|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
107-522 |
1.38e-161 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
:
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 477.10 E-value: 1.38e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 107 DAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 186
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 187 efnwkrhrlfnhtaclvlyqlcvedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 266
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 267 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYE 340
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 341 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSP 419
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 420 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 499
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 1002819406 500 ICDGKKDKFVVLRQQVQKYKQVF 522
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOPRIM super family |
cl00718 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
18-98 |
2.48e-25 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
The actual alignment was detected with superfamily member cd03362:
Pssm-ID: 469888 [Multi-domain] Cd Length: 151 Bit Score: 102.70 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 18 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 97
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 1002819406 98 L 98
Cdd:cd03362 151 L 151
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
800-844 |
1.81e-18 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
:
Pssm-ID: 462017 Cd Length: 45 Bit Score: 79.37 E-value: 1.81e-18
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1002819406 800 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 844
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
716-757 |
1.05e-16 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
:
Pssm-ID: 462017 Cd Length: 45 Bit Score: 74.36 E-value: 1.05e-16
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1002819406 716 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 757
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
560-599 |
6.92e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
:
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 60.74 E-value: 6.92e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1002819406 560 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 599
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
107-522 |
1.38e-161 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 477.10 E-value: 1.38e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 107 DAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 186
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 187 efnwkrhrlfnhtaclvlyqlcvedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 266
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 267 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYE 340
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 341 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSP 419
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 420 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 499
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 1002819406 500 ICDGKKDKFVVLRQQVQKYKQVF 522
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
14-616 |
6.92e-140 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 436.74 E-value: 6.92e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 14 NPLVLFEAEIEKYCP-ENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVR 92
Cdd:PRK07219 69 DPAELIDADPVKKITkQNYINALKKLAKDADE---IIIATDYDREGELIGKEAYHILREVC-QVPVKRARFSSLTKKEIR 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 93 TACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQ-LISYGSCQFPTLGFVVERFKAIQAFVPEI 171
Cdd:PRK07219 145 KAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLSVRQ-----LGRWdFLSVGRVQTPTLAFIVDREREIRAFDPED 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 172 FHRIKVTHD----HKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRI 247
Cdd:PRK07219 220 YWKIEALLDkeaqYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGI 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 248 NAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY 327
Cdd:PRK07219 300 SPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDV 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 328 --TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHF 405
Cdd:PRK07219 380 pkREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKL 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 406 QPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMS 485
Cdd:PRK07219 460 KVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIV 537
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 486 KPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLdealaqyfgnGTELAQQEDIYPAMPEPIRKCPQ 565
Cdd:PRK07219 538 SEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEI----------GDHLAGSLKAENRSLKTIGKCPE 607
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1002819406 566 CNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPD----SVLeasrdSSVCPVCQPH 616
Cdd:PRK07219 608 CGGDLIIIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----DEVCEKCGLP 657
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
100-507 |
5.43e-136 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 412.41 E-value: 5.43e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 100 EPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT- 178
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKG-------NKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 179 HDHKDGIVEFNWKRHRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEK 258
Cdd:pfam01131 74 KDGGGVFANAKWKRGRIFDKEEAEAILEKL-KKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 259 LYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPDP-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNNLQG 333
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEYLTKNYgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 334 DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD-KILPVYEQGSHFQPSTVEM 412
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 413 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAE 492
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAE 390
|
410
....*....|....*
gi 1002819406 493 LEADLKLICDGKKDK 507
Cdd:pfam01131 391 LEEKLDEIAEGKLDW 405
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
220-473 |
1.15e-107 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 332.67 E-value: 1.15e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 220 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 298
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 299 QSILERGGptPRNGNKSDQAHPPIHPTKYTN------NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 372
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 373 HGLMILARNYLDVYPYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 451
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 1002819406 452 ARMYVGLTPdKRFLPGHLGMGL 473
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
36-513 |
3.04e-92 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 302.01 E-value: 3.04e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 115
Cdd:COG0550 63 KELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKP---VKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 116 DLRIGAAFTRFQTLRLQRifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR--- 192
Cdd:COG0550 140 DRLVGYNLSPLLWKKVKR---------GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKidg 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 193 HRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 271
Cdd:COG0550 211 KKILDEEEAEAILAAL-KGKTFTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 272 -TNIfPRDLNltvlveqqtpdprwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNNLQGDEQRLY 339
Cdd:COG0550 289 sVRL-SEDAV--------------AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 340 EFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDH-----WSDKILPVYEQGSHFQPSTVEMVD 414
Cdd:COG0550 354 DLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQ 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 415 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRA 491
Cdd:COG0550 434 HFTKPPPRYTEASLVKAMEELGIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTA 509
|
490 500
....*....|....*....|..
gi 1002819406 492 ELEADLKLICDGKKDKFVVLRQ 513
Cdd:COG0550 510 KMEEKLDEIAEGKLDWKDVLEE 531
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
36-590 |
5.15e-83 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 279.79 E-value: 5.15e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 115
Cdd:TIGR01057 85 KALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVER---AKRMKFSTLTKQDIRRAYANPEEIDYGMVDAGMARHIL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 116 DLRIGAAFTRFQTLRLQRIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRL 195
Cdd:TIGR01057 162 DWYWGINLSRALMEAIRAAAGRWV---ILSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKGGGVFDARPEKWKI 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 196 FNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIF 275
Cdd:TIGR01057 239 WSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIAQELYEEALISYPRTSSQKL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 276 PRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNNLQGDEQRLYEFIVRHFLACCSQD 353
Cdd:TIGR01057 319 PPSINYRAILDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELSKDEKKVYDLIVRRFLAAFSEE 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 354 AQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME 433
Cdd:TIGR01057 399 AIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREME 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 434 KHGIGTDATHAEHIETIKARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQ 513
Cdd:TIGR01057 479 SRGLGTKATRARIIETLYKRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRRFESKLEDIMSGRITKDEVIDE 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 514 QVQKYKQVFIEAvakAKKLDEAlaqyfgnGTELA---QQEDIypampepIRKCPQCNKDMVLKTKKNGGFYLsCMGFPEC 590
Cdd:TIGR01057 557 AKKRLRKILEEF---KKRLDDI-------GIELGkslGSVEV-------VGKCPKCGGKLVSKYAKKGRFVG-CSNYPEC 618
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
18-98 |
2.48e-25 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 102.70 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 18 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 97
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 1002819406 98 L 98
Cdd:cd03362 151 L 151
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
800-844 |
1.81e-18 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 79.37 E-value: 1.81e-18
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1002819406 800 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 844
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
716-757 |
1.05e-16 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 74.36 E-value: 1.05e-16
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1002819406 716 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 757
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
560-599 |
6.92e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 60.74 E-value: 6.92e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1002819406 560 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 599
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
33-86 |
6.32e-08 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 51.20 E-value: 6.32e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1002819406 33 DIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlQVLRARFSEI 86
Cdd:pfam01751 42 KALKALKELALKAKEVILATDPDREGEAIALKLLELKELLEN--AGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
33-73 |
8.94e-07 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 47.26 E-value: 8.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1002819406 33 DIKKTLERETRQCQaLVIWTDCDREGENIGFEIIHVCKAVK 73
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAELLKPAG 75
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
107-522 |
1.38e-161 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 477.10 E-value: 1.38e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 107 DAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKvthdhkdgiv 186
Cdd:cd00186 5 NAQLARRILDRLVGFNLSRLLTKKLRR-------KGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK---------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 187 efnwkrhrlfnhtaclvlyqlcvedpMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYIS 266
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLIT 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 267 YPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERggPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYE 340
Cdd:cd00186 122 YPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGR--RNPKRGKKEQGAHEAIRPTKVAptpeleANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 341 FIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK-ILPVYEQGSHFQPSTVEMVDGETSP 419
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEeEPPPLKEGDELKLEEVELEEKETQP 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 420 PKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKL 499
Cdd:cd00186 280 PPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEK-KKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 1002819406 500 ICDGKKDKFVVLRQQVQKYKQVF 522
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
14-616 |
6.92e-140 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 436.74 E-value: 6.92e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 14 NPLVLFEAEIEKYCP-ENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVR 92
Cdd:PRK07219 69 DPAELIDADPVKKITkQNYINALKKLAKDADE---IIIATDYDREGELIGKEAYHILREVC-QVPVKRARFSSLTKKEIR 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 93 TACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQ-LISYGSCQFPTLGFVVERFKAIQAFVPEI 171
Cdd:PRK07219 145 KAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLSVRQ-----LGRWdFLSVGRVQTPTLAFIVDREREIRAFDPED 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 172 FHRIKVTHD----HKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRI 247
Cdd:PRK07219 220 YWKIEALLDkeaqYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGI 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 248 NAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY 327
Cdd:PRK07219 300 SPKRAMEIAEKLYTAGYISYPRTDNTVYPDDLDPKELLKKLSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDV 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 328 --TNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHF 405
Cdd:PRK07219 380 pkREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKELPDLEEGEKL 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 406 QPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDKRFLPGHLGMGLVEGYDSMGYEMS 485
Cdd:PRK07219 460 KVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV--IEGDPPRPTDLGIAVIEALEKYAPEIV 537
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 486 KPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLdealaqyfgnGTELAQQEDIYPAMPEPIRKCPQ 565
Cdd:PRK07219 538 SEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEI----------GDHLAGSLKAENRSLKTIGKCPE 607
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1002819406 566 CNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPD----SVLeasrdSSVCPVCQPH 616
Cdd:PRK07219 608 CGGDLIIIRTDKGSRFVGCSGYPDCRNTFPLPStgriKVL-----DEVCEKCGLP 657
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
100-507 |
5.43e-136 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 412.41 E-value: 5.43e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 100 EPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT- 178
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKG-------NKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATl 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 179 HDHKDGIVEFNWKRHRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEK 258
Cdd:pfam01131 74 KDGGGVFANAKWKRGRIFDKEEAEAILEKL-KKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 259 LYTQ-GYISYPRTETNIFPRDLNLTVLVEQQTPDP-RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY---TNNLQG 333
Cdd:pfam01131 153 LYEKhGLITYPRTDSTYLSDDATLKAILEYLTKNYgKYLPYAPRLLKKTKGKLTVGNAKVTAHEAIRPTGDipvLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 334 DEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD-KILPVYEQGSHFQPSTVEM 412
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDeEELPELKEGEELKVTQVEV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 413 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdKRFLPGHLGMGLVEGYDSMgYEMSKPDLRAE 492
Cdd:pfam01131 313 EEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKK-KSLVPTELGKALVEALEKF-PDLVDPELTAE 390
|
410
....*....|....*
gi 1002819406 493 LEADLKLICDGKKDK 507
Cdd:pfam01131 391 LEEKLDEIAEGKLDW 405
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
220-473 |
1.15e-107 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 332.67 E-value: 1.15e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 220 RSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR-WGAFA 298
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKeYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 299 QSILERGGptPRNGNKSDQAHPPIHPTKYTN------NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVA 372
Cdd:smart00437 81 VVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpelekELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 373 HGLMILARNYLDVYPYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIK 451
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKKeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLL 238
|
250 260
....*....|....*....|..
gi 1002819406 452 ARMYVGLTPdKRFLPGHLGMGL 473
Cdd:smart00437 239 DRGYVTKKK-KKLIPTELGIAV 259
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
11-631 |
2.55e-105 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 342.89 E-value: 2.55e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 11 QSCNPLVLFEAEIEK-YCPENFVDIKKTLERE-TRqcqaLVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITP 88
Cdd:PRK07220 66 QKVDARDLIDAEIITtPTQKKIVTALKKLGKEaDR----VTIATDYDREGELIGVEALNIIKKVNPDIKFDRVRYSAITK 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 89 HAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQLISYGSCQFPTLGFVVERFKAIQAFV 168
Cdd:PRK07220 142 KEIERAFSNPVEVDFNLADAGHSRQVIDLVWGAALTRYISLAAGR-----LGKMFLSVGRVQSPTLALIVDREKEREAFV 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 169 PEIFHRIKVTHDHKDGIVEFNWKRHRLFNHT-ACLVLYQLCVEdpmATVVEVRSKPKSKWRPQALDTVELEKLASrKLRI 247
Cdd:PRK07220 217 PTPYWEIYATLENNGETFVAQHSTRRFWEKEeADRVFEKLGKT---AEVTEVEKGTKTDKPPTPFNTTEFISAAN-SIGF 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 248 NAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKY 327
Cdd:PRK07220 293 SAANAMRIAESLYTNGYISYPRTDNTVYPESLDLREQIEIFAEGP-FGEYAQKLLEKGELVPTRGKKETTDHPPIYPASL 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 328 T--NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHF 405
Cdd:PRK07220 372 AkkSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPEDRLLPELSEGEEL 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 406 QPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPdkrFLPGHLGMGLVEGYDSMGYEMS 485
Cdd:PRK07220 452 KVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHGNP---IQPTNTAFAVVDALEKYAPTIT 528
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 486 KPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAqyfgNGTelaqQEDiypampEPIRKCPQ 565
Cdd:PRK07220 529 KPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELDKNREKIRESLR----EGL----RED------KIIGKCPL 594
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 566 CNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDS----VLEAsrdssvcpVCQPHPVYRLKLKfKRGSLP 631
Cdd:PRK07220 595 CGSDLMVRRSKRGSRFIGCEGYPECTFSLPLPKSgqiiVTDK--------VCEAHGLNHIRII-NGGKRP 655
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
36-513 |
3.04e-92 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 302.01 E-value: 3.04e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 115
Cdd:COG0550 63 KELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKP---VKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRIL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 116 DLRIGAAFTRFQTLRLQRifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR--- 192
Cdd:COG0550 140 DRLVGYNLSPLLWKKVKR---------GLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKidg 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 193 HRLFNHTACLVLYQLCvEDPMATVVEVRSKPKSKwRPQAL-DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 271
Cdd:COG0550 211 KKILDEEEAEAILAAL-KGKTFTVTSVEKKPKKR-NPPPPfTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRTD 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 272 -TNIfPRDLNltvlveqqtpdprwGAFAQSILERGGP-----TPR--NGNKSDQ-AHPPIHPT---KYTNNLQGDEQRLY 339
Cdd:COG0550 289 sVRL-SEDAV--------------AAAREYIEALYGKeylpeKPRvyKTSKNAQeAHEAIRPTgvtRTPESLSGDEFKLY 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 340 EFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDH-----WSDKILPVYEQGSHFQPSTVEMVD 414
Cdd:COG0550 354 DLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeEEEKRLPPLKEGEKLKLKKIEPEQ 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 415 GETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGM---GLVEGYDSmgyEMSKPDLRA 491
Cdd:COG0550 434 HFTKPPPRYTEASLVKAMEELGIGRPSTYASIIETLQDRGYVERE-GKRLVPTELGFiviDLLEEHFP---DLVDYEFTA 509
|
490 500
....*....|....*....|..
gi 1002819406 492 ELEADLKLICDGKKDKFVVLRQ 513
Cdd:COG0550 510 KMEEKLDEIAEGKLDWKDVLEE 531
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
24-631 |
6.11e-88 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 300.61 E-value: 6.11e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 24 EKYCPENFVD---IKKTLERE--------TRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVR 92
Cdd:PRK14973 65 EEHTPRSLIDadtIKKPTEKKivgliqklAKKADRVTIATDFDTEGELIGKEAYELVRAVNPKVPIDRARFSAITKEEIV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 93 TACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIF 172
Cdd:PRK14973 145 TAFAEPTDLDFALAAAGEARQIIDLIWGASLTRFISLAAHR-----GGDNILSVGRVQSPTLAMIVDREKEIEAFVPEKY 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 173 HRIKVTHDhKDGI-VEfnwKRH---RLFNHTACLVLYQLCVEDPMATvvEVRSKPKSKWRPQALDTVELEKLASRkLRIN 248
Cdd:PRK14973 220 WMLSLATE-KDGEgIE---ARHthgRFTDSAAAEAAYDATKEPLVVT--EVKEGHKVDRAPTPFDTTTFIVAASR-LGFS 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 249 AKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVE--QQTPDPRWGAFAQSILErggPTPRNGNKSDQAHPPIHPTK 326
Cdd:PRK14973 293 AANAMRIAEDLYMNGYISYPRTDNTIYPKSLDLNGVLAtlAKGAFSKDVAWVKDNRR---PVPTRGKKSSTDHPPIHPTG 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 327 YTNNLQ-GDEQ-RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSH 404
Cdd:PRK14973 370 VATREElGDDRwKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEAKENILPAFALGEK 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 405 FQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKrflPGHLGMGLVEGYDSMGYEM 484
Cdd:PRK14973 450 LPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKYIEGNPLR---PTLVGRAVTESLEEHAGTI 526
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 485 SKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFieavakaKKLDEALAQYfgnGTELAQQEdiypAMPEPIRKCP 564
Cdd:PRK14973 527 TEPDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAF-------DELEANEAVI---GRDIMERT----AEELTIGPCP 592
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002819406 565 QCNKDMVLKtKKNGGFYLSCMGFPECRSAVWLPDSVL-EASRDSSVCPVcqpHPVYRLKLkFKRGSLP 631
Cdd:PRK14973 593 VCGKDLRIK-HIGSSQFIGCSGYPDCTFNIGLPGTTWgWAIRTDEVCPI---HHLNHVRL-IRKGARP 655
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
36-590 |
5.15e-83 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 279.79 E-value: 5.15e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQEL 115
Cdd:TIGR01057 85 KALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVER---AKRMKFSTLTKQDIRRAYANPEEIDYGMVDAGMARHIL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 116 DLRIGAAFTRFQTLRLQRIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRL 195
Cdd:TIGR01057 162 DWYWGINLSRALMEAIRAAAGRWV---ILSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKGGGVFDARPEKWKI 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 196 FNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIF 275
Cdd:TIGR01057 239 WSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIAQELYEEALISYPRTSSQKL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 276 PRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPT--KYTNNLQGDEQRLYEFIVRHFLACCSQD 353
Cdd:TIGR01057 319 PPSINYRAILDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTgeIPSQELSKDEKKVYDLIVRRFLAAFSEE 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 354 AQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME 433
Cdd:TIGR01057 399 AIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEKELPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREME 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 434 KHGIGTDATHAEHIETIKARMYVGLTPDKRFLPghLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQ 513
Cdd:TIGR01057 479 SRGLGTKATRARIIETLYKRGYIEGKKSIKVTP--LGEAVIETLQRYCPEIISEELTRRFESKLEDIMSGRITKDEVIDE 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 514 QVQKYKQVFIEAvakAKKLDEAlaqyfgnGTELA---QQEDIypampepIRKCPQCNKDMVLKTKKNGGFYLsCMGFPEC 590
Cdd:TIGR01057 557 AKKRLRKILEEF---KKRLDDI-------GIELGkslGSVEV-------VGKCPKCGGKLVSKYAKKGRFVG-CSNYPEC 618
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
18-591 |
1.50e-70 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 246.83 E-value: 1.50e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 18 LFEAEIEKYCPENFVDIKKTLERETRQcqaLVIWTDCDREGENIGFEIIhvcKAVKPNLQVLRARFSEITPHAVRTACEN 97
Cdd:PRK05776 73 LYEIDKGSKYTKKYYELLSSLSKYADE---FINACDYDIEGSVIGYLII---KYLGDPKKAKRMKFSALTKSDIRRAFRN 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 98 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV 177
Cdd:PRK05776 147 LETLDYEMINAGIARHELDWLWGINVSRALMSSVRDASGKRV---ILSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSI 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 178 THDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 257
Cdd:PRK05776 224 IIEKNGYEFTLKYENKKFETKEEAKEILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAE 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 258 KLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGP--TPRNGNKSDQAHPPIHPT-KYTNNLQGD 334
Cdd:PRK05776 304 DLYLDGLISYPRTNSQKLPPTLNIRNILKGLSRSPQYRPLVNLLLKETKGvlKPVQGPKDDPAHPAIYPTgEPPKNLSKD 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 335 EQRLYEFIVRHFLACCSQDAQGQETTVEIDI--AQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEM 412
Cdd:PRK05776 384 EFKLYDLIVRRFLASFAAPAVLSNTIVTLRVpgFPLVFSASGQRIEERGWLKYYPFHKFDEEELPLLKKGERVKIVDVKV 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 413 VDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYvgLTPDKRFL-PGHLGMGLVEGYDSMGYEMSKPDLRA 491
Cdd:PRK05776 464 RKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGY--LTSNGKYIeVTPLGFGVAEVLEKYFPDIVSVELTR 541
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 492 ELEADLKLICDGKkdkfvVLRQQVqkykqvfieaVAKAKK-LDEALAQYFGN----GTELAQqediYPAMPEPIRKCPQC 566
Cdd:PRK05776 542 DFEEKLEMIRTGK-----ATREEV----------IEEAKEtLNKLLEEFKKNkdeiGEELAK----ALGLIKPVGKCKIC 602
|
570 580 590
....*....|....*....|....*....|...
gi 1002819406 567 NKDMV--------LKTKKNggfYLSCMGFPECR 591
Cdd:PRK05776 603 GREAYkdglckyhYEAKKR---LVKAYEEWKER 632
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
36-590 |
1.73e-60 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 218.11 E-value: 1.73e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENL-----TEPdqrVSDAVD 110
Cdd:PRK07726 84 NVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKP---IKRLWISSLTDKAIKRAFANLkpgkeTIP---LYYSAL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 111 VRQELDLRIGAAFTRFQTLRLQRI-FPEVLaeqliSYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIvEFN 189
Cdd:PRK07726 158 ARSRADWLVGINMTRAYTLLGRKAgYNGVL-----SVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGERF-TAK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 190 W--------KRHRLFNHTACLVLYQLCVEDPmATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLY- 260
Cdd:PRK07726 232 WqpsepyqdEEGRLLDRPLAEQVVARIQGQP-AKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYe 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 261 TQGYISYPRTETNIFPRDLNLTVlveqqtPD-----PRWGAFAQSILERGGPTPRNG---NKSDQAHPPIHPTKYT---N 329
Cdd:PRK07726 311 THKLITYPRTDSRYLPEDMVATL------PEvlnaiSKVDPYLLLAPPVLDPSIRSRawnDKKVTAHHAIIPTEQPpnlS 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 330 NLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDK---ILPVYEQGSHFQ 406
Cdd:PRK07726 385 KLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEkeqPLPVLAKGDELK 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 407 PSTVEMVDGETSPPKLLTEADLIALM-----------------EKHGIGTDATHAEHIETIKARMYvgLTPDKRFL-PGH 468
Cdd:PRK07726 465 VEKGEVKEGQTQPPKRFTEGTLLSAMeniarfvqdkelkktlkETDGLGTEATRAGIIEKLFKRGY--LEKKGKYIhATD 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 469 LGMGLVegyDSMGYEMSKPDLRAELEADLKLICDGKKDkfvvlrqqvqkyKQVFI-EAVAKAKKLdeaLAQYfgngtelA 547
Cdd:PRK07726 543 KGKQLI---DALPEELTSPDMTAKWEQALDQISEGQLS------------YQDFMqPLKQWLKQL---VEQA-------K 597
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 1002819406 548 QQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPEC 590
Cdd:PRK07726 598 QSSEKYKFDNLTGPKCPDCGKPMLKVKGKNGKM-LVCQDRECG 639
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
36-613 |
2.30e-49 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 186.22 E-value: 2.30e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFEIIHVCK-AVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQE 114
Cdd:PRK06599 65 DALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKeAKLKDKNVKRVVFNEITKKAVQEAIENPRDIDMDLVDAQQARRA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 115 LDLRIGAAFTRFqtlrLQRIFPEVLaeqliSYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDG------IVEF 188
Cdd:PRK06599 145 LDYLVGFKLSPL----LWKKVRRGL-----SAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGepftakLVEV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 189 NWKR---HRLFNHTACLVLYQLcVEDPMATVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLY---- 260
Cdd:PRK06599 216 NGKKlekFSITNEEQAKALVKA-LEGQAYTVDKIEKKERKR-NPPPpFITSTLQQEASRKLGFSAKKTMRIAQKLYegid 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 261 ----TQGYISYPRTETnifprdlnlTVLVEQQTPDPRwgafaQSILERGGP-----TPR---NGNKSDQ-AHPPIHPT-- 325
Cdd:PRK06599 294 lgegTVGLITYMRTDS---------VRLSNEALDEAR-----KYITKKYGKeylpaKPRvykKKSKNAQeAHEAIRPTsi 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 326 KYT-----NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFV--AHGLMILARNYLDVYPYD-----HWSD 393
Cdd:PRK06599 360 NRTpeslkPYLTPDQFKLYELIWKRTVASQMAPAILDQTSVDIASENGKYVfrATGSVILFPGFLKVYGESkddeeEDDE 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 394 KILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGHLGMG- 472
Cdd:PRK06599 440 KLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELE-KKRFIPTDLGRIv 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 473 ---LVEGY-DSMGYemskpDLRAELEADLKLICDGKKDKFVVLRQQVQKykqvFIEAVAKAKKLDEalaqyfgngTELAQ 548
Cdd:PRK06599 519 ndfLVEHFpKYVDY-----DFTAGLEDELDEIAEGKKDWKPVLREFWEP----FISNLEKVEEDVR---------TEKVT 580
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002819406 549 QEDIYpampepiRKCPQCN-KDMVLKTKKNGGFyLSCMGFPECRSAVWLPDS-----VLEASRDSSVCPVC 613
Cdd:PRK06599 581 QEETD-------ETCPKCGgGPLVLKLGKNGKF-LGCSGYPECKYTKNITRDedepiEEEEIVEEEKCPKC 643
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
52-643 |
1.04e-47 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 183.46 E-value: 1.04e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 52 TDCDREGENIGFEIIHVCKavKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGaaFTrfqtlrl 131
Cdd:PRK07561 94 TDPDREGEAIAWHLLEVLG--GDDVPVKRVVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVG--YM------- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 132 qrIFPeVLAEQL---ISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGI------VEFNWKRHRLF---NHT 199
Cdd:PRK07561 163 --VSP-LLWKKIargLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDafearlTHLDGKKFAPVdllNEA 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 200 ACLVLYQLcVEDPMATVVEVRSKPKSKwRPQA-LDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE-TNIFP- 276
Cdd:PRK07561 240 QAEAAVAA-LEGARYSVASVEDKPTTR-KPSApFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYITYMRTDsTNLSQe 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 277 -----RDLnltvlveqqtpdprwgafaqsILERGG-----PTPRN-GNKSD---QAHPPIHPT------KYTNNLQGDEQ 336
Cdd:PRK07561 318 ainaaRGY---------------------IGDNYGkkylpEKPRQySSKAKnaqEAHEAIRPSdvfrtpDQLKGLEGDAQ 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 337 RLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYP-----YDHWSDKILPVYEQGSHFQPSTVE 411
Cdd:PRK07561 377 RLYELIWKRFVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVegrddALDDEDRRLPALKVGDALTLEKLD 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 412 MVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVglTPDK-RFLPGHLGM---GLVEGY--DSMGYems 485
Cdd:PRK07561 457 PTQHFTKPPARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYV--RLENrRFYPEKMGRivtDRLEEFfpRLVDY--- 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 486 kpDLRAELEADLKLICDGKKDKFVVLRqqvQKYKQvFIEAVAKAKKLDEAlaqyfgNGTELAQqediypaMPEPIRKCPQ 565
Cdd:PRK07561 532 --DFTARMEEELDDIANGEADWKPVLD---DFYKD-FSQQLEKAEELREE------GGMRPNQ-------MVITDRDCPT 592
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 566 CNKDMVLKTKKNGGFyLSCMGF---PECR---------SAVWLPDSVLEASRDSSVCPVCQpHPVYRLKLKF-------- 625
Cdd:PRK07561 593 CGRGMGIRTGKTGVF-LGCSGYalkERCKttrnltpeeETLNVLEGEDAETRALGADPECG-TAMVLRSGRFgpyvqege 670
|
650 660
....*....|....*....|..
gi 1002819406 626 ----KRGSLPPTMPLEfvcCIG 643
Cdd:PRK07561 671 gdkpRRLSLPKGNNPE---CVG 689
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
38-620 |
9.32e-37 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 149.20 E-value: 9.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 38 LERETRQCQALVIWTDCDREGENIGFeiiHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDL 117
Cdd:PRK06319 67 ICKLAKKCDVVYLSPDPDREGEAIAW---HIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDR 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 118 RIGAAFTRFQTLRLQRifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKV-THDHKDG------IVEFNW 190
Cdd:PRK06319 144 IVGYKISPILSRKLQR-------RSGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVhLKDPKTQktfwahLYSVDG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 191 KRHR-------------LFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAE 257
Cdd:PRK06319 217 KKWEkeipegktedevlLINSKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 258 KLY---------TQGYISYPRTET-NIFPRDLNLTVLVEQQTpdprwgaFAQSILERGgPTPRNGNKSDQ-AHPPIHPT- 325
Cdd:PRK06319 297 TLYegvdldsegATGLITYMRTDSvRTDPEALKQVRKYIEGT-------FGKEFLPSS-PNVYTTKKMAQdAHEAIRPTd 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 326 ------KYTNNLQGDEQRLYEFIVRHFLAccSQDAQGQETTVEIDIAQERFV---AHGLMILARNYLDVYP------YDH 390
Cdd:PRK06319 369 itltpeKLRSKLTEDQYKLYSLIWKRFVA--SQMIPAIYDTLAIRITTNKGIdlrATGSLLKFKGFLAVYEekrddeGDE 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 391 WSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVgLTPDKRFLPGHLG 470
Cdd:PRK06319 447 EENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYT-LKENQRLRPTELG 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 471 MGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKA----------------KKLDE 534
Cdd:PRK06319 526 KIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKEAfiprivteidcpkchkGKLVK 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 535 ALAQ---YFG-----------NGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFyLSCMGFPECRSAVWLPDSV 600
Cdd:PRK06319 606 IWAKnryFYGcseypecdyktSEEELTFNKEDYAEDTPWDSPCPLCGGEMKVRHGRFGTF-LGCENYPECRGIINIHKKG 684
|
650 660
....*....|....*....|....
gi 1002819406 601 LEAS--RDSSVCPV--CQPHPVYR 620
Cdd:PRK06319 685 EEGIepEETVPCPAigCTGHIVKR 708
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
54-534 |
4.64e-36 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 147.12 E-value: 4.64e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 54 CD--REGENIGFEIIHVCKAVKPnlqVLRARFSEITPHAVRTACENLTEPDQRVS--DAVDVRQELDLRIGAAFTRFQTL 129
Cdd:PRK08173 104 CDagREGELIFRLIAQHAKAKKP---VKRLWLQSMTPQAIRDGFANLRSDEDMQPlaDAARCRSEADWLVGINGTRAMTA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 130 RLQRI--FpevlaeQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNW-------------KR-H 193
Cdd:PRK08173 181 FNSKGggF------FLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVAAAGFYEGRWfdpkfkkdefdpeKRaS 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 194 RLFNHTACLVLYQLCvEDPMATVVEvRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GYISYPRTET 272
Cdd:PRK08173 255 RLWSEAAAEAIVAAC-RGKPGTVTE-ESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDS 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 273 NIFPRDLNLTVL--VEQQTPDPRWGAFAQSILERG--GPTPR---NGNKSDqaHPPIHPTKYT-NNLQGDEQRLYEFIVR 344
Cdd:PRK08173 333 RALPEDYLGTVKqtLEMLKESNNYLPHAKQILDKGwvKPNKRifdNSKISD--HFAIIPTLQApKSLSEPEQKLYDLVVK 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 345 HFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYD-HWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLL 423
Cdd:PRK08173 411 RFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVYGKEaQGADANLVPVQKGEKVKTDKIEAVALTTKPPARY 490
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 424 TEADLIALME----------------KHGIGTDATHAEHIETIKARMYV-----GLTPD-KRFlpgHLgMGLVEGYDSMg 481
Cdd:PRK08173 491 NEATLLSAMEgagklveddelreamaEKGLGTPATRAAIIEGLLGEKYLvregrELIPTaKAF---QL-MTLLRGLGVE- 565
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1002819406 482 yEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVfieaVAKAKKLDE 534
Cdd:PRK08173 566 -ELTSPELTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQI----VKRAKEYDS 613
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
23-513 |
3.53e-32 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 134.50 E-value: 3.53e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 23 IEKycPENFVD-IKKTLeretRQCQALVIWTDCDREGENIGFEIIHVCK--AVKPNLQVLRARFSEITPHAVRTACENlt 99
Cdd:PRK08780 57 IDK--NEKHVEaIAKAA----KSADDLYLATDPDREGEAISWHLAEILKerGLLKDKPMQRVVFTEITPRAIKEAMAK-- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 100 ePDQRVSDAVDVRQE---LDLRIGAAFTRFQTLRLQRifpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIK 176
Cdd:PRK08780 129 -PRDIASDLVDAQQArraLDYLVGFNLSPLLWRKIQR---------GLSAGRVQSPALRMIVEREEEIEAFIAREYWSIE 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 177 VTHDHKDGivEFNWKRHRLFNH-----------TACLVLYQLC-VEDPMATVVEVRSKPKsKWRPQA-LDTVELEKLASR 243
Cdd:PRK08780 199 ADCAHPSQ--PFNAKLIKLDGQkfeqftitdgdTAEAARLRIQqAAQGTLHVTDVESKER-KRNPAPpFTTSTLQQEASR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 244 KLRINAKETMRIAEKLY---------TQGYISYPRTETnifprdLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNK 314
Cdd:PRK08780 276 KLGFTTRRTMQVAQKLYegvdlgdegSVGLITYMRTDS------VNLSQDALAEIRDVIARDYGTASLPDQPNTYKTKSK 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 315 SDQ-AHPPIHPT-------KYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQER-FVAHGLMILARNYLDV 385
Cdd:PRK08780 350 NAQeAHEAVRPTsalrtpaQVARFLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGSEHvFRATGSTVVVPGFLAV 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 386 Y--------PYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVG 457
Cdd:PRK08780 430 YeegkddksAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQFRKYVE 509
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002819406 458 LTpDKRFLPGHLGMG----LVEGYDS-MGYemskpDLRAELEADLKLICDGKKDKFVVLRQ 513
Cdd:PRK08780 510 ME-GRRFRPTDVGRAvnkfLTGHFTRyVDY-----DFTARLEDDLDAVSRGEKEWIPLMEK 564
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
78-173 |
6.17e-32 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 119.22 E-value: 6.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 78 VLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRifpevlaeQLISYGSCQFPTLGFV 157
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRN--------GVLSAGRVQTPTLGLI 72
|
90
....*....|....*.
gi 1002819406 158 VERFKAIQAFVPEIFH 173
Cdd:smart00436 73 VEREREIKNFVPKPYW 88
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
47-533 |
8.99e-31 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 130.46 E-value: 8.99e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 47 ALVIWTDCDREGENIGFEIIHVCKAVKPNLQ--VLRARFSEITPHAVRTACENLTEPDQR--VSDAVDVRQELDLRIGAA 122
Cdd:PRK14724 102 ELVNACDAGREGELIFRLIEQYAGGAKGGLGkpVKRLWLQSMTPQAIRDGFDNLRSDAQMqgLASAARSRSEADWLVGIN 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 123 FTRFQTLRLQR---IFpevlaeqLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDG-----IVEFNWKRH- 193
Cdd:PRK14724 182 GTRAMTAFNSRdggFF-------LTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGeylgkWFDPQWKKAs 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 194 --------RLFNHTACLVLYQlCVEDPMATVVEvRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQ-GY 264
Cdd:PRK14724 255 ddpearadRVWSEREARAIAD-AVRGKAATVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKA 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 265 ISYPRTETNIFPRDLnltVLVEQQTPDPRWGA-------FAQSILERG--GPTPR---NGNKSDqaHPPIHPT-KYTNNL 331
Cdd:PRK14724 333 LTYPRTDSRALPEDY---LPVAKQTFEMLATSgmrhlapFAQQALDGNyvRPSKRifdNSKVSD--HFAIIPTtQAPSGL 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 332 QGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD-----------KILPVyE 400
Cdd:PRK14724 408 SEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEvedakdgdkgqPLVPV-K 486
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 401 QGSHFQPSTVEMVDGETSPPKLLTEADLIALME----------------KHGIGTDATHAEHIETIKARMYVgLTPDKRF 464
Cdd:PRK14724 487 PGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYM-LREGREL 565
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002819406 465 LPGHLG---MGLVEGYDSMgyEMSKPDLRAELEADLKLICDGK--KDKFVvlrQQVQKYKQvfiEAVAKAKKLD 533
Cdd:PRK14724 566 IPTAKAfqlMTLLRGLGVE--ELSRAELTGEWEYKLAQMEKGQlsREAFM---QQIAAMTE---KLVKKAKEYD 631
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
18-98 |
2.48e-25 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 102.70 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 18 LFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKpNLQVLRARFSEITPHAVRTACEN 97
Cdd:cd03362 72 LFPAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVK-RKPVKRAWFSSLTPKAIRRAFKN 150
|
.
gi 1002819406 98 L 98
Cdd:cd03362 151 L 151
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
33-628 |
2.70e-24 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 109.18 E-value: 2.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 33 DIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVR 112
Cdd:COG0551 72 KKLKKDKKKKAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 113 QELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFptLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKR 192
Cdd:COG0551 152 RLLLLAAASRALRLLLLLAAGRLRLLSAVAAGLLELEEL--LKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKK 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 193 HRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKET------MRIAEKLYTQGYIS 266
Cdd:COG0551 230 DKEEETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASAlaaallEEEGELLYTGGYIR 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 267 YPRTETNIFPRDLNLTVLVEQQTPDPrWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNN---LQGDEQRLYEFIV 343
Cdd:COG0551 310 YTRTPKSSEADALAALEALKKIAEEP-PDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALlelLEDRKLLLELLVR 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 344 RHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLL 423
Cdd:COG0551 389 RRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRY 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 424 TEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDG 503
Cdd:COG0551 469 TTELLLKKLEEEGGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGK 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 504 KKDKFVVLRqqvqKYKQVFIEAVAKAKKldealaqyfgngtelaQQEDIYPAMPEPI-RKCPQCNKDMVLKTKKNGGFyL 582
Cdd:COG0551 549 EDKVVEIRE----EEYPFFKKLLEIAEE----------------EGEEELSEEDEVLgEKCPKCGKPLVIKKGRYGKF-L 607
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 1002819406 583 SCMGFPECRSAvwLPdsvLEASRDSSV-CPVCQphpVYRLKLKFKRG 628
Cdd:COG0551 608 GCSNYPECKYT--KP---LPKPEVTGVkCPKCG---KKLVLRKSKKG 646
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
10-98 |
5.10e-24 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 98.45 E-value: 5.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 10 RQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAvkPNLQVLRARFSEITPH 89
Cdd:cd01028 56 WDKDWPLELFPFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKC--DNKPVKRAWFSEITPK 133
|
....*....
gi 1002819406 90 AVRTACENL 98
Cdd:cd01028 134 AIREAFKNL 142
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
800-844 |
1.81e-18 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 79.37 E-value: 1.81e-18
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1002819406 800 TSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDEN 844
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
716-757 |
1.05e-16 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 74.36 E-value: 1.05e-16
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1002819406 716 VTCNCGQEAVLLTVRKEGPNRGRQFFKCNGG---SCNFFLWADSP 757
Cdd:pfam06839 1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGrekQCGFFQWADEV 45
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
560-599 |
6.92e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 60.74 E-value: 6.92e-12
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1002819406 560 IRKCPQCNKDMVLKTKKNGGFYlSCMGFPECRSAVWLPDS 599
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFV-GCSNYPECRFTRPLKKN 39
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
36-97 |
6.72e-09 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 54.87 E-value: 6.72e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002819406 36 KTLERETRQCQALVIWTDCDREGENIGFeiiHVCKAVKPNLQVLRARFSEITPHAVRTACEN 97
Cdd:cd03363 64 KELKKLAKKADEIYLATDPDREGEAIAW---HLAEVLKLKKNVKRVVFNEITKEAIKEALKN 122
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
34-475 |
3.40e-08 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 57.64 E-value: 3.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 34 IKKTLER----ETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQV--LRARFSEITPHAVRTACE--NLTEPDQRV 105
Cdd:PTZ00407 110 IQETLERyieeKADNVTEIILATDPDREGELIAVHALQTIKRLYPKLKVpfSRAYMHSITEDGIRKAMRerHVEACDYDL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 106 SDAVDVRQELDlRI----GAAFTRFQTlrlqrifpevlaEQLISYGSCQFPTLGFVVERFKAIQAFV------------- 168
Cdd:PTZ00407 190 ANAAETRHAMD-RIfgflGSSVVRAAN------------SQMRSIGRVQTPALILINEREDKIKAFLesnkstfevqamc 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 169 --PEIFHR-----IKVTHDHKDGIVEFNWK---RHRLfNHTACLVLYQLCVEdPMATVVEVRSKPkskwrPQALDTVELE 238
Cdd:PTZ00407 257 qfPSPHGTtfsqvVTITPDRKGGASHWATEaeaRRCL-EQWKLNNCTGFSVP-LEPKPQPSVVPP-----PQPFTMATAI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 239 KLASRKLRINAKETMRIAEKLYTQGYISYPRTET-----NIFP----------------RDLNLTVLVEQQTPDPRWGAF 297
Cdd:PTZ00407 330 AKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDStrideSALPdiyaavkkefgkeflyRLEDRTVSAQEGKGSKKTGKK 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 298 AQSILERGGPTPRnGNKSDqAHPPIHPTKYtnNLQGDE-------QRLYEFIVRHFLA----------------CCSqdA 354
Cdd:PTZ00407 410 RSTKQKKGADTPV-GNVED-AHEAIRPTNI--DTTGESlslspptRAVYDLVRRNTLAvfmipmktekivatvkFTS--G 483
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 355 QGQETTVEI-------------------------------------------DIAQERFVAhgLMILARnyldvypydhw 391
Cdd:PTZ00407 484 SGEKLEFELqgkrvvepgwtrafhkgdkgttgpaeetdeditaveegapvvpSLSQEEFKA--IMNLRS----------- 550
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 392 sdkILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGM 471
Cdd:PTZ00407 551 ---QLGSGVQKGFFELRSPQVRENRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKGRCETTPVGR 627
|
....
gi 1002819406 472 GLVE 475
Cdd:PTZ00407 628 MLVE 631
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
33-86 |
6.32e-08 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 51.20 E-value: 6.32e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1002819406 33 DIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPnlQVLRARFSEI 86
Cdd:pfam01751 42 KALKALKELALKAKEVILATDPDREGEAIALKLLELKELLEN--AGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
33-73 |
8.94e-07 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 47.26 E-value: 8.94e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1002819406 33 DIKKTLERETRQCQaLVIWTDCDREGENIGFEIIHVCKAVK 73
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAELLKPAG 75
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
30-80 |
2.50e-05 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 43.57 E-value: 2.50e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1002819406 30 NFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLR 80
Cdd:cd00188 32 ALNKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLL 82
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
214-637 |
6.91e-04 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 43.65 E-value: 6.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 214 ATVVEVRSKPKSKWRPQAldtvelEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPR 293
Cdd:COG1754 256 AAAAAVREPPTPTTTTTA------QAATTTTTRAAAARTTRSAQQAARRTRLGGEGTYTTTTTTTTTTSAAAAAAAAAAA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 294 WGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT----------NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEI 363
Cdd:COG1754 330 ALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAaarrppaaraALLSDDRLLLELLLLRRTAAAAAAAAAATATTTAA 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 364 DIAQE----------RFVAHGLMILARNYLDVYPYDHwSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALME 433
Cdd:COG1754 410 AAAAGagavgtaaagAVFFFGGFLLFAEEEDDDEEDD-DDDDLPALEEGLPLLKEGVLADQHFTQPPPRYTEAPLVKRME 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 434 KHGIGTDATHAEHIETIKARMYVGLTpDKRFLPGhlGMGLV------------EGYdsmgyemskpDLRAELEADLKLIC 501
Cdd:COG1754 489 ELGIGRPSTYASILSTLADRIYVRLD-KRRLIPE--DKGRLvtaflfsffrryVEY----------DFTADLEEFLDDVS 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 502 DGKKDKFVVLRQQVQKYKQvFIEAVAKAKKLDEALAqyfgngteLAQQEDIypaMPEPIRKCPQCNKDMVLKTKKNGGfY 581
Cdd:COG1754 556 DGELDWKAVLRRFWRDFSA-AYDETGDLRISEVLDA--------LEDLGEI---DPREINSCPLGTGGLSLRVGRYGP-F 622
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002819406 582 LSCMG-------FPECRSavwlPDS-VLEASRDSSVCPVCQP----------HPVYRLKLKF-----------------K 626
Cdd:COG1754 623 IECSNyeprrasIPECLA----PDElTPEKAEELLEAPADGPrvlgtdpetgKPIVLKDGRFgpyvqlgepekedkpkpK 698
|
490
....*....|.
gi 1002819406 627 RGSLPPTMPLE 637
Cdd:COG1754 699 RASLPKGMSPE 709
|
|
| |
