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Conserved domains on  [gi|1018191652|ref|NP_001309800|]
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DNA-binding protein SATB1 isoform 2 [Homo sapiens]

Protein Classification

CUT homeobox family transcription factor; homeobox domain-containing protein( domain architecture ID 11243836)

CUT homeobox family transcription factor regulates gene networks by controlling the expression of other transcription factors and plays an important role in cell differentiation and metabolism; homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 72-170 8.01e-55

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


:

Pssm-ID: 465165  Cd Length: 105  Bit Score: 184.08  E-value: 8.01e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191652  72 TMLPVFCVVEHYENAIEYDCKE------EHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYV 145
Cdd:pfam16534   1 KSLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESI 80

                          90       100
                  ....*....|....*....|....*
gi 1018191652 146 TDAPDATVADMLQDVYHVVTLKIQL 170
Cdd:pfam16534  81 TDDPDATVGDMLGDLTTVATLRIQL 105
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 176-247 2.30e-39

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


:

Pssm-ID: 435427  Cd Length: 72  Bit Score: 139.68  E-value: 2.30e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1018191652 176 LEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTK 247
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 497-567 3.84e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 82.26  E-value: 3.84e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652 497 SIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRwkeDPSPenrtlWENLSM-------IRRFLSLPQPERDAIY 567
Cdd:pfam02376   9 DIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPEDERMEIL 78
CUT super family cl08348
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 372-444 1.20e-18

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


The actual alignment was detected with superfamily member pfam02376:

Pssm-ID: 460543  Cd Length: 78  Bit Score: 80.71  E-value: 1.20e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1018191652 372 SSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKeedPKTASQSLLV--NLRAMQNFLQLPEAERDRIY 444
Cdd:pfam02376   7 TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEIL 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 676-733 3.87e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.02  E-value: 3.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652  676 KTRPRTKISVEALGILQSFIQDvGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLK 733
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 72-170 8.01e-55

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 184.08  E-value: 8.01e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191652  72 TMLPVFCVVEHYENAIEYDCKE------EHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYV 145
Cdd:pfam16534   1 KSLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESI 80

                          90       100
                  ....*....|....*....|....*
gi 1018191652 146 TDAPDATVADMLQDVYHVVTLKIQL 170
Cdd:pfam16534  81 TDDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 74-169 2.63e-50

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 171.36  E-value: 2.63e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191652  74 LPVFCVVEHYENAIE----YDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAP 149
Cdd:cd11585     1 LPVHCVVETVDSLHEsvwrRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPFDQITDNP 80

                          90       100
                  ....*....|....*....|
gi 1018191652 150 DATVADMLQDVYHVVTLKIQ 169
Cdd:cd11585    81 DATVGDMLGELTHVATLRIQ 100
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 176-247 2.30e-39

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


Pssm-ID: 435427  Cd Length: 72  Bit Score: 139.68  E-value: 2.30e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1018191652 176 LEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTK 247
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 497-567 3.84e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 82.26  E-value: 3.84e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652 497 SIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRwkeDPSPenrtlWENLSM-------IRRFLSLPQPERDAIY 567
Cdd:pfam02376   9 DIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPEDERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 372-444 1.20e-18

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 80.71  E-value: 1.20e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1018191652 372 SSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKeedPKTASQSLLV--NLRAMQNFLQLPEAERDRIY 444
Cdd:pfam02376   7 TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEIL 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 676-733 3.87e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.02  E-value: 3.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652  676 KTRPRTKISVEALGILQSFIQDvGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLK 733
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 678-735 6.54e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 6.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652 678 RPRTKISVEALGILQSFIQDVGlYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHH 735
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNP-YPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
678-729 1.91e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.87  E-value: 1.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1018191652 678 RPRTKISVEALGILQS-FIQDVglYPDEEAIQTLSAQLDLPKYTIIKFFQNQR 729
Cdd:pfam00046   2 RKRTTFTPEQLEELEKeFQENP--YPSAEEREELAAQLGLTERQVKVWFQNRR 52
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 72-170 8.01e-55

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 184.08  E-value: 8.01e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191652  72 TMLPVFCVVEHYENAIEYDCKE------EHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYV 145
Cdd:pfam16534   1 KSLPVHCVVEQVESLQESNECDertpnvEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPLSLESI 80

                          90       100
                  ....*....|....*....|....*
gi 1018191652 146 TDAPDATVADMLQDVYHVVTLKIQL 170
Cdd:pfam16534  81 TDDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 74-169 2.63e-50

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 171.36  E-value: 2.63e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191652  74 LPVFCVVEHYENAIE----YDCKEEHAEFVLVRKDMLFNQLIEMALLSLGYSHSSAAQAKGLIQVGKWNPVPLSYVTDAP 149
Cdd:cd11585     1 LPVHCVVETVDSLHEsvwrRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPFDQITDNP 80

                          90       100
                  ....*....|....*....|
gi 1018191652 150 DATVADMLQDVYHVVTLKIQ 169
Cdd:cd11585    81 DATVGDMLGELTHVATLRIQ 100
CUTL pfam16557
CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, ...
 176-247 2.30e-39

CUT1-like DNA-binding domain of SATB; CUTL is part of the N-terminal region of SATB proteins, special AT-rich sequence-binding proteins that are global chromatin organizers and gene expression regulators essential for T-cell development and breast cancer tumour growth and metastasis. CUTL carries a DNA-binding region just as CUT domains do.


Pssm-ID: 435427  Cd Length: 72  Bit Score: 139.68  E-value: 2.30e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1018191652 176 LEDLPPEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWYKHFKKTK 247
Cdd:pfam16557   1 PELLPPDKWTDQTVRCAVKELLKEMLQSTLAKLCPLTQSMISSIVNSTYYANVSADKCQEFGRWYKQYKKIK 72
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 497-567 3.84e-19

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 82.26  E-value: 3.84e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652 497 SIYDEIQQEMKRAKVSQALFAKVAATKSQGWLCELLRwkeDPSPenrtlWENLSM-------IRRFLSLPQPERDAIY 567
Cdd:pfam02376   9 DIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLR---KPKP-----WEKLKSggrtfirMYNWLSLPEDERMEIL 78
CUT pfam02376
CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in ...
 372-444 1.20e-18

CUT domain; The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein.


Pssm-ID: 460543  Cd Length: 78  Bit Score: 80.71  E-value: 1.20e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1018191652 372 SSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKeedPKTASQSLLV--NLRAMQNFLQLPEAERDRIY 444
Cdd:pfam02376   7 TKDIADRIKEELKRHKISQAVFAEKVLNRSQGTLSDLLRK---PKPWEKLKSGgrTFIRMYNWLSLPEDERMEIL 78
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 676-733 3.87e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.02  E-value: 3.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652  676 KTRPRTKISVEALGILQSFIQDvGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLK 733
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 678-735 6.54e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 6.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1018191652 678 RPRTKISVEALGILQSFIQDVGlYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHH 735
Cdd:cd00086     2 RKRTRFTPEQLEELEKEFEKNP-YPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
678-729 1.91e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.87  E-value: 1.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1018191652 678 RPRTKISVEALGILQS-FIQDVglYPDEEAIQTLSAQLDLPKYTIIKFFQNQR 729
Cdd:pfam00046   2 RKRTTFTPEQLEELEKeFQENP--YPSAEEREELAAQLGLTERQVKVWFQNRR 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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