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Conserved domains on  [gi|1002096894|ref|NP_001307567|]
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leukocyte surface antigen CD53 isoform 2 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509|32974937
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
9-149 5.41e-19

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 78.90  E-value: 5.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002096894   9 LKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFIL 88
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002096894  89 LLIILLAEVTLAILLFVYEQK------------------------------------------GCYAKARLWFHSNFLYI 126
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKlsgllsnwlkksledgyrdwldlysclnsaldslqsefgccgGCKEKLLEWLRKNLKII 160

                         170       180
                  ....*....|....*....|...
gi 1002096894 127 GIITICVCVIEVLGMSFALTLNC 149
Cdd:pfam00335 161 GAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
9-149 5.41e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 78.90  E-value: 5.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002096894   9 LKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFIL 88
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002096894  89 LLIILLAEVTLAILLFVYEQK------------------------------------------GCYAKARLWFHSNFLYI 126
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKlsgllsnwlkksledgyrdwldlysclnsaldslqsefgccgGCKEKLLEWLRKNLKII 160

                         170       180
                  ....*....|....*....|...
gi 1002096894 127 GIITICVCVIEVLGMSFALTLNC 149
Cdd:pfam00335 161 GAGVIALGVIQLLGIILACCLCC 183
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 106-127 1.13e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 44.39  E-value: 1.13e-06
                          10        20
                  ....*....|....*....|..
gi 1002096894 106 YEQKGCYAKARLWFHSNFLYIG 127
Cdd:cd03164    65 YKVEGCYKKLKNWFESNFLYTG 86
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
9-149 5.41e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 78.90  E-value: 5.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002096894   9 LKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFIL 88
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002096894  89 LLIILLAEVTLAILLFVYEQK------------------------------------------GCYAKARLWFHSNFLYI 126
Cdd:pfam00335  81 LLLLFLAELAAGILAFVYRDKlsgllsnwlkksledgyrdwldlysclnsaldslqsefgccgGCKEKLLEWLRKNLKII 160

                         170       180
                  ....*....|....*....|...
gi 1002096894 127 GIITICVCVIEVLGMSFALTLNC 149
Cdd:pfam00335 161 GAGVIALGVIQLLGIILACCLCC 183
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 106-127 1.13e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 44.39  E-value: 1.13e-06
                          10        20
                  ....*....|....*....|..
gi 1002096894 106 YEQKGCYAKARLWFHSNFLYIG 127
Cdd:cd03164    65 YKVEGCYKKLKNWFESNFLYTG 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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