NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1012282618|ref|NP_001308614|]
View 

zinc finger protein 225 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.26e-22

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 3.26e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1012282618    8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVGHQ-SLHRDTFHFLKEEKFWM 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQvPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-634 3.92e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.67  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 202 KLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKC--EQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFihDSQLQEHQ 279
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 280 RIHTGEKPFKCDICCK-----SFRSRANLNRHSMVHMREKPFRcdTCGKSFGLKSALNSHRMVHTGEkrykcEECGKRFI 354
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 355 YRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSgETTFKCEECGKGFYTNSQRYSHQRAHSgekPYRCEECG 434
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 435 KGYKRRLDLDFHQRVHrgekpynckecgksfGWASCLLNHQRIhsgEKPFKCEECGKRFTQNSQLYTHRR--VHSGE--K 510
Cdd:COG5048   259 ESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 511 PFKCEE--CGKRFTQNSQLYSHRRVHTGVKPYKC--EECGKGFNSKFNLDMHQRVH-----TGERPYNC--KECGKSFSR 579
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1012282618 580 ASSILNHKRLH--GDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFR 634
Cdd:COG5048   401 DSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.26e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 3.26e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1012282618    8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVGHQ-SLHRDTFHFLKEEKFWM 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQvPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 3.32e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 3.32e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1012282618   8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 3.34e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 3.34e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1012282618   8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLS 46
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-634 3.92e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.67  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 202 KLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKC--EQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFihDSQLQEHQ 279
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 280 RIHTGEKPFKCDICCK-----SFRSRANLNRHSMVHMREKPFRcdTCGKSFGLKSALNSHRMVHTGEkrykcEECGKRFI 354
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 355 YRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSgETTFKCEECGKGFYTNSQRYSHQRAHSgekPYRCEECG 434
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 435 KGYKRRLDLDFHQRVHrgekpynckecgksfGWASCLLNHQRIhsgEKPFKCEECGKRFTQNSQLYTHRR--VHSGE--K 510
Cdd:COG5048   259 ESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 511 PFKCEE--CGKRFTQNSQLYSHRRVHTGVKPYKC--EECGKGFNSKFNLDMHQRVH-----TGERPYNC--KECGKSFSR 579
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1012282618 580 ASSILNHKRLH--GDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFR 634
Cdd:COG5048   401 DSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 209-250 8.66e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 8.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1012282618 209 CGKEFNQSSHLQIHQRIHTgekpFKCEQCGKGFSRRSGLYVH 250
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-299 6.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.13e-04
                          10        20
                  ....*....|....*....|....*
gi 1012282618 275 LQEHQRIHTGEKPFKCDICCKSFRS 299
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.26e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 3.26e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1012282618    8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVGHQ-SLHRDTFHFLKEEKFWM 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQvPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 3.32e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 3.32e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1012282618   8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLSVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 3.34e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 3.34e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1012282618   8 VTFKDVAVVFTEEELRLLDLAQRKLYREVMLENFRNLLS 46
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-634 3.92e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.67  E-value: 3.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 202 KLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKC--EQCGKGFSRRSGLYVHRKLHTGVKPHICEKCGKAFihDSQLQEHQ 279
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLS--NSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 280 RIHTGEKPFKCDICCK-----SFRSRANLNRHSMVHMREKPFRcdTCGKSFGLKSALNSHRMVHTGEkrykcEECGKRFI 354
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP--GNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 355 YRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVRVHSgETTFKCEECGKGFYTNSQRYSHQRAHSgekPYRCEECG 434
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 435 KGYKRRLDLDFHQRVHrgekpynckecgksfGWASCLLNHQRIhsgEKPFKCEECGKRFTQNSQLYTHRR--VHSGE--K 510
Cdd:COG5048   259 ESPRSSLPTASSQSSS---------------PNESDSSSEKGF---SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 511 PFKCEE--CGKRFTQNSQLYSHRRVHTGVKPYKC--EECGKGFNSKFNLDMHQRVH-----TGERPYNC--KECGKSFSR 579
Cdd:COG5048   321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKR 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1012282618 580 ASSILNHKRLH--GDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFR 634
Cdd:COG5048   401 DSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-586 3.51e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 3.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 117 SMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPSEgrTCKKSFSDVSVLDLHQQLQSREKSHTC--DECGKSFCYSSALRIH 194
Cdd:COG5048     5 SSQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 195 QR-VHMGEKLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFKCEQCGKGFSRRsglyvHRKLHTgvkPHICEKCGKAFIHDS 273
Cdd:COG5048    83 LRtHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR-----DPQLPD---LLSISNLRNNPLPGN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 274 QLQEHQRIHTGEKPFKCDICCKSF---RSRANLNRHSMVHMrEKPFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECG 350
Cdd:COG5048   155 NSSSVNTPQSNSLHPPLPANSLSKdpsSNLSLLISSNVSTS-IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 351 KRFIYRQDLYKHQidhTGEKPYNCKECGKSFR---------WASGLSRHVRVHSGETT-FKCEECGKGFYTNSQRYSHQR 420
Cdd:COG5048   234 QLSPKSLLSQSPS---SLSSSDSSSSASESPRsslptassqSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLR 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 421 A--HSGEkpyrceecgkgykrrldldfhqrvhrGEKPYNCKE--CGKSFGWASCLLNHQRIHSGEKPFKC--EECGKRFT 494
Cdd:COG5048   311 SvnHSGE--------------------------SLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFS 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 495 QNS-----QLYTHRRVHSGEKPFKCE--ECGKRFTQNSQLYSHRRVHTGVKP--YKCEECGKGFNSKFNLDMHQRVHTGE 565
Cdd:COG5048   365 PLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                         490       500
                  ....*....|....*....|.
gi 1012282618 566 RPYNCkeCGKSFSRASSILNH 586
Cdd:COG5048   445 APLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-307 2.08e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618  98 LFSHQTWEQISSDLtrfqDSMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPS-EGRTCKKSFSDVSVLDLH-QQLQSREKS 175
Cdd:COG5048   214 SSSDQNLENSSSSL----PLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpRSSLPTASSQSSSPNESDsSSEKGFSLP 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 176 HTCDECGKSFCYSSALRIHQR--VHMGEKL--YNCDV--CGKEFNQSSHLQIHQRIHTGEKPFKC--------------- 234
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspllnn 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 235 ----------------------EQCGKGFSRRSGLYVHRKLHTGVKPH--ICEKCGKAFIHDSQLQEHQRIHTGEKPFKC 290
Cdd:COG5048   370 eppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                         250
                  ....*....|....*..
gi 1012282618 291 dICCKSFRSRANLNRHS 307
Cdd:COG5048   450 -SILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
370-647 1.25e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 370 KPYNCKECGKSFRWASGLSRHVRVHSGETTFKC--EECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKG--YKRRLDLDF 445
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 446 HQRVH--RGEKPYNCKECGKSFGWASCLLnHQRIHSGEKPFK--------------------CEECGKRFTQNSQLYTHR 503
Cdd:COG5048   112 SSSSNsnDNNLLSSHSLPPSSRDPQLPDL-LSISNLRNNPLPgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 504 RVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECGkgFNSKFNLDMHQRVHTGErPYNCKECGKSFSRASSI 583
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSS-SDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 584 LNHKRLHGDE----------KPFKCEECGKRFTENSQLHSHQR--VHTGE--KPYKC--EKCGKSFRWASTHLTHQRLHS 647
Cdd:COG5048   268 ASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-390 3.12e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 213 FNQSSHLQIHQRIHTG-EKPFKCEQCGKGFSRRSGLYVHR--KLHTG--VKPHIC--EKCGKAFIHDSQLQEHQRIHTGE 285
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 286 KPFKC--DICCKSFRSRANLNRHSMVHMR-----EKPFRCD--TCGKSFGLKSALNSHRMVHT--GEKRYKCEECGKRFI 354
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFN 429

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1012282618 355 YRQDLYKHQIDHTGEKPYNCkECGKSFRWASGLSRH 390
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-450 3.27e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 368 GEKPYNCK--ECGKSFRWASGLSRHvRVHSgettfkceECGKGFYTNSQRYSHQRAHSGEKPYRCEECGKGYKRRLDLDF 445
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*
gi 1012282618 446 HqRVH 450
Cdd:COG5189   417 H-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-507 6.85e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 6.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 383 WASGLSRHVRVHSGETTFKCEECGKGFYTNSQRYSHQRAHS----GEKPYRCE--ECGKGYKRRLDLDFHqRVHrgekpy 456
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMlkvkDGKPYKCPveGCNKKYKNQNGLKYH-MLH------ 373

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1012282618 457 ncKECGKSFGWASCLLNHQRIHSGEKPFKCEECGKRFTQNSQLYTHRRvHS 507
Cdd:COG5189   374 --GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 209-250 8.66e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 8.66e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1012282618 209 CGKEFNQSSHLQIHQRIHTgekpFKCEQCGKGFSRRSGLYVH 250
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 509-647 9.04e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 9.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282618 509 EKPFKCEECGKRFTQNSQLY----SHRRVHTGVKPYKCE--ECGKGFNSKFNLDMHqrvhtgerpynckecgksfsrass 582
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH------------------------ 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1012282618 583 ilnhkRLHGdekpfkceECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFRwASTHLTHQRLHS 647
Cdd:COG5189   371 -----MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK-NLNGLKYHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-299 6.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.13e-04
                          10        20
                  ....*....|....*....|....*
gi 1012282618 275 LQEHQRIHTGEKPFKCDICCKSFRS 299
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-243 6.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 1012282618 218 HLQIHQRIHTGEKPFKCEQCGKGFSR 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
554-579 8.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 1012282618 554 NLDMHQRVHTGERPYNCKECGKSFSR 579
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 293-362 1.58e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1012282618 293 CCKSFRSRANLNRHSMVH------MREKPFRCD--TCGKSFGLKSALNSHRMVHTGEKRY-KCEECGKRFIYRQDLYKH 362
Cdd:pfam15909   7 CCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSalSCTETFPSMQELVAHSKLHYKPNRYfKCENCLLRFRTHRSLFKH 85
zf-H2C2_2 pfam13465
Zinc-finger double domain;
471-495 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*
gi 1012282618 471 LLNHQRIHSGEKPFKCEECGKRFTQ 495
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 480-531 2.65e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012282618 480 GEKPFKCE--ECGKRFTQNSQLYTHRR-------------------VHSGEKPFKCEECGKRFTQNSQLYSHR 531
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-523 3.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.25e-03
                          10        20
                  ....*....|....*....|....*
gi 1012282618 499 LYTHRRVHSGEKPFKCEECGKRFTQ 523
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
527-551 6.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 1012282618 527 LYSHRRVHTGVKPYKCEECGKGFNS 551
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 454-506 6.92e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1012282618 454 KPYnCKECGKSFGWASCLLNHQRihsgEKPFKCEECGKRFTQNSQLYTH-RRVH 506
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
613-633 8.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.19e-03
                          10        20
                  ....*....|....*....|.
gi 1012282618 613 SHQRVHTGEKPYKCEKCGKSF 633
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 260-310 9.84e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 9.84e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1012282618 260 HICEKCGKAFIHDSQLQEHQRIHTgekpFKCDICCKSFRSRANLNRHSM-VH 310
Cdd:cd20908     2 PWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLqVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH