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Conserved domains on  [gi|1015215017|ref|NP_001309010|]
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major facilitator superfamily domain-containing protein 9 isoform 2 [Homo sapiens]

Protein Classification

major facilitator superfamily domain-containing protein 9( domain architecture ID 13024407)

major facilitator superfamily domain-containing protein 9 may facilitate the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-400 1.09e-144

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 415.47  E-value: 1.09e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17390    14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPwr 160
Cdd:cd17390    94 LGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLL-- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 161 eakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVML 240
Cdd:cd17390   172 -------------------------------------------------------------SKLWDLLLVRFLMGFSVLL 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 241 YYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSS 320
Cdd:cd17390   191 FRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCL 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 321 TLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKR 400
Cdd:cd17390   271 TPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQR 350
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-400 1.09e-144

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 415.47  E-value: 1.09e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17390    14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPwr 160
Cdd:cd17390    94 LGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLL-- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 161 eakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVML 240
Cdd:cd17390   172 -------------------------------------------------------------SKLWDLLLVRFLMGFSVLL 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 241 YYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSS 320
Cdd:cd17390   191 FRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCL 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 321 TLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKR 400
Cdd:cd17390   271 TPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQR 350
MFS_1 pfam07690
Major Facilitator Superfamily;
1-366 2.09e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.19  E-value: 2.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHV-KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARV 79
Cdd:pfam07690  14 LLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  80 PAGIFK-HTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFP 158
Cdd:pfam07690  94 LQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILAILSLLAAVLLLLPR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 159 wreakpgstekglplrkthvllgrshdtvqEAATSRRARASKKTAQPWVEVVLALRNMKNLLfsemwdiFLVRLLMAMAV 238
Cdd:pfam07690 173 ------------------------------PPPESKRPKPAEEARLSLIVAWKALLRDPVLW-------LLLALLLFGFA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 239 MLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVV 317
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1015215017 318 LSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAP 366
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-361 5.31e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 5.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:COG2814    28 IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFpw 159
Cdd:COG2814   108 QGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRL-- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 160 reakpgstekglplrkthvllgrshdtVQEAATSRRARASKKTAQPWVEVVLALrnmknllfsemwdIFLVRLLMAMAVM 239
Cdd:COG2814   185 ---------------------------LPESRPAARARLRGSLRELLRRPRLLL-------------LLLLAFLLGFGFF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 240 LYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLS 319
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1015215017 320 STLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVG 361
Cdd:COG2814   303 LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
1-149 8.63e-08

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 53.77  E-value: 8.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVA-----GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFV 75
Cdd:PRK09874   32 LVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1015215017  76 LARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LEDGFYLTAFICFLVFIL 149
Cdd:PRK09874  112 ILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADsygLRPVFFITASVLFLCFLV 188
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 10-156 2.49e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 42.75  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  10 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHT-L 88
Cdd:TIGR00881  22 VEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMgW 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1015215017  89 SISRALLSDVVPEKERPLVIGHFNTASGVGFILGP-VVGGYLTELEDG---FYLTAFICFLVfilnaGLVWF 156
Cdd:TIGR00881 102 PPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWhwvFIVPGIIAIIV-----SLICF 168
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-400 1.09e-144

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 415.47  E-value: 1.09e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17390    14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIP 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPwr 160
Cdd:cd17390    94 LGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLVWFLL-- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 161 eakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVML 240
Cdd:cd17390   172 -------------------------------------------------------------SKLWDLLLVRFLMGFSVLL 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 241 YYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSS 320
Cdd:cd17390   191 FRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCL 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 321 TLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSLNKR 400
Cdd:cd17390   271 TPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQR 350
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-397 2.39e-58

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 194.33  E-value: 2.39e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKS---LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLA 77
Cdd:cd17330    14 IVFPVLPFYVREfnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  78 RVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFF 157
Cdd:cd17330    94 RFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP-YGYALPFLVAAALALLNLVLVLFF 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 158 PWReakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLLMAMA 237
Cdd:cd17330   173 LPP---------------------------------------------------------------LRRLLLVYFLIALA 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 238 VMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVV 317
Cdd:cd17330   190 FAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLA-KRLGERKLLRLGLLLAIIGLLLLPFASSVPLLV 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 318 LSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSLGAVLALVAIFIMS 396
Cdd:cd17330   269 LAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLySFLGPGVPFLLAAGLLLIALFLLS 348


                  .
gi 1015215017 397 L 397
Cdd:cd17330   349 L 349
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 2-397 3.18e-36

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 136.19  E-value: 3.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   2 VVPLLslhVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPA 81
Cdd:cd17331    22 VLPYL---TKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  82 gIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFPwre 161
Cdd:cd17331    99 -VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKF-GEQAAALVAAVGSLLSIVLVILLI--- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 162 akPGSTekglplrkthvllgrshdtvQEAATSRRARASKKTAQPWVEVVLALRNMKNLlfsemWDIFLVRLLMAMAVMLY 241
Cdd:cd17331   174 --PSNT--------------------KSKREKEAKESASPPSVFNLKEILRLLRLPGV-----AFLLLVKLLSGLPIGMF 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 242 YSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSST 321
Cdd:cd17331   227 QSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTK-RFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLL 305

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1015215017 322 LLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSLGAVLALVAIFIMSL 397
Cdd:cd17331   306 PLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALlQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-397 3.83e-29

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 116.91  E-value: 3.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17325    14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFPW 159
Cdd:cd17325    94 QGLASAAVWpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLLP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 160 REAKPGSTEKGLPLRKTHVLLGRSHDtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDIFLVRLLMAMAVM 239
Cdd:cd17325   173 EPRPPPNKRAVSAARLRSGLRLLLRD------------------------------------RRLLALFLAIFVLAFAFG 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 240 LYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPIlrLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLS 319
Cdd:cd17325   217 ALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL--SDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLL 294

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015215017 320 STLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFIMSL 397
Cdd:cd17325   295 LALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_1 pfam07690
Major Facilitator Superfamily;
1-366 2.09e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 100.19  E-value: 2.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHV-KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARV 79
Cdd:pfam07690  14 LLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  80 PAGIFK-HTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFP 158
Cdd:pfam07690  94 LQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILAILSLLAAVLLLLPR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 159 wreakpgstekglplrkthvllgrshdtvqEAATSRRARASKKTAQPWVEVVLALRNMKNLLfsemwdiFLVRLLMAMAV 238
Cdd:pfam07690 173 ------------------------------PPPESKRPKPAEEARLSLIVAWKALLRDPVLW-------LLLALLLFGFA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 239 MLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVV 317
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1015215017 318 LSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAP 366
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-361 5.31e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 5.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:COG2814    28 IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFpw 159
Cdd:COG2814   108 QGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRL-- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 160 reakpgstekglplrkthvllgrshdtVQEAATSRRARASKKTAQPWVEVVLALrnmknllfsemwdIFLVRLLMAMAVM 239
Cdd:COG2814   185 ---------------------------LPESRPAARARLRGSLRELLRRPRLLL-------------LLLLAFLLGFGFF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 240 LYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLS 319
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLA 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1015215017 320 STLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVG 361
Cdd:COG2814   303 LFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 21-395 1.82e-19

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 89.26  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  21 GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVP 100
Cdd:cd17389    67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 101 EKERPLVIGHFNTASGVGFILGPVVGGYL----TELEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGStekglpLRkt 176
Cdd:cd17389   147 PKKRSKGMALIGVAFSLGFIIGPMIGAYFasftRSLGEVFFSMPALFALVLALADLLFIFFFLPETLPSN------LR-- 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 177 hvLLGRSHdtvqeaatsrraraskktaqpwvevVLALrnmknLLFSEMWdiFLVRLLMAmavmlyysnfvlaleERFgvr 256
Cdd:cd17389   219 --RLGLVY-------------------------FLYL-----FLFSGLE--FTLTFLTH---------------QRF--- 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 257 pkvtgyliSYSSM--------LGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVVLSSTLLSFST 327
Cdd:cd17389   247 --------QYTSMqqgkmfffIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPaFLLIGWASSVTVLYAGLFLYSFAA 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015215017 328 AIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLL-SGVAQEVSPCGPPSLGAVLALVAIFIM 395
Cdd:cd17389   319 ATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVaCTVYWLAGSEACYTIGALLFLLPLLLL 387
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-397 2.55e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 82.86  E-value: 2.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd06174    14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTLSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFPW 159
Cdd:cd06174    94 LGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 160 REAKPGSTEKGlplrkthvllgrshdtvqeaatsrrarASKKTAQPWVEVVLALRNMKnllfseMWDIFLVRLLMAMAVM 239
Cdd:cd06174   174 PDPPESARAKN---------------------------EEASSKSVLKLLKRVLKNPG------LWLLLLAIFLVNLAYY 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 240 LYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYsLAPTMGAVVLS 319
Cdd:cd06174   221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLL-LAPSLLLLLLL 299

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017 320 STLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVLALVAIFIMSL 397
Cdd:cd06174   300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-394 5.33e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 78.77  E-value: 5.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17474    17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLtAFICFLVFILNAGLVWFFpw 159
Cdd:cd17474    97 QGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI--SWRY-PFFLLAALIPVAFLAILF-- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 160 reakpgstekglplrkthvLLGRSHDTVQEAATSRRARASKKTAQPWVEVVLALRNMKNLLFsemwdiFLVrllmamavm 239
Cdd:cd17474   172 -------------------LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY------FAF--------- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 240 LYYSNFVlaLEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLS 319
Cdd:cd17474   218 LTYLPFL--LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK-RFGARRILVIGLLLYALSLLLLGFVPSLALLLIA 294

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015215017 320 STLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFI 394
Cdd:cd17474   295 IVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGlLLEIFGLSAPFLVGAAIALAAAVL 370
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-395 6.85e-15

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 75.75  E-value: 6.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVA----GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVL 76
Cdd:cd17388    17 LIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  77 ARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE--LEDGFYLTAFICFLVFIlnagLV 154
Cdd:cd17388    97 GRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEisPRAPFLVAAGLNGLNFL----LG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 155 WFFpwreakpgstekglpLRKTHvllgrshdtvqeaATSRRARASKKTAQPWVEVVlALRNMKNLLFsemwdIFLVRLLM 234
Cdd:cd17388   173 LFV---------------LPESL-------------PPERRRAFRWRRANPFGSLR-WLTGFPGLLG-----LLAVFFLI 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 235 AMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVA-GLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTm 313
Cdd:cd17388   219 QLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAK--RLGEKRAILLGLAADALGFLLLAFATQ- 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 314 GAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSL----GAVLAL 389
Cdd:cd17388   296 GWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLawiiGAALYL 375


                  ....*.
gi 1015215017 390 VAIFIM 395
Cdd:cd17388   376 ICLVLA 381
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-182 5.53e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 69.55  E-value: 5.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17489    14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFFPW 159
Cdd:cd17489    94 HGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLFIVAAVLALLALLLVFLVKD 172

                         170       180
                  ....*....|....*....|...
gi 1015215017 160 REAKPGSTEKGLPLRKTHVLLGR 182
Cdd:cd17489   173 PPPVAAEEAEAGTRAFRRLVEKK 195
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-157 1.41e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.37  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSL-GASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARV 79
Cdd:cd17325   217 ALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015215017  80 PAGIFKHTLSIS-RALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFF 157
Cdd:cd17325   297 LLGLGLGLVFPAtLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLL 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
11-400 1.94e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.97  E-value: 1.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  11 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSI 90
Cdd:COG2271    38 ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  91 SR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFILNaglvwffpwreakpgs 166
Cdd:COG2271   118 AAlKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwraAFLILGLPGLLLALLR---------------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 167 tekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLLMAMAVMLYYSNFV 246
Cdd:COG2271   182 ---------------------------------------------------------FWLLALAYFLVYFALYGFLTWLP 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 247 LALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFS 326
Cdd:COG2271   205 TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1015215017 327 TAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPP-SLGAVLALVAIFIMSLNKR 400
Cdd:COG2271   285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAfLLLAALALLAALLALLLLR 359
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-175 3.65e-12

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 67.29  E-value: 3.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTV-----AGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFV 75
Cdd:cd17391    14 LIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  76 LARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFIlnag 152
Cdd:cd17391    94 ILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGirnVFFITGGLLFLAFL---- 169

                         170       180
                  ....*....|....*....|...
gi 1015215017 153 LVWFFPWREAKPGSTEKGLPLRK 175
Cdd:cd17391   170 LTLFFVKEDFKPVEKKKMVSTKE 192
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 1-371 1.35e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 65.71  E-value: 1.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHV-KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARV 79
Cdd:cd17329    17 MVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  80 PAGIFKhTLSI--SRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLteLEDGFYLTAFICFLVFILNAGLVWFf 157
Cdd:cd17329    97 LTGFGG-GLFEpaSEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLFLAAAVLFLLAALVLLF- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 158 pwreakpgstekglplrkthvllgrshdTVQEAATSRRARASKKTAQPWVEVvlaLRNMKNLLFsemwdiFLVRLLMAMA 237
Cdd:cd17329   173 ----------------------------LLPETRPKRRAAEKTEILRGYKIV---LRDRAFLLF------LLASFLISLI 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 238 VMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLalgPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAV 316
Cdd:cd17329   216 YFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQF---PVARLVERFRLRKILMIGILLFAIgFAVLAFANTLAVL 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1015215017 317 VLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGV 371
Cdd:cd17329   293 ILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 1-158 3.87e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 61.05  E-value: 3.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17323    17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHT-LSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFILnagLVWF 156
Cdd:cd17323    97 QGFFGSSpLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGwrwIFWFLAIISGFCLIL---IFLF 173


                  ..
gi 1015215017 157 FP 158
Cdd:cd17323   174 LP 175
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-395 4.81e-10

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 60.66  E-value: 4.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  13 LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKH-TLSIS 91
Cdd:cd17473    30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAgIMTLA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  92 RALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdgfYLTAFICFLVFILNAGLVWFFPWreakpgstekgl 171
Cdd:cd17473   110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG---WRAPFLVYLLALPVLILVLLFLP------------ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 172 plrkthvllgrshDTVQEAATSRRARASKKTAQPWVEVVLALrnmknllfsemwdiflvrLLMAMAVMLYYS---NFVLA 248
Cdd:cd17473   175 -------------EPARKSKSAASPGAATAAALPWKRVLPIY------------------FLAFLAMLLFYVipiQLPFL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 249 LEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHnsQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTA 328
Cdd:cd17473   224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK--RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFG 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015215017 329 IGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG--VAQEVSPCGPPSLGAVLALVAIFIM 395
Cdd:cd17473   302 LLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGplVNLTGGLSGAFLILGVLALVLAIVL 370
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 1-158 7.24e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 60.31  E-value: 7.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSL-GASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARV 79
Cdd:cd17472    14 LVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  80 PAGIFKHTLSISrALLSDVVPEKERPLVIGH----FNTASGVGFILGPVVGGYLTeLEDGFYLTAFICFLVFILnagLVW 155
Cdd:cd17472    94 LQGSGAISSVVM-ALLADLTREENRTKAMALigasIGIAFAISMVLGPLLAAHLG-VSGLFLITAILSLVSLLI---LLF 168


                  ...
gi 1015215017 156 FFP 158
Cdd:cd17472   169 FVP 171
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-149 8.57e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.44  E-value: 8.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:COG0477    32 IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARAL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015215017  81 AGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFIL 149
Cdd:COG0477   112 QGIGAGGLMpGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGwrwIFLINAPLGLLALVL 184
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 23-131 1.57e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 59.11  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  23 VGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTL-SISRALLSDVVPE 101
Cdd:cd17502    35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPP 114

                          90       100       110
                  ....*....|....*....|....*....|
gi 1015215017 102 KERPLVIGHFNTASGVGFILGPVVGGYLTE 131
Cdd:cd17502   115 RERGKYQGYIGAVFGIASVAGPLIGGAFTD 144
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-395 1.41e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.02  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17324    17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFkHTL--SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFP 158
Cdd:cd17324    97 AGLA-HGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 159 wreakpgstekglplrkthvllgrshdtvqeaatsrRARASKKTAQPWVEVVLALRNMKNLLFsemwdIFLVRLLMAMAV 238
Cdd:cd17324   176 ------------------------------------SLPPKKPGSLGLLSSLLLLLRNPRLRL-----AYLITFLLFGGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 239 MLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVL 318
Cdd:cd17324   215 FALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD--RGGRRALLIALLLLAAALLLLTLLGPSPLLLLV 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 319 SSTLLSFSTAIGRTCitdLQLTVG--GAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSLGAVLALVAIFIM 395
Cdd:cd17324   293 GLVLWGLGFFAAHSA---LQTRVLrlAPEARGLASSLYLAAYNLGGALGAALGGLVlDHGGWAGVGWVGAALLLLALLLA 369
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 10-158 2.89e-08

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 55.71  E-value: 2.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  10 VKSLGASPTVAGIVgSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLS 89
Cdd:cd06179    25 VADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQG 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1015215017  90 ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG-----FYLTAFICFLVFILnaGLVWFFP 158
Cdd:cd06179   104 LGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgwrwiFYINAIFNALALIL--LFFFYHP 175
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 1-175 6.18e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 54.10  E-value: 6.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17477    14 LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHTLSI-SRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVfilnAGLVWFFPW 159
Cdd:cd17477    94 MGIGLAGLFVvSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL----ALVPLLLTR 169

                         170
                  ....*....|....*.
gi 1015215017 160 REAKPGSTEKGLPLRK 175
Cdd:cd17477   170 RAAPEIEEAESISLRR 185
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
1-149 8.63e-08

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 53.77  E-value: 8.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVA-----GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFV 75
Cdd:PRK09874   32 LVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1015215017  76 LARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LEDGFYLTAFICFLVFIL 149
Cdd:PRK09874  112 ILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADsygLRPVFFITASVLFLCFLV 188
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-397 9.38e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 53.72  E-value: 9.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   2 VVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPA 81
Cdd:COG2807    37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  82 GIfkhTLSISRALLSDVVPE---KERPLVIGHFNTASGVGFILGPVVGGYLTELEDgfYLTAFICFLVFILNAGLVWFFP 158
Cdd:COG2807   117 GA---GIAVGNVLLPGLIKRwfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG--WRGALAVWALLALLALLLWLPL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 159 WREAKPGSTEKGLPLRKTHVLlgrshdtvqeaatsrraraskKTAQPWvevvlalrnmknllfsemwdifLVRLLMAMAV 238
Cdd:COG2807   192 LRRRPAAAAAAPAAASLRSLW---------------------RSPLAW----------------------LLTLFFGLQS 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 239 MLYYS--NFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLhSSILTCTLLLLYSLAPTmGAV 316
Cdd:COG2807   229 LLYYAvvAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL-LGLLGLAGLLGLLLAPG-SLP 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 317 VLSSTLLSFSTAIGRT-CITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSpcGPPSLGAVLALVAIFIM 395
Cdd:COG2807   307 WLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAT--GSWTAALLLLAALAVLM 384


                  ..
gi 1015215017 396 SL 397
Cdd:COG2807   385 LV 386
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 3-395 1.18e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 53.38  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   3 VPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLL-ACILLSALGYLLLGAATNVFLFVLARVPA 81
Cdd:cd17490    16 VPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLIARFLS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  82 GIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LEDGFYLTAFICFLVFILNAGLvwffp 158
Cdd:cd17490    96 GIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEhfgMRAPFLLAALAGVLGFILSLFI----- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 159 wreaKPGSTEKglplrkthvllgrshdtvqeaatsrrarasKKTAQPWVEVVLALRNMKNLLFSEMwdiFLVRLLMAMAV 238
Cdd:cd17490   171 ----KEERREK------------------------------KPVLTELKELLSVLKDKKLLFFSLL---AILQQMITFST 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 239 MLYYSNfvLALEERFGVRPKVTgyLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVL 318
Cdd:cd17490   214 TFGFTP--LIAKQLGASSFQLG--LLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYL 289

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017 319 SSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFIM 395
Cdd:cd17490   290 LQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGiISEAFGLQTGFFVIGVIALLAAILS 367
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 3-157 2.76e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.16  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   3 VPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAG 82
Cdd:cd17370   219 FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWG 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015215017  83 IFKH-TLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdgFYLTAFIcFLVFILNAGLVWFF 157
Cdd:cd17370   299 LYMGaQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI--SPSAAFL-FSAVLALIALLLLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 10-149 6.12e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 51.02  E-value: 6.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  10 VKSLGASPTVAGIVGSSY----GILQLFSSTLvgcwSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFK 85
Cdd:cd17321    23 ARDLGASPSQLQWVVNAYllafAALLLLAGRL----GDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017  86 HTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFIL 149
Cdd:cd17321    99 AAImPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGwrwIFLINVPIGLVALLL 166
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
11-401 7.49e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  11 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSI 90
Cdd:COG0738    36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDV 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  91 S-RALLSDVVPEKERPLvIGHFNTASGVGFILGPVVGGYLTELEDGFYLTA--FICFLVFILNAGLVWFFPWREAKPGST 167
Cdd:COG0738   116 AaNPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLpyLILAVLLLLLALLFLRSKLPEIEEEEE 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 168 EKGLPLRKTHVLLGRSHdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLLMAMAVMLYYSNFVL 247
Cdd:COG0738   195 EAAGSAASLKSLLKNPR---------------------------------------LLLGGLAIFLYVGAEGAIGDWLPL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 248 ALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFST 327
Cdd:COG0738   236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGL 313

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1015215017 328 AIGRTCITDLQLTVGGAqASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGAVLALVAIFIMSLNKRH 401
Cdd:COG0738   314 SLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGfLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
11-400 1.10e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.26  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  11 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFK-HTLS 89
Cdd:COG2223    33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGgGSFA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  90 ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLteLEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEK 169
Cdd:COG2223   113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 170 glplrkthvllgrshdtvqEAATSRRARASKKTAQPWVevvlalrnmknllfsemwdIFLVRLLMAMAVMLYYSNFVLAL 249
Cdd:COG2223   191 -------------------AKASLRDQLEALRDPRFWL-------------------LSLLYFGTFGSFIGFSSWLPPYL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 250 EERFGVRPKVTGYLISYSSMLGAVAGLALGPIL-RLYKHNSQALLLhsSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTA 328
Cdd:COG2223   233 VDQFGLSAATAGLLAALFALLGALGRPLGGWLSdRIGGRRVLLIVF--ALMALGLLLLALALGSLWLFLVLFLLLGLALG 310

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015215017 329 IGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSpcGPPSLG----AVLALVAIFIMSLNKR 400
Cdd:COG2223   311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT--GSYTAAflvfAVLALVALVLTLLLYR 384
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 1-149 1.50e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.88  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17504    14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1015215017  81 AGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL---EDGFYLTAFICFLVFIL 149
Cdd:cd17504    94 QGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHlgwRWIFWTAAPVAVLLAAL 165
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-163 1.62e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  10 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSS--LLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHT 87
Cdd:COG2271   208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1015215017  88 LSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLTAFICFLVFILNAGLVWFFPWREAK 163
Cdd:COG2271   288 AFGLLwALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA--TGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 3-397 3.79e-06

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 3.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   3 VPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLAC--ILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17335    17 LPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLslLAAVLFFLSLFFVAQIFWLLLLLVIL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKH-TLSISRALLSDVVpeKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGF--YLTAFICFLVF-ILNAGLVWF 156
Cdd:cd17335    97 GAFFSApVVPLVDSITLQYL--GEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYknYTIAFYVFAVLmLLALLLALK 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 157 FPWREAKPGSTEKGLPLRKthvllgrshdtvqeaatsrraraskktaqpwvevvlALRNMKNLLFsemwdiFLVRLLMAM 236
Cdd:cd17335   175 FPFRPKHPEPNENTGGLLA------------------------------------LLRNPRVLAF------LLVAFLMGF 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 237 AVMLYYSNFVLALEERFGvrpkvTGYLISYSSMLGAVAGLAL----GPILRLYKHNsqaLLLHSSILTCTL-LLLYSLAP 311
Cdd:cd17335   213 GHGLIYSFLFWHLQDLGG-----SKTLIGLLWTVGVVSEIPFfffsSRLIQRFGHV---GLLYLGLLAYVVrWLLYSFLE 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 312 TMGAVVLSSTL--LSFSTAIGrTCITDLQLTVgGAQASGTLIGVGQSVTA-VGRIIAPLLSGVA-QEVSPCGPPSLGAVL 387
Cdd:cd17335   285 NPWLVLPIELLhgLTFALVWA-AAVSYASAAA-PPGLRATAQGLLQGLYFgLGGGLGSLIGGYLyEAFGARTTFRFFAIA 362

                         410
                  ....*....|
gi 1015215017 388 ALVAIFIMSL 397
Cdd:cd17335   363 ALAGLLAFFL 372
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 13-170 7.62e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 47.62  E-value: 7.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  13 LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLS-IS 91
Cdd:cd17328    29 FLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSpIA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  92 RALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG----FYLTAficfLVFILNAGLVWFFPwREAKPGST 167
Cdd:cd17328   109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGwrwaFRVTG----VLGVLLAILLLLFV-REPPRGAA 183


                  ...
gi 1015215017 168 EKG 170
Cdd:cd17328   184 EGG 186
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 11-131 9.75e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.19  E-value: 9.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  11 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTL-S 89
Cdd:cd17503    24 GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLiP 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1015215017  90 ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE 131
Cdd:cd17503   104 LAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTD 145
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 11-157 1.02e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 47.18  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  11 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTL-S 89
Cdd:cd17319    31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFfP 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017  90 ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILnaGLVWFF 157
Cdd:cd17319   111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL--AVLWWF 176
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-158 1.15e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 47.19  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSY----GILQLFsstlVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVL 76
Cdd:cd17320    17 MYLPALPAIARDLGASASAVQLTLSAYllgfALGQLL----YGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  77 ARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVW 155
Cdd:cd17320    93 ARFLQGLGAAAGSvVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL 172


                  ...
gi 1015215017 156 FFP 158
Cdd:cd17320   173 FLP 175
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 13-157 2.22e-05

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 46.05  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  13 LGASPTVAGIVGSSYGILQLFSSTLVGCWSD---------VVGRRSSLLACILLSALGYLLLGaatNVFLFVLARVPAGI 83
Cdd:cd17326    31 PTATASFFGWVVAAYSLGQLVFSPVFGYWSNktssvkeplIVSILIAIVGNILYALAEYFPSN---RKYVMLVARFLIGV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  84 FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL-EDGFYLT-----------AFICFLVFILNA 151
Cdd:cd17326   108 GAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIgYPGYVIGiklrfnmytapAWLMAILGIINI 187


                  ....*.
gi 1015215017 152 GLVWFF 157
Cdd:cd17326   188 ILILFF 193
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 6-397 2.48e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.07  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   6 LSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRR------SSLLACILLSALGYLLLGAATNVFLFVLARV 79
Cdd:cd06173    22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilaDLLRALLAAVLALLALLGSLSLWLLLVLAFL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  80 PAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVFILNAGLVWFFPW 159
Cdd:cd06173   102 LGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLFIRR 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 160 REAKPGSTEKGLPLRKTHVLLgrshdtvqeaatsRRARASKktaqpwvevvlalrnmknllfsEMWDIFLVRLLMAMAVM 239
Cdd:cd06173   181 PPPAAPGESSSLLLRDLREGL-------------RYLRRSP----------------------LLRLLLLALALFALLGG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 240 LYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSqaLLLHSSILTCTLLLLYSLAPTMGAVVLS 319
Cdd:cd06173   226 ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR--LLLIGALLLGLALLVLGLSPSLWLLLAA 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 320 STLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPP--SLGAVLALVAIFIMSL 397
Cdd:cd06173   304 LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVflLAGALLLLAALLLLLL 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-394 5.29e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 5.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  13 LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVV----GRR-------SSLLACILLSALGYLLLGAATNVFLFVLARVPA 81
Cdd:COG2211    41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRrpwiligAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  82 GIFKHTLSIS-RALLSDVVPE-KERPLVIGHFNTASGVGFILGPVVGGYLTEL-----EDGFYLTAFICFLVFILnAGLV 154
Cdd:COG2211   121 GLAYTLVNIPySALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaALGYRLTALIFAVLGLL-AFLL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 155 WFFPWREAKPGSTEKglplrkthvllgrshdtvqeaatsrraraskktaQPWVEVVLALRNMKNLLFsemwdIFLVRLLM 234
Cdd:COG2211   200 TFFGTKERPVPEEEK----------------------------------VSLKESLKALLKNRPFLL-----LLLAYLLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 235 AMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLY-KHNsqALLLHSSILTCTLLLLYSLAPT- 312
Cdd:COG2211   241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKK--AFIIGLLLAALGLLLLFFLGPGn 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 313 ----MGAVVLSSTLLSFSTAIGRTCITDL---QLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVS---PCGPPS 382
Cdd:COG2211   319 lwllLVLAALAGIGLGAILVLPWAMLADVvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvAGAAQS 398

                         410
                  ....*....|..
gi 1015215017 383 LGAVLALVAIFI 394
Cdd:COG2211   399 PSALTGIRLLFF 410
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-167 5.54e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.87  E-value: 5.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  13 LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLAC-ILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSIS 91
Cdd:COG2223   236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVfALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017  92 R-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFLVF-ILNAGLVWFFPWREAKPGST 167
Cdd:COG2223   316 VfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA-TGSYTAAFLVFAVLaLVALVLTLLLYRRPRRAAAA 392
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 1-156 1.52e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 43.40  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLhVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17476    17 VIVILPII-GDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGI-FKHTLSISRALLSDVVPE-KERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVFIlnAGLVW 155
Cdd:cd17476    96 QGLgPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWwpwIFWFLAILAAIVAV--AAIFW 173


                  .
gi 1015215017 156 F 156
Cdd:cd17476   174 T 174
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 1-178 1.60e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 43.69  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLH-VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDV-VGRRSSLLACILLSALGYLLLGAATNVFLFVLAR 78
Cdd:cd17471    14 FVLPYLSLFlTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  79 VP-----AGIFKHTLSISRALLsDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED--GFYLTAFICFLVFILna 151
Cdd:cd17471    94 VVllslgAAAFPQLFALAREYA-DRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGftGLFLLAALLYLVVAL-- 170

                         170       180
                  ....*....|....*....|....*...
gi 1015215017 152 gLVWFF-PWREAKPGSTEKGLPLRKTHV 178
Cdd:cd17471   171 -LVLFLlPSVKPPAQKATPASSLVKAPV 197
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-157 1.70e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.35  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASptVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17489   212 AISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVL 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017  81 AGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLTAFICFLVFILNAGLVWFF 157
Cdd:cd17489   290 YGLgFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL--FGYRAMFLLAAVVVLLALVLYIF 365
Sugar_tr pfam00083
Sugar (and other) transporter;
6-158 1.77e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 43.41  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   6 LSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAAT---NVFLFVLARVPAG 82
Cdd:pfam00083  34 LSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVG 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  83 IFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVgGYLTEL---EDGFYLTAFICFLVFILNAGLVWFFP 158
Cdd:pfam00083 114 IGVGGASvLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF-GLGLNKtsnSDGWRIPLGLQLVPALLLIIGLLFLP 192
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 10-156 2.49e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 42.75  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  10 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHT-L 88
Cdd:TIGR00881  22 VEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMgW 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1015215017  89 SISRALLSDVVPEKERPLVIGHFNTASGVGFILGP-VVGGYLTELEDG---FYLTAFICFLVfilnaGLVWF 156
Cdd:TIGR00881 102 PPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWhwvFIVPGIIAIIV-----SLICF 168
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-157 3.42e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.64  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGAS----PTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVL 76
Cdd:cd17391   219 SIEPILTLYIRQLMGDasnlAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGI 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  77 ARVPAGIFKHTLSIS-RALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LEDGFYLTAficfLVFILNAG 152
Cdd:cd17391   299 LRFLLGLATGGLLPAiNSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAhfgYRAVFVVTA----LLVLLNAI 374


                  ....*
gi 1015215017 153 LVWFF 157
Cdd:cd17391   375 WSFIF 379
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 5-395 3.86e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 42.23  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   5 LLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVV----GRR------SSLLACI------------LLSALGY 62
Cdd:cd17313    21 YVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCnsriGRRrpfilvGAPLAALglilipnaadigLALGDGP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  63 LLLGAATNVFLFVLARVPAGIFkhtLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYL-----------TE 131
Cdd:cd17313   101 RTWALVLFVLGIVLLDFAMNVC---QGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwfgfalgGN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 132 LEDGFYLTAFIcFLVFILnaGLVWFFPWREAKPGSTEKGLPlrkthvllgrshdtvqeaatsrraraskktaQPWVEVVL 211
Cdd:cd17313   178 LKVPFYIGAII-LLVCVL--VTLFFVKEPPLSPEAGEHSEN-------------------------------PSLGEVLK 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 212 ALRNMKNLLFSEMWDIFLVRLL--MA-MAVMLYYSNFVlALEERFGVRPKVTGYLISYS---------SMLGAVAGLALG 279
Cdd:cd17313   224 SLLKLLKIMPRSLLRLLLVIFFwwIAfFPFELFFTDYM-GEEVYHGTSAASSHYGAGVRmgawgllifSLAFLIFSLPIG 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 280 PILRLYKHnsQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIgrTCITDLQLTV----GGAQASGTLIGVGQ 355
Cdd:cd17313   303 KLGKKIGR--KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWAT--ININPYPLVSdyhsESGRGQGTDTGLLN 378

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1015215017 356 SVTAVGRIIAPLLSGVAQEVSPCGPP-SLGAVLALVAIFIM 395
Cdd:cd17313   379 LAISLAQILVSLLAGPIIDVKGYGTVfPVAAVASFLSLVGA 419
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 10-157 3.99e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.17  E-value: 3.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  10 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSD---VVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKH 86
Cdd:cd17319   207 KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIG 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1015215017  87 TLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLtAFICFLVFILNAGLVWFF 157
Cdd:cd17319   287 AASpVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA-AFLFLAAVALLAALLVLL 357
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 5-149 4.73e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.16  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   5 LLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLAC--ILLSALGYLLLGAATNVFLFVLARVpAG 82
Cdd:cd17477   210 LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCalLGALAALLLPLVPGLPLALLVLLFL-WG 288

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  83 IFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL--EDGFYLTAFICFLVFIL 149
Cdd:cd17477   289 GAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAfgPHGLFLFLAAVALLFLL 358
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-169 6.18e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.77  E-value: 6.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd17478    14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGI---FKHTLSISRALLsdvVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedgFYLTAFICFLVFILNAGLVWFF 157
Cdd:cd17478    94 AGIgsaAFHPEGARLASQ---AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAL---FGGLGLLILLIIPGLAVALLLL 167

                         170
                  ....*....|..
gi 1015215017 158 PWREAKPGSTEK 169
Cdd:cd17478   168 RLRPLKKPEAKK 179
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 12-149 7.04e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 7.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  12 SLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIF-KHTLSI 90
Cdd:cd17316    30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGiGGEYPG 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015215017  91 SRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG-------FYLTAFICFLVFIL 149
Cdd:cd17316   110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrilFLIGALPALLALLL 175
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 13-132 7.19e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 41.60  E-value: 7.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  13 LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLS-IS 91
Cdd:TIGR00711  32 LGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIpLS 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1015215017  92 RALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL 132
Cdd:TIGR00711 112 FSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEN 152
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 28-149 1.37e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 40.72  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  28 GILQLFSSTLVGCWSDVVGRRSSLLACI------LLSALGYLLLGAATNVFLFVLARVPAGIFKH---TLSISRALLSDV 98
Cdd:cd17386    40 SIPPLFSSLFLGSWSDRYGRKPPLLMSLvglllsSLILVLIVYFTTVPSVWWFYLSAIPLALFGGftaFLSASFAYISDI 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1015215017  99 VPEKERPLVIGHFNTASGVGFILGPVVGGYLTElEDGFYLTAFI--CFLVFIL 149
Cdd:cd17386   120 SSEKKRTYRMAILEVALGLGGFLGSLLSGHLFK-ALGYAWSFSIsaALLLIAL 171
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 11-130 2.05e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 40.03  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  11 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGI-FKHTLS 89
Cdd:TIGR00895  45 AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMP 124

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1015215017  90 ISRALLSDVVPEKERPLVIGHFntasGVGFILGPVVGGYLT 130
Cdd:TIGR00895 125 NLNALVSEYAPKRFRGTAVGLM----FCGYPIGAAVGGFLA 161
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 32-162 2.29e-03

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 40.18  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  32 LFSSTLVGCWSDVVGRRSSL-LACI---LLSALGYLLLGAATNVFLFVLARVPAGI---FKHTLSISRALLSDVVPEKER 104
Cdd:cd17449    79 LFSVTLLGPWSDSVGRRPVLiLPSLglaLQAAVYLLVMYLQLHVAYFLIGRILSGLlgdFNGILAGCFAYVADVSDRRSR 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1015215017 105 PLVIGHFNTASGVGFILGPVVGGYLTELEDgfYLTAFICFLVFILNAGLVWFFPWREA 162
Cdd:cd17449   159 TFRVAVLEACLGLAGMLASIIGGQWRKAQG--YINPFWLVLALNLAAALYAAFCVGES 214
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 21-294 3.81e-03

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 39.32  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  21 GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLgAATNVFLFVLARVpAGIFKHTLSISRALLSDVVP 100
Cdd:cd17387    39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-RISPWWYFAMISV-SGIFSVTFSVIFAYVADITT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 101 EKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFfpwreAKPGStekgLPLRkthvll 180
Cdd:cd17387   117 EEERSTAYGLVSATFAASLVTSPALGAYLSESY-GDNLVVLVATIVALLDICFILL-----AVPES----LPEK------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 181 grshdtvqEAATSRRARASKKTAQPWvEVVLALRNMKNLLFsemwdIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVT 260
Cdd:cd17387   181 --------MRPASWGAPISWEQADPF-ASLRKVGKDKTVLL-----ICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEV 246

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1015215017 261 GYLISYSSMLGAVAGLALGPILRLYKHNSQALLL 294
Cdd:cd17387   247 AAFIAVVGILSITAQTLLLSILMRSIGAKNTILL 280
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 6-158 4.79e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 38.82  E-value: 4.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   6 LSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGI-F 84
Cdd:cd06180   219 LPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGtF 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1015215017  85 KHTLSISRALLSDVVPEKeRPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFP 158
Cdd:cd06180   299 MAITALVMALARELAPPA-APRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 1-164 6.18e-03

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 38.52  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:TIGR00710  23 MYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  81 AGIFKHT-LSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFIcFLVFILNAGLVWFFpW 159
Cdd:TIGR00710 103 QAFGASAgSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL-SLAGILLSALIFFI-L 180


                  ....*
gi 1015215017 160 REAKP 164
Cdd:TIGR00710 181 PETLP 185
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 1-395 7.14e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.29  E-value: 7.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRR-------SSLLACILLSALGYLLLGAAtnVFL 73
Cdd:cd17370    17 MARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkplvilgYGLSALAKPLLALAGSWQLV--LLL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017  74 FVLARVPAGIFKhtlSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGL 153
Cdd:cd17370    95 RILERLGKGIRT---PPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 154 VWFFPWREAKPGSTEKGLPLRKTHVLLGRShdtvqeaatsrraraskktaqpwvevvlalrnmknllfseMWDIFLVRLL 233
Cdd:cd17370   172 ILLFVVKEYPRPPKLRKKSKKTSLKKLPKA----------------------------------------FWLYLLAVAL 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 234 MAMAvmlYYSNFVLALE-ERFGVRPKVTGYLISYSSMLGAVAGLALGpilRLYKHNSQALLLHSSILTCTL-LLLYSLAP 311
Cdd:cd17370   212 FALG---NFSFAFLILRaQELGLSAALIPLLYALFNLVYALAAYPAG---RLSDRIGRKKLLILGYLSLALaYLGFALGS 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017 312 TMGAVVLSSTL----LSFSTAIGRTCITDLqltvGGAQASGTLIGVGQSVTAVGRIIAPLLSGV-AQEVSPCGPPSLGAV 386
Cdd:cd17370   286 SLWLLLLGFILwglyMGAQESIERAAVADL----VPAELRGTAYGLFNTVVGIGWLLASLIAGYlWDLISPSAAFLFSAV 361


                  ....*....
gi 1015215017 387 LALVAIFIM 395
Cdd:cd17370   362 LALIALLLL 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-149 7.22e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.37  E-value: 7.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015215017   1 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 80
Cdd:cd06173   227 LTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFL 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015215017  81 AGIFKHTLSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG---FYLTAFICFLVFIL 149
Cdd:cd06173   307 LGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLsavFLLAGALLLLAALL 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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