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Conserved domains on  [gi|1012443730|ref|NP_001308671|]
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intraflagellar transport protein 56 isoform 9 [Homo sapiens]

Protein Classification

lipopolysaccharide assembly protein LapB( domain architecture ID 11459274)

lipopolysaccharide assembly protein LapB is a tetratricopeptide repeat (TPR) protein that modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-224 3.16e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 3.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  29 KLEELLSKR-DFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMY 107
Cdd:COG2956    47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 108 KQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKLMSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956   127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1012443730 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNL 224
Cdd:COG2956   207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-224 3.16e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 3.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  29 KLEELLSKR-DFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMY 107
Cdd:COG2956    47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 108 KQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKLMSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956   127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1012443730 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNL 224
Cdd:COG2956   207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-252 3.13e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  33 LLSKRDFTGAITLLEfkRHVGEEEEDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110
Cdd:TIGR02917 169 ALAENRFDEARALID--EVLTADPGNVDALLlkGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 111 EAAgFKASKSRLQNRLLFHLAHkfndekklmsfhqnlqdvtedqlslASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:TIGR02917 247 EKH-ADALLKKAPNSPLAHYLK-------------------------ALVDFQKKNYEDARETLQDALKSAPEYLPALLL 300

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012443730 191 VALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACnhFRLYNGRAAEA--ELKSLMDNASSS 252
Cdd:TIGR02917 301 AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLAS--IQLRLGRVDEAiaTLSPALGLDPDD 362
TPR_19 pfam14559
Tetratricopeptide repeat;
167-226 4.40e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 34.87  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 167 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-224 3.16e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 3.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  29 KLEELLSKR-DFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMY 107
Cdd:COG2956    47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 108 KQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKLMSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956   127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1012443730 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNL 224
Cdd:COG2956   207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-252 1.91e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  55 EEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN----RLLFHL 130
Cdd:COG2956    40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaealRLLAEI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 131 AHKFNDEKKLMSFHQNLQDVTEDQ----LSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQE 206
Cdd:COG2956   120 YEQEGDWEKAIEVLERLLKLGPENahayCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1012443730 207 VLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSS 252
Cdd:COG2956   200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
55-261 8.48e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 8.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  55 EEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLA-- 131
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDaEALNNLGla 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 132 --HKFNDEKKLMSFHQNLQ---DVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQE 206
Cdd:COG0457    86 lqALGRYEEALEDYDKALEldpDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALE 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1012443730 207 VLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSSFEFAKELIR 261
Cdd:COG0457   166 LLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 63-218 1.99e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  63 IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAagfkasksrlqnrlLFHLAHKFNdekklms 142
Cdd:COG4783    10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIV--------------LLHEALELD------- 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1012443730 143 fhqnlQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDS 218
Cdd:COG4783    69 -----PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
63-213 5.37e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.46  E-value: 5.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  63 IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKA-----SKSRLQNRLLFHLAHKFNDE 137
Cdd:COG0457    82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAleldpDDADALYNLGIALEKLGRYE 161

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1012443730 138 KKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQ 213
Cdd:COG0457   162 EALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAA 237
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 45-178 7.00e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 7.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  45 LLEFKRHVGEEEEDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKAsksrl 122
Cdd:COG4235     3 IARLRQALAANPNDAEGWLllGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA----- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1012443730 123 qnrllfhLAHKFNDEKKLMsfhqnlqdvtedqlSLASIHYMRSHYQEAIDIYKRIL 178
Cdd:COG4235    78 -------LALDPDNPEALY--------------LLGLAAFQQGDYAEAIAAWQKLL 112
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 30-230 1.14e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.06  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  30 LEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQ 109
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 110 AEAAgfkasksrlqnrllFHLAHKFNDEKklmsfhqnlqdvTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNV 189
Cdd:COG3914   165 AIAA--------------LRRALELDPDN------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHS 218

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1012443730 190 YVALCYYKL---DYYDVSQEVLAVYLQQ-----------IPDSTIALNLKACNHF 230
Cdd:COG3914   219 NLLFALRQAcdwEVYDRFEELLAALARGpselspfallyLPDDDPAELLALARAW 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
62-192 2.83e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  62 WIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLM 141
Cdd:COG0457   115 NLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAE 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1012443730 142 SFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVA 192
Cdd:COG0457   195 VLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 31-113 3.90e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 3.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  31 EELLSKRDFTGAITLLEfkRHVGEEEEDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYK 108
Cdd:COG4783    12 QALLLAGDYDEAEALLE--KALELDPDNPEAFalLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89


                  ....*
gi 1012443730 109 QAEAA 113
Cdd:COG4783    90 EALAL 94
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-232 1.73e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  64 GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAgFKASksrlqnrllfhLAHKFNDekklmsf 143
Cdd:COG4785    80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALED-FDRA-----------LELDPDY------- 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 144 hqnlqdvTEDQLSLASIHYMRSHYQEAIDIYKR--ILLDNREYLALNVYvaLCYYKLDYydvsQEVLAVYLQQIPDSTIA 221
Cdd:COG4785   141 -------AYAYLNRGIALYYLGRYELAIADLEKalELDPNDPERALWLY--LAERKLDP----EKALALLLEDWATAYLL 207

                         170
                  ....*....|...
gi 1012443730 222 LNL--KACNHFRL 232
Cdd:COG4785   208 QGDteEARELFKL 220
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
66-186 2.58e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  66 CAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAagfkasksrlqnrllFHLAHKFNdekklmsfhq 145
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA---------------LEKALKLD---------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1012443730 146 nlQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLA 186
Cdd:COG3063    56 --PNNAEALLNLAELLLELGDYDEALAYLERALELDPSALR 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 27-117 2.73e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 37.63  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  27 IPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGM 106
Cdd:COG5010    24 VEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGD 103

                          90
                  ....*....|.
gi 1012443730 107 YKQAEAAGFKA 117
Cdd:COG5010   104 KDEAKEYYEKA 114
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-252 3.13e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  33 LLSKRDFTGAITLLEfkRHVGEEEEDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110
Cdd:TIGR02917 169 ALAENRFDEARALID--EVLTADPGNVDALLlkGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 111 EAAgFKASKSRLQNRLLFHLAHkfndekklmsfhqnlqdvtedqlslASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:TIGR02917 247 EKH-ADALLKKAPNSPLAHYLK-------------------------ALVDFQKKNYEDARETLQDALKSAPEYLPALLL 300

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1012443730 191 VALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACnhFRLYNGRAAEA--ELKSLMDNASSS 252
Cdd:TIGR02917 301 AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLAS--IQLRLGRVDEAiaTLSPALGLDPDD 362
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 154-246 3.46e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 154 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 233
Cdd:COG4783    41 FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120

                          90
                  ....*....|...
gi 1012443730 234 NGRAAEAELKSLM 246
Cdd:COG4783   121 RPDEAIAALEKAL 133
TPR_19 pfam14559
Tetratricopeptide repeat;
167-226 4.40e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 34.87  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 167 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 32-113 5.28e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 35.74  E-value: 5.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730  32 ELLSKRDFTGAITLLE--FKRHVGEE-EEDTNLWIGYCAFHLGDYKRALEEYENATK---EENCNSEVWVNLACTYFFLG 105
Cdd:COG1729     2 ALLKAGDYDEAIAAFKafLKRYPNSPlAPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELG 81


                  ....*...
gi 1012443730 106 MYKQAEAA 113
Cdd:COG1729    82 DYDKARAT 89
TPR_19 pfam14559
Tetratricopeptide repeat;
71-112 7.00e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 34.48  E-value: 7.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1012443730  71 GDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEA 112
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEA 43
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 107-241 7.37e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 37.67  E-value: 7.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 107 YKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQL----------SLASIHYMRSHYQEAIDIYKR 176
Cdd:COG3914    24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaalleLAALLLQALGRYEEALALYRR 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1012443730 177 ILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLynGRAAEAE 241
Cdd:COG3914   104 ALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL--GRLEEAI 166
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 154-269 8.25e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.02  E-value: 8.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443730 154 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 233
Cdd:COG2956    45 HLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEG 124

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1012443730 234 NGRAAEAELKSLMDNASSSFEFAKELIRHNLVNNDF 269
Cdd:COG2956   125 DWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDY 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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