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Conserved domains on  [gi|1003701568|ref|NP_001307808|]
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annexin A7 isoform 4 [Homo sapiens]

Protein Classification

Drf_FH1 and Annexin domain-containing protein( domain architecture ID 12069954)

Drf_FH1 and Annexin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 127-192 3.16e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.03  E-value: 3.16e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 127 RDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILAL 192
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 199-264 8.27e-29

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 107.17  E-value: 8.27e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 199 YDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSM 264
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 358-423 4.37e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 102.55  E-value: 4.37e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 358 FFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAI 423
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 283-348 2.70e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 81.37  E-value: 2.70e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 283 DAQRLYQAgEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTI 348
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 40-107 4.96e-04

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


:

Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 40.62  E-value: 4.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003701568  40 GAPSYPGVPPGQG-FGVPP-----GGAGFSGYPQPPSQSYGGGPAQVPLPGGfPGGQMPSQYPGGqPTYPSQPA 107
Cdd:pfam06346  65 GAASIPPPPPLPGsTGIPPppplpGGAGIPPPPPPLPGGAGVPPPPPPLPGG-PGIPPPPPFPGG-PGIPPPPP 136
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 127-192 3.16e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.03  E-value: 3.16e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 127 RDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILAL 192
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 199-264 8.27e-29

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 107.17  E-value: 8.27e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 199 YDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSM 264
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 358-423 4.37e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 102.55  E-value: 4.37e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 358 FFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAI 423
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
140-192 6.74e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 90.93  E-value: 6.74e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1003701568  140 GTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILAL 192
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
212-264 1.75e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 89.77  E-value: 1.75e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1003701568  212 GTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSM 264
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
371-423 1.55e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 84.38  E-value: 1.55e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1003701568  371 GTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAI 423
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 283-348 2.70e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 81.37  E-value: 2.70e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 283 DAQRLYQAgEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTI 348
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
296-345 6.24e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.42  E-value: 6.24e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1003701568  296 GTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGL 345
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 40-107 4.96e-04

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 40.62  E-value: 4.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003701568  40 GAPSYPGVPPGQG-FGVPP-----GGAGFSGYPQPPSQSYGGGPAQVPLPGGfPGGQMPSQYPGGqPTYPSQPA 107
Cdd:pfam06346  65 GAASIPPPPPLPGsTGIPPppplpGGAGIPPPPPPLPGGAGVPPPPPPLPGG-PGIPPPPPFPGG-PGIPPPPP 136
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 38-151 7.13e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 38.51  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701568  38 PGGAPSYPGVP-PGQGFGVPPGGAGFSGYPQPPSQSYGGGPAQVPLPGGFP----GGQMPSQYPGGQPTYPSQPATVTQV 112
Cdd:COG5180   362 VPGKPLEQGAPrPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQaaldGGGRETASLGGAAGGAGQGPKADFV 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1003701568 113 TQGTIRPAANFDAIRDAE---ILRKAMKGFGTDEQAIVDVVA 151
Cdd:COG5180   442 PGDAESVSGPAGLADQAGaaaSTAMADFVAPVTDATPVDVAD 483
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 127-192 3.16e-30

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 111.03  E-value: 3.16e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 127 RDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILAL 192
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 199-264 8.27e-29

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 107.17  E-value: 8.27e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 199 YDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSM 264
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 358-423 4.37e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 102.55  E-value: 4.37e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 358 FFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAI 423
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
140-192 6.74e-23

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 90.93  E-value: 6.74e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1003701568  140 GTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILAL 192
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
212-264 1.75e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 89.77  E-value: 1.75e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1003701568  212 GTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSM 264
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
371-423 1.55e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 84.38  E-value: 1.55e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1003701568  371 GTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAI 423
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 283-348 2.70e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 81.37  E-value: 2.70e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1003701568 283 DAQRLYQAgEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTI 348
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
296-345 6.24e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.42  E-value: 6.24e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1003701568  296 GTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGL 345
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 40-107 4.96e-04

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 40.62  E-value: 4.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1003701568  40 GAPSYPGVPPGQG-FGVPP-----GGAGFSGYPQPPSQSYGGGPAQVPLPGGfPGGQMPSQYPGGqPTYPSQPA 107
Cdd:pfam06346  65 GAASIPPPPPLPGsTGIPPppplpGGAGIPPPPPPLPGGAGVPPPPPPLPGG-PGIPPPPPFPGG-PGIPPPPP 136
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 38-151 7.13e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 38.51  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003701568  38 PGGAPSYPGVP-PGQGFGVPPGGAGFSGYPQPPSQSYGGGPAQVPLPGGFP----GGQMPSQYPGGQPTYPSQPATVTQV 112
Cdd:COG5180   362 VPGKPLEQGAPrPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQaaldGGGRETASLGGAAGGAGQGPKADFV 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1003701568 113 TQGTIRPAANFDAIRDAE---ILRKAMKGFGTDEQAIVDVVA 151
Cdd:COG5180   442 PGDAESVSGPAGLADQAGaaaSTAMADFVAPVTDATPVDVAD 483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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