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Conserved domains on  [gi|1013071100|ref|NP_001308794|]
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izumo sperm-egg fusion protein 1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Izumo-Ig pfam16706
Izumo-like Immunoglobulin domain; Izumo-Ig is the immunoglobulin domain on Izumo proteins from ...
 1-81 1.65e-58

Izumo-like Immunoglobulin domain; Izumo-Ig is the immunoglobulin domain on Izumo proteins from higher eukaryotes. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif - glycosylation site. The full-length protein, eg Swiss:Q8IYV9, is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.


:

Pssm-ID: 465242  Cd Length: 88  Bit Score: 177.66  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013071100   1 MEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLP 80
Cdd:pfam16706   8 MEDLILDCELSWHRASQGLTDYSFYRVWGNSSETLLSKGKDPTLTKPMVGPEDAGTYRCELDTVNSSPATIIHFHVTVLP 87


                  .
gi 1013071100  81 K 81
Cdd:pfam16706  88 L 88
 
Name Accession Description Interval E-value
Izumo-Ig pfam16706
Izumo-like Immunoglobulin domain; Izumo-Ig is the immunoglobulin domain on Izumo proteins from ...
 1-81 1.65e-58

Izumo-like Immunoglobulin domain; Izumo-Ig is the immunoglobulin domain on Izumo proteins from higher eukaryotes. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif - glycosylation site. The full-length protein, eg Swiss:Q8IYV9, is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.


Pssm-ID: 465242  Cd Length: 88  Bit Score: 177.66  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013071100   1 MEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLP 80
Cdd:pfam16706   8 MEDLILDCELSWHRASQGLTDYSFYRVWGNSSETLLSKGKDPTLTKPMVGPEDAGTYRCELDTVNSSPATIIHFHVTVLP 87


                  .
gi 1013071100  81 K 81
Cdd:pfam16706  88 L 88
 
Name Accession Description Interval E-value
Izumo-Ig pfam16706
Izumo-like Immunoglobulin domain; Izumo-Ig is the immunoglobulin domain on Izumo proteins from ...
 1-81 1.65e-58

Izumo-like Immunoglobulin domain; Izumo-Ig is the immunoglobulin domain on Izumo proteins from higher eukaryotes. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif - glycosylation site. The full-length protein, eg Swiss:Q8IYV9, is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.


Pssm-ID: 465242  Cd Length: 88  Bit Score: 177.66  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013071100   1 MEDMILDCELNWHQASEGLTDYSFYRVWGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLP 80
Cdd:pfam16706   8 MEDLILDCELSWHRASQGLTDYSFYRVWGNSSETLLSKGKDPTLTKPMVGPEDAGTYRCELDTVNSSPATIIHFHVTVLP 87


                  .
gi 1013071100  81 K 81
Cdd:pfam16706  88 L 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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