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Conserved domains on  [gi|1008806480|ref|NP_001308245|]
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muskelin isoform 3 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
77-401 1.47e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480  77 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 156
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 157 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 236
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 237 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 316
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 317 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWScvykndqAAKDNPTkslqeeepcPRFAHQLV-YDElhKVhYLFG 395
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT-------ALGELPT---------PRHGHAAVlTDG--KV-YVIG 258


                  ....*...
gi 1008806480 396 G--NPGKS 401
Cdd:COG3055   259 GetKPGVR 266
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
77-401 1.47e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480  77 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 156
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 157 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 236
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 237 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 316
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 317 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWScvykndqAAKDNPTkslqeeepcPRFAHQLV-YDElhKVhYLFG 395
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT-------ALGELPT---------PRHGHAAVlTDG--KV-YVIG 258


                  ....*...
gi 1008806480 396 G--NPGKS 401
Cdd:COG3055   259 GetKPGVR 266
Kelch_3 pfam13415
Galactose oxidase, central domain;
75-127 2.82e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 2.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1008806480  75 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 127
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 100-268 8.87e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 8.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 100 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 179
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 180 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 259
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1008806480 260 NRCLYVFGG 268
Cdd:PLN02153  137 ENHVYVFGG 145
Kelch smart00612
Kelch domain;
78-104 9.85e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 9.85e-04
                           10        20
                   ....*....|....*....|....*..
gi 1008806480   78 VYLFGGWDGTQDLADFWAYSVKENQWT 104
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
77-401 1.47e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480  77 TVYLFGGWDGTQDLADFWAYSVKENQWtcisrdTEKENGPSARSCHKMCIdIQRRQIYTLGRYldSSVRNSKSLKSDFYR 156
Cdd:COG3055    24 KVYVAGGLSGGSASNSFEVYDPATNTW------SELAPLPGPPRHHAAAV-AQDGKLYVFGGF--TGANPSSTPLNDVYV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 157 YDIDTNTWmllsedTAADGGPKLVFDHQMCMDSEKhmIYTFGGRilTCNGSVDDsrasepqfsgLFAFNCQCQTWKLLre 236
Cdd:COG3055    95 YDPATNTW------TKLAPMPTPRGGATALLLDGK--IYVVGGW--DDGGNVAW----------VEVYDPATGTWTQL-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 237 dscnagPEDIQSRIGHCMLFHSKNRcLYVFGGQRSktylndffsydvdsdhvdiiSDGTKKDSGMVPMTGFTQRATIDPE 316
Cdd:COG3055   153 ------APLPTPRDHLAAAVLPDGK-ILVIGGRNG--------------------SGFSNTWTTLAPLPTARAGHAAAVL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 317 LNEIHVLSGlskdkekrEENVRNSFWIYDIVRNSWScvykndqAAKDNPTkslqeeepcPRFAHQLV-YDElhKVhYLFG 395
Cdd:COG3055   206 GGKILVFGG--------ESGFSDEVEAYDPATNTWT-------ALGELPT---------PRHGHAAVlTDG--KV-YVIG 258


                  ....*...
gi 1008806480 396 G--NPGKS 401
Cdd:COG3055   259 GetKPGVR 266
Kelch_3 pfam13415
Galactose oxidase, central domain;
75-127 2.82e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.28  E-value: 2.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1008806480  75 TETVYLFGGWD--GTQDLADFWAYSVKENQWTCISrdtekeNGPSARSCHKMCID 127
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 100-268 8.87e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 8.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 100 ENQWtcISRDTEKENGPSARSCHKMCIdiQRRQIYTLGryldSSVRNSKSLKSDFYRYDIDTNTWMLlsedTAADGGPKL 179
Cdd:PLN02153    6 QGGW--IKVEQKGGKGPGPRCSHGIAV--VGDKLYSFG----GELKPNEHIDKDLYVFDFNTHTWSI----APANGDVPR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 180 VFDHQMCMDSEKHMIYTFGGRiltcngsvDDSRAsepqFSGLFAFNCQCQTWKLLREDSCNAGPEdiqSRIGHCMLfhSK 259
Cdd:PLN02153   74 ISCLGVRMVAVGTKLYIFGGR--------DEKRE----FSDFYSYDTVKNEWTFLTKLDEEGGPE---ARTFHSMA--SD 136


                  ....*....
gi 1008806480 260 NRCLYVFGG 268
Cdd:PLN02153  137 ENHVYVFGG 145
PLN02153 PLN02153
epithiospecifier protein
 78-169 3.12e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.21  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480  78 VYLFGGWDGTQDLADFWAYSVKENQWTCISRdTEKENGPSARSCHKMCIDiqRRQIYTLGRYLDSSVRNSKSLKSDFYRY 157
Cdd:PLN02153   88 LYIFGGRDEKREFSDFYSYDTVKNEWTFLTK-LDEEGGPEARTFHSMASD--ENHVYVFGGVSKGGLMKTPERFRTIEAY 164

                          90
                  ....*....|..
gi 1008806480 158 DIDTNTWMLLSE 169
Cdd:PLN02153  165 NIADGKWVQLPD 176
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 63-107 4.07e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 4.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1008806480  63 MRGGHQMVidVQTETVYLFGGWDGTQDLADFWAYSVKENQWTCIS 107
Cdd:pfam01344   1 RRSGAGVV--VVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP 43
PLN02193 PLN02193
nitrile-specifier protein
 77-179 7.11e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 7.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480  77 TVYLFGGWDGTQDLADFWAYSVKENQWTCIsrdTEKENGPSARSCHKMCIDiqRRQIYTLGRYldSSVRNSKSLKSdfyr 156
Cdd:PLN02193  230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAAD--EENVYVFGGV--SATARLKTLDS---- 298

                          90       100
                  ....*....|....*....|....*.
gi 1008806480 157 YDIDTNTWMLLS---EDTAADGGPKL 179
Cdd:PLN02193  299 YNIVDKKWFHCStpgDSFSIRGGAGL 324
PLN02153 PLN02153
epithiospecifier protein
 164-351 1.59e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 164 WMLLSEDTAADGGPKLvfDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLLredSCNAGP 243
Cdd:PLN02153    9 WIKVEQKGGKGPGPRC--SHGIAVVGDK--LYSFGGE-LKPNEHIDKD---------LYVFDFNTHTWSIA---PANGDV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 244 EDIqSRIGHCMLfhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRATIDPelNEIHVL 323
Cdd:PLN02153   72 PRI-SCLGVRMV--AVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFL---TKLDEEGGPEARTFHSMASDE--NHVYVF 143

                         170       180
                  ....*....|....*....|....*...
gi 1008806480 324 SGLSKDKEKREENVRNSFWIYDIVRNSW 351
Cdd:PLN02153  144 GGVSKGGLMKTPERFRTIEAYNIADGKW 171
PLN02193 PLN02193
nitrile-specifier protein
 176-351 3.90e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 3.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 176 GPKLVFDHQMCMDSEKhmIYTFGGRiLTCNGSVDDSrasepqfsgLFAFNCQCQTWKLlredSCNAGPEDIQSRIGHCML 255
Cdd:PLN02193  162 GPGLRCSHGIAQVGNK--IYSFGGE-FTPNQPIDKH---------LYVFDLETRTWSI----SPATGDVPHLSCLGVRMV 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008806480 256 fhSKNRCLYVFGGQRSKTYLNDFFSYDVDSDHVDIIsdgTKKDSGMVPMTGFTQRAtidpELNEIHVLSGLSKdkekree 335
Cdd:PLN02193  226 --SIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLL---TPVEEGPTPRSFHSMAA----DEENVYVFGGVSA------- 289

                         170
                  ....*....|....*..
gi 1008806480 336 NVR-NSFWIYDIVRNSW 351
Cdd:PLN02193  290 TARlKTLDSYNIVDKKW 306
Kelch_4 pfam13418
Galactose oxidase, central domain;
64-107 4.75e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 4.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1008806480  64 RGGHQMVIdVQTETVYLFGG--WDGTQdLADFWAYSVKENQWTCIS 107
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGegEDGTL-LSDLWVFDLSTNEWTRLG 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 249-286 9.17e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 9.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1008806480 249 RIGHCMLFHskNRCLYVFGGQRSKTYLNDFFSYDVDSD 286
Cdd:pfam01344   2 RSGAGVVVV--GGKIYVIGGFDGNQSLNSVEVYDPETN 37
Kelch smart00612
Kelch domain;
78-104 9.85e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.15  E-value: 9.85e-04
                           10        20
                   ....*....|....*....|....*..
gi 1008806480   78 VYLFGGWDGTQDLADFWAYSVKENQWT 104
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWT 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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