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Conserved domains on  [gi|1017029417|ref|NP_001309399|]
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IQ domain-containing protein H isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
oat super family cl36740
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 57-119 7.78e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


The actual alignment was detected with superfamily member TIGR00805:

Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 39.71  E-value: 7.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029417  57 FFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWDYDFL----------IYDGVIDNTAPDFLAFKEHFS 119
Cdd:TIGR00805 278 FFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPkfikrllcnkIYMLVILAQVIDVLAFNGYIT 350
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 57-119 7.78e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 39.71  E-value: 7.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029417  57 FFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWDYDFL----------IYDGVIDNTAPDFLAFKEHFS 119
Cdd:TIGR00805 278 FFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPkfikrllcnkIYMLVILAQVIDVLAFNGYIT 350
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 57-119 7.78e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 39.71  E-value: 7.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1017029417  57 FFPKKQRSKGKSRRSRGHHDRKAMKVKTPLRALKSLWDYDFL----------IYDGVIDNTAPDFLAFKEHFS 119
Cdd:TIGR00805 278 FFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPkfikrllcnkIYMLVILAQVIDVLAFNGYIT 350
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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