NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1000837101|ref|NP_001307387|]
View 

protein Wnt-9b isoform 2 precursor [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 60-302 2.39e-179

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19354:

Pssm-ID: 393294  Cd Length: 297  Bit Score: 497.50  E-value: 2.39e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 139
Cdd:cd19354     1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 140 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 219
Cdd:cd19354    81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 220 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 299
Cdd:cd19354   161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240


                  ...
gi 1000837101 300 TAG 302
Cdd:cd19354   241 TAG 243
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 60-302 2.39e-179

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 497.50  E-value: 2.39e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 139
Cdd:cd19354     1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 140 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 219
Cdd:cd19354    81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 220 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 299
Cdd:cd19354   161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240


                  ...
gi 1000837101 300 TAG 302
Cdd:cd19354   241 TAG 243
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 57-302 8.75e-109

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 319.11  E-value: 8.75e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR----MGLLKRGFKETAFLYAVSSAALTHTL 131
Cdd:pfam00110   2 LPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCStLENKrpvfGKVLKRGTRETAFVYAISSAGVTHAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 132 ARACSAGRMERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:pfam00110  82 TRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAReKKRRDARALMNLHNNEAGRKAVKSNMRT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlGRLELWAPARQgsltkglAPRSGDLVYMEDSP 288
Cdd:pfam00110 162 ECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKR-GRLVPRNSRFK-------PPTKNDLVYLEKSP 233

                         250
                  ....*....|....*.
gi 1000837101 289 SFCRPSKY--SPGTAG 302
Cdd:pfam00110 234 DYCERNPKtgSLGTRG 249
WNT1 smart00097
found in Wnt-1;
57-302 7.11e-80

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 245.31  E-value: 7.11e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101   57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRM---GLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:smart00097   2 LPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCStLDNASvfgKVLRQGTRETAFVYAISSAGVAHAVT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  133 RACSAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCK 211
Cdd:smart00097  82 RACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  212 CHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnEALGRLELWAPARQGSLTKglAPRSGDLVYMEDSPSFC 291
Cdd:smart00097 162 CHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-----EVDKRGTNKAPVPKNSTFK--PPTETDLVYLESSPDFC 234

                          250
                   ....*....|...
gi 1000837101  292 R--PSKYSPGTAG 302
Cdd:smart00097 235 EknPKTGSLGTQG 247
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 60-302 2.39e-179

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 497.50  E-value: 2.39e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 139
Cdd:cd19354     1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 140 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 219
Cdd:cd19354    81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 220 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 299
Cdd:cd19354   161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240


                  ...
gi 1000837101 300 TAG 302
Cdd:cd19354   241 TAG 243
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 60-302 1.86e-136

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 388.95  E-value: 1.86e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLE-GRMGLLKRGFKETAFLYAVSSAALTHTLARACSAG 138
Cdd:cd19341     1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGkYRINLLKKGYKETAFLYAISSAGLTHSVARACSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 139 RMERCTCDDSPGLE-SRQAWQWGVCGDNLKYSTKFLSNFLGSKRGN-KDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 216
Cdd:cd19341    81 RLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 217 GSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELwAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY 296
Cdd:cd19341   161 GSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGGSQL-RKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRY 239


                  ....*.
gi 1000837101 297 SPGTAG 302
Cdd:cd19341   240 SPGTKG 245
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 60-302 2.55e-124

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 358.19  E-value: 2.55e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR--MGLLKRGFKETAFLYAVSSAALTHTLARACSA 137
Cdd:cd19353     1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRyrASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 138 GRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGsKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSG 217
Cdd:cd19353    81 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLG-RKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 218 SCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYS 297
Cdd:cd19353   160 SCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFS 239


                  ....*
gi 1000837101 298 PGTAG 302
Cdd:cd19353   240 PGTSG 244
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 57-302 8.75e-109

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 319.11  E-value: 8.75e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR----MGLLKRGFKETAFLYAVSSAALTHTL 131
Cdd:pfam00110   2 LPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCStLENKrpvfGKVLKRGTRETAFVYAISSAGVTHAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 132 ARACSAGRMERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:pfam00110  82 TRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAReKKRRDARALMNLHNNEAGRKAVKSNMRT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlGRLELWAPARQgsltkglAPRSGDLVYMEDSP 288
Cdd:pfam00110 162 ECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKR-GRLVPRNSRFK-------PPTKNDLVYLEKSP 233

                         250
                  ....*....|....*.
gi 1000837101 289 SFCRPSKY--SPGTAG 302
Cdd:pfam00110 234 DYCERNPKtgSLGTRG 249
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 74-302 3.04e-87

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 263.77  E-value: 3.04e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  74 LAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSP 149
Cdd:cd13113     1 LMESIAEGAQLALKECQRQFANRRWNCSTFNEPLLfgkiLKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 150 -GLESRQAWQWGVCGDNLKYSTKFLSNFL--GSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWK 226
Cdd:cd13113    81 qGPEGQGDWTWGGCSDNIKFGIKFSRKFLdaREKKKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1000837101 227 QLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAPARQGSLTkglaPRSGDLVYMEDSPSFCRP--SKYSPGTAG 302
Cdd:cd13113   161 QLPSFREIGDYLKEKYDNAVKVKLNNN---GSGLRLVPKRSRFRS----PTETDLVYLEESPDYCEPnpTLGSLGTAG 231
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 59-302 7.99e-84

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 255.61  E-value: 7.99e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  59 KLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM--GLLKRGFKETAFLYAVSSAALTHTLARACS 136
Cdd:cd19338    12 RLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSfgKILKRDTRETAFVYAITSAGVTYSVTRACS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 137 AGRMERCTCDDSPGLESRQ-AWQWGVCGDNLKYSTKFLSNFL-GSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG 214
Cdd:cd19338    92 MGELLQCGCDKSKRGKSTEgEWEWGGCSDNVRYGYRKSREFMdAKEKNRSDIRTLMNLHNNEAGRLAVKNNMRKECKCHG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 215 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSsatnealgrlelwaPARQGsltKGLAPRS--------GDLVYMED 286
Cdd:cd19338   172 LSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVK--------------GSNDG---KSLIPEGktikpptkEDLVYLEE 234

                         250
                  ....*....|....*...
gi 1000837101 287 SPSFCRPSKY--SPGTAG 302
Cdd:cd19338   235 SPDFCEPNKKtgSLGTRG 252
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 60-302 1.09e-82

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 252.96  E-value: 1.09e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR------MGLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19342    10 LTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSsLETKnknphtSPILSRGYRETAFAYAISAAGVAHQVA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDDS--PGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTC 210
Cdd:cd19342    90 RACSLGKLLSCGCDRSrrGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 211 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSaTNEALGRLELWAPARQGSLTkglaPRSGDLVYMEDSPSF 290
Cdd:cd19342   170 KCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQ-SNLNNGARRRRLTRRKRRRR----PPKTDLVYYERSPNF 244

                         250
                  ....*....|....
gi 1000837101 291 CRPSKY--SPGTAG 302
Cdd:cd19342   245 CEADPSldSPGTRG 258
WNT1 smart00097
found in Wnt-1;
57-302 7.11e-80

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 245.31  E-value: 7.11e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101   57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRM---GLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:smart00097   2 LPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCStLDNASvfgKVLRQGTRETAFVYAISSAGVAHAVT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  133 RACSAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCK 211
Cdd:smart00097  82 RACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  212 CHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnEALGRLELWAPARQGSLTKglAPRSGDLVYMEDSPSFC 291
Cdd:smart00097 162 CHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-----EVDKRGTNKAPVPKNSTFK--PPTETDLVYLESSPDFC 234

                          250
                   ....*....|...
gi 1000837101  292 R--PSKYSPGTAG 302
Cdd:smart00097 235 EknPKTGSLGTQG 247
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 60-302 8.09e-79

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 242.91  E-value: 8.09e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM----GLLKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19344     1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQnvfgKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 136 SAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFL-----GSKRGNKDLRARADAHNTHVGIKAVKSGLRTT 209
Cdd:cd19344    81 SAGNLTDCSCDSRRqGQSASEGWKWGGCSDNVDYGIWFARKFVdapekSERKRSRDVRSLMNLHNNEVGRQAIARLMKVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 210 CKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssATNEALGRLElwapaRQGSLTKGLAPRSGDLVYMEDSPS 289
Cdd:cd19344   161 CRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQI--ATKKSKRRLR-----RRERRKRKVPISKDELVYIHKSPN 233

                         250
                  ....*....|....*
gi 1000837101 290 FCR--PSKYSPGTAG 302
Cdd:cd19344   234 YCVrdPKKGILGTSG 248
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 55-302 3.13e-76

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 236.46  E-value: 3.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  55 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMG-----LLKRGFKETAFLYAVSSAALT 128
Cdd:cd19334     6 CDNIPgLVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDAtvfgkVLLKGSREAAFVYAISSAGVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 129 HTLARACSAGRMERCTCDDSP---GLESRQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKS 204
Cdd:cd19334    86 HAITRACSKGELLNCACDPTKrgkGRDSKGEFDWGGCSDNVKYGINFARKFVDAReRRVRDARALMNLHNNRAGRKAVKK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 205 GLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAPARQGSLTKglaprsGDLVYM 284
Cdd:cd19334   166 NLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQS---GTNLLAANKGHKKPTR------SDLVYF 236

                         250       260
                  ....*....|....*....|
gi 1000837101 285 EDSPSFCRPSKY--SPGTAG 302
Cdd:cd19334   237 ESSPDYCVPNPEtgSLGTAG 256
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 60-302 8.02e-74

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 230.32  E-value: 8.02e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMG-------LLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19333     1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRGgpnvfgkILNRGCRETAFIYAITSAAVTHSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 212
Cdd:cd19333    81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 213 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKV-------SSATNEA-LGRLELWAPARQgsltkglAPRSGDLVYM 284
Cdd:cd19333   161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVaygnngnNRGSRRAkKFLLEPENPNHK-------PPTSKDLVYF 233

                         250       260
                  ....*....|....*....|
gi 1000837101 285 EDSPSFCRPSKY--SPGTAG 302
Cdd:cd19333   234 EESPNFCEKNPKlgTLGTRG 253
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 60-302 1.61e-72

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 226.75  E-value: 1.61e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS---LEGRMGL-LKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19343     1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSsieLAPNFTPdLTRGTREQAFVYALSSAALTHTIARAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 136 SAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFL-GSKRGNKDLRARADA----HNTHVGIKAVKSGLRTTC 210
Cdd:cd19343    81 ASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTdAPEKKKKKKKRQARAlmnlHNNRVGRKAVRDSLETQC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 211 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEalGRLELWAPARQGSLTkglapRSGDLVYMEDSPSF 290
Cdd:cd19343   161 KCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVG--SRRKLVPKSLKVRPY-----TKDDLIYLTKSPDY 233

                         250
                  ....*....|....
gi 1000837101 291 CRPSKY--SPGTAG 302
Cdd:cd19343   234 CLPDEKlgSLGTRG 247
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 55-302 1.13e-71

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 224.82  E-value: 1.13e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  55 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTH 129
Cdd:cd19337     1 CDQLRgLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVFGPvtniGTREAAFTYAISAAGVVH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 130 TLARACSAGRMERCTCDDSPGLES-RQAWQWGVCGDNLKYSTKFLSNFLGS-------KRGNKDL-RARADAHNTHVGIK 200
Cdd:cd19337    81 AIARACREGNLSTCGCSRERRPKDlPRDWLWGGCGDNIEYGYKFAKEFIDAreretnyPRHSRELaRVLMNLHNNEAGRR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 201 AVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATneaLGRLELwapARQGSLTKglaPRSGD 280
Cdd:cd19337   161 AVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNR---RGTLLR---RRNSRFNK---PTKDD 231

                         250       260
                  ....*....|....*....|....
gi 1000837101 281 LVYMEDSPSFCRPSKY--SPGTAG 302
Cdd:cd19337   232 LVYLDDSPDYCERNPKtgSLGTKG 255
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 60-302 3.05e-70

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 221.01  E-value: 3.05e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR----MGLLKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19339     8 LTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGErtvfGQELPVGSREAAFTYAITSAGVAYAITQAC 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 136 SAGRMERCTCD--DSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 213
Cdd:cd19339    88 SQGNLSDCGCDksKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCH 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 214 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKglaPRSGDLVYMEDSPSFCR- 292
Cdd:cd19339   168 GVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKLKISRKYKK---PRPRDLVYLEKSPNYCEk 244

                         250
                  ....*....|.
gi 1000837101 293 -PSKYSPGTAG 302
Cdd:cd19339   245 dPLTGSLGTVG 255
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 55-302 9.19e-70

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 219.49  E-value: 9.19e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  55 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM----GLLKRGFKETAFLYAVSSAALTH 129
Cdd:cd19336     1 CESLKgLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEpvfgKVLNQGTREAAFVHAISSAGVAH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 130 TLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGS----KRGNKDLRARADAHNTHVGIKAVKSG 205
Cdd:cd19336    81 AVTRACSSGELEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFVDArerrKGRASSSRALMNLHNNEAGRKAIEKN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 206 LRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnealgrlelwAPARQGSlTKGLAPR-------- 277
Cdd:cd19336   161 MRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEV--------------QQKRIGS-RPVLVPKnpqfkpht 225

                         250       260
                  ....*....|....*....|....*..
gi 1000837101 278 SGDLVYMEDSPSFCR--PSKYSPGTAG 302
Cdd:cd19336   226 DADLVYLDSSPDFCEpdPKTGSLGTHG 252
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 74-306 7.00e-67

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 212.15  E-value: 7.00e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  74 LAETLRDAAHLGLLECQFQFRHERWNCSLEGRM--GLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS-PG 150
Cdd:cd19340     9 LSDSVAAGAQLAMEECQYQFKWDRWNCPESAFFsqKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSkKG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 151 LESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSP 230
Cdd:cd19340    89 SKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLAP 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1000837101 231 FRETGQVLKLRYDSAVKVSSATnealGRLELWAPARQgslTKGLAPRSGDLVYMEDSPSFCRPSKyspgTAGWSAV 306
Cdd:cd19340   169 FREIGTDLKRKYDRAVRVDYEN----GGLRETNGSRA---IKLLNIKKNDLVYLEKSPNYCRANV----TLGWPGT 233
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 60-302 1.31e-62

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 201.46  E-value: 1.31e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRMGL----LKRGFKETAFLYAVSSAALTHTLARA 134
Cdd:cd19335    10 LVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTtIEGDLSVfgpvLDKASRESAFVHAIASAGVAHAVTRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 135 CSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG 214
Cdd:cd19335    90 CAEGDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 215 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVK-VSSATNEALGRLELWAParqgSLTKGLAPRSGDLVYMEDSPSFCR- 292
Cdd:cd19335   170 LSGSCELKTCWWAQPDFRKIGDYLKDKYDSASEmVVERHRESRGWVETLRP----KYKLFKPPTERDLIYYEESPNFCEp 245

                         250
                  ....*....|.
gi 1000837101 293 -PSKYSPGTAG 302
Cdd:cd19335   246 nPETGSFGTRG 256
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 60-302 2.62e-58

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 190.52  E-value: 2.62e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-------LEGRMGLlkRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19346    12 LVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCStldrdhtVFGRVML--RSSREAAFVYAISSAGVVYAIT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDDSPGLES---RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:cd19346    90 RACSQGELKSCSCDPHKRGRShdeRGEFDWGGCSDNINYGIKFAKAFVDAKeKKEKDARALMNLHNNRCGRMAVKRFMKL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGrlelWAPARQGSltkgLAPRSGDLVYMEDSP 288
Cdd:cd19346   170 ECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQV-TMNQDGTG----FTVANKNF----RKATKTDLVYFENSP 240

                         250
                  ....*....|....*.
gi 1000837101 289 SFCRPSKY--SPGTAG 302
Cdd:cd19346   241 DYCVMDKSagSLGTAG 256
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 60-302 2.04e-55

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 182.83  E-value: 2.04e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNC-------SLEGRmgLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19345    12 LVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCntldrdhSLFGR--LLLRSSRESAFVYAISSAGVVFAIT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDDSPGLESRQA---WQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:cd19345    90 RACSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAKeRKGKDARALMNLHNNRAGRKAVKRFMTL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGRLELWAPARQgsltkglaPRSGDLVYMEDSP 288
Cdd:cd19345   170 ECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQV-VMNQDGTGFTVANKHFKK--------PTKNDLVYFENSP 240

                         250
                  ....*....|....*.
gi 1000837101 289 SFCRPSKY--SPGTAG 302
Cdd:cd19345   241 DYCVRDRDagSLGTAG 256
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 60-302 1.90e-54

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 180.18  E-value: 1.90e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRMGL------LKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19355    10 LTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSsLETRNKIpyesvvFSRGFRESAFAYAIAAAGVVHAVS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDdspglesrqaWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 212
Cdd:cd19355    90 NACAMGKLKACGCD----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 213 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGRLElwaparQGSLTKGLAPRSGDLVYMEDSPSFCR 292
Cdd:cd19355   160 HGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLI-KPHNRNTGQLE------PGHAPHRRRASINDLVYFEKSPDFCE 232

                         250
                  ....*....|..
gi 1000837101 293 --PSKYSPGTAG 302
Cdd:cd19355   233 rePRLDSAGTQG 244
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 60-302 7.74e-54

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 179.09  E-value: 7.74e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19349    13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVfgkeLKVGSREAAFTYAIIAAGVAHAITAAC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 136 SAGRMERCTCDDSP--GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 213
Cdd:cd19349    93 TQGNLSDCGCDKEKqgQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCH 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 214 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKglaPRSGDLVYMEDSPSFCR- 292
Cdd:cd19349   173 GVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRK---PMDTDLVYIEKSPNYCEe 249

                         250
                  ....*....|.
gi 1000837101 293 -PSKYSPGTAG 302
Cdd:cd19349   250 dPVTGSVGTQG 260
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 60-302 2.92e-51

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 171.61  E-value: 2.92e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LE--GRM----GLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19356    10 LSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSsLEggGKLphdsAILKRGFRESAFSFSLLAAGVMHSVA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCddspglesrqAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 212
Cdd:cd19356    90 TACSLGKLRGCGC----------EWEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 213 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlgrlelwaparqGSLTKGLAPR--SGDLVYMEDSPSF 290
Cdd:cd19356   160 HGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNKNS------------GVFLPRLRPRrlARELVYFEKSPDF 227

                         250
                  ....*....|....
gi 1000837101 291 CR--PSKYSPGTAG 302
Cdd:cd19356   228 CErdPAVDSPGTQG 241
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 60-291 4.39e-50

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 169.03  E-value: 4.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19350    13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTVfgqeLRVGSREAAFTYAITAAGVAHAVTAAC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 136 SAGRMERCTCDDSPG--LESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 213
Cdd:cd19350    93 SQGNLSNCGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCH 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1000837101 214 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEalgRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFC 291
Cdd:cd19350   173 GVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRAS---RLRQPTFLKIKKRRSYQKPMETDLVYIERSPNYC 247
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 57-302 1.05e-49

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 167.93  E-value: 1.05e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTHTLA 132
Cdd:cd19347     4 LAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRvmqiGSRETAFTYAISAAGVVNAVS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDDSPGLESRQA-WQWGVCGDNLKYSTKFLSNFLGSKRGNK--------DLRARADAHNTHVGIKAVK 203
Cdd:cd19347    84 RACREGELSTCGCSRAARPKDLPRdWLWGGCGDNLEYGYRFAKEFVDAREREKiyqkgsyeSARTLMNLHNNEAGRRTVY 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 204 SGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLElwaparqgslTKGLAPRSGDLVY 283
Cdd:cd19347   164 NLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQVN----------SRFNPPTTLDLVY 233

                         250       260
                  ....*....|....*....|.
gi 1000837101 284 MEDSPSFC--RPSKYSPGTAG 302
Cdd:cd19347   234 IDPSPDYCvrNESTGSLGTQG 254
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 75-291 5.54e-48

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 163.53  E-value: 5.54e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  75 AETLRDAAHLGLLECQFQFRHERWNCSlEGRMGL-----LKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS- 148
Cdd:cd19351    10 SSSVAAGAQSGIEECKHQFAWERWNCP-ESALQLsthngLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSr 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 149 PGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQL 228
Cdd:cd19351    89 NGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQL 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1000837101 229 SPFRETGQVLKLRYDSAVKVS------SATNEALGRlelWAPARQGSltkglAPRSGDLVYMEDSPSFC 291
Cdd:cd19351   169 ADFREIGNYLKVKHDQALKLEmdkrrmRAGNSADNR---GAIAEAFG-----SVAETELIYLEDSPDYC 229
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 81-318 2.27e-47

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 161.73  E-value: 2.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  81 AAHLGLLECQFQFRHERWNC-----SLEGRMGLlKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS-PGLESR 154
Cdd:cd19352    17 GAQSGIEECKYQFAWDRWNCperalQLSSHSGL-RSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSrNGQLGG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 155 QAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRET 234
Cdd:cd19352    96 QGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 235 GQVLKLRYDSAVKVS---SATNEALGRlelwaparqGSLTKGLAPRS-GDLVYMEDSPSFCRPSKY--SPGTAGWSAVAR 308
Cdd:cd19352   176 GNYLKEKYHRALKVDllqGAGNSAASR---------GAIAETFRSISkKELVHLEDSPDYCLENKTlgLLGTEGRECLKR 246

                         250
                  ....*....|
gi 1000837101 309 SQLITTSTSR 318
Cdd:cd19352   247 GKALSKWEKR 256
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 57-302 1.14e-44

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 154.75  E-value: 1.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101  57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTHTLA 132
Cdd:cd19348     4 LTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRvmqiGSRETAFTYAVSAAGVVNAIS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 133 RACSAGRMERCTCDDS--PGLESRQaWQWGVCGDNLKYSTKFLSNFLGSKRGNKDL--------RARADAHNTHVGIKAV 202
Cdd:cd19348    84 RACREGELSTCGCSRAarPKDLPRD-WLWGGCGDNVEYGYRFAKEFVDAREREKNYpkgseehaRTLMNLQNNEAGRRAV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000837101 203 KSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAparqgslTKGLAPRSGDLV 282
Cdd:cd19348   163 YNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRK---GKLELVN-------SRFNPPTAEDLV 232

                         250       260
                  ....*....|....*....|..
gi 1000837101 283 YMEDSPSFC--RPSKYSPGTAG 302
Cdd:cd19348   233 YIDPSPDYClrNETTGSLGTQG 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH