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Conserved domains on  [gi|1013382281|ref|NP_001308921|]
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zinc finger protein 570 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 7.25e-12

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.30  E-value: 7.25e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1013382281    1 MLENYRILVSLGLCFSKPSVILLLEQGKAPWM 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-474 6.90e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 209 CGKAFSQRSNLVQHQRIHTGEKPYECKECRKAFSQNaHLVQHLRVHTGEKPYECKVCRKAFSQFAYLAQHQRVHTGEKPY 288
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIP-SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 289 ECIECGKAF--SNRSSIAQHQRVHTGE-----KPYECNVCGKAFSLRAYLTVHQR--IHTGE--RPYECKE--CGKAFSQ 355
Cdd:COG5048   256 SASESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSR 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 356 NSHLAQHQRIHTGEKPYKC--QECRKAFSQIAYLAQHQRVH-----TGEKPYECI--ECGKAFSNDSSLTQHQRVHTGEK 426
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1013382281 427 PYEC--TVCGKAFSYCGSLAQHQRIHTGERPYECkECKKTFRQHAHLAHH 474
Cdd:COG5048   416 PYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-215 2.17e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 190 SLTLHQRIHTGEKPYKCIECGKAFSQ 215
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 7.25e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.30  E-value: 7.25e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1013382281    1 MLENYRILVSLGLCFSKPSVILLLEQGKAPWM 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-474 6.90e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 209 CGKAFSQRSNLVQHQRIHTGEKPYECKECRKAFSQNaHLVQHLRVHTGEKPYECKVCRKAFSQFAYLAQHQRVHTGEKPY 288
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIP-SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 289 ECIECGKAF--SNRSSIAQHQRVHTGE-----KPYECNVCGKAFSLRAYLTVHQR--IHTGE--RPYECKE--CGKAFSQ 355
Cdd:COG5048   256 SASESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSR 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 356 NSHLAQHQRIHTGEKPYKC--QECRKAFSQIAYLAQHQRVH-----TGEKPYECI--ECGKAFSNDSSLTQHQRVHTGEK 426
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1013382281 427 PYEC--TVCGKAFSYCGSLAQHQRIHTGERPYECkECKKTFRQHAHLAHH 474
Cdd:COG5048   416 PYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-383 7.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.18e-05
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 358 HLAQHQRIHTGEKPYKCQECRKAFSQ 383
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-215 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 190 SLTLHQRIHTGEKPYKCIECGKAFSQ 215
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 398-450 6.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 6.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1013382281 398 KPYeCIECGKAFSNDSSLTQHQRvhtgEKPYECTVCGKAFSYCGSLAQH-QRIH 450
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 7.25e-12

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 60.30  E-value: 7.25e-12
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1013382281    1 MLENYRILVSLGLCFSKPSVILLLEQGKAPWM 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-474 6.90e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 209 CGKAFSQRSNLVQHQRIHTGEKPYECKECRKAFSQNaHLVQHLRVHTGEKPYECKVCRKAFSQFAYLAQHQRVHTGEKPY 288
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIP-SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 289 ECIECGKAF--SNRSSIAQHQRVHTGE-----KPYECNVCGKAFSLRAYLTVHQR--IHTGE--RPYECKE--CGKAFSQ 355
Cdd:COG5048   256 SASESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSR 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 356 NSHLAQHQRIHTGEKPYKC--QECRKAFSQIAYLAQHQRVH-----TGEKPYECI--ECGKAFSNDSSLTQHQRVHTGEK 426
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFR 415

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1013382281 427 PYEC--TVCGKAFSYCGSLAQHQRIHTGERPYECkECKKTFRQHAHLAHH 474
Cdd:COG5048   416 PYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
173-480 1.25e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 173 KKLLKCNDCEKVFSQSSSLTLHQRIHTGEKPYKC--IECGKAFSQRSNLVQHQRIHTGEKPYECkecrkafSQNAHLVQH 250
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN-------SKSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 251 LRVHTGEKPYECKVCRKAFSQFAYLAQHQRV---HTGEKPYECIECGKAFSNRSSIAQHQRVHTgEKPYECNVCGKAFSL 327
Cdd:COG5048   104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSRDpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSL-HPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 328 RAYLTVHQRIHTGERPYECKECGKAFSQNSHLAQHQRIHTGEKPYKCQECRKAFSQIAYLAQHQRVHTGEKPYECIECGK 407
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 408 AFSNDSSLTQHQRVHTGE-------KPYECTVCGKAFSYCGSLAQHQR--IHTGE--RPYECKE--CKKTFRQHAHLAHH 474
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342


                  ....*.
gi 1013382281 475 QRIHIG 480
Cdd:COG5048   343 ILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-383 7.18e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.18e-05
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 358 HLAQHQRIHTGEKPYKCQECRKAFSQ 383
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-243 7.46e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.46e-05
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 218 NLVQHQRIHTGEKPYECKECRKAFSQ 243
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-215 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 190 SLTLHQRIHTGEKPYKCIECGKAFSQ 215
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
386-411 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 386 YLAQHQRVHTGEKPYECIECGKAFSN 411
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-299 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 274 YLAQHQRVHTGEKPYECIECGKAFSN 299
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-271 2.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 246 HLVQHLRVHTGEKPYECKVCRKAFSQ 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-439 3.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 414 SLTQHQRVHTGEKPYECTVCGKAFSY 439
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 3.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 330 YLTVHQRIHTGERPYECKECGKAFSQ 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 398-450 6.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 6.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1013382281 398 KPYeCIECGKAFSNDSSLTQHQRvhtgEKPYECTVCGKAFSYCGSLAQH-QRIH 450
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-467 8.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013382281 442 SLAQHQRIHTGERPYECKECKKTFRQ 467
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-301 8.50e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013382281 179 NDCEKVFSQSSSLTLHQRIHTGEKPYKCI--ECGKAFSQRSN-----LVQHQRIHTGEKPYEC--KECRKAFSQNAHLVQ 249
Cdd:COG5048   327 SLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1013382281 250 HLRVHTGEKPYECK--VCRKAFSQFAYLAQHQRVHTGEKPYECIECGKAFSNRS 301
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 344-366 1.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|...
gi 1013382281 344 YECKECGKAFSQNSHLAQHQRIH 366
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-326 2.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|..
gi 1013382281 305 QHQRVHTGEKPYECNVCGKAFS 326
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 456-478 7.34e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.34e-03
                          10        20
                  ....*....|....*....|...
gi 1013382281 456 YECKECKKTFRQHAHLAHHQRIH 478
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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