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Conserved domains on  [gi|1002095820|ref|NP_001307539|]
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MICOS complex subunit MIC25 isoform 1 [Homo sapiens]

Protein Classification

MICOS complex subunit MIC19 family protein( domain architecture ID 12062584)

MICOS complex subunit MIC19 family protein is a DUF737 domain-containing protein similar to vertebrate MICOS complex subunits MIC19 and MIC25

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 31-189 6.70e-50

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


:

Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 161.01  E-value: 6.70e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002095820  31 SENVVNRMKE-------PSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEG--------VKRYEQEHA 95
Cdd:pfam05300   1 SENVINRMKEpsappppSAPSPPPPSPPPPSPTPGPSQAPESTSAPPSAESSGGRQPVDEEELrkkikeelYKRLEQEQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002095820  96 AIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLqARELESREAELRRRDTFYKEQLERIERKNAEMYKLSS 175
Cdd:pfam05300  81 KVQEELARLAEREREAAQESLTRAILRERASTEDERLKAQQL-AKQLEEKEAELKKQDAFYKEQLARLEEKNAEFYKVTT 159

                         170
                  ....*....|....
gi 1002095820 176 EQFHEAASKMESTI 189
Cdd:pfam05300 160 EQFHKAATKAEARF 173
 
Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 31-189 6.70e-50

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 161.01  E-value: 6.70e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002095820  31 SENVVNRMKE-------PSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEG--------VKRYEQEHA 95
Cdd:pfam05300   1 SENVINRMKEpsappppSAPSPPPPSPPPPSPTPGPSQAPESTSAPPSAESSGGRQPVDEEELrkkikeelYKRLEQEQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002095820  96 AIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLqARELESREAELRRRDTFYKEQLERIERKNAEMYKLSS 175
Cdd:pfam05300  81 KVQEELARLAEREREAAQESLTRAILRERASTEDERLKAQQL-AKQLEEKEAELKKQDAFYKEQLARLEEKNAEFYKVTT 159

                         170
                  ....*....|....
gi 1002095820 176 EQFHEAASKMESTI 189
Cdd:pfam05300 160 EQFHKAATKAEARF 173
 
Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 31-189 6.70e-50

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 161.01  E-value: 6.70e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002095820  31 SENVVNRMKE-------PSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEG--------VKRYEQEHA 95
Cdd:pfam05300   1 SENVINRMKEpsappppSAPSPPPPSPPPPSPTPGPSQAPESTSAPPSAESSGGRQPVDEEELrkkikeelYKRLEQEQA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002095820  96 AIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLqARELESREAELRRRDTFYKEQLERIERKNAEMYKLSS 175
Cdd:pfam05300  81 KVQEELARLAEREREAAQESLTRAILRERASTEDERLKAQQL-AKQLEEKEAELKKQDAFYKEQLARLEEKNAEFYKVTT 159

                         170
                  ....*....|....
gi 1002095820 176 EQFHEAASKMESTI 189
Cdd:pfam05300 160 EQFHKAATKAEARF 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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