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Conserved domains on  [gi|1021312108|ref|NP_001310498|]
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centriolar coiled-coil protein of 110 kDa isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CaM_bind pfam16025
Calcium-dependent calmodulin binding; This domain is found at the N-terminus of centriolar ...
 29-106 8.51e-23

Calcium-dependent calmodulin binding; This domain is found at the N-terminus of centriolar coiled-coil protein of 110 kDa (CCP110), where it binds calmodulin. Binding of calmodulin to this domain is calcium dependent.


:

Pssm-ID: 464981  Cd Length: 78  Bit Score: 93.17  E-value: 8.51e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1021312108   29 QSESISLIRFHGVAILSPLLNIEKRKEMQQEKQKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQWEME 106
Cdd:pfam16025    1 ESEFVSCIKINGVPILPPLMTDEKREEMQQYRQKAIAIEERLRKQRKAALLIRVQEILKNEQRRKLPTLEQTSTLDAE 78
Stathmin super family cl02980
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 638-704 8.27e-04

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


The actual alignment was detected with superfamily member pfam00836:

Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 40.79  E-value: 8.27e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  638 SKESEELLKSKMLAFEEMRKRLEeqhAQQLSLLIAEQEREQERLQKEIEEQE---KMLKEKKAMTAEASE 704
Cdd:pfam00836   40 KDSSLEEIQKKLEAAEERRKSLE---AQKLKQLAEKREKEEEALQKADEENNnfsKMAEEKLKQKMEAYK 106
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 639-808 3.82e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  639 KESEELLKSKMLAFEEMRKRLEEQhAQQLSLLIAEQEREQERLQKEIEEQEKMLKE-KKAMTAEASELDinnavELEWRK 717
Cdd:COG4942    149 REQAEELRADLAELAALRAELEAE-RAELEALLAELEEERAALEALKAERQKLLARlEKELAELAAELA-----ELQQEA 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  718 ISDSSLLETmLSQADSLHTSNSNSSGFTNSAMQYSFvsaneaPfylwgssTSGltklSVTRPFGRAKTRWSQVFSLEIQA 797
Cdd:COG4942    223 EELEALIAR-LEAEAAAAAERTPAAGFAALKGKLPW------P-------VSG----RVVRRFGERDGGGGRNKGIDIAA 284

                          170
                   ....*....|..
gi 1021312108  798 KFN-KITAVAKG 808
Cdd:COG4942    285 PPGaPVRAVADG 296
 
Name Accession Description Interval E-value
CaM_bind pfam16025
Calcium-dependent calmodulin binding; This domain is found at the N-terminus of centriolar ...
 29-106 8.51e-23

Calcium-dependent calmodulin binding; This domain is found at the N-terminus of centriolar coiled-coil protein of 110 kDa (CCP110), where it binds calmodulin. Binding of calmodulin to this domain is calcium dependent.


Pssm-ID: 464981  Cd Length: 78  Bit Score: 93.17  E-value: 8.51e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1021312108   29 QSESISLIRFHGVAILSPLLNIEKRKEMQQEKQKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQWEME 106
Cdd:pfam16025    1 ESEFVSCIKINGVPILPPLMTDEKREEMQQYRQKAIAIEERLRKQRKAALLIRVQEILKNEQRRKLPTLEQTSTLDAE 78
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 638-704 8.27e-04

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 40.79  E-value: 8.27e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  638 SKESEELLKSKMLAFEEMRKRLEeqhAQQLSLLIAEQEREQERLQKEIEEQE---KMLKEKKAMTAEASE 704
Cdd:pfam00836   40 KDSSLEEIQKKLEAAEERRKSLE---AQKLKQLAEKREKEEEALQKADEENNnfsKMAEEKLKQKMEAYK 106
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 653-702 3.59e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.95  E-value: 3.59e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  653 EEMRKRLEEQHAQQLSL-LIAEQER----EQERL-----QKEIEEQEKMLKEKKAMTAEA 702
Cdd:PRK09510    78 EEQRKKKEQQQAEELQQkQAAEQERlkqlEKERLaaqeqKKQAEEAAKQAALKQKQAEEA 137
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 639-808 3.82e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  639 KESEELLKSKMLAFEEMRKRLEEQhAQQLSLLIAEQEREQERLQKEIEEQEKMLKE-KKAMTAEASELDinnavELEWRK 717
Cdd:COG4942    149 REQAEELRADLAELAALRAELEAE-RAELEALLAELEEERAALEALKAERQKLLARlEKELAELAAELA-----ELQQEA 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  718 ISDSSLLETmLSQADSLHTSNSNSSGFTNSAMQYSFvsaneaPfylwgssTSGltklSVTRPFGRAKTRWSQVFSLEIQA 797
Cdd:COG4942    223 EELEALIAR-LEAEAAAAAERTPAAGFAALKGKLPW------P-------VSG----RVVRRFGERDGGGGRNKGIDIAA 284

                          170
                   ....*....|..
gi 1021312108  798 KFN-KITAVAKG 808
Cdd:COG4942    285 PPGaPVRAVADG 296
 
Name Accession Description Interval E-value
CaM_bind pfam16025
Calcium-dependent calmodulin binding; This domain is found at the N-terminus of centriolar ...
 29-106 8.51e-23

Calcium-dependent calmodulin binding; This domain is found at the N-terminus of centriolar coiled-coil protein of 110 kDa (CCP110), where it binds calmodulin. Binding of calmodulin to this domain is calcium dependent.


Pssm-ID: 464981  Cd Length: 78  Bit Score: 93.17  E-value: 8.51e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1021312108   29 QSESISLIRFHGVAILSPLLNIEKRKEMQQEKQKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQWEME 106
Cdd:pfam16025    1 ESEFVSCIKINGVPILPPLMTDEKREEMQQYRQKAIAIEERLRKQRKAALLIRVQEILKNEQRRKLPTLEQTSTLDAE 78
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 638-704 8.27e-04

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 40.79  E-value: 8.27e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  638 SKESEELLKSKMLAFEEMRKRLEeqhAQQLSLLIAEQEREQERLQKEIEEQE---KMLKEKKAMTAEASE 704
Cdd:pfam00836   40 KDSSLEEIQKKLEAAEERRKSLE---AQKLKQLAEKREKEEEALQKADEENNnfsKMAEEKLKQKMEAYK 106
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 630-709 2.85e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 40.73  E-value: 2.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  630 KNKMLGTSSKESEELLKSKMLAFEEMRKRLEEQHAQQLSLLIAEQEREQERLQKeieEQEKMLKEKKAMTAEASELDINN 709
Cdd:pfam02841  219 EQELLREKQKEEEQMMEAQERSYQEHVKQLIEKMEAEREQLLAEQERMLEHKLQ---EQEELLKEGFKTEAESLQKEIQD 295
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 653-702 3.59e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.95  E-value: 3.59e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  653 EEMRKRLEEQHAQQLSL-LIAEQER----EQERL-----QKEIEEQEKMLKEKKAMTAEA 702
Cdd:PRK09510    78 EEQRKKKEQQQAEELQQkQAAEQERlkqlEKERLaaqeqKKQAEEAAKQAALKQKQAEEA 137
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 639-808 3.82e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  639 KESEELLKSKMLAFEEMRKRLEEQhAQQLSLLIAEQEREQERLQKEIEEQEKMLKE-KKAMTAEASELDinnavELEWRK 717
Cdd:COG4942    149 REQAEELRADLAELAALRAELEAE-RAELEALLAELEEERAALEALKAERQKLLARlEKELAELAAELA-----ELQQEA 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312108  718 ISDSSLLETmLSQADSLHTSNSNSSGFTNSAMQYSFvsaneaPfylwgssTSGltklSVTRPFGRAKTRWSQVFSLEIQA 797
Cdd:COG4942    223 EELEALIAR-LEAEAAAAAERTPAAGFAALKGKLPW------P-------VSG----RVVRRFGERDGGGGRNKGIDIAA 284

                          170
                   ....*....|..
gi 1021312108  798 KFN-KITAVAKG 808
Cdd:COG4942    285 PPGaPVRAVADG 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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