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Conserved domains on  [gi|1012443663|ref|NP_001308773|]
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COMM domain-containing protein 4 isoform 5 [Homo sapiens]

Protein Classification

COMM domain-containing protein 4( domain architecture ID 10140832)

COMM domain-containing protein 4 (COMMD4) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 1-174 9.76e-103

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 292.41  E-value: 9.76e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663   1 MSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 80
Cdd:cd04752     1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  81 SLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVL 160
Cdd:cd04752    81 SLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVL 160

                         170
                  ....*....|....
gi 1012443663 161 LAELKQAQTLMSSL 174
Cdd:cd04752   161 LAELKQAQTLMETL 174
 
Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 1-174 9.76e-103

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 292.41  E-value: 9.76e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663   1 MSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 80
Cdd:cd04752     1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  81 SLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVL 160
Cdd:cd04752    81 SLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVL 160

                         170
                  ....*....|....
gi 1012443663 161 LAELKQAQTLMSSL 174
Cdd:cd04752   161 LAELKQAQTLMETL 174
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 103-167 4.31e-12

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 58.33  E-value: 4.31e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1012443663 103 RMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVaAAPGTPAQPVAMSLSADKFQVLLAELKQA 167
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKL-SDGDGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 1-174 9.76e-103

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 292.41  E-value: 9.76e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663   1 MSSVKLRLLCSQVLKELLGQGIDYEKILKLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAA 80
Cdd:cd04752     1 ISSVKMKLLCAQVLKDLLGEGIDYEKVLKLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  81 SLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVL 160
Cdd:cd04752    81 SLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVL 160

                         170
                  ....*....|....
gi 1012443663 161 LAELKQAQTLMSSL 174
Cdd:cd04752   161 LAELKQAQTLMETL 174
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 103-167 4.31e-12

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 58.33  E-value: 4.31e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1012443663 103 RMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVaAAPGTPAQPVAMSLSADKFQVLLAELKQA 167
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKL-SDGDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd7 cd04755
COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of ...
 39-173 1.63e-07

COMM_Domain containing protein 7. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240103  Cd Length: 180  Bit Score: 48.60  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  39 GDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTL 118
Cdd:cd04755    48 GPLKNIVKSILLVPNGALKRNLTAEQLREDLIQLGLSEEKASYFSEQWKQHYSTLSRSAVGQTLMVNQLVDMEWKFGVTA 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1012443663 119 SSSLLQSVEEPMVHLRLEVAAapGTPAQPVAMSLSADKFQVLLAELKQAQTLMSS 173
Cdd:cd04755   128 GSSELQKVGSIFLQLKLVVRK--GNQTENVYMELTLPQFYSFLHEMERAKASLEC 180
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 85-168 2.36e-07

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 46.53  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  85 CYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAEL 164
Cdd:cd04748     1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKL 80


                  ....
gi 1012443663 165 KQAQ 168
Cdd:cd04748    81 KKIK 84
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 29-174 2.54e-06

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 45.45  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  29 KLTADAKFESGDVKATVAVLSFILSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLA 108
Cdd:cd04758    42 KLQEAFKLLSQDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAFVNAWEAEGEDVLEKLRSRILAPNQLE 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1012443663 109 GVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTpAQPVAMSLSADKFQVLLAELKQAQTLMSSL 174
Cdd:cd04758   122 DVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEDGN-LEKINLEFNHEELLEFYNQLESIQEQLDSL 186
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 52-174 8.19e-03

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 35.47  E-value: 8.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443663  52 LSSAAKHSVDGESLSSELQQL--GLPKEHAASLCRCYEEKQSPLQKHL--RVCSLRMNRLAGVGWRVDYTLSSSLLQSVE 127
Cdd:cd04756    52 LATLFKQAVGKNSNDEEAKAQlsDLSSSHQEALLKCVKSRKEEIRQALvnKTNSISSAQLQDFDWQLKLALSSDKLSSLQ 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1012443663 128 EPMVHLRLEVAAApGTpAQPVAMSLSADKFQVLLAELKQAQTLMSSL 174
Cdd:cd04756   132 EPLLNLDLDVKEN-GI-LKPVSIEMNKEELQNLISSLEAANKVVLQL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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