NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1018191667|ref|NP_001309809|]
View 

zeta-sarcoglycan isoform 3 [Homo sapiens]

Protein Classification

sarcoglycan( domain architecture ID 10521547)

sarcoglycan beta/delta/gamma/zeta is a component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Sarcoglycan_1 pfam04790
Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a ...
38-258 7.08e-93

Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.


:

Pssm-ID: 461428  Cd Length: 255  Bit Score: 274.50  E-value: 7.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667  38 PVGIYGWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLPLYVKEIHSRKDSPLV 117
Cdd:pfam04790   1 KTGIYGWRKRCLYLLVLLLLILAVVNLALTIWILKVLRFSSNGMGSLEITPDGVRFEGESEFLDPLYAKEIHSFKDSPLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667 118 LQSDRNVTVNARNHMGQLTGQLTIGTEGAVFG-------------------------------------HSVETPHIRAE 160
Cdd:pfam04790  81 ITSDRNVVLNARNENGSVTSQLVVGPDGAVEAsvnrfevkdpdggktlfsadrpevtvgadkgkklrvtGSVETPRIRSP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667 161 PSQDLRLESPTRSLIMEAPRGVQVSAAAGDFKATCRKELHLQSTEGEIFLNAETIKLGNL-PTGSFSSSSPSSsssrQTV 239
Cdd:pfam04790 161 PDEDLRLESPTRSLSLRAPEGVHIEARAGNISATSLKDIKLRSTNGSIVLDASGIFLPNLrPVSSSSGSSQTV----STQ 236
                         250
                  ....*....|....*....
gi 1018191667 240 YELCVCPNGKLYLSPAGVG 258
Cdd:pfam04790 237 YKLCVCPNGKLFLVPANAG 255
 
Name Accession Description Interval E-value
Sarcoglycan_1 pfam04790
Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a ...
38-258 7.08e-93

Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.


Pssm-ID: 461428  Cd Length: 255  Bit Score: 274.50  E-value: 7.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667  38 PVGIYGWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLPLYVKEIHSRKDSPLV 117
Cdd:pfam04790   1 KTGIYGWRKRCLYLLVLLLLILAVVNLALTIWILKVLRFSSNGMGSLEITPDGVRFEGESEFLDPLYAKEIHSFKDSPLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667 118 LQSDRNVTVNARNHMGQLTGQLTIGTEGAVFG-------------------------------------HSVETPHIRAE 160
Cdd:pfam04790  81 ITSDRNVVLNARNENGSVTSQLVVGPDGAVEAsvnrfevkdpdggktlfsadrpevtvgadkgkklrvtGSVETPRIRSP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667 161 PSQDLRLESPTRSLIMEAPRGVQVSAAAGDFKATCRKELHLQSTEGEIFLNAETIKLGNL-PTGSFSSSSPSSsssrQTV 239
Cdd:pfam04790 161 PDEDLRLESPTRSLSLRAPEGVHIEARAGNISATSLKDIKLRSTNGSIVLDASGIFLPNLrPVSSSSGSSQTV----STQ 236
                         250
                  ....*....|....*....
gi 1018191667 240 YELCVCPNGKLYLSPAGVG 258
Cdd:pfam04790 237 YKLCVCPNGKLFLVPANAG 255
 
Name Accession Description Interval E-value
Sarcoglycan_1 pfam04790
Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a ...
38-258 7.08e-93

Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.


Pssm-ID: 461428  Cd Length: 255  Bit Score: 274.50  E-value: 7.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667  38 PVGIYGWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLPLYVKEIHSRKDSPLV 117
Cdd:pfam04790   1 KTGIYGWRKRCLYLLVLLLLILAVVNLALTIWILKVLRFSSNGMGSLEITPDGVRFEGESEFLDPLYAKEIHSFKDSPLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667 118 LQSDRNVTVNARNHMGQLTGQLTIGTEGAVFG-------------------------------------HSVETPHIRAE 160
Cdd:pfam04790  81 ITSDRNVVLNARNENGSVTSQLVVGPDGAVEAsvnrfevkdpdggktlfsadrpevtvgadkgkklrvtGSVETPRIRSP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1018191667 161 PSQDLRLESPTRSLIMEAPRGVQVSAAAGDFKATCRKELHLQSTEGEIFLNAETIKLGNL-PTGSFSSSSPSSsssrQTV 239
Cdd:pfam04790 161 PDEDLRLESPTRSLSLRAPEGVHIEARAGNISATSLKDIKLRSTNGSIVLDASGIFLPNLrPVSSSSGSSQTV----STQ 236
                         250
                  ....*....|....*....
gi 1018191667 240 YELCVCPNGKLYLSPAGVG 258
Cdd:pfam04790 237 YKLCVCPNGKLFLVPANAG 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH