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Conserved domains on  [gi|1002623483|ref|NP_001307629|]
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annexin A4 isoform b [Homo sapiens]

Protein Classification

Annexin and ANX domain-containing protein( domain architecture ID 10446072)

Annexin and ANX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 229-294 3.20e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 100.63  E-value: 3.20e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002623483 229 YFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVL 294
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 21-79 1.24e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 1.24e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002623483  21 DAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFE 79
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFE 60
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 153-219 1.53e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.00  E-value: 1.53e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002623483 153 QDAQdLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAI 219
Cdd:pfam00191   1 YDAE-LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
83-135 1.05e-19

Annexin repeats;


:

Pssm-ID: 197661  Cd Length: 53  Bit Score: 80.53  E-value: 1.05e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483   83 GTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSL 135
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 229-294 3.20e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 100.63  E-value: 3.20e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002623483 229 YFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVL 294
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 21-79 1.24e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 1.24e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002623483  21 DAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFE 79
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFE 60
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 153-219 1.53e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.00  E-value: 1.53e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002623483 153 QDAQdLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAI 219
Cdd:pfam00191   1 YDAE-LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
242-294 7.74e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 83.61  E-value: 7.74e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483  242 GTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVL 294
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
83-135 1.05e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 80.53  E-value: 1.05e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483   83 GTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSL 135
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 79-135 5.60e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 5.60e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002623483  79 EQGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSL 135
Cdd:pfam00191  10 MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
167-219 2.97e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.68  E-value: 2.97e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483  167 GTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAI 219
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
33-79 5.49e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 73.21  E-value: 5.49e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1002623483   33 GTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFE 79
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFE 47
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 229-294 3.20e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 100.63  E-value: 3.20e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002623483 229 YFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVL 294
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 21-79 1.24e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 1.24e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002623483  21 DAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFE 79
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFE 60
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 153-219 1.53e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.00  E-value: 1.53e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002623483 153 QDAQdLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAI 219
Cdd:pfam00191   1 YDAE-LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
242-294 7.74e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 83.61  E-value: 7.74e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483  242 GTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVL 294
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
83-135 1.05e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 80.53  E-value: 1.05e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483   83 GTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSL 135
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 79-135 5.60e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 5.60e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1002623483  79 EQGAGTDEGCLIEILASRTPEEIRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSL 135
Cdd:pfam00191  10 MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
167-219 2.97e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.68  E-value: 2.97e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1002623483  167 GTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAI 219
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
33-79 5.49e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 73.21  E-value: 5.49e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1002623483   33 GTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNFE 79
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFE 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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