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Conserved domains on  [gi|1022943151|ref|NP_001311061|]
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xaa-Pro aminopeptidase 1 isoform 5 [Homo sapiens]

Protein Classification

aminopeptidase P family protein( domain architecture ID 11047996)

aminopeptidase P family protein (metallopeptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

EC:  3.4.11.9
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
PubMed:  16229471

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 329-551 3.38e-143

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


:

Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 414.65  E-value: 3.38e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 329 GMRRAHIKDAVALCELFNWLEKEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLS 407
Cdd:cd01085     1 GMRAAHIRDGVALVEFLAWLEQEVPKGEtITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGT 487
Cdd:cd01085    81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022943151 488 GHGVGSFLNVHEGPCGIsYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNF 551
Cdd:cd01085   161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 1.89e-66

Creatinase/Prolidase N-terminal domain;


:

Pssm-ID: 465053  Cd Length: 159  Bit Score: 214.28  E-value: 1.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 157 DRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 237 IDGDRIDaPSVKEHLlldlgleAEYRIQVHPYKSILSELKALCADlsprEKVWV-SDKASYAVSETIPKDHRCCMPYTPI 315
Cdd:pfam16189  81 VDPEKLS-DEVRAHL-------EENGVEIRPYDDIYEDLAALAAG----KKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148

                         170
                  ....*....|.
gi 1022943151 316 CIAKAVKNSAE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 557-619 1.57e-25

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


:

Pssm-ID: 465052  Cd Length: 63  Bit Score: 99.41  E-value: 1.57e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1022943151 557 LTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGrqEALEWLIRETQPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
Creatinase_N super family cl46291
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 10-154 1.76e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


The actual alignment was detected with superfamily member pfam01321:

Pssm-ID: 480631  Cd Length: 128  Bit Score: 56.16  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151  10 LRQLRQAMRNSEyvtepIQAYIIPSGDahqseyiapcdcRRAFVSGFDGSAGTAI-ITEEHAAMWTD-GRYFLQAAKQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1022943151  88 snWTLMKM-GLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAghHLIPVkENLVDKI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 329-551 3.38e-143

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 414.65  E-value: 3.38e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 329 GMRRAHIKDAVALCELFNWLEKEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLS 407
Cdd:cd01085     1 GMRAAHIRDGVALVEFLAWLEQEVPKGEtITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGT 487
Cdd:cd01085    81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022943151 488 GHGVGSFLNVHEGPCGIsYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNF 551
Cdd:cd01085   161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
183-566 7.08e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 233.56  E-value: 7.08e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 183 ADLRLKMAERNVMWFVVTALDEIAWLFNLRGSdvehnPVFFSYAIIgletimlFIDGDRIdapsvkehLLLDlGLEAEYR 262
Cdd:COG0006     1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-----PERLAALLV-------TADGEPV--------LFVD-ELEAERE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 263 IQvhpyksilsELKALCADLsprekvwvsdkasyavsetipkdhrccmpytpiciaKAVKNSAESEGMRRAHIKDAVALC 342
Cdd:COG0006    60 LV---------DASDLLEEL------------------------------------RAIKSPEEIELMRKAARIADAAHE 94

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 343 ELFNWLEKevpkgGVTEISAADKAEEFRRQQaDFVDLSFPTISSTGPNGAIIHYAPvpeTNRTLSLDEVYLIDSGAQYKD 422
Cdd:COG0006    95 AALAALRP-----GVTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTP---TDRPLKPGDLVLIDAGAEYDG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 423 GTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVfPTGTKGHLLDSFARSALWDSGL--DYLHGTGHGVGsfLNVHEG 500
Cdd:COG0006   166 YTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHEG 242

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1022943151 501 PcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPvktkynfnnRGsltFEPLTLVP 566
Cdd:COG0006   243 P---QISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTE---------DG---AEVLTRLP 293
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 1.89e-66

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 214.28  E-value: 1.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 157 DRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 237 IDGDRIDaPSVKEHLlldlgleAEYRIQVHPYKSILSELKALCADlsprEKVWV-SDKASYAVSETIPKDHRCCMPYTPI 315
Cdd:pfam16189  81 VDPEKLS-DEVRAHL-------EENGVEIRPYDDIYEDLAALAAG----KKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148

                         170
                  ....*....|.
gi 1022943151 316 CIAKAVKNSAE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 328-544 1.14e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 208.63  E-value: 1.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 328 EGMRRAHIKDAVALCELFNWLEKevpkgGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPvpeTNRTLS 407
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRP-----GVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP---NDRVLK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 408 LDEVYLIDSGAQYKDG-TTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGLD--YL 484
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLGeyFP 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1022943151 485 HGTGHGVGsfLNVHEGPcgISYKTFSDEPLEAGMIVTDEPGYYE-DGAFGIRIENVVLVVP 544
Cdd:pfam00557 152 HGLGHGIG--LEVHEGP--YISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 557-619 1.57e-25

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 99.41  E-value: 1.57e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1022943151 557 LTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGrqEALEWLIRETQPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
 356-544 4.79e-19

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 89.23  E-value: 4.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 356 GVTEISAADKAEEFRRQQADfVDLSFPTISSTGPNGAIIHYAPvpeTNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-- 433
Cdd:PRK09795  157 GMSEREIAAELEWFMRQQGA-EKASFDTIVASGWRGALPHGKA---SDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVng 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 434 -GTPTAYEKECFTY--VLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL-DYL-HGTGHGVGsfLNVHEGPcgiSYKT 508
Cdd:PRK09795  233 eGVSAESHPLFNVYqiVLQAQLAAISAIRP-GVRCQQVDDAARRVITEAGYgDYFgHNTGHAIG--IEVHEDP---RFSP 306

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1022943151 509 FSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVP 544
Cdd:PRK09795  307 RDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTP 342
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 10-154 1.76e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 56.16  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151  10 LRQLRQAMRNSEyvtepIQAYIIPSGDahqseyiapcdcRRAFVSGFDGSAGTAI-ITEEHAAMWTD-GRYFLQAAKQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1022943151  88 snWTLMKM-GLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAghHLIPVkENLVDKI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 329-551 3.38e-143

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 414.65  E-value: 3.38e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 329 GMRRAHIKDAVALCELFNWLEKEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLS 407
Cdd:cd01085     1 GMRAAHIRDGVALVEFLAWLEQEVPKGEtITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGT 487
Cdd:cd01085    81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1022943151 488 GHGVGSFLNVHEGPCGIsYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNF 551
Cdd:cd01085   161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
183-566 7.08e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 233.56  E-value: 7.08e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 183 ADLRLKMAERNVMWFVVTALDEIAWLFNLRGSdvehnPVFFSYAIIgletimlFIDGDRIdapsvkehLLLDlGLEAEYR 262
Cdd:COG0006     1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-----PERLAALLV-------TADGEPV--------LFVD-ELEAERE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 263 IQvhpyksilsELKALCADLsprekvwvsdkasyavsetipkdhrccmpytpiciaKAVKNSAESEGMRRAHIKDAVALC 342
Cdd:COG0006    60 LV---------DASDLLEEL------------------------------------RAIKSPEEIELMRKAARIADAAHE 94

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 343 ELFNWLEKevpkgGVTEISAADKAEEFRRQQaDFVDLSFPTISSTGPNGAIIHYAPvpeTNRTLSLDEVYLIDSGAQYKD 422
Cdd:COG0006    95 AALAALRP-----GVTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTP---TDRPLKPGDLVLIDAGAEYDG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 423 GTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVfPTGTKGHLLDSFARSALWDSGL--DYLHGTGHGVGsfLNVHEG 500
Cdd:COG0006   166 YTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHEG 242

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1022943151 501 PcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPvktkynfnnRGsltFEPLTLVP 566
Cdd:COG0006   243 P---QISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTE---------DG---AEVLTRLP 293
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 1.89e-66

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 214.28  E-value: 1.89e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 157 DRPERPCKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 237 IDGDRIDaPSVKEHLlldlgleAEYRIQVHPYKSILSELKALCADlsprEKVWV-SDKASYAVSETIPKDHRCCMPYTPI 315
Cdd:pfam16189  81 VDPEKLS-DEVRAHL-------EENGVEIRPYDDIYEDLAALAAG----KKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148

                         170
                  ....*....|.
gi 1022943151 316 CIAKAVKNSAE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 328-544 1.14e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 208.63  E-value: 1.14e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 328 EGMRRAHIKDAVALCELFNWLEKevpkgGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPvpeTNRTLS 407
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRP-----GVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP---NDRVLK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 408 LDEVYLIDSGAQYKDG-TTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGLD--YL 484
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLGeyFP 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1022943151 485 HGTGHGVGsfLNVHEGPcgISYKTFSDEPLEAGMIVTDEPGYYE-DGAFGIRIENVVLVVP 544
Cdd:pfam00557 152 HGLGHGIG--LEVHEGP--YISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 333-542 2.58e-41

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 148.81  E-value: 2.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 333 AHIKDAVAL-CELFNWLEKEVpKGGVTEISAADKAE-EFRRQQADfvDLSFPTISSTGPNGAIIHYAPvpeTNRTLSLDE 410
Cdd:cd01092     2 ELLRKAARIaDKAFEELLEFI-KPGMTEREVAAELEyFMRKLGAE--GPSFDTIVASGPNSALPHGVP---SDRKIEEGD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 411 VYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL-DYL-HGTG 488
Cdd:cd01092    76 LVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKP-GVTAKEVDKAARDVIEEAGYgEYFiHRTG 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1022943151 489 HGVGsfLNVHEGPcGISykTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:cd01092   155 HGVG--LEVHEAP-YIS--PGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLV 203
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 328-544 3.99e-36

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 134.50  E-value: 3.99e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 328 EGMRRAHIKDAVALCELFNWLekevpKGGVTEISAAdkAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPvpeTNRTLS 407
Cdd:cd01066     2 ARLRKAAEIAEAAMAAAAEAI-----RPGVTEAEVA--AAIEQALRAAGGYPAGPTIVGSGARTALPHYRP---DDRRLQ 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL--DYLH 485
Cdd:cd01066    72 EGDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRP-GVTAEEVDAAAREVLEEHGLgpNFGH 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1022943151 486 GTGHGVGsfLNVHEGPcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVP 544
Cdd:cd01066   151 RTGHGIG--LEIHEPP---VLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTE 204
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 557-619 1.57e-25

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 99.41  E-value: 1.57e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1022943151 557 LTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKELQKQGrqEALEWLIRETQPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
 356-544 4.79e-19

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 89.23  E-value: 4.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 356 GVTEISAADKAEEFRRQQADfVDLSFPTISSTGPNGAIIHYAPvpeTNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-- 433
Cdd:PRK09795  157 GMSEREIAAELEWFMRQQGA-EKASFDTIVASGWRGALPHGKA---SDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVng 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 434 -GTPTAYEKECFTY--VLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL-DYL-HGTGHGVGsfLNVHEGPcgiSYKT 508
Cdd:PRK09795  233 eGVSAESHPLFNVYqiVLQAQLAAISAIRP-GVRCQQVDDAARRVITEAGYgDYFgHNTGHAIG--IEVHEDP---RFSP 306

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1022943151 509 FSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVP 544
Cdd:PRK09795  307 RDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTP 342
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 368-542 3.48e-18

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 84.16  E-value: 3.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 368 EFRRQQADfvdLSFPTISSTGPNGAIIHYApvpETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-GTPTAYEKECFTY 446
Cdd:cd01087    38 EFRSRGAR---LAYSYIVAAGSNAAILHYV---HNDQPLKDGDLVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 447 VLKGHIAVSAAVFPtGTK---GHLL-DSFARSALWDSGLD----------------YLHGTGHGVGsfLNVHEgpCGISY 506
Cdd:cd01087   112 VLAAQKAAIAACKP-GVSyedIHLLaHRVLAEGLKELGILkgdvdeivesgayakfFPHGLGHYLG--LDVHD--VGGYL 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1022943151 507 KTFS-DEPLEAGMIVTDEPGYY---EDGAF-------GIRIENVVLV 542
Cdd:cd01087   187 RYLRrARPLEPGMVITIEPGIYfipDLLDVpeyfrggGIRIEDDVLV 233
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 322-542 1.37e-11

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 67.06  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 322 KNSAESEGMRRA-------HIKdAVALCE--LFNW-LEKEVpkggvteisaadkAEEFRRQQADFVdlSFPTISSTGPNG 391
Cdd:PRK10879  174 KSPEEIAVLRRAgeisalaHTR-AMEKCRpgMFEYqLEGEI-------------HHEFNRHGARYP--SYNTIVGSGENG 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 392 AIIHYApvpETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-GTPTAYEKECFTYVLKGhIAVSAAVFPTGT------- 463
Cdd:PRK10879  238 CILHYT---ENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLES-LETSLRLYRPGTsirevtg 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 464 ----------------KG---HLLDSFARSALwdsgldYLHGTGHGVGsfLNVHEgpCGiSYKTFSDEPLEAGMIVTDEP 524
Cdd:PRK10879  314 evvrimvsglvklgilKGdvdQLIAENAHRPF------FMHGLSHWLG--LDVHD--VG-VYGQDRSRILEPGMVLTVEP 382

                         250       260
                  ....*....|....*....|....*..
gi 1022943151 525 GYY---------EDGAFGIRIENVVLV 542
Cdd:PRK10879  383 GLYiapdadvpeQYRGIGIRIEDDIVI 409
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 10-154 1.76e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 56.16  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151  10 LRQLRQAMRNSEyvtepIQAYIIPSGDahqseyiapcdcRRAFVSGFDGSAGTAI-ITEEHAAMWTD-GRYFLQAAKQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1022943151  88 snWTLMKM-GLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAghHLIPVkENLVDKI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
PRK15173 PRK15173
peptidase; Provisional
 359-542 1.12e-06

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 50.87  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 359 EISAADKAEEFRRQQADFVDLSFPTIsstgpnGAIIHYAPVPETNRTLSLDEVYLiDSGAQYKDGTTDVTRTMHFGTPTA 438
Cdd:PRK15173  130 ELTAAYKAAVMSKSETHFSRFHLISV------GADFSPKLIPSNTKACSGDLIKF-DCGVDVDGYGADIARTFVVGEPPE 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 439 YEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSfARSALWDSGL-DYLHG-TGHGVGSFLNVHEGPCgisYKTFSDEPLEA 516
Cdd:PRK15173  203 ITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDS-TMEVIKKSGLpNYNRGhLGHGNGVFLGLEESPF---VSTHATESFTS 278

                         170       180
                  ....*....|....*....|....*.
gi 1022943151 517 GMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:PRK15173  279 GMVLSLETPYYGYNLGSIMIEDMILI 304
PRK14575 PRK14575
putative peptidase; Provisional
 359-542 1.91e-06

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 50.47  E-value: 1.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 359 EISAADKAEEFRRQQADFVDLSFPTIsstgpnGAIIHYAPVPETNRTLSLDEVYLiDSGAQYKDGTTDVTRTMHFGTPTA 438
Cdd:PRK14575  213 ELTAAYKAAVMSKSETHFSRFHLISV------GADFSPKLIPSNTKACSGDLIKF-DCGVDVDGYGADIARTFVVGEPPE 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 439 YEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSfARSALWDSGL-DYLHG-TGHGVGSFLNVHEGPcgiSYKTFSDEPLEA 516
Cdd:PRK14575  286 ITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDS-TMEVIKKSGLpNYNRGhLGHGNGVFLGLEESP---FVSTHATESFTS 361

                         170       180
                  ....*....|....*....|....*.
gi 1022943151 517 GMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:PRK14575  362 GMVLSLETPYYGYNLGSIMIEDMILI 387
PRK14576 PRK14576
putative endopeptidase; Provisional
 415-542 1.89e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 44.24  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1022943151 415 DSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSfARSALWDSGLDYLH--GTGHGVG 492
Cdd:PRK14576  261 DCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDS-TMAVIKTSGLPHYNrgHLGHGDG 339

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1022943151 493 SFLNVHEGPCgisYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:PRK14576  340 VFLGLEEVPF---VSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILI 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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