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Conserved domains on  [gi|1001624602|ref|NP_001307476|]
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tRNA (34-2'-O)-methyltransferase regulator WDR6 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 124-274 1.25e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 1.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  124 IVAGAVSNQLLVWypatALADNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHC 203
Cdd:cd00200    150 VASSSQDGTIKLW----DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTL 215

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1001624602  204 FGHSARVWQVKLLEN--YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLW 274
Cdd:cd00200    216 RGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
123-466 3.97e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 3.97e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATALadnkpvaPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 202
Cdd:COG2319     92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  203 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 279
Cdd:COG2319    160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  280 ------GYRGLGVSALCFksrSRPGTlkavtlagswRLLAVTDTGALYLYDVEvkcWEQLLEDKHFQSYCLLEAAPGPEG 353
Cdd:COG2319    237 kllrtlTGHSGSVRSVAF---SPDGR----------LLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDG 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  354 fGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGyeELLLLASGPGGVVacleISAAPSGKAIFVKErcry 433
Cdd:COG2319    301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVR----LWDLATGELLRTLT---- 369

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1001624602  434 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVLL 466
Cdd:COG2319    370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 super family cl43672
WD40 repeat [General function prediction only];
825-1028 3.47e-06

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLqDSGRILQLLAetfHHKRCVLKVhSFTheaPNQRRrllLCSAATDGSLAFWDLTTmldhdst 904
Cdd:COG2319    216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTREghhLVASGSEDGSLHVFvlavemlqleeavgEAGLVPQLRVL 984
Cdd:COG2319    278 --------------GELLRTLTGHSGGVNSVAFSPDGK---LLASGSDDGTVRLW--------------DLATGKLLRTL 326

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1001624602  985 EeysvpcAHAAHVTGLKIlSP--SIMVSASIDQRLTFWRLGHGEPT 1028
Cdd:COG2319    327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 124-274 1.25e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 1.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  124 IVAGAVSNQLLVWypatALADNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHC 203
Cdd:cd00200    150 VASSSQDGTIKLW----DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTL 215

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1001624602  204 FGHSARVWQVKLLEN--YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLW 274
Cdd:cd00200    216 RGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
123-276 6.20e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnigh 202
Cdd:COG2319    260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1001624602  203 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 276
Cdd:COG2319    328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
123-466 3.97e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 3.97e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATALadnkpvaPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 202
Cdd:COG2319     92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  203 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 279
Cdd:COG2319    160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  280 ------GYRGLGVSALCFksrSRPGTlkavtlagswRLLAVTDTGALYLYDVEvkcWEQLLEDKHFQSYCLLEAAPGPEG 353
Cdd:COG2319    237 kllrtlTGHSGSVRSVAF---SPDGR----------LLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDG 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  354 fGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGyeELLLLASGPGGVVacleISAAPSGKAIFVKErcry 433
Cdd:COG2319    301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVR----LWDLATGELLRTLT---- 369

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1001624602  434 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVLL 466
Cdd:COG2319    370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
825-1028 3.47e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLqDSGRILQLLAetfHHKRCVLKVhSFTheaPNQRRrllLCSAATDGSLAFWDLTTmldhdst 904
Cdd:COG2319    216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTREghhLVASGSEDGSLHVFvlavemlqleeavgEAGLVPQLRVL 984
Cdd:COG2319    278 --------------GELLRTLTGHSGGVNSVAFSPDGK---LLASGSDDGTVRLW--------------DLATGKLLRTL 326

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1001624602  985 EeysvpcAHAAHVTGLKIlSP--SIMVSASIDQRLTFWRLGHGEPT 1028
Cdd:COG2319    327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 815-959 4.04e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 4.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  815 AVCELDQPGLGPLVAAACSDGAVRLFllqdSGRILQLLAETFHHKRCVLKVhSFTheaPNQRRrllLCSAATDGSLAFWD 894
Cdd:cd00200    137 WVNSVAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWD 205

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1001624602  895 LTTmldhdstvleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTReghHLVASGSEDGSLHVF 959
Cdd:cd00200    206 LST---------------------GKCLGTLRGHENGVNSVAFSPDG---YLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-186 4.60e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1001624602   150 PDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWK 186
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-274 3.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1001624602  236 GEILQAFRGHQGrGIRAIAAHERQAWVITGGDDSGIRLW 274
Cdd:pfam00400    1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 124-274 1.25e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 1.25e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  124 IVAGAVSNQLLVWypatALADNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHC 203
Cdd:cd00200    150 VASSSQDGTIKLW----DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTL 215

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1001624602  204 FGHSARVWQVKLLEN--YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLW 274
Cdd:cd00200    216 RGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
123-276 6.20e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnigh 202
Cdd:COG2319    260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1001624602  203 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 276
Cdd:COG2319    328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
123-280 8.03e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 8.03e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATaladNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGH 202
Cdd:COG2319    218 LLASGSADGTVRLWDLAT----GKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT----GELLRTLTG 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  203 cfgHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 279
Cdd:COG2319    287 ---HSGGVNSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDDGTVRLWDLATG 362


                   .
gi 1001624602  280 G 280
Cdd:COG2319    363 E 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 152-276 3.60e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 3.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  152 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnighcfGHSARVWQVKLL--ENYLISAGEDCVC 229
Cdd:cd00200      3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASadGTYLASGSSDKTI 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1001624602  230 LVWS-HEGEILQAFRGHQGrGIRAIAAHERQAWVITGGDDSGIRLWHL 276
Cdd:cd00200     76 RLWDlETGECVRTLTGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
123-276 5.30e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 5.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 202
Cdd:COG2319    176 LLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT----GKLLRTLT- 243

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1001624602  203 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 276
Cdd:COG2319    244 --GHSGSVRSVAFSPDgrLLASGSADGTVRLWDlATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
123-466 3.97e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 3.97e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  123 TIVAGAVSNQLLVWYPATALadnkpvaPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 202
Cdd:COG2319     92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  203 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 279
Cdd:COG2319    160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  280 ------GYRGLGVSALCFksrSRPGTlkavtlagswRLLAVTDTGALYLYDVEvkcWEQLLEDKHFQSYCLLEAAPGPEG 353
Cdd:COG2319    237 kllrtlTGHSGSVRSVAF---SPDGR----------LLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDG 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  354 fGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGyeELLLLASGPGGVVacleISAAPSGKAIFVKErcry 433
Cdd:COG2319    301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVR----LWDLATGELLRTLT---- 369

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1001624602  434 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVLL 466
Cdd:COG2319    370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 68-233 2.28e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 2.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602   68 IWDARWLEGnIALALGHNSVVlydpvvgcilqevpctdrctlSSACLIGDawkELTIVAGAVSNQLLVWypatalaDNKP 147
Cdd:cd00200    161 LWDLRTGKC-VATLTGHTGEV---------------------NSVAFSPD---GEKLLSSSSDGTIKLW-------DLST 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  148 VAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVpggrvqnIGHCFGHSARVWQVKLLE--NYLISAGE 225
Cdd:cd00200    209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-------VQTLSGHTNSVTSLAWSPdgKRLASGSA 281


                   ....*...
gi 1001624602  226 DCVCLVWS 233
Cdd:cd00200    282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
825-1028 3.47e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLqDSGRILQLLAetfHHKRCVLKVhSFTheaPNQRRrllLCSAATDGSLAFWDLTTmldhdst 904
Cdd:COG2319    216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTREghhLVASGSEDGSLHVFvlavemlqleeavgEAGLVPQLRVL 984
Cdd:COG2319    278 --------------GELLRTLTGHSGGVNSVAFSPDGK---LLASGSDDGTVRLW--------------DLATGKLLRTL 326

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1001624602  985 EeysvpcAHAAHVTGLKIlSP--SIMVSASIDQRLTFWRLGHGEPT 1028
Cdd:COG2319    327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 815-959 4.04e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 4.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  815 AVCELDQPGLGPLVAAACSDGAVRLFllqdSGRILQLLAETFHHKRCVLKVhSFTheaPNQRRrllLCSAATDGSLAFWD 894
Cdd:cd00200    137 WVNSVAFSPDGTFVASSSQDGTIKLW----DLRTGKCVATLTGHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWD 205

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1001624602  895 LTTmldhdstvleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTReghHLVASGSEDGSLHVF 959
Cdd:cd00200    206 LST---------------------GKCLGTLRGHENGVNSVAFSPDG---YLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
825-1022 1.04e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLqDSGRILQLLAetfHHKRCVLKVhSFTheaPNQRRrllLCSAATDGSLAFWDLTTmldhdst 904
Cdd:COG2319    258 GRLLASGSADGTVRLWDL-ATGELLRTLT---GHSGGVNSV-AFS---PDGKL---LASGSDDGTVRLWDLAT------- 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTReghHLVASGSEDGSLHVFvlavemlqleeavgEAGLVPQLRVL 984
Cdd:COG2319    320 --------------GKLLRTLTGHTGAVRSVAFSPDG---KTLASGSDDGTVRLW--------------DLATGELLRTL 368

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1001624602  985 EeysvpcAHAAHVTGLKIlSP--SIMVSASIDQRLTFWRL 1022
Cdd:COG2319    369 T------GHTGAVTSVAF-SPdgRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 825-959 2.09e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLqDSGRILQLLAEtfhHKRCVLKVHSFTHeapnqrrRLLLCSAATDGSLAFWDLTTmldhdst 904
Cdd:cd00200    189 GEKLLSSSSDGTIKLWDL-STGKCLGTLRG---HENGVNSVAFSPD-------GYLLASGSEDGTIRVWDLRT------- 250

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPTReghHLVASGSEDGSLHVF 959
Cdd:cd00200    251 --------------GECVQTLSGHTNSVTSLAWSPDG---KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
139-276 4.82e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 4.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  139 ATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnighcfGHSARVWQVKLLEN 218
Cdd:COG2319     17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-------GHTAAVLSVAFSPD 89

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1001624602  219 --YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 276
Cdd:COG2319     90 grLLASASADGTVRLWDLAtGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 COG2319
WD40 repeat [General function prediction only];
825-1027 5.83e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 5.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLqDSGRILQLLAetfHHKRCVLKVhSFtheAPNQRRrllLCSAATDGSLAFWDLTTmldhdst 904
Cdd:COG2319    174 GKLLASGSDDGTVRLWDL-ATGKLLRTLT---GHTGAVRSV-AF---SPDGKL---LASGSADGTVRLWDLAT------- 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPtrEGHHLvASGSEDGSLHVFVLAVEMLqleeavgeaglvpqLRVL 984
Cdd:COG2319    236 --------------GKLLRTLTGHSGSVRSVAFSP--DGRLL-ASGSADGTVRLWDLATGEL--------------LRTL 284

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1001624602  985 EeysvpcAHAAHVTGLKIlSP--SIMVSASIDQRLTFWRLGHGEP 1027
Cdd:COG2319    285 T------GHSGGVNSVAF-SPdgKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
825-1027 1.07e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLQDsGRILQLLAetfHHKRCVLKVhSFTheaPNqRRRLLlcSAATDGSLAFWDLTTmldhdst 904
Cdd:COG2319    132 GKTLASGSADGTVRLWDLAT-GKLLRTLT---GHSGAVTSV-AFS---PD-GKLLA--SGSDDGTVRLWDLAT------- 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  905 vleppvdpglpyrlGTPSLTLQAHSCGINSLHTLPtrEGHHLvASGSEDGSLHVFvlavemlqleeavgEAGLVPQLRVL 984
Cdd:COG2319    194 --------------GKLLRTLTGHTGAVRSVAFSP--DGKLL-ASGSADGTVRLW--------------DLATGKLLRTL 242

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1001624602  985 EeysvpcAHAAHVTGLKIlSP--SIMVSASIDQRLTFWRLGHGEP 1027
Cdd:COG2319    243 T------GHSGSVRSVAF-SPdgRLLASGSADGTVRLWDLATGEL 280
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-186 4.60e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1001624602   150 PDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWK 186
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 825-1030 5.42e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  825 GPLVAAACSDGAVRLFLLQDSgrilQLLAETFHHKRCVLKVHsFTHEapnqrrRLLLCSAATDGSLAFWDL------TTM 898
Cdd:cd00200     63 GTYLASGSSDKTIRLWDLETG----ECVRTLTGHTSYVSSVA-FSPD------GRILSSSSRDKTIKVWDVetgkclTTL 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1001624602  899 LDHDSTVLEPPVDPGLPY---------------RLGTPSLTLQAHSCGINSLHTLPTreGHHLVASGSeDGSLHVFVLAV 963
Cdd:cd00200    132 RGHTDWVNSVAFSPDGTFvasssqdgtiklwdlRTGKCVATLTGHTGEVNSVAFSPD--GEKLLSSSS-DGTIKLWDLST 208

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1001624602  964 EMlqleeavgeaglvpQLRVLEeysvpcAHAAHVTGLKILSPS-IMVSASIDQRLTFWRLGHGEPTFM 1030
Cdd:cd00200    209 GK--------------CLGTLR------GHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
123-189 1.75e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.75e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1001624602  123 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD 189
Cdd:COG2319    344 TLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
236-274 3.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1001624602  236 GEILQAFRGHQGrGIRAIAAHERQAWVITGGDDSGIRLW 274
Cdd:pfam00400    1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
152-185 4.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 4.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1001624602  152 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIW 185
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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