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Conserved domains on  [gi|1005261186|ref|NP_001307965|]
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probable proton-coupled zinc antiporter SLC30A4 isoform 2 [Homo sapiens]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 1750094)

cation diffusion facilitator (CDF) family transporter facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Gene Ontology:  GO:0008324
PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcD super family cl40534
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
113-180 6.60e-26

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1230:

Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 100.58  E-value: 6.60e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1005261186 113 RLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLG 180
Cdd:COG1230    19 RLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAE 86
 
Name Accession Description Interval E-value
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
113-180 6.60e-26

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 100.58  E-value: 6.60e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1005261186 113 RLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLG 180
Cdd:COG1230    19 RLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAE 86
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 123-179 7.09e-22

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 89.20  E-value: 7.09e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261186 123 LFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRL 179
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRA 57
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
 123-179 1.91e-17

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 75.77  E-value: 1.91e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261186 123 LFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRL 179
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRL 57
PRK03557 PRK03557
CDF family zinc transporter ZitB;
113-179 7.61e-15

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 70.93  E-value: 7.61e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261186 113 RLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRL 179
Cdd:PRK03557   20 RLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRL 86
 
Name Accession Description Interval E-value
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
113-180 6.60e-26

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 100.58  E-value: 6.60e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1005261186 113 RLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLG 180
Cdd:COG1230    19 RLLIALALTLGFMVVEIVGGLLSGSLALLADAGHMLSDALALGLALFAYRLARRPADARFTFGYKRAE 86
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
 123-179 7.09e-22

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 89.20  E-value: 7.09e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261186 123 LFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRL 179
Cdd:TIGR01297   1 LLMLIKIVGGLLSGSLALLADAIHSLSDVAASAIALLALRISRRPADERHPFGHGRA 57
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
 123-179 1.91e-17

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 75.77  E-value: 1.91e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261186 123 LFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRL 179
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISSLLALLALRLSRKPPDERFPFGHGRL 57
PRK03557 PRK03557
CDF family zinc transporter ZitB;
113-179 7.61e-15

CDF family zinc transporter ZitB;


Pssm-ID: 235130 [Multi-domain]  Cd Length: 312  Bit Score: 70.93  E-value: 7.61e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1005261186 113 RLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRL 179
Cdd:PRK03557   20 RLLYAFGVTAGFMLVEVIGGFLSGSLALLADAGHMLTDAAALLFALLAVQFSRRPPTIRHTFGWLRL 86
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
116-178 8.76e-14

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 67.44  E-value: 8.76e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1005261186 116 IAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHR 178
Cdd:COG0053     7 ASLAANLLLAVLKLVAGLLTGSVALLADALHSLSDLVASLLVLLGLRLAAKPADEEHPYGHGK 69
COG3965 COG3965
Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and ...
 114-176 6.89e-09

Predicted Co/Zn/Cd cation transporter, cation efflux family [Inorganic ion transport and metabolism];


Pssm-ID: 443165 [Multi-domain]  Cd Length: 300  Bit Score: 53.68  E-value: 6.89e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1005261186 114 LTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGF 176
Cdd:COG3965     8 LKLSIAGTLLFAVLGIVFGLLSGSQAILFDGVYSLIDAGMTLLSLLVARLIARPDSRRFQFGY 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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