|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
54-436 |
2.90e-149 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 433.03 E-value: 2.90e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 54 IKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMfcleqekRLPFSKREGPY 133
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQ-------RLDPSRPRAPQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 134 GLIICPSRELARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICR 213
Cdd:COG0513 74 ALILAPTRELALQVAEELRKLAKYLG------LRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 214 YLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEA 293
Cdd:COG0513 148 TLVLDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 294 KMVYLLECLQKTPPP-VLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDF 372
Cdd:COG0513 228 KLELLRRLLRDEDPErAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDI 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012431804 373 PAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFinkaCDESVLMDLKALLLEAKQKVPPV 436
Cdd:COG0513 308 DDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISL----VTPDERRLLRAIEKLIGQKIEEE 367
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
66-271 |
2.26e-148 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 422.13 E-value: 2.26e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMID 225
Cdd:cd17951 81 QTHEVIEYYCKALQEGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMID 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1012431804 226 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTIN 271
Cdd:cd17951 161 MGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTVN 206
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
26-440 |
5.33e-126 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 377.96 E-value: 5.33e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 26 VLSMSEERHERVRKKYHI-LVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSG 104
Cdd:PTZ00110 100 VSALSSKEVDEIRKEKEItIIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 105 KTLVFTLPVIMFCLEQEKrlpFSKREGPYGLIICPSRELARQthgILEyycRLLQEDSSPLLRCALCIGGMSVKEQMETI 184
Cdd:PTZ00110 180 KTLAFLLPAIVHINAQPL---LRYGDGPIVLVLAPTRELAEQ---IRE---QCNKFGASSKIRNTVAYGGVPKRGQIYAL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 185 RHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSaL 264
Cdd:PTZ00110 251 RRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARD-L 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 265 VK--PVTINVGRAG-AASLDVIQEVEYVKEEAKMVYLLECLQKTPPP---VLIFAEKKADVDAIHEYLLLKGVEAVAIHG 338
Cdd:PTZ00110 330 CKeePVHVNVGSLDlTACHNIKQEVFVVEEHEKRGKLKMLLQRIMRDgdkILIFVETKKGADFLTKELRLDGWPALCIHG 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 339 GKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKacDESV 418
Cdd:PTZ00110 410 DKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP--DKYR 487
|
410 420
....*....|....*....|...
gi 1012431804 419 LM-DLKALLLEAKQKVPPVLQVL 440
Cdd:PTZ00110 488 LArDLVKVLREAKQPVPPELEKL 510
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
56-434 |
3.73e-90 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 282.85 E-value: 3.73e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEkrlPFSKREGPY-G 134
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQ---PHAKGRRPVrA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 135 LIICPSRELARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRY 214
Cdd:PRK10590 79 LILTPTRELAAQIGENVRDYSKYLN------IRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 215 LALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAK 294
Cdd:PRK10590 153 LVLDEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 295 MVYLLECLQKTP-PPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFP 373
Cdd:PRK10590 233 RELLSQMIGKGNwQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIE 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 374 AIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFInkACDE-SVLMDLKALLleaKQKVP 434
Cdd:PRK10590 313 ELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLV--CVDEhKLLRDIEKLL---KKEIP 369
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
55-411 |
4.99e-89 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 279.76 E-value: 4.99e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 55 KSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPfSKREGPYG 134
Cdd:PRK11776 4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLL-------QKLD-VKRFRVQA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 135 LIICPSRELA-----------RQTHGIleyycRLLqedsspllrcALCiGGMSVKEQMETIRHGVHMMVATPGRLMDLLQ 203
Cdd:PRK11776 76 LVLCPTRELAdqvakeirrlaRFIPNI-----KVL----------TLC-GGVPMGPQIDSLEHGAHIIVGTPGRILDHLR 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 204 KKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASldVI 283
Cdd:PRK11776 140 KGTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDLP--AI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 284 QEVEY-VKEEAKM--VYLLeCLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVL 360
Cdd:PRK11776 218 EQRFYeVSPDERLpaLQRL-LLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1012431804 361 VATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFIN 411
Cdd:PRK11776 297 VATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVA 347
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
66-270 |
4.45e-88 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 268.16 E-value: 4.45e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRlpfsKREGPYGLIICPSRELAR 145
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKK----KGRGPQALVLAPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRllqedsSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMID 225
Cdd:cd00268 77 QIAEVARKLGK------GTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLD 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1012431804 226 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd00268 151 MGFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
27-434 |
2.80e-81 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 261.65 E-value: 2.80e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 27 LSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKT 106
Cdd:PLN00206 93 SGLSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKT 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 107 LVFTLPVIMFCLEQEKRLPfSKREGPYGLIICPSRELARQThgileyycrllqEDSSPLL------RCALCIGGMSVKEQ 180
Cdd:PLN00206 173 ASFLVPIISRCCTIRSGHP-SEQRNPLAMVLTPTRELCVQV------------EDQAKVLgkglpfKTALVVGGDAMPQQ 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 181 METIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKgQRQTLLFSATMPKKIQNFA 260
Cdd:PLN00206 240 LYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALS-QPQVLLFSATVSPEVEKFA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 261 KSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECL---QKTPPPVLIFAEKKADVDAIHEYL-LLKGVEAVAI 336
Cdd:PLN00206 319 SSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDILkskQHFKPPAVVFVSSRLGADLLANAItVVTGLKALSI 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 337 HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKAcDE 416
Cdd:PLN00206 399 HGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEE-DR 477
|
410
....*....|....*...
gi 1012431804 417 SVLMDLKALLLEAKQKVP 434
Cdd:PLN00206 478 NLFPELVALLKSSGAAIP 495
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
57-410 |
2.66e-76 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 246.01 E-value: 2.66e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREgpygLI 136
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRI----LI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 137 ICPSRELARQTHGileyYCRLLQEDSSplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSldiCR--- 213
Cdd:PRK11192 79 LTPTRELAMQVAD----QARELAKHTH--LDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFD---CRave 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 214 YLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMP-KKIQNFAKSALVKPVTINVgragAASLdviqeveyvKEE 292
Cdd:PRK11192 150 TLILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEVEA----EPSR---------RER 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 293 AKM---VY----------LLECLQKTPPP--VLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKK 357
Cdd:PRK11192 217 KKIhqwYYraddlehktaLLCHLLKQPEVtrSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRV 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1012431804 358 DVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFI 410
Cdd:PRK11192 297 NVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLV 349
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
51-409 |
5.08e-76 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 246.75 E-value: 5.08e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 51 PPPIKS-FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLE---QEKRLpf 126
Cdd:PRK01297 82 PQEGKTrFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQtppPKERY-- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 127 skREGPYGLIICPSRELARQthgileyycrlLQEDSSPL-----LRCALCIGGMSVKEQMETI--RHgVHMMVATPGRLM 199
Cdd:PRK01297 160 --MGEPRALIIAPTRELVVQ-----------IAKDAAALtkytgLNVMTFVGGMDFDKQLKQLeaRF-CDILVATPGRLL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 200 DLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSY--FKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGA 277
Cdd:PRK01297 226 DFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQtpRKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENV 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 278 ASLDVIQEVEYVKEEAKMVYLLECLQKTP-PPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGK 356
Cdd:PRK01297 306 ASDTVEQHVYAVAGSDKYKLLYNLVTQNPwERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGK 385
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1012431804 357 KDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTF 409
Cdd:PRK01297 386 IRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISF 438
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
56-276 |
2.13e-72 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 228.91 E-value: 2.13e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREG--PY 133
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRRKayPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 134 GLIICPSRELARQTHGILEYYCRllqeDSSplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICR 213
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSY----RSG--VRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIK 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012431804 214 YLALDEADRMIDMGFEGDIRTIFSYF----KGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAG 276
Cdd:cd17967 155 FLVLDEADRMLDMGFEPQIRKIVEHPdmppKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGRVG 221
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
66-419 |
6.14e-72 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 234.48 E-value: 6.14e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFtLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELAR 145
Cdd:PRK04837 19 VVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAF-LTATFHYLLSHPAPEDRKVNQPRALIMAPTRELAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHgileyycrllqEDSSPL-----LRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEA 220
Cdd:PRK04837 98 QIH-----------ADAEPLaqatgLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 221 DRMIDMGFEGDIRTIFSYF--KGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYL 298
Cdd:PRK04837 167 DRMFDLGFIKDIRWLFRRMppANQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 299 LECLQKT-PPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQH 377
Cdd:PRK04837 247 QTLIEEEwPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTH 326
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1012431804 378 VINYDMPEEIENYVHRIGRTGRSGNTGIATTFinkACDESVL 419
Cdd:PRK04837 327 VFNYDLPDDCEDYVHRIGRTGRAGASGHSISL---ACEEYAL 365
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
56-434 |
3.78e-71 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 236.39 E-value: 3.78e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFtLPVIMFCLEQEKRLPFSKREGPYGL 135
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAF-LVAVMNRLLSRPALADRKPEDPRAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 136 IICPSRELARQTHGileyycRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLL-QKKMVSLDICRY 214
Cdd:PRK04537 89 ILAPTRELAIQIHK------DAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVkQHKVVSLHACEI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 215 LALDEADRMIDMGFEGDIRTIFSYF--KGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEE 292
Cdd:PRK04537 163 CVLDEADRMFDLGFIKDIRFLLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 293 AKMVYLLECLQKTP-PPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLD 371
Cdd:PRK04537 243 EKQTLLLGLLSRSEgARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLH 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012431804 372 FPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFinkACdESVLMDLKALLLEAKQKVP 434
Cdd:PRK04537 323 IDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF---AC-ERYAMSLPDIEAYIEQKIP 381
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
45-270 |
2.28e-68 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 218.40 E-value: 2.28e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 45 VEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQekrL 124
Cdd:cd17953 2 VRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQ---R 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 125 PFSKREGPYGLIICPSRELARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLL-- 202
Cdd:cd17953 79 PVKPGEGPIGLIMAPTRELALQIYVECKKFSKALG------LRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILta 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1012431804 203 -QKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17953 153 nNGRVTNLRRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
66-270 |
4.84e-66 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 211.50 E-value: 4.84e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKrlpFSKREGPYGLIICPSRELAR 145
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRE---LEKGEGPIAVIVAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMID 225
Cdd:cd17952 78 QIYLEAKKFGKAYN------LRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1012431804 226 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17952 152 MGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
40-276 |
4.40e-65 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 211.36 E-value: 4.40e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 40 KY-HILVE--GDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMF 116
Cdd:cd18052 25 KYdEIPVEvtGRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 117 CLEQEKRLP-FSKREGPYGLIICPSRELARQTHgiLEyyCRLLQEDSSplLRCALCIGGMSVKEQMETIRHGVHMMVATP 195
Cdd:cd18052 105 MMKEGLTASsFSEVQEPQALIVAPTRELANQIF--LE--ARKFSYGTC--IRPVVVYGGVSVGHQIRQIEKGCHILVATP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 196 GRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYF----KGQRQTLLFSATMPKKIQNFAKSAL-VKPVTI 270
Cdd:cd18052 179 GRLLDFIGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLkEDYLFL 258
|
....*.
gi 1012431804 271 NVGRAG 276
Cdd:cd18052 259 TVGRVG 264
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
54-410 |
3.05e-64 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 213.53 E-value: 3.05e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 54 IKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPFSKReGPY 133
Cdd:PTZ00424 27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAAL-------QLIDYDLN-ACQ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 134 GLIICPSRELARQTHGI---LEYYCRLlqedsspllRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLD 210
Cdd:PTZ00424 99 ALILAPTRELAQQIQKVvlaLGDYLKV---------RCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 211 ICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVgRAGAASLDVIQEVeYV- 289
Cdd:PTZ00424 170 DLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILV-KKDELTLEGIRQF-YVa 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 290 --KEEAKMVYLLECLQK-TPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVA 366
Cdd:PTZ00424 248 veKEEWKFDTLCDLYETlTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLL 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1012431804 367 SKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFI 410
Cdd:PTZ00424 328 ARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFV 371
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
56-410 |
3.82e-64 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 219.33 E-value: 3.82e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPvIMFCLEQEKRlpfskreGPYGL 135
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLP-LLHNLDPELK-------APQIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 136 IICPSRELARQTHGILEYYCRLLQEdssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYL 215
Cdd:PRK11634 79 VLAPTRELAVQVAEAMTDFSKHMRG-----VNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 216 ALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYV----KE 291
Cdd:PRK11634 154 VLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVwgmrKN 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 292 EAkMVYLLEClqKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLD 371
Cdd:PRK11634 234 EA-LVRFLEA--EDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLD 310
|
330 340 350
....*....|....*....|....*....|....*....
gi 1012431804 372 FPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFI 410
Cdd:PRK11634 311 VERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
66-270 |
5.74e-64 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 206.79 E-value: 5.74e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QthgILEYYCRLLQedssPL-LRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMI 224
Cdd:cd17945 81 Q---IEEETQKFAK----PLgIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMI 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1012431804 225 DMGFEGDIRTIFSYF--------------------KGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17945 154 DMGFEPQVTKILDAMpvsnkkpdteeaeklaasgkHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
35-273 |
2.05e-62 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 203.32 E-value: 2.05e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 35 ERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVI 114
Cdd:cd18049 4 EQYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 115 MFCLEQekrlPFSKR-EGPYGLIICPSRELARQTHGILEYYCRLLQEDSSpllrcalCI-GGMSVKEQMETIRHGVHMMV 192
Cdd:cd18049 84 VHINHQ----PFLERgDGPICLVLAPTRELAQQVQQVAAEYGRACRLKST-------CIyGGAPKGPQIRDLERGVEICI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 193 ATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINV 272
Cdd:cd18049 153 ATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
|
.
gi 1012431804 273 G 273
Cdd:cd18049 233 G 233
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
66-271 |
3.58e-60 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 196.05 E-value: 3.58e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEkrlPFSKREGPYGLIICPSRELAR 145
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQP---PLERGDGPIVLVLAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMID 225
Cdd:cd17966 78 QIQQEANKFGGSSR------LRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1012431804 226 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTIN 271
Cdd:cd17966 152 MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
26-273 |
1.70e-59 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 197.16 E-value: 1.70e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 26 VLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGK 105
Cdd:cd18050 33 VARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 106 TLVFTLPVIMFCLEQekrlPFSKR-EGPYGLIICPSRELARQTHGILEYYCRllqedsSPLLRCALCIGGMSVKEQMETI 184
Cdd:cd18050 113 TLAYLLPAIVHINHQ----PYLERgDGPICLVLAPTRELAQQVQQVADDYGK------SSRLKSTCIYGGAPKGPQIRDL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 185 RHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSAL 264
Cdd:cd18050 183 ERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFL 262
|
....*....
gi 1012431804 265 VKPVTINVG 273
Cdd:cd18050 263 RDYVQINIG 271
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
66-270 |
1.62e-58 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 191.70 E-value: 1.62e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPFSKREGPY--GLIICPSREL 143
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPIL-------ERLLYRPKKKAAtrVLVLVPTREL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 144 ARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKM-VSLDICRYLALDEADR 222
Cdd:cd17947 74 AMQCFSVLQQLAQFTD------ITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPsFDLDSIEILVLDEADR 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1012431804 223 MIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17947 148 MLEEGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
40-277 |
2.30e-58 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 193.33 E-value: 2.30e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 40 KYH-ILVE--GDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVI-- 114
Cdd:cd18051 3 KYEdIPVEatGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILsq 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 115 MF------CLEQEKRLPFSKREGPYGLIICPSRELARQthgILEYYCRLLQEDsspLLRCALCIGGMSVKEQMETIRHGV 188
Cdd:cd18051 83 IYeqgpgeSLPSESGYYGRRKQYPLALVLAPTRELASQ---IYDEARKFAYRS---RVRPCVVYGGADIGQQMRDLERGC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 189 HMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYF----KGQRQTLLFSATMPKKIQNFAKSAL 264
Cdd:cd18051 157 HLLVATPGRLVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDtmppTGERQTLMFSATFPKEIQMLARDFL 236
|
250
....*....|...
gi 1012431804 265 VKPVTINVGRAGA 277
Cdd:cd18051 237 DNYIFLAVGRVGS 249
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
282-410 |
6.20e-58 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 188.10 E-value: 6.20e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 282 VIQEVEYVKEEAKMVYLLECL--QKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDV 359
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLleKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1012431804 360 LVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFI 410
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
56-271 |
4.28e-56 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 185.97 E-value: 4.28e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqEKRLPFSKREGPYGL 135
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMI------EKLKAHSPTVGARAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 136 IICPSRELARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYL 215
Cdd:cd17959 76 ILSPTRELALQTLKVTKELGKFTD------LRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYV 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1012431804 216 ALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTIN 271
Cdd:cd17959 150 VFDEADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
66-271 |
1.46e-54 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 181.62 E-value: 1.46e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLpfsKREGPYGLIICPSRELAR 145
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANL---KKGQVGALIISPTRELAT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCrllqEDSSPLLRCALCIGGMSVKEQMETI-RHGVHMMVATPGRLMDLLQK-----KMVSLDIcryLALDE 219
Cdd:cd17960 78 QIYEVLQSFL----EHHLPKLKCQLLIGGTNVEEDVKKFkRNGPNILVGTPGRLEELLSRkadkvKVKSLEV---LVLDE 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 220 ADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTIN 271
Cdd:cd17960 151 ADRLLDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
57-268 |
1.46e-52 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 176.65 E-value: 1.46e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLpfskREGPYG-- 134
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPIL-------QRL----SEDPYGif 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 135 -LIICPSRELARQthgILEYYCRLlqedSSPL-LRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQ---KKMVSL 209
Cdd:cd17955 70 aLVLTPTRELAYQ---IAEQFRAL----GAPLgLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVL 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1012431804 210 DICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPV 268
Cdd:cd17955 143 SRVKFLVLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
56-270 |
4.12e-52 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 175.20 E-value: 4.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLpfskregpYGL 135
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRF--------FAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 136 IICPSRELARQthgILEYYCRLlqeDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQK-KMVSLDICRY 214
Cdd:cd17954 73 VLAPTRELAQQ---ISEQFEAL---GSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENtKGFSLKSLKF 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1012431804 215 LALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17954 147 LVMDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
64-264 |
7.84e-52 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 174.69 E-value: 7.84e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 64 AAILRGLKKKGIHHPTPIQIQGIPTILS-GRDMIGIAFTGSGKTLVFTLPVIMFCLeqeKRLPFSKREGPYGLIICPSRE 142
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLL---NTKPAGRRSGVSALIISPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 143 LARQthgILEYYCRLLQedSSPLLRCALCIGGMSVKEQM-ETIRHGVHMMVATPGRLMDLLQKKMV--SLDICRYLALDE 219
Cdd:cd17964 80 LALQ---IAAEAKKLLQ--GLRKLRVQSAVGGTSRRAELnRLRRGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1012431804 220 ADRMIDMGFEGDIRTIFSY----FKGQRQTLLFSATMPKKIQNFAKSAL 264
Cdd:cd17964 155 ADRLLDMGFRPDLEQILRHlpekNADPRQTLLFSATVPDEVQQIARLTL 203
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
79-259 |
1.19e-50 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 170.12 E-value: 1.19e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 79 TPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPFSKrEGPYGLIICPSRELARQTHGILEYYCRLL 158
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPAL-------EALDKLD-NGPQALVLAPTRELAEQIYEELKKLGKGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 159 QedssplLRCALCIGGMSVKEQMETIRhGVHMMVATPGRLMDLLQKKmVSLDICRYLALDEADRMIDMGFEGDIRTIFSY 238
Cdd:pfam00270 73 G------LKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQER-KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRR 144
|
170 180
....*....|....*....|.
gi 1012431804 239 FKGQRQTLLFSATMPKKIQNF 259
Cdd:pfam00270 145 LPKKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
66-271 |
1.51e-49 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 168.31 E-value: 1.51e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfclEQEKRLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17942 1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAI----ELLYKLKFKPRNGTGVIIISPTRELAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLQEDsspllrCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQ-KKMVSLDICRYLALDEADRMI 224
Cdd:cd17942 77 QIYGVAKELLKYHSQT------FGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQnTKGFLYKNLQCLIIDEADRIL 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1012431804 225 DMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALV-KPVTIN 271
Cdd:cd17942 151 EIGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKkKPLYVG 198
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
66-272 |
1.82e-49 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 168.24 E-value: 1.82e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVimfcLEQEKRLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17941 1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPL----LEKLYRERWTPEDGLGALIISPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILeyycRLLQEDSSplLRCALCIGGMSVKEQMETIrHGVHMMVATPGRLMDLLQKKmVSLDI--CRYLALDEADRM 223
Cdd:cd17941 77 QIFEVL----RKVGKYHS--FSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDET-PGFDTsnLQMLVLDEADRI 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1012431804 224 IDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINV 272
Cdd:cd17941 149 LDMGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
66-270 |
4.62e-49 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 167.26 E-value: 4.62e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEkrLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQP--IPREQRNGPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHG-ILEYYCRLLQedsspllrcALCI-GGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRM 223
Cdd:cd17958 79 QIEAeCSKYSYKGLK---------SVCVyGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRM 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1012431804 224 IDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17958 150 LDMGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
57-271 |
3.64e-48 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 164.78 E-value: 3.64e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPvimfCLEQEKrlpfSKREGPYGLI 136
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIP----ILEKID----PKKDVIQALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 137 ICPSRELARQTHGIleyyCRLLQEdsSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLA 216
Cdd:cd17940 73 LVPTRELALQTSQV----CKELGK--HMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLV 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1012431804 217 LDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTIN 271
Cdd:cd17940 147 LDEADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEIN 201
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
68-270 |
2.35e-46 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 160.44 E-value: 2.35e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 68 RGLKKK-GIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRlpFSKREGPYGLIICPSRELARQ 146
Cdd:cd17949 3 SHLKSKmGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPR--VDRSDGTLALVLVPTRELALQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 147 THGILEyycRLLQedSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQK-KMVSLDICRYLALDEADRMID 225
Cdd:cd17949 81 IYEVLE---KLLK--PFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLD 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1012431804 226 MGFEGDIRTIFSYFKGQ-------------RQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17949 156 MGFEKDITKILELLDDKrskaggekskpsrRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
66-273 |
9.98e-46 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 158.14 E-value: 9.98e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMfcleqeKRLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQ------KLGKPRKKKGLRALILAPTRELAS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEyycRLLQEDSsplLRCALCIGGMSVK-EQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMI 224
Cdd:cd17957 75 QIYRELL---KLSKGTG---LRIVLLSKSLEAKaKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLF 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1012431804 225 DMGFEGDIRTIFSYFKGQR-QTLLFSATMPKKIQNFAKSALVKPVTINVG 273
Cdd:cd17957 149 EPGFREQTDEILAACTNPNlQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
70-283 |
2.20e-45 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 157.65 E-value: 2.20e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 70 LKKKGIHHPTPIQIQGIPTILSG-RDMIGIAFTGSGKTLVFTLPVIMFcleqekrlpFSKREGPYGLIICPSRELARQTH 148
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEA---------LKRGKGGRVLVLVPTRELAEQWA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 149 GILEYYCrllqedSSPLLRCALCIGGMSVKEQMETIRHGV-HMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMG 227
Cdd:smart00487 72 EELKKLG------PSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1012431804 228 FEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVI 283
Cdd:smart00487 146 FGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
66-270 |
3.46e-45 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 156.94 E-value: 3.46e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEqekrlpfsKREGPYGLIICPSRELAR 145
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLT--------EHRNPSALILTPTRELAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLqedssPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMID 225
Cdd:cd17962 73 QIEDQAKELMKGL-----PPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLK 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1012431804 226 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17962 148 MGFQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
66-262 |
1.71e-44 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 156.25 E-value: 1.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIP-TILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQ-EKRLPFSKREGPYGLIICPSREL 143
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQkSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 144 ARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKK---MVSLDICRYLALDEA 220
Cdd:cd17946 81 AVQVKDHLKAIAKYTN------IKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGnehLANLKSLRFLVLDEA 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1012431804 221 DRMIDMG-FEgDIRTIFSYFKG-------QRQTLLFSATMPKKIQNFAKS 262
Cdd:cd17946 155 DRMLEKGhFA-ELEKILELLNKdragkkrKRQTFVFSATLTLDHQLPLKL 203
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
57-252 |
2.82e-42 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 149.39 E-value: 2.82e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLeqekrlpfskregpyGLI 136
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV---------------ALI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 137 ICPSRELARQTHGILEYYCRLLqedSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLA 216
Cdd:cd17938 66 LEPSRELAEQTYNCIENFKKYL---DNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFV 142
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1012431804 217 LDEADRMIDMGFEGDIRTIFSYF-----KGQR-QTLLFSATM 252
Cdd:cd17938 143 LDEADRLLSQGNLETINRIYNRIpkitsDGKRlQVIVCSATL 184
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
66-270 |
2.68e-41 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 146.96 E-value: 2.68e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLpfSKREGPYGLIICPSRELAR 145
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAES--GEEQGTRALILVPTRELAQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILE---YYCRllqedssPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKK-MVSLDICRYLALDEAD 221
Cdd:cd17961 83 QVSKVLEqltAYCR-------KDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEAD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1012431804 222 RMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17961 156 LVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
59-270 |
3.11e-39 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 140.92 E-value: 3.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 59 EMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPFSKREgPYGLIIC 138
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGAL-------QRIDTTVRE-TQALVLA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 139 PSRELARQThgilEYYCRLLQEDSSplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALD 218
Cdd:cd17939 73 PTRELAQQI----QKVVKALGDYMG--VKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLD 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 219 EADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17939 147 EADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
66-270 |
8.77e-39 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 139.71 E-value: 8.77e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLeqekrlpfSKREGPYGLIICPSRELAR 145
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD--------LERRHPQVLILAPTREIAV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLQEdssplLRCALCIGGMSVKEQMETIRhGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMID 225
Cdd:cd17943 73 QIHDVFKKIGKKLEG-----LKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLME 146
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1012431804 226 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17943 147 GSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
57-270 |
4.81e-37 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 135.27 E-value: 4.81e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPFSKREgPYGLI 136
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISIL-------QQIDTSLKA-TQALV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 137 ICPSRELARQTHGI---LEYYCRLlqedsspllRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICR 213
Cdd:cd18046 73 LAPTRELAQQIQKVvmaLGDYMGI---------KCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIK 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1012431804 214 YLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd18046 144 MFVLDEADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
57-270 |
4.67e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 129.89 E-value: 4.67e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMfCLEqekrlpFSKREgPYGLI 136
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQ-CLD------IQVRE-TQALI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 137 ICPSRELARQTHGILEYYCRLLQedssplLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLA 216
Cdd:cd18045 73 LSPTRELAVQIQKVLLALGDYMN------VQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLV 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1012431804 217 LDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd18045 147 LDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
293-401 |
5.72e-35 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 126.56 E-value: 5.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 293 AKMVYLLECLQKTPPP-VLIFAEKKADVDAihEYLLLK-GVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGL 370
Cdd:pfam00271 1 EKLEALLELLKKERGGkVLIFSQTKKTLEA--ELLLEKeGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 1012431804 371 DFPAIQHVINYDMPEEIENYVHRIGRTGRSG 401
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
66-254 |
6.05e-35 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 130.56 E-value: 6.05e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQeKRLPFSKREGPYGLIICPSRELAR 145
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRY-KLLAEGPFNAPRGLVITPSRELAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 146 QTHGILEYYCRLLqedssPLLrcALCIGGMSVKEQMETIRHG-VHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMI 224
Cdd:cd17948 80 QIGSVAQSLTEGL-----GLK--VKVITGGRTKRQIRNPHFEeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLL 152
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1012431804 225 DMGFEGDIRTIFSYF---KGQR----------QTLLFSATMPK 254
Cdd:cd17948 153 DDSFNEKLSHFLRRFplaSRRSentdgldpgtQLVLVSATMPS 195
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
63-270 |
1.86e-34 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 128.08 E-value: 1.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 63 PAAILRGLKKKGIHHPTPIQIQGIPTILSG--RDMIGIAFTGSGKTLVFTLPviMFCleqekRLPFSKREgPYGLIICPS 140
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLA--MLS-----RVDPTLKS-PQALCLAPT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 141 RELARQthgILEYYCRLLQEDSsplLRCALCIGGMSVKEQmETIRHgvHMMVATPGRLMDLLQKKMVSLDICRYLALDEA 220
Cdd:cd17963 74 RELARQ---IGEVVEKMGKFTG---VKVALAVPGNDVPRG-KKITA--QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEA 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1012431804 221 DRMIDM-GFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd17963 145 DVMLDTqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
70-261 |
4.32e-31 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 119.18 E-value: 4.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 70 LKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCleQEKRLPFSKREGPYGLIICPSRELARQTHG 149
Cdd:cd17944 5 LQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKL--QEDQQPRKRGRAPKVLVLAPTRELANQVTK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 150 ILEyycrllqeDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFE 229
Cdd:cd17944 83 DFK--------DITRKLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFA 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 1012431804 230 GDIRTIFS--YFKGQR---QTLLFSATMPKKIQNFAK 261
Cdd:cd17944 155 EQVEEILSvsYKKDSEdnpQTLLFSATCPDWVYNVAK 191
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
56-272 |
1.37e-30 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 117.83 E-value: 1.37e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 56 SFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVimfcLEQEKRLPfskrEGPYGL 135
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLST----LQQLEPVD----GQVSVL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 136 IICPSRELARQthgILEYYCRLLQedSSPLLRCALCIGGMSVKEQMETIRHGV-HMMVATPGRLMDLLQKKMVSLDICRY 214
Cdd:cd17950 75 VICHTRELAFQ---ISNEYERFSK--YMPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKH 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1012431804 215 LALDEADRMI-DMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINV 272
Cdd:cd17950 150 FVLDECDKMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
320-401 |
1.23e-29 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 111.15 E-value: 1.23e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 320 DAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGR 399
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1012431804 400 SG 401
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
66-259 |
3.90e-27 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 108.87 E-value: 3.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 66 ILRGLKKKGIHHPTPIQIQGIPTILSG---------RDMIGIAFTGSGKTLVFTLPVImfcleQEkrlpFSKREGP--YG 134
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIV-----QA----LSKRVVPrlRA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 135 LIICPSRELARQTHGILEYYCRllqedSSPLLRCALCiGGMSVKEQMETIRHGVH--------MMVATPGRLMD-LLQKK 205
Cdd:cd17956 72 LIVVPTKELVQQVYKVFESLCK-----GTGLKVVSLS-GQKSFKKEQKLLLVDTSgrylsrvdILVATPGRLVDhLNSTP 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012431804 206 MVSLDICRYLALDEADRMIDMGFEG-------------------DIRTIFSYFKGQR-QTLLFSATM---PKKIQNF 259
Cdd:cd17956 146 GFTLKHLRFLVIDEADRLLNQSFQDwletvmkalgrptapdlgsFGDANLLERSVRPlQKLLFSATLtrdPEKLSSL 222
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
101-379 |
7.57e-19 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 89.31 E-value: 7.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 101 TGSGKTLVFTLpvIMFCLEQEKRLpfskregpygLIICPSRELARQTHgilEYYCRLLQEDSSPLLRcalciggmsvkeq 180
Cdd:COG1061 109 TGTGKTVLALA--LAAELLRGKRV----------LVLVPRRELLEQWA---EELRRFLGDPLAGGGK------------- 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 181 metIRHGVHMMVATPGRLMDLLQKKMVSlDICRYLALDEADRMIDMGFegdiRTIFSYFKGQRqTLLFSAT------MPK 254
Cdd:COG1061 161 ---KDSDAPITVATYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSY----RRILEAFPAAY-RLGLTATpfrsdgREI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 255 KIQNFA-----------------KSALVKPVTINVGRAGAASLDVIQEVEYV---KEEAKMVYLLECLQKTPP--PVLIF 312
Cdd:COG1061 232 LLFLFDgivyeyslkeaiedgylAPPEYYGIRVDLTDERAEYDALSERLREAlaaDAERKDKILRELLREHPDdrKTLVF 311
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012431804 313 AEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVI 379
Cdd:COG1061 312 CSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
82-409 |
2.43e-18 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 87.50 E-value: 2.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 82 QIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMfcleqekrlpfskREGPyGLIIcpsrelarqthgileyycrllqed 161
Cdd:COG0514 22 QEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALL-------------LPGL-TLVV------------------------ 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 162 sSPLLrcAL----------------CI-GGMSVKEQMET---IRHG-VHMMVATPGRLM-----DLLQKKMVSLdicryL 215
Cdd:COG0514 64 -SPLI--ALmkdqvdalraagiraaFLnSSLSAEERREVlraLRAGeLKLLYVAPERLLnprflELLRRLKISL-----F 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 216 ALDEA--------D-----RMIdmgfeGDIRTIFsyfkGQRQTLLFSATMPKKIQN--FAKSALVKPVTINvgragaASL 280
Cdd:COG0514 136 AIDEAhcisqwghDfrpdyRRL-----GELRERL----PNVPVLALTATATPRVRAdiAEQLGLEDPRVFV------GSF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 281 DV--IQ-EVEYVKEEAKMVYLLECLQKTPP-PVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGK 356
Cdd:COG0514 201 DRpnLRlEVVPKPPDDKLAQLLDFLKEHPGgSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDE 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1012431804 357 KDVLVATdVA-SKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTF 409
Cdd:COG0514 281 VDVIVAT-IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLL 333
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
294-401 |
8.78e-17 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 83.24 E-value: 8.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 294 KMVYLLECLQKT-----PPPVLIFAEKKADVDAIHEYLLLKGVEAV-----AIHGGKD---QEERTKAIEAFREGKKDVL 360
Cdd:COG1111 336 KLSKLREILKEQlgtnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGrfvgqASKEGDKgltQKEQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1012431804 361 VATDVASKGLDFPAIQHVINYD-MPEEIEnYVHRIGRTGRSG 401
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEpVPSEIR-SIQRKGRTGRKR 456
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
57-254 |
1.53e-16 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 79.34 E-value: 1.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 57 FKEMK-FP---AAILRGLKKKGIH-----HPTPIQIQGIPtILSGRDMIGI-----------------AFTGSGKTLVFT 110
Cdd:cd17965 1 FDQLKlLPsvrEAIIKEILKGSNKtdeeiKPSPIQTLAIK-KLLKTLMRKVtkqtsneepklevfllaAETGSGKTLAYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 111 LPVIMFCLEQEKRL---------PFSKREGPYGLIICPSRELARQTHGILE-------YYCRLLQEDSSPllrcalcigg 174
Cdd:cd17965 80 APLLDYLKRQEQEPfeeaeeeyeSAKDTGRPRSVILVPTHELVEQVYSVLKklshtvkLGIKTFSSGFGP---------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 175 mSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPK 254
Cdd:cd17965 150 -SYQRLQLAFKGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPK 228
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
293-395 |
1.36e-14 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 70.58 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 293 AKMVYLLECLQKTPPP---VLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKD--VLVATDVAS 367
Cdd:cd18793 11 GKLEALLELLEELREPgekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFLLSTKAGG 90
|
90 100 110
....*....|....*....|....*....|....
gi 1012431804 368 KGLDFPAIQHVINYDMP------EEIENYVHRIG 395
Cdd:cd18793 91 VGLNLTAANRVILYDPWwnpaveEQAIDRAHRIG 124
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
54-272 |
1.51e-14 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 73.13 E-value: 1.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 54 IKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSG--RDMIGIAFTGSGKTLVFTLPVImfcleqeKRLPfSKREG 131
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAML-------SRVD-ALKLY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 132 PYGLIICPSRELARQTHGILEYYCRLlqedsspllrCAlcigGMSVKEQMETIRHG------VHMMVATPGRLMDLLQK- 204
Cdd:cd18048 89 PQCLCLSPTFELALQTGKVVEEMGKF----------CV----GIQVIYAIRGNRPGkgtdieAQIVIGTPGTVLDWCFKl 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1012431804 205 KMVSLDICRYLALDEADRMIDM-GFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINV 272
Cdd:cd18048 155 RLIDVTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKL 223
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
310-409 |
2.93e-13 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 66.85 E-value: 2.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 310 LIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIEN 389
Cdd:cd18794 34 IIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMES 113
|
90 100
....*....|....*....|
gi 1012431804 390 YVHRIGRTGRSGNTGIATTF 409
Cdd:cd18794 114 YYQESGRAGRDGLPSECILF 133
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
287-397 |
8.35e-13 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 70.64 E-value: 8.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 287 EYVKEEAKMVYLLECLQKTPP---PVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGK--KDVLV 361
Cdd:COG0553 527 ELSGRSAKLEALLELLEELLAegeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLI 606
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1012431804 362 ATDVASKGLDFPAIQHVINYDMP-----EE-----IenyvHRIGRT 397
Cdd:COG0553 607 SLKAGGEGLNLTAADHVIHYDLWwnpavEEqaidrA----HRIGQT 648
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
101-251 |
8.78e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 65.89 E-value: 8.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 101 TGSGKTLVFTLPVIMFCLEQEKRLpfskregpygLIICPSRELARQTHgileyycRLLQEDSSPLLRCALCIGGMSVKEQ 180
Cdd:cd00046 10 TGSGKTLAALLAALLLLLKKGKKV----------LVLVPTKALALQTA-------ERLRELFGPGIRVAVLVGGSSAEER 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012431804 181 METIRHGVHMMVATPGRL-MDLLQKKMVSLDICRYLALDEADRMIDMGFEGDI--RTIFSYFKGQRQTLLFSAT 251
Cdd:cd00046 73 EKNKLGDADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALIldLAVRKAGLKNAQVILLSAT 146
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
284-401 |
2.02e-12 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 69.52 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 284 QEVEYVKEEAKMVYLLECLQKTPPP-VLIFAEKKADVDAIHEYLLLKGVEAVAIHG--------GKDQEERTKAIEAFRE 354
Cdd:PRK13766 342 LDIEHPKLEKLREIVKEQLGKNPDSrIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGqaskdgdkGMSQKEQIEILDKFRA 421
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1012431804 355 GKKDVLVATDVASKGLDFPAIQHVINYD-MPEEIENyVHRIGRTGRSG 401
Cdd:PRK13766 422 GEFNVLVSTSVAEEGLDIPSVDLVIFYEpVPSEIRS-IQRKGRTGRQE 468
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
55-270 |
1.06e-11 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 63.97 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 55 KSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSG--RDMIGIAFTGSGKTLVFTLPVIMFCleqEKRLPFSKregp 132
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV---EPANKYPQ---- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 133 yGLIICPSRELARQTHGILEYYCRLLqedssPLLRCALCIGGmsvkEQMET-IRHGVHMMVATPGRLMD-LLQKKMVSLD 210
Cdd:cd18047 74 -CLCLSPTYELALQTGKVIEQMGKFY-----PELKLAYAVRG----NKLERgQKISEQIVIGTPGTVLDwCSKLKFIDPK 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 211 ICRYLALDEADRMIDMGFEGD--IRTIFSYFKGQrQTLLFSATMPKKIQNFAKSALVKPVTI 270
Cdd:cd18047 144 KIKVFVLDEADVMIATQGHQDqsIRIQRMLPRNC-QMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
340-396 |
4.59e-11 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 60.68 E-value: 4.59e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1012431804 340 KDQEErtkAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGR 396
Cdd:cd18802 77 RKQKE---TLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR 130
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
310-401 |
5.57e-10 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 61.65 E-value: 5.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 310 LIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIEN 389
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
90
....*....|..
gi 1012431804 390 YVHRIGRTGRSG 401
Cdd:PRK11057 320 YYQETGRAGRDG 331
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
294-399 |
3.57e-09 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 55.44 E-value: 3.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 294 KMVYLLECL----QKTPPP----VLIFAEKKADVDAIHEYLL--LKGVEAVAIHG--------GKDQEERTKAIEAFREG 355
Cdd:cd18801 10 KLEKLEEIVkehfKKKQEGsdtrVIIFSEFRDSAEEIVNFLSkiRPGIRATRFIGqasgksskGMSQKEQKEVIEQFRKG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1012431804 356 KKDVLVATDVASKGLDFPAIQHVINYD-MPEEIENyVHRIGRTGR 399
Cdd:cd18801 90 GYNVLVATSIGEEGLDIGEVDLIICYDaSPSPIRM-IQRMGRTGR 133
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
63-406 |
2.75e-08 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 56.38 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 63 PAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQekrlpfskrEGPYGLIICPSRE 142
Cdd:COG1205 42 PPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLED---------PGATALYLYPTKA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 143 LAR-QTHGILEYYCRLLQEdssplLRCALCIGGMSVKEQmETIRHGVHMMVATPgrlmDllqkkMVSLDI---------- 211
Cdd:COG1205 113 LARdQLRRLRELAEALGLG-----VRVATYDGDTPPEER-RWIREHPDIVLTNP----D-----MLHYGLlphhtrwarf 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 212 ---CRYLALDEA---------------DRMidmgfegdiRTIFSYFKGQRQTLLFSATM--PKKiqnFAkSALV-KPVTI 270
Cdd:COG1205 178 frnLRYVVIDEAhtyrgvfgshvanvlRRL---------RRICRHYGSDPQFILASATIgnPAE---HA-ERLTgRPVTV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 271 nVGRAGAAS-----------LDVIQEVEYVKEEAKMVyLLECLQ---KTpppvLIFAEKKADVDAIHEYL---LLKGVEA 333
Cdd:COG1205 245 -VDEDGSPRgertfvlwnppLVDDGIRRSALAEAARL-LADLVReglRT----LVFTRSRRGAELLARYArraLREPDLA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 334 VAI---HGGKDQEERTKAIEAFREGKKDVLVAT-------DVAskGLDFpaiqhVINYDMPEEIENYVHRIGRTGRSGNT 403
Cdd:COG1205 319 DRVaayRAGYLPEERREIERGLRSGELLGVVSTnalelgiDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRGQD 391
|
...
gi 1012431804 404 GIA 406
Cdd:COG1205 392 SLV 394
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
359-410 |
2.97e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.78 E-value: 2.97e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1012431804 359 VLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNT-GIATTFI 410
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDeGEVILFV 77
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
331-402 |
2.25e-07 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 50.34 E-value: 2.25e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012431804 331 VEAVAIHGGK-DQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGN 402
Cdd:cd18796 68 PDFIALHHGSlSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPG 140
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
63-401 |
3.90e-06 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 49.51 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 63 PAAILRGLKKKGIHHPTPIQIQGIP-TILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKrlpfskregpyGLIICPSR 141
Cdd:COG1204 8 LEKVIEFLKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGK-----------ALYIVPLR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 142 ELARQTHGILEyycRLLQEDSsplLRCALCIGGMSVKEQmETIRHGVhmMVATPGRLMDLLQKK---MVSLDicrYLALD 218
Cdd:COG1204 77 ALASEKYREFK---RDFEELG---IKVGVSTGDYDSDDE-WLGRYDI--LVATPEKLDSLLRNGpswLRDVD---LVVVD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 219 EAdRMIDMGFEG----DIRTIFSYFKGQRQTLLFSATMPKkIQNFAK---SALVK----PVTINVGRAGAASLDVIQEVE 287
Cdd:COG1204 145 EA-HLIDDESRGptleVLLARLRRLNPEAQIVALSATIGN-AEEIAEwldAELVKsdwrPVPLNEGVLYDGVLRFDDGSR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 288 YVKEEAkmVYLLECLQKTPPPVLIFAEKKADV---------------------------DAIHEY------------LLL 328
Cdd:COG1204 223 RSKDPT--LALALDLLEEGGQVLVFVSSRRDAeslakkladelkrrltpeereeleelaEELLEVseethtnekladCLE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 329 KGVeavAIH-GGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAiQHVI--------NYDMP-EEIENYvhrIGRTG 398
Cdd:COG1204 301 KGV---AFHhAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPA-RRVIirdtkrggMVPIPvLEFKQM---AGRAG 373
|
...
gi 1012431804 399 RSG 401
Cdd:COG1204 374 RPG 376
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
309-376 |
9.42e-06 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 45.70 E-value: 9.42e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 309 VLIFAEKKADVDAIHEYLLLKgveavAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFP----AIQ 376
Cdd:cd18789 52 IIVFTDNVEALYRYAKRLLKP-----FITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPeanvAIQ 118
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
288-405 |
1.26e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 45.76 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 288 YVKEEAKMVYLLECLQKTPPPVLIFAEK---KADVDAIHEYLLLKGVEAVAIHggkdqEERTKAIEAFREGKKDVLVAT- 363
Cdd:cd18798 6 YIEDSDSLEKLLELVKKLGDGGLIFVSIdygKEYAEELKEFLERHGIKAELAL-----SSTEKNLEKFEEGEIDVLIGVa 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1012431804 364 ---DVASKGLDFPA-IQHVINYDMPeeIENYVHRIGRTGRSGNTGI 405
Cdd:cd18798 81 syyGVLVRGIDLPErIKYAIFYGVP--VTTYIQASGRTSRLYAGGL 124
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
77-148 |
6.62e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 45.48 E-value: 6.62e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1012431804 77 HPTPIQIQGIPTILSGRDMIGIAFTGSGKTL-VFtLPVIMFCLEQEKrlPFSKREGPYGLIICPSRELARQTH 148
Cdd:COG1201 24 APTPPQREAWPAIAAGESTLLIAPTGSGKTLaAF-LPALDELARRPR--PGELPDGLRVLYISPLKALANDIE 93
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
80-255 |
9.91e-05 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 43.40 E-value: 9.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 80 PIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMfcleqekrlpFSKREGPYGLIICPSRELARQthgileyycrllQ 159
Cdd:cd18018 15 PGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALL----------LRRRGPGLTLVVSPLIALMKD------------Q 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 160 EDSSPLLRCALCIGGMSVKEQMET----IRHG-VHMMVATPGRLMD------LLQKKMVSLdicryLALDEADRMIDMG- 227
Cdd:cd18018 73 VDALPRAIKAAALNSSLTREERRRilekLRAGeVKILYVSPERLVNesfrelLRQTPPISL-----LVVDEAHCISEWSh 147
|
170 180 190
....*....|....*....|....*....|..
gi 1012431804 228 -FEGDIRTIFSY---FKGQRQTLLFSATMPKK 255
Cdd:cd18018 148 nFRPDYLRLCRVlreLLGAPPVLALTATATKR 179
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
79-253 |
1.88e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 42.25 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 79 TPIQIQGIPTI-LSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFskregpygliICPSRELARQThgileyyCRL 157
Cdd:cd17921 3 NPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAVY----------IAPTRALVNQK-------EAD 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 158 LQEDSSPL-LRCALCIGGMSVKEQMETIRHGVhmmVATPGRLMDLLQK-KMVSLDICRYLALDEAdRMIDMGFEGDI--R 233
Cdd:cd17921 66 LRERFGPLgKNVGLLTGDPSVNKLLLAEADIL---VATPEKLDLLLRNgGERLIQDVRLVVVDEA-HLIGDGERGVVleL 141
|
170 180
....*....|....*....|..
gi 1012431804 234 TI--FSYFKGQRQTLLFSATMP 253
Cdd:cd17921 142 LLsrLLRINKNARFVGLSATLP 163
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
74-401 |
1.89e-04 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 44.12 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 74 GIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMfCleqekrlpfskreGPYGLIICPSRELarqthgILEY 153
Cdd:PLN03137 457 GNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALI-C-------------PGITLVISPLVSL------IQDQ 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 154 YCRLLQEDSSpllrCALCIGGMSVKEQMETIRH------GVHMMVATPGRLM--DLLQKKMVSLDICRYLA---LDEADR 222
Cdd:PLN03137 517 IMNLLQANIP----AASLSAGMEWAEQLEILQElsseysKYKLLYVTPEKVAksDSLLRHLENLNSRGLLArfvIDEAHC 592
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 223 MIDMGFEgdirtifsyFKGQRQTLlfsATMPKKIQNFAKSALVKPVTINVGRagaaslDVIQEVEYVK--------EEAK 294
Cdd:PLN03137 593 VSQWGHD---------FRPDYQGL---GILKQKFPNIPVLALTATATASVKE------DVVQALGLVNcvvfrqsfNRPN 654
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 295 MVYLL-----ECLQKTPPPV---------LIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVL 360
Cdd:PLN03137 655 LWYSVvpktkKCLEDIDKFIkenhfdecgIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINII 734
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1012431804 361 VATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSG 401
Cdd:PLN03137 735 CATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDG 775
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
318-401 |
1.99e-04 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 41.95 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 318 DVDAIHEYL--LLKGVEAVA-IHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFP-AIQHVInydmpEEIENY--- 390
Cdd:cd18811 46 AAVAMYEYLkeRFRPELNVGlLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPnATVMVI-----EDAERFgls 120
|
90
....*....|...
gi 1012431804 391 -VHRI-GRTGRSG 401
Cdd:cd18811 121 qLHQLrGRVGRGD 133
|
|
| ComFA |
COG4098 |
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, ... |
245-400 |
2.19e-04 |
|
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair];
Pssm-ID: 443274 [Multi-domain] Cd Length: 451 Bit Score: 43.71 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 245 TLLFSATMPKKIQNFAKSALVKPVTINV---GRAgaasLDVIQ---------EVEYVKEEAKMVYLLECLQKTPPPVLIF 312
Cdd:COG4098 250 LIYLTATPSKALQRQVKRGKLKVVKLPAryhGHP----LPVPKfkwlgnwkkRLRRGKLPRKLLKWLKKRLKEGRQLLIF 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 313 AEKKADVDAIHEYL--LLKGVEAVAIHGgKDqEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQ-HVINYDmpeeien 389
Cdd:COG4098 326 VPTIELLEQLVALLqkLFPEERIAGVHA-ED-PERKEKVQAFRDGEIPILVTTTILERGVTFPNVDvAVLGAD------- 396
|
170 180
....*....|....*....|.
gi 1012431804 390 yvHRI----------GRTGRS 400
Cdd:COG4098 397 --HPVfteaalvqiaGRVGRS 415
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
59-396 |
2.19e-04 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 44.04 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 59 EMKFPAAILRGLKKKGIHHPTPIQIQGIPT-ILSGRDMIGIAFTGSGKTLVFTLPVIMFCLeqekrlpfskREGPYGLII 137
Cdd:PRK00254 5 ELRVDERIKRVLKERGIEELYPPQAEALKSgVLEGKNLVLAIPTASGKTLVAEIVMVNKLL----------REGGKAVYL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 138 CPSRELARQTHGILEYYCRLLqedssplLRCALCIGGMSVKEQMetiRHGVHMMVATPGRLMDLLQKKMVSLDICRYLAL 217
Cdd:PRK00254 75 VPLKALAEEKYREFKDWEKLG-------LRVAMTTGDYDSTDEW---LGKYDIIIATAEKFDSLLRHGSSWIKDVKLVVA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 218 DEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATM--PKKIQNFAKSALV----KPVTINVG------------------ 273
Cdd:PRK00254 145 DEIHLIGSYDRGATLEMILTHMLGRAQILGLSATVgnAEELAEWLNAELVvsdwRPVKLRKGvfyqgflfwedgkierfp 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 274 -----------RAGAASL-----------------DVIQEVEYVKEEAKMVYLLECLQKTPPpvlifAEKKADVdaihey 325
Cdd:PRK00254 225 nsweslvydavKKGKGALvfvntrrsaekealelaKKIKRFLTKPELRALKELADSLEENPT-----NEKLKKA------ 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 326 lLLKGVeaVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVI-------NYDMPE----EIENYVHRI 394
Cdd:PRK00254 294 -LRGGV--AFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIrdtkrysNFGWEDipvlEIQQMMGRA 370
|
..
gi 1012431804 395 GR 396
Cdd:PRK00254 371 GR 372
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
289-397 |
3.09e-04 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 43.64 E-value: 3.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 289 VKEEAKMVYL---LECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAF-REG--KKDVLVA 362
Cdd:PLN03142 467 VENSGKMVLLdklLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFnKPGseKFVFLLS 546
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1012431804 363 TDVASKGLDFPAIQHVINYD------MPEEIENYVHRIGRT 397
Cdd:PLN03142 547 TRAGGLGINLATADIVILYDsdwnpqVDLQAQDRAHRIGQK 587
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
65-116 |
9.56e-04 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 40.60 E-value: 9.56e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 65 AILRglKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMF 116
Cdd:cd17920 2 QILK--EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLL 51
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
101-220 |
1.83e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 39.56 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 101 TGSGKTLVftlpVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCrllqedsspLLRCALCIGGMSV--- 177
Cdd:cd18034 25 TGSGKTLI----AVMLIKEMGELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRSHT---------DLKVGEYSGEMGVdkw 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1012431804 178 -----KEQMETIrhgvHMMVATPGRLMDLLQKKMVSLDICRYLALDEA 220
Cdd:cd18034 92 tkerwKEELEKY----DVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
329-402 |
2.01e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 38.78 E-value: 2.01e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1012431804 329 KGVEAVAIH-GGKDQEERtKAIEA-FREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGN 402
Cdd:cd18797 64 PLASKVASYrAGYLAEDR-REIEAeLFNGELLGVVATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGK 138
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
308-406 |
2.13e-03 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 38.69 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 308 PVLIFAEKKADVDAIHEYLLlkgveAVAI-HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVIN----YD 382
Cdd:cd18795 45 PVLVFCSSRKECEKTAKDLA-----GIAFhHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKgtqrYD 119
|
90 100 110
....*....|....*....|....*....|
gi 1012431804 383 MPEEIE----NYVHRIGRTGRSG--NTGIA 406
Cdd:cd18795 120 GKGYRElsplEYLQMIGRAGRPGfdTRGEA 149
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
330-409 |
4.08e-03 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 37.54 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012431804 330 GVEAVAIHGGKDQEERTKAIEAFREGKK--DVLVATDVASKGLDFPaIQHVINYDM------------PEEIENYVHRIG 395
Cdd:cd18805 42 GLKCAVIYGALPPETRRQQARLFNDPESgyDVLVASDAIGMGLNLN-IRRVIFSSLskfdgnemrplsPSEVKQIAGRAG 120
|
90
....*....|....
gi 1012431804 396 RTGRSGNTGIATTF 409
Cdd:cd18805 121 RFGSHFPEGEVTTL 134
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
317-365 |
4.46e-03 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 39.65 E-value: 4.46e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1012431804 317 ADVDAIHEYL--LLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDV 365
Cdd:COG1200 488 QAAEETYEELreAFPGLRVGLLHGRMKPAEKDAVMAAFKAGEIDVLVATTV 538
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
322-373 |
4.65e-03 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 38.00 E-value: 4.65e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1012431804 322 IHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFP 373
Cdd:cd18790 43 LTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLP 94
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
310-375 |
7.22e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 36.38 E-value: 7.22e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1012431804 310 LIFAEKKADVDAIHEYLLLKGVEAVAIHGG-KDQEERTKAIEAFREGKK--DVLVATDVASKGLDFPAI 375
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDySDRERGDEALILLFFGELkpPILVTVDLLTTGVDIPEV 78
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
318-373 |
8.61e-03 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 37.25 E-value: 8.61e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1012431804 318 DVDAIHEYLLLKGVEA-VAI-HGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFP 373
Cdd:cd18792 46 SIEALAEELKELVPEArVALlHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVP 103
|
|
| |
