkppcelkyihlvtgededngkQQIEALEEIKQSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1000232094 149 RSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKH 216
Cdd:cd02685    81 ASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 100-208 1.57e-62

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 191.20  E-value: 1.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232094 100 GFSYESLFREYLNETVTEVWIEDPYIRHTHQGI----------------------------EQVQQSRGLQEIEESLRSH 151
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRnlvrfcellvkkcgnlkkihlltgedeeNLDQQLDNLEELKDSLASR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1000232094 152 GVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETT 208
Cdd:pfam16565  81 GVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKFSLGYCDQDLRKCKETT 137
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 7.01e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 136.79  E-value: 7.01e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1000232094  10 PQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683     1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
8-81 3.56e-19

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 78.12  E-value: 3.56e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000232094    8 QDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQ 81
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 14-77 1.84e-16

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 70.65  E-value: 1.84e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000232094  14 AAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 77
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
 
Name Accession Description Interval E-value
MIT_C cd02685
MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and ...
 97-216 4.84e-63

MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown.


Pssm-ID: 239148  Cd Length: 148  Bit Score: 192.84  E-value: 4.84e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232094  97 NATGFSYESLFREYLNETVTEVWIEDPYIRHTHQ------GIEQV----------------------QQSRGLQEIEESL 148
Cdd:cd02685     1 NATGFSYDRLFGPYLDDGVTEITVEDPYIRNFHQirnflrFCELVvkppcelkyihlvtgededngkQQIEALEEIKQSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1000232094 149 RSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKH 216
Cdd:cd02685    81 ASHGVEFTWEFSDTIHDREIRTDNGWIIKIGRGLDYFKPPEGKFSLGNRDQDFRPCKATEVDIFHTKH 148
MIT_C pfam16565
Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of ...
 100-208 1.57e-62

Phospholipase D-like domain at C-terminus of MIT; MIT_C is the C-terminal domain of MIT-containing proteins, pfam04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.


Pssm-ID: 465180  Cd Length: 137  Bit Score: 191.20  E-value: 1.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232094 100 GFSYESLFREYLNETVTEVWIEDPYIRHTHQGI----------------------------EQVQQSRGLQEIEESLRSH 151
Cdd:pfam16565   1 GYSYESLFGPYLDGTATEITIEDPYIRAPHQIRnlvrfcellvkkcgnlkkihlltgedeeNLDQQLDNLEELKDSLASR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1000232094 152 GVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETT 208
Cdd:pfam16565  81 GVTLTVEFSSTLHDREIRFDNGWIIKIGRGLDYFKKPESKFSLGYCDQDLRKCKETT 137
MIT_1 cd02683
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-86 7.01e-42

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with unknown function, co-occuring with an as yet undescribed domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239146  Cd Length: 77  Bit Score: 136.79  E-value: 7.01e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1000232094  10 PQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDG 86
Cdd:cd02683     1 SLELAAKEVLKRAVELDQEGRFQEALVCYQEGIDLLMQVLKGTKDEAKKKNLRQKISEYMDRAEAIKKRLDQEKEDG 77
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
8-81 3.56e-19

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 78.12  E-value: 3.56e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000232094    8 QDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQ 81
Cdd:smart00745   1 TRDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLLE 74
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 14-83 4.13e-19

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 78.12  E-value: 4.13e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232094  14 AAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEK 83
Cdd:cd02656     5 QAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKEPKLRKLLRKKVKEYLDRAEFLKELLKKQK 74
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 14-77 1.84e-16

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 70.65  E-value: 1.84e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000232094  14 AAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 77
Cdd:pfam04212   3 KALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 20-83 8.06e-12

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 58.82  E-value: 8.06e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1000232094  20 KRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEK 83
Cdd:cd02678    11 KKAIEEDNAGNYEEALRLYQHALEYFMHALKYEKNPKSKESIRAKCTEYLDRAEKLKEYLAKKE 74
MIT_SNX15 cd02677
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT ...
 15-75 3.29e-09

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.


Pssm-ID: 239140  Cd Length: 75  Bit Score: 51.96  E-value: 3.29e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1000232094  15 AATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENI 75
Cdd:cd02677     6 AAELIRLALEKEEEGDYEAAFEFYRAGVDLLLKGVQGDSSPERREAVKRKIAEYLKRAEEI 66
MIT_2 cd02684
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 15-79 3.31e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239147  Cd Length: 75  Bit Score: 38.26  E-value: 3.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1000232094  15 AATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYL 79
Cdd:cd02684     6 AIALVVQAVKKDQRGDAAAALSLYCSALQYFVPALHYETDAQRKEALRQKVLQYVSRAEELKALI 70
MIT_AAA_Arch cd02682
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 22-77 7.74e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in mostly archaebacterial AAA-ATPases. The molecular function of the MIT domain is unclear.


Pssm-ID: 239145  Cd Length: 75  Bit Score: 37.12  E-value: 7.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1000232094  22 AVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKK 77
Cdd:cd02682    13 AVKAEKEGNAEDAITNYKKAIEVLSQIVKNYPDSPTRLIYEQMINEYKRRIEVLEK 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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