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Conserved domains on  [gi|1021312399|ref|NP_001310560|]
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HAUS augmin-like complex subunit 2 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HAUS2 super family cl20881
HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins ...
 1-96 1.27e-39

HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organizing centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis. This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.


The actual alignment was detected with superfamily member pfam15003:

Pssm-ID: 373465  Cd Length: 191  Bit Score: 131.54  E-value: 1.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312399   1 MNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHL------ETIRNIPHLA-ANLKKMN 73
Cdd:pfam15003  89 MTTHLKAVIQNKDRIIARLQQPYSLDCLPIEAEYHRQFSELLPKAASDYGALTAHLsdfqwsQSFKNPPSLWdENLRPIP 168

                          90       100
                  ....*....|....*....|...
gi 1021312399  74 QALAKMDILVTETEELAENILKW 96
Cdd:pfam15003 169 VALASCTRLFEATEAMRENIAKW 191
 
Name Accession Description Interval E-value
HAUS2 pfam15003
HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins ...
 1-96 1.27e-39

HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organizing centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis. This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.


Pssm-ID: 373465  Cd Length: 191  Bit Score: 131.54  E-value: 1.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312399   1 MNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHL------ETIRNIPHLA-ANLKKMN 73
Cdd:pfam15003  89 MTTHLKAVIQNKDRIIARLQQPYSLDCLPIEAEYHRQFSELLPKAASDYGALTAHLsdfqwsQSFKNPPSLWdENLRPIP 168

                          90       100
                  ....*....|....*....|...
gi 1021312399  74 QALAKMDILVTETEELAENILKW 96
Cdd:pfam15003 169 VALASCTRLFEATEAMRENIAKW 191
 
Name Accession Description Interval E-value
HAUS2 pfam15003
HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins ...
 1-96 1.27e-39

HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organizing centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis. This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.


Pssm-ID: 373465  Cd Length: 191  Bit Score: 131.54  E-value: 1.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021312399   1 MNNHLEAVLKEKRSLRQRLLKPMCQENLPIEAVYHRYMVHLLELAVTFIERLETHL------ETIRNIPHLA-ANLKKMN 73
Cdd:pfam15003  89 MTTHLKAVIQNKDRIIARLQQPYSLDCLPIEAEYHRQFSELLPKAASDYGALTAHLsdfqwsQSFKNPPSLWdENLRPIP 168

                          90       100
                  ....*....|....*....|...
gi 1021312399  74 QALAKMDILVTETEELAENILKW 96
Cdd:pfam15003 169 VALASCTRLFEATEAMRENIAKW 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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