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Conserved domains on  [gi|1015576882|ref|NP_001309052|]
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tRNA pseudouridine synthase Pus10 isoform 1 [Homo sapiens]

Protein Classification

Pus10 superfamily protein( domain architecture ID 1904588)

Pus10 superfamily protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pus10 super family cl43369
tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis] ...
288-525 2.07e-72

tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]; tRNA U54 and U55 pseudouridine synthase Pus10 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG1258:

Pssm-ID: 440870 [Multi-domain]  Cd Length: 411  Bit Score: 236.29  E-value: 2.07e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWI------------IDGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRP 355
Cdd:COG1258   164 LFIYGRYRKLERGIPQTEWPcrecrgsgcercGGTGKQYPESVEELIGPPVIEAFDGEDAVFHGAGREDIDARMLGTGRP 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 356 FAIELVNPHRVHFtsqEIKELQQKINNSSN-KIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDI-EFLN 433
Cdd:COG1258   244 FVIEVKEPRRRDV---DLDELEAEINEFADgKVEVEGLRFATREMVERVKE--SKASKTYRALVEFEGPVSEEKLkEALE 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 434 DIKDLKIDQKTPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILE 513
Cdd:COG1258   319 ELEGATIEQRTPTRVLHRRADLVRERTVYEIKLELLDDRHAELEIHGEGGLYVKELVSGDEGRTEPSLAGLLGVQAEVTE 398
                         250
                  ....*....|..
gi 1015576882 514 LDVESVDVDWPP 525
Cdd:COG1258   399 LDVLGVEGEDEP 410
 
Name Accession Description Interval E-value
Pus10 COG1258
tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis] ...
288-525 2.07e-72

tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]; tRNA U54 and U55 pseudouridine synthase Pus10 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440870 [Multi-domain]  Cd Length: 411  Bit Score: 236.29  E-value: 2.07e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWI------------IDGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRP 355
Cdd:COG1258   164 LFIYGRYRKLERGIPQTEWPcrecrgsgcercGGTGKQYPESVEELIGPPVIEAFDGEDAVFHGAGREDIDARMLGTGRP 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 356 FAIELVNPHRVHFtsqEIKELQQKINNSSN-KIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDI-EFLN 433
Cdd:COG1258   244 FVIEVKEPRRRDV---DLDELEAEINEFADgKVEVEGLRFATREMVERVKE--SKASKTYRALVEFEGPVSEEKLkEALE 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 434 DIKDLKIDQKTPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILE 513
Cdd:COG1258   319 ELEGATIEQRTPTRVLHRRADLVRERTVYEIKLELLDDRHAELEIHGEGGLYVKELVSGDEGRTEPSLAGLLGVQAEVTE 398
                         250
                  ....*....|..
gi 1015576882 514 LDVESVDVDWPP 525
Cdd:COG1258   399 LDVLGVEGEDEP 410
PRK14554 PRK14554
tRNA pseudouridine(54/55) synthase Pus10;
288-523 3.06e-68

tRNA pseudouridine(54/55) synthase Pus10;


Pssm-ID: 237754 [Multi-domain]  Cd Length: 422  Bit Score: 225.59  E-value: 3.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWII-DGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRV 366
Cdd:PRK14554  191 LFIYGRYRKLVRGIPQTRWPCrKCKKQYPESVEELIAKPVIEAFGGEDAVFHGAGREDVDARMLGTGRPFVIEVKEPRKR 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 367 HFtsqEIKELQQKINnSSNKIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDIEFLND-IKDLKIDQKTP 445
Cdd:PRK14554  271 KV---DLEALEEEIN-ADGKVEVENLRFATRKEVERIKE--EKASKTYRALVESDEPVSEEELEKLLDeLSGATIEQRTP 344
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015576882 446 LRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDVESVDVDW 523
Cdd:PRK14554  345 RRVKHRRADLVRVRKVYDISGELIDDKHFELRIKCEGGLYIKELISGDEGRTTPSLSELLGTPAIVTELDVLDVEGED 422
pseudo_Pus10arc TIGR01213
tRNA pseudouridine(54/55) synthase; Members of this family show twilight-zone similarity to ...
288-516 2.49e-58

tRNA pseudouridine(54/55) synthase; Members of this family show twilight-zone similarity to several predicted RNA pseudouridine synthases. All trusted members of this family are archaeal. Several eukaryotic homologs lack N-terminal homology including two CXXC motifs. [Hypothetical proteins, Conserved]


Pssm-ID: 273504 [Multi-domain]  Cd Length: 388  Bit Score: 198.44  E-value: 2.49e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWIIdgERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVH 367
Cdd:TIGR01213 159 LFIYGRYRKLVRGIPQTRWPC--RKNYPESVEELIASPFLKATGGTDAYFHGAGREDVDVRMLGTGRPFVLEVKEPRYRK 236
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 368 FtsqEIKELQQKINNS-SNKIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDIEFLndIKDLK---IDQK 443
Cdd:TIGR01213 237 I---DLDPLEEEINTSgKGKVEVEGLKFATREEVEEVKE--EKHRKVYRALVEVDGPVSDEDLEEL--CKELEgatIYQR 309
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015576882 444 TPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDV 516
Cdd:TIGR01213 310 TPLRVLHRRADLVRERRVYQVDLSGLDGNHAELIIEAEGGLYIKELVSGDGGRTRPSVSEVLGVEAVCKELDV 382
 
Name Accession Description Interval E-value
Pus10 COG1258
tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis] ...
288-525 2.07e-72

tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]; tRNA U54 and U55 pseudouridine synthase Pus10 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440870 [Multi-domain]  Cd Length: 411  Bit Score: 236.29  E-value: 2.07e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWI------------IDGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRP 355
Cdd:COG1258   164 LFIYGRYRKLERGIPQTEWPcrecrgsgcercGGTGKQYPESVEELIGPPVIEAFDGEDAVFHGAGREDIDARMLGTGRP 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 356 FAIELVNPHRVHFtsqEIKELQQKINNSSN-KIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDI-EFLN 433
Cdd:COG1258   244 FVIEVKEPRRRDV---DLDELEAEINEFADgKVEVEGLRFATREMVERVKE--SKASKTYRALVEFEGPVSEEKLkEALE 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 434 DIKDLKIDQKTPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILE 513
Cdd:COG1258   319 ELEGATIEQRTPTRVLHRRADLVRERTVYEIKLELLDDRHAELEIHGEGGLYVKELVSGDEGRTEPSLAGLLGVQAEVTE 398
                         250
                  ....*....|..
gi 1015576882 514 LDVESVDVDWPP 525
Cdd:COG1258   399 LDVLGVEGEDEP 410
PRK14554 PRK14554
tRNA pseudouridine(54/55) synthase Pus10;
288-523 3.06e-68

tRNA pseudouridine(54/55) synthase Pus10;


Pssm-ID: 237754 [Multi-domain]  Cd Length: 422  Bit Score: 225.59  E-value: 3.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWII-DGERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRV 366
Cdd:PRK14554  191 LFIYGRYRKLVRGIPQTRWPCrKCKKQYPESVEELIAKPVIEAFGGEDAVFHGAGREDVDARMLGTGRPFVIEVKEPRKR 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 367 HFtsqEIKELQQKINnSSNKIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDIEFLND-IKDLKIDQKTP 445
Cdd:PRK14554  271 KV---DLEALEEEIN-ADGKVEVENLRFATRKEVERIKE--EKASKTYRALVESDEPVSEEELEKLLDeLSGATIEQRTP 344
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1015576882 446 LRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDVESVDVDW 523
Cdd:PRK14554  345 RRVKHRRADLVRVRKVYDISGELIDDKHFELRIKCEGGLYIKELISGDEGRTTPSLSELLGTPAIVTELDVLDVEGED 422
pseudo_Pus10arc TIGR01213
tRNA pseudouridine(54/55) synthase; Members of this family show twilight-zone similarity to ...
288-516 2.49e-58

tRNA pseudouridine(54/55) synthase; Members of this family show twilight-zone similarity to several predicted RNA pseudouridine synthases. All trusted members of this family are archaeal. Several eukaryotic homologs lack N-terminal homology including two CXXC motifs. [Hypothetical proteins, Conserved]


Pssm-ID: 273504 [Multi-domain]  Cd Length: 388  Bit Score: 198.44  E-value: 2.49e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 288 VFVAGRYNKYSRNLPQTPWIIdgERKLESSVEELISDHLLAVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVH 367
Cdd:TIGR01213 159 LFIYGRYRKLVRGIPQTRWPC--RKNYPESVEELIASPFLKATGGTDAYFHGAGREDVDVRMLGTGRPFVLEVKEPRYRK 236
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015576882 368 FtsqEIKELQQKINNS-SNKIQVRDLQLVTREAIGHMKEgeEEKTKTYSALIWTNKAIQKKDIEFLndIKDLK---IDQK 443
Cdd:TIGR01213 237 I---DLDPLEEEINTSgKGKVEVEGLKFATREEVEEVKE--EKHRKVYRALVEVDGPVSDEDLEEL--CKELEgatIYQR 309
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015576882 444 TPLRVLHRRPLAVRARVIHFMETQYVDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTADILELDV 516
Cdd:TIGR01213 310 TPLRVLHRRADLVRERRVYQVDLSGLDGNHAELIIEAEGGLYIKELVSGDGGRTRPSVSEVLGVEAVCKELDV 382
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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