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Conserved domains on  [gi|1023300921|ref|NP_001311150|]
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putative P2Y purinoceptor 10 isoform b [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606880)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
52-333 1.32e-169

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


:

Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 473.51  E-value: 1.32e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15153     1 SLYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDL-NNNKSCFADLGYKQMNAV 210
Cdd:cd15153    81 LNMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLsNNNRSCFADLGMKKLNFG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15153   161 AAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15153   241 ITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
 
Name Accession Description Interval E-value
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
52-333 1.32e-169

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 473.51  E-value: 1.32e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15153     1 SLYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDL-NNNKSCFADLGYKQMNAV 210
Cdd:cd15153    81 LNMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLsNNNRSCFADLGMKKLNFG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15153   161 AAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15153   241 ITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
69-304 3.81e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 128.95  E-value: 3.81e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  69 NSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYASICFLTCISL 146
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 147 QRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFV 225
Cdd:pfam00001  82 DRYLAIVHPLRYKRRrTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 226 IPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAA---VFFICFTPYHInFIFYTMVKETIISSCPVVRIALY 302
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVvvvVFILCWLPYHI-VNLLDSLALDCELSRLLDKALSV 240

                  ..
gi 1023300921 303 FH 304
Cdd:pfam00001 241 TL 242
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
55-353 6.53e-27

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 108.71  E-value: 6.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIiFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:PHA03087   44 IVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDI-YLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGF 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTD-LNNNKSCFADLGYKQMNAVAL 212
Cdd:PHA03087  123 YNSMNFITVMSVDRYIAIVHPVKSNKINtVKYGYIVSLVIWIISIIETTPILFVYTTKkDHETLICCMFYNNKTMNWKLF 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMitVAELAGFVIPVIIIAWCTWKTTISLRQppmaFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS 292
Cdd:PHA03087  203 INF--EINIIGMLIPLTILLYCYSKILITLKG----INKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS 276
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRhgssvtRSRLMSKESGSS 353
Cdd:PHA03087  277 GCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK------SLKLMFTSSGKS 331
 
Name Accession Description Interval E-value
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
52-333 1.32e-169

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 473.51  E-value: 1.32e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15153     1 SLYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDL-NNNKSCFADLGYKQMNAV 210
Cdd:cd15153    81 LNMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAVWIVVGLACLPFPLLRSKSLsNNNRSCFADLGMKKLNFG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15153   161 AAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSESI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15153   241 ITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
53-333 9.32e-107

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 313.97  E-value: 9.32e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15152     2 IYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVAL 212
Cdd:cd15152    82 NMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAGWLVVCVGCLPFPLLRQSQDTNPTCCFADLPLRNVGLTTS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS 292
Cdd:cd15152   162 VIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSNKIK 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15152   242 SCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
53-333 8.48e-103

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 304.19  E-value: 8.48e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKY 131
Cdd:cd14982     2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGgWWPFGDFLCRLTGLLFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDL--NNNKSCFADLgykQMN 208
Cdd:cd14982    82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRkRYAVGVCAGVWILVLVASVPLLLLRSTIAkeNNSTTCFEFL---SEW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd14982   159 LASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 289 TIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14982   239 SFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
58-333 1.30e-48

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 165.18  E-value: 1.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15168     7 YGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGdHWIFGDFMCKLVRFLFYFNLYG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15168    87 SILFLTCISVHRYLGICHPLRSLGKlKKRHAVAISVAVWILVLLQLLPiLFFATTGRKNNRTTCYDTTSPEELNDYVIYS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKET-IISS 293
Cdd:cd15168   167 MVLT--GLGFLLPLLIILACYGLIVRALIRKLGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLsGTAS 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 294 CPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15168   245 CATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
52-333 8.79e-47

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 160.47  E-value: 8.79e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15155     1 NLYGAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-CFAdlGYKQMNA 209
Cdd:cd15155    81 TNIYGSMLFLTCISVDRFLAIVYPFRSRTIRtRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTtCFE--GFSKSIW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITV-AELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15155   159 KTYLSKITIfIEVVGFIIPLLLNLTCSSLVLRTLRKPATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRS 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 289 TIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15155   239 QAIANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
52-333 1.35e-45

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 157.18  E-value: 1.35e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLK 130
Cdd:cd15161     1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSgNHWPFGEVPCRLAGFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNA 209
Cdd:cd15161    81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKpLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREKASR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMItvaelAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISErqKALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15161   161 GALVSLA-----VAFTIPFVTTVTCYLLIIRSLRTGKREEKPLKD--KAIKMIILVLTIFLICFVPYHISRYIYILSHNG 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 290 IISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15161   234 AGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
52-324 1.28e-44

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 154.62  E-value: 1.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15156     1 TLYGCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGI-SAAIWIVVGTACLPFPILRSTDL---NNNKSCFADLGYKQM 207
Cdd:cd15156    81 TNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIvCAAVWLTVLAGSLPASFFQSTNNqlnNNSETCFENFSSKTW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVaLVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd15156   161 KTY-LSKIVIFIEIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVR 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1023300921 288 ETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYF 324
Cdd:cd15156   240 TQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
58-332 5.98e-43

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 150.18  E-value: 5.98e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYiSHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15165     7 YIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSS-KKQWPLGRTLCSFLESLYFVNMYGS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRStDLNNNKSCFADLGYKQMNAVALVgmi 216
Cdd:cd15165    86 ILIIVCISVDRYIAIRHPFLAKRLRSpRKAAIVCLTIWVFVWAGSIPIYSFHD-KPTNNTRCFHGFSNKTWSKKVIV--- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 tVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPV 296
Cdd:cd15165   162 -VVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIINDCST 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1023300921 297 VRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQ 332
Cdd:cd15165   241 KQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRES 276
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-332 2.63e-38

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 138.74  E-value: 2.63e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  42 CNVTNVKFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNK-AIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQ 119
Cdd:cd15190     1 CDYTEWKPSYALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRRRsADTFIANLALADLTFVVTLPLwAVYTALGYHWPFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 120 RALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPF-RARDWKRRYDVGISAAIWIVVGTACLPFPILRST--DLNNNK 196
Cdd:cd15190    81 SFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLaSAKLRSRTSGIVALGVIWLLAALLALPALILRTTsdLEGTNK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 197 -SCFAD---LGYKQMNAVALVGMITVAELAGFVIP--VIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFF 270
Cdd:cd15190   161 vICDMDysgVVSNESEWAWIAGLGLSSTVLGFLLPflIMLTCYFFIGRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFA 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 271 ICFTPYHINFIFYTMVKETIIS-SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQ 332
Cdd:cd15190   241 LCWLPFHLVKTLYALMYLGILPfSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
57-330 3.86e-38

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 137.59  E-value: 3.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYiSHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15923     6 IYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSY-RRESAGLQKLCNFVLSLYYINMYV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTdlNNNKSCFADLGYKQMNAVALvgm 215
Cdd:cd15923    85 SIFTITAISVDRYVAIRYPLRARELRSpRKAAVVCAVIWVLVVTISIPYFLLDSS--NEKTMCFQRTKQTESLKVFL--- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 itVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETiiSSCP 295
Cdd:cd15923   160 --LLEIFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKS--YSCD 235
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1023300921 296 VVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15923   236 SKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
52-333 3.28e-37

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 135.28  E-value: 3.28e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15154     1 TLHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISA-AIWIVVGTACLPFPILRSTD---LNNNKSCFADLGYKQM 207
Cdd:cd15154    81 MNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLClAVWALILGGSVPAAIVHSSSdclLHGEKVYRCFESFSDN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGisERQKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd15154   161 DWKGLLPLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQG--RRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLR 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 288 ETIISSCPVVRIALY-FHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15154   239 ANLVEDTWNIKDTLRkVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
58-330 5.95e-36

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 131.82  E-value: 5.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15968     7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdRWLFGDFMCRLVRFLFYFNLYG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-CFADLGYKQMNAVALVG 214
Cdd:cd15968    87 SILFLTCISVHRYLGICHPMRPWHKEtRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTvCYDLAPPALFPHYVPYG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITvaELAGFVIPVIIIAWCTWKTTISLRQP--PMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS 292
Cdd:cd15968   167 MAL--TVSGFLLPFSIILWCYCLVVRTLCRTlgPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPGV 244
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15968   245 PCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFG 282
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
53-333 1.08e-35

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 131.08  E-value: 1.08e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKY 131
Cdd:cd15921     2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVlNSHWPFGDIACRIILYVLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGI-SAAIWIVVGTACLPFPILRSTDLN-NNKSCFAdlgyKQMNA 209
Cdd:cd15921    82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIiCGLIWILMGLASSPLLFAKSKQHDeGSTRCLE----LAHDA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMIT-VAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGIS-ERQKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd15921   158 VDKLLLINyVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRpSRRKACALIIISLGIFLVCFLPYHIVRTIHLITE 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 288 ETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15921   238 RQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
69-304 3.81e-35

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 128.95  E-value: 3.81e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  69 NSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYASICFLTCISL 146
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHgDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 147 QRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFV 225
Cdd:pfam00001  82 DRYLAIVHPLRYKRRrTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLGFL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 226 IPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAA---VFFICFTPYHInFIFYTMVKETIISSCPVVRIALY 302
Cdd:pfam00001 162 LPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVvvvVFILCWLPYHI-VNLLDSLALDCELSRLLDKALSV 240

                  ..
gi 1023300921 303 FH 304
Cdd:pfam00001 241 TL 242
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
58-331 6.32e-35

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 129.10  E-value: 6.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15162     7 YTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHgNNWIFGEALCRLVTVAFYGNMYC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRST---DLNNNKSCFaDLGYKQMNAVAL 212
Cdd:cd15162    87 SILLLTCISIDRYLAIVHPMGHRRLRaRRYALGTCLAIWLLALLVTLPLYLVKQTiflPALDITTCH-DVLPEQLLVGDW 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS 292
Cdd:cd15162   166 FYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSE-KKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLISSSGT 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 293 ScpvvriALYF-HPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15162   245 G------HLYFaYLLALCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
53-333 1.53e-34

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 128.33  E-value: 1.53e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKY 131
Cdd:cd15373     2 LLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYAdENDWPFSEALCKIVRFLFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVgTACLPfPIL---RSTDLNNNKSCFADLGYKQM 207
Cdd:cd15373    82 TNLYCSILFLLCISVHRFLGVCYPVRSLRWLKvRYARIVSVVVWVIV-LACQS-PVLyfvTTSDKGGNITCHDTSSPELF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELagFVIPVIIIAWCTWKTTISLRQPPMAFQGISE-RQKALRMVFMCAAVFFICFTPYHINFIFYTMV 286
Cdd:cd15373   160 DQFVVYSSVMLVLL--FCVPFVVILVCYALMVRKLLKPSAGTSTNSRsKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSF 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 287 KETIIsSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15373   238 RSMDL-SCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
57-323 2.06e-34

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 127.95  E-value: 2.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd16001     6 TYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAmRDRWPFGDFLCKLVRFLFYTNLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYKQMNAVALV 213
Cdd:cd16001    86 GSILFLTCISVHRFLGVCYPIRSLAYRtRRLAVIGSAATWILVVLQLLPtLVYARTGSINNRTVCYDLTSPDNFGNYFPY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMitVAELAGFVIPVIIIAWCTWKTTISL-RQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS 292
Cdd:cd16001   166 GM--VLTVTGFLIPFLIILLCYCLMIKSLiRSEEAAGVGKAARAKSIRTILLVCGLFALCFVPFHITRTIYLFVRVYLVQ 243
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYY 323
Cdd:cd16001   244 DCPLLQFVSLAYKIWRPLVSFNSCINPLLYF 274
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
56-330 3.22e-34

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 127.11  E-value: 3.22e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd14985     5 ALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLwATYTANQYDWPFGAFLCKVSSYVISVNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAA-IWIVVGTACLPFPILRSTDL--NNNKS-CFADLGYKQmnav 210
Cdd:cd14985    85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCAlIWVVACLLSLPTFLLRSLQAieNLNKTaCIMLYPHEA---- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQP-PMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd14985   161 WHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRyERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLG 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 290 IISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14985   241 AIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
56-278 3.43e-34

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 127.11  E-value: 3.43e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLP-LRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15967     5 PVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPfLVVYYLKGRKWIFGQVFCKITRFCFNLNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWIVVGTACLPFPILRSTDlNNNKSCFaDLGYKQMNAVALV 213
Cdd:cd15967    85 YGSIGFLTCISVYRYLAIVHPMRVMGrITTTHSVVISALVWLLVVIQSLPDLFFSKTN-SNGTKCF-DTTFNDYLESYLT 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 214 GMITVAeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGIseRQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15967   163 YSLGWT-VTGFVIPLLIILGCYGHVVVVLCRNNNVDKGL--KQRCLKLVIILIVLFSVCYIPYHV 224
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
56-333 4.67e-34

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 126.56  E-value: 4.67e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIsHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd14984     5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAA-DGWVFGSFLCKLVSALYTINFY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKP---FRARdwKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-CfaDLGYKQMNAVA 211
Cdd:cd14984    84 SGILFLACISIDRYLAIVHAvsaLRAR--TLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSiC--SYDYPEDTATT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVGMITVAE-LAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHInFIFYTMVKET- 289
Cdd:cd14984   160 WKTLLRLLQnILGFLLPLLVMLFCYSRIIRTLLRARN-----HKKHRALRVIFAVVVVFFLCWLPYNI-VLLLDTLQLLg 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 290 -IISSCPV---VRIAL-------YFHpfclclaslcCLLDPILYYFMASEFRDQL 333
Cdd:cd14984   234 iISRSCELsksLDYALqvteslaFSH----------CCLNPVLYAFVGVKFRKYL 278
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
58-333 5.90e-34

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 126.70  E-value: 5.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15159     7 YSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYAlGFDWPFGDWLCRLTALLFYINTYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNK-SCFADLGYKQMNAVALvg 214
Cdd:cd15159    87 GVNFMTCLSVDRYIAVVHPLRrHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRiTCMEYPNFEKIKRLPL-- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELAGFVIPVIIIAWCTWKTTISLRQ-----PPMAFQGISerQKALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15159   165 ILLGACVIGFGVPVGIILFCYSQITLKLCRtakenPLTEKSGHH--KKACNVILLVLLVFVVCFSPYHLNIIQFMIRKLL 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 290 IISSCP---VVRIALYfhpFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15159   243 YQPSCSelkAFKISLQ---ITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
58-333 3.41e-33

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 124.48  E-value: 3.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15191     7 YSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLwATYYSYGYNWLFGSVMCKICGSLLTLNLFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRST---DLNNNKSCFADLGYKQMnAVALV 213
Cdd:cd15191    87 SIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLLVWVLACLSSLPTFYFRDTyyiEELGVNACIMAFPNEKY-AQWSA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISS 293
Cdd:cd15191   166 GLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGVINN 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 294 CPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15191   246 CWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
58-333 7.60e-33

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 123.72  E-value: 7.60e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15368     7 YSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQrNHWIFGKPLCNVVTVLFYANMYS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPfpiLRSTDLN------NNKSCFADLGYKQM-N 208
Cdd:cd15368    87 SILTMTCISIERYLGVVYPMRSMRWrKKRYAVAACIGMWLLVLTALSP---LERTDLTyyvkelNITTCFDVLKWTMLpN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFqGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15368   164 IAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERY-GREQKRRAIYLALIVLLVFITCFAPNNFILLAHMVSRL 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 289 TIISSC-PVVRIALYFhpfclclASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15368   243 FYGKSLyHAYKLTLSL-------SCLNSCLDPFIYYFASKEFRKKL 281
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
58-333 1.57e-32

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 122.88  E-value: 1.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15160     7 YSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHnWTFGPLSCKVVGFFFYTNIYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRST--DLNNNKSCFAdlGYKQMNAVALV 213
Cdd:cd15160    87 SIGFLCCIAVDRYLAVVHPLRFRGLRtRRFALKVSASIWVLELGTHSVFLGHDELfrDEPNHTLCYE--KYPMEGWQASY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQgiSERQKALRMVFMCAAVFFICFTPYHInFIFYTMVKETIISS 293
Cdd:cd15160   165 NYARF--LVGFLIPLSLILFFYRRVLRAVRQSPSLER--EEKRKIIGLLLSIVVIFLLCFLPYHV-VLLVRSVIELVQNG 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 294 CPVVRIALY-FHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15160   240 LCGFEKRVFtAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
53-333 6.50e-32

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 121.06  E-value: 6.50e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKY 131
Cdd:cd15374     2 LLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHnHWPFGVVACKIVRFLFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAv 210
Cdd:cd15374    82 ANLYCSILFLTCISVHRYVGICHPIRALRWvKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEFD- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAF---QGISERQKALRMVFMCAAVFFICFTPYHINFIFYtMVK 287
Cdd:cd15374   161 HYVHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSsrqQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLY-YVA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 288 ETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15374   240 RLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
52-278 1.33e-31

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 120.63  E-value: 1.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCR-FISKK-NKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFY 128
Cdd:cd15147     1 TLFPIVYSIIFVLGLIANCYVLWVFARlYPSKKlNEIKIFMVNLTIADLLFLITLPFWIVYYHNEgNWILPKFLCNVAGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 129 LKYLNMYASICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLPFPILRST-----DLNNNKSCFADL 202
Cdd:cd15147    81 LFFINTYCSVAFLGVISYNRYQAVTRPIKtAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTntvkiDSGNFTRCFEGY 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1023300921 203 GYKQMNAVALVGMITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15147   161 EKDNSKPVLIIHFIII--GLFFLVFLLILVCNLVIARTLLSQPVQGQRNAGVKRRALWMVCTVLAVFVICFVPHHV 234
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
54-333 1.77e-31

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 119.85  E-value: 1.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYL 132
Cdd:cd15158     3 YSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKgQWLFGDFLCRISSYALYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCF---FLLKPFRARDWKRRYDVGISaaIWIVVGTACLPFPILRSTDLNNNKS-CFADLGYKQMN 208
Cdd:cd15158    83 NLYCSIYFMTAMSFTRFLaivFPVQNLNLVTVKKARIVCVG--IWIFVTLTSSPFLMSGSHDTETNKTkCFEPPQSNQQL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVgMITVAELAGFVIPVIIIAWCTWKTTISLRQPPM-AFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd15158   161 TKLLV-LNYISLVVGFIIPFLVILICYAMIIRTLLKNTMkARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIQRTIHLHFL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 288 ETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15158   240 SRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
57-333 2.82e-31

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 119.33  E-value: 2.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLcRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYY-ISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd14974     6 LYALIFLLGLPGNGLVIWVA-GFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIaMGHHWPFGSVLCKLNSFVISLNMF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRST--DLNNNKSCF-----ADLGYKQM 207
Cdd:cd14974    85 ASVFLLTAISLDRCLLVLHPVWAQNHRTvRLASVVCVGIWILALVLSVPYFVFRDTvtHHNGRSCNLtcvedYDLRRSRH 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMitvaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGiserqKALRMVFMCAAVFFICFTPYHInFIFYTMV- 286
Cdd:cd14974   165 KALTVIRF-----LCGFLLPLLIIAICYSVIAVKLRRKRLAKSS-----KPLRVLLAVVVAFFLCWLPYHV-FALLELVa 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 287 ----KETIISSCPVVRIALYFHPFclclaslcclLDPILYYFMASEFRDQL 333
Cdd:cd14974   234 aaglPEVVLLGLPLATGLAYFNSC----------LNPILYVFMGQDFRKRL 274
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
54-303 6.85e-31

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 118.16  E-value: 6.85e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIV-VGTACLPFPILRSTDLNNNKSCFADLGYKQMNAV 210
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRfTRRRAKLLIALIWLLsLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVaelaGFVIPVIIIAWCTWKTTISLRQ----------PPMAFQGISERQKALRMVFMCAAVFFICFTPYHINF 280
Cdd:cd00637   161 YTIFLFVL----LFLLPLLVIIVCYVRIFRKLRRhrrrirssssNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILL 236
                         250       260
                  ....*....|....*....|...
gi 1023300921 281 IFYTMVKETIISSCPVVRIALYF 303
Cdd:cd00637   237 LLDVFGPDPSPLPRILYFLALLL 259
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
58-329 1.62e-30

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 116.98  E-value: 1.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPfqRALCLLCFYLKYLNMYAS 137
Cdd:cd15164     7 YIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSWPD--DELCLVLQSIYFINRYMS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVV-GTACLPFpilrSTDLNNNKSCFADLGYKQmNAVALVGM 215
Cdd:cd15164    85 IYIITAIAVDRYIAIKYPLKAKSLRSpRKAALTCGLLWVLViISVSLRL----AWEEQEENFCFGKTSTRP-SKRTLIFS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITvaelaGFVIPVIIIAWCTWKTTISL-RQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI-NFIFYTMvkETIISS 293
Cdd:cd15164   160 LL-----GFFIPLIILSFCSIQVIRSLkKKKKTNPHEEKLIQKAIYIVSANLIVFIVCFLPLHIgLLVRFVM--ESNKAS 232
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1023300921 294 CPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEF 329
Cdd:cd15164   233 CSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
52-333 4.38e-30

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 116.00  E-value: 4.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCrFISKKNKAIIFMINLSVADLAHVLSLPLRI-YYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15372     1 RLVPSLYTLVFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLLILVLPFKIsYHFLGNNWPFGEGLCRVVTAFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRST---DLNNNKSCFADLGYKQ 206
Cdd:cd15372    80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLRsRRFALCMCTAIWLIAAALTLPLTLQRQSyplERLNITLCHDVLPLDE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 207 MNAVALVGMITVAELaGFVIPVIIIAWCTWKTTISLrqppmafqgISERQK---ALRMVFMCAAVFFICFTPYHINFIF- 282
Cdd:cd15372   160 QDTYLFYYFACLAVL-GFLLPLVVILFCYGSVLHTL---------LRSGQRyghAMKLTVLVLVSFVLCFTPSNLLLLLh 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 283 ---YTMVKETIISSCPVVRIALyfhpfclclASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15372   230 ysdPTLDDGGNLYIVYMVSLAI---------STLNSCVDPFIYYYVSEEFRDKV 274
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
58-330 4.59e-30

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 116.24  E-value: 4.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd14970     7 YSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMI 216
Cdd:cd14970    87 IFCLTVMSVDRYLAVVHPVKSLRFRTpRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISCNLQWPDPPDYWGRVFT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIAWCTWKTTISLR---QPPMAFQGISER--QKALRMVFMCAAVFFICFTPYHInfifYTMVKetII 291
Cdd:cd14970   167 IYTFVLGFAVPLLVITVCYSLIIRRLRssrNLSTSGAREKRRarRKVTRLVLVVVAVFVVCWLPFHV----FQIVR--LL 240
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1023300921 292 SSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14970   241 IDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFR 279
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
58-330 5.40e-29

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 113.43  E-value: 5.40e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15379     7 YSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKdYWPFGDFTCRLVRFQFYTNLHG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK--RRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15379    87 SILFLTCISVQRYLGICHPLASWHKKkgKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARSTAYFPY 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELaGFVIP--VIIIAWCTWKTTISLRQPPMAFQGIS--ERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15379   167 GITLTRT-GFLLPfaARLACYCSMATILCRVVIAVAVVAAPgeKRGKAARMIIVVAAVFLISFLPFHYTKTRYLQVRSWD 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15379   246 GGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFR 285
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
58-330 5.68e-29

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 112.97  E-value: 5.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYyisHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15920     7 YSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY---QNTAGPLSFCKIVGAFFYLNMYAS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRA-RDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFAdlgYKQMNAVAlvGMI 216
Cdd:cd15920    84 ILFLSLISLDRYLKIIKPLQQfKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPCDNKCFH---FRSKGLTA--GGI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIAWCTWKTTISLRQppmAFQGISERQ------KALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15920   159 NLTAVVIFYILSLLFLYFYAKISHKLYK---VSLGNAQQQikkaskRAIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDV 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15920   236 ISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
56-333 1.25e-28

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 112.52  E-value: 1.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15192     5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLwAAYTAMEYHWPFGNFLCKIASALVSFNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISA-AIWIVVGTACLPFPILRSTDL--NNNKSCFAdLGYKQMNAVA 211
Cdd:cd15192    85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCiVIWLLAGVASLPAIIHRDVFFieNTNITVCA-FHYPSQNSTL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETII 291
Cdd:cd15192   164 LVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLKVI 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 292 SSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15192   244 QDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
56-333 1.54e-28

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 111.81  E-value: 1.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15370     5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDL--NNNKSCFADLGYKQMNAVAL 212
Cdd:cd15370    85 YCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFipALDITTCHDVLPEQLLVGDM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINF-IFYTMVKETII 291
Cdd:cd15370   165 FNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSINDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLvVHYFLLKNQGQ 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 292 SSCPVVRIAlyfhpfCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15370   245 SSVYAFYIT------ALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
58-330 1.30e-27

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 109.47  E-value: 1.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCrFISKKNKAIIFMINLSVADLAHVLSLPLRIYYY-ISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15116     7 YSVVFVLGVLGNGLVIFITG-FKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTaMDFHWPFGRFMCKLNSFLLFLNMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRST---DLNNNKSCF------ADLGYKQ 206
Cdd:cd15116    86 SVFLLTVISIDRCISVVFPVWSQNHRSvRLASLVSLAVWVVAFFLSSPSFIFRDTapsQNNNKIICFnnfslsGDNSSPE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 207 MNAVALV---GMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAfqgisERQKALRMVFMCAAVFFICFTPYHinfIFY 283
Cdd:cd15116   166 VNQLRNMrhqVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLA-----KSSKPFKIIAAVIVTFFLCWAPYH---ILN 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 284 TMVKETIISSCPVVRIAlyfHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15116   238 LLEMEATRSPASVFKIG---LPITSSLAFINSCLNPILYVFMGQDFK 281
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
56-278 5.67e-27

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 108.07  E-value: 5.67e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNM 134
Cdd:cd15377     5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKtDWIFGDAMCKLQRFIFHVNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS--CFADLGYKQMNAVA 211
Cdd:cd15377    85 YGSILFLTCISVHRYTGVVHPLKSLGrLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTitCYDTTSDEYLRSYF 164
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVGMITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISE---RQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15377   165 IYSMCTT--VAMFCVPFILILGCYGLIVRALIYKDMKYTEENNaplRRKSIYLVIIVLTVFAVSYLPFHV 232
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
55-353 6.53e-27

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 108.71  E-value: 6.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIiFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:PHA03087   44 IVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDI-YLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGF 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTD-LNNNKSCFADLGYKQMNAVAL 212
Cdd:PHA03087  123 YNSMNFITVMSVDRYIAIVHPVKSNKINtVKYGYIVSLVIWIISIIETTPILFVYTTKkDHETLICCMFYNNKTMNWKLF 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMitVAELAGFVIPVIIIAWCTWKTTISLRQppmaFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS 292
Cdd:PHA03087  203 INF--EINIIGMLIPLTILLYCYSKILITLKG----INKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS 276
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRhgssvtRSRLMSKESGSS 353
Cdd:PHA03087  277 GCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK------SLKLMFTSSGKS 331
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
54-333 6.83e-27

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 107.49  E-value: 6.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYL 132
Cdd:cd15157     3 YPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLmGSHWVFGDIACRIMSYSLYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRArdWK---RRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCfadLGYKQMNA 209
Cdd:cd15157    83 NMYCSIYFLTVLSIVRFLAIVHPFKL--WKvtsIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQTKC---LDLHPSKI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQP--PMAFQGISERqKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd15157   158 DKLLILNYIVLVVGFILPFCTLSICYILIIKALLKPrvPQSKLRVSHK-KALLTIIITLILFLLCFLPYHILRTVHLMQW 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1023300921 288 ETIISSCPV---VRIALyfhpfclCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15157   237 SEGQCNLRLhkaVVITL-------CLAAANSCLDPLLYYFAGENFKERL 278
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
57-278 7.00e-27

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 107.47  E-value: 7.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15375     6 MYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINgESWIFGEFMCKFIRFIFHFNLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLG-YKQMNAVALV 213
Cdd:cd15375    86 GSILFLTCFSIFRYVVIVHPLRAFQvQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLDFTsSDNLNTIWWY 165
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 214 GMITVAelAGFVIPVIIIAWCTWKTTISLRQPPmaFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15375   166 NWILTV--LGFLLPLVIVTLCYTRIIYTLAKGP--HTGSASKQKARRLIILILLVFYVCFLPFHI 226
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
56-333 7.08e-27

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 107.49  E-value: 7.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANsaaLWVLCRFI-SKKN--KAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15378     5 TMYSIEFVLGFIGN---TIVILGYIfCLKNwkSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSC--FADLGYKQMN 208
Cdd:cd15378    82 NLYSSILFLTFISIDRYLLIKYPFREHILqKKRSAVAISLAIWVLVTLELLPiLTFIGPNLKDNVTKCkdYASSGDATNS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMItvaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI--NFIFYTMV 286
Cdd:cd15378   162 LIYSLFLT----VTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVmrNVRIASRL 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1023300921 287 KETIISSCPVVRI-ALYFhpFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15378   238 DSIGVSECTLIIIkSLYI--VTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
57-333 8.80e-27

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 106.97  E-value: 8.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLrIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15178     6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPF-WAVSVVKGWIFGTFMCKLVSLLQEANFYS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS---CFADLGYKQMNAVALV 213
Cdd:cd15178    85 GILLLACISVDRYLAIVHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGrtvCYENLGNESADKWRVV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITvAELAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS- 292
Cdd:cd15178   165 LRIL-RHTLGFLLPLVVMLFCYGFTIKTLLQTRS-----FQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITe 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 293 SCPV---VRIALYFHPfclCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15178   239 TCELrnhVDVALYVTQ---ILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
58-332 1.17e-25

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 103.70  E-value: 1.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVlCRFISKKNKAIIFMINLSVADLAHVLSLPLRI-YYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15115     7 LSLTFLLGVPGNGLVIWV-AGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIaHLLLNGHWPYGRFLCKLLPSIIVLNMFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKScfaDLGYKQMNAVALVGM 215
Cdd:cd15115    86 SVFTLTAISLDRFLLVIKPVWAQNHRSvLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHT---RCGYDFLVAITITRA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITvaelaGFVIPVIIIAWCTWKTTISLRQPPMAFQGiserQKALRMVFMCAAVFFICFTPYHINFIFYTMVKEtiisscP 295
Cdd:cd15115   163 VF-----GFLLPLLIIAACYSFIAFRMQRGRFAKSQ----SKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDP------P 227
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1023300921 296 VVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQ 332
Cdd:cd15115   228 LSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
53-325 2.23e-25

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 103.32  E-value: 2.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKY 131
Cdd:cd15365     2 LFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDnWTLSGFVCIFSAFLLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGtaCLPFPILRSTDLNNNKSCFADLGYKQMNAV 210
Cdd:cd15365    82 TNFYTSTALLTCIALDRYLAVVHPLKFMHLrTIRTALSVSVAIWLLEI--CFNAVILTWEDSFHESSSHTLCYDKFPLED 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKEti 290
Cdd:cd15365   160 WQARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNQATED--QEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEP-- 235
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1023300921 291 iSSCPVVRIALYFHPFCLCLASLCCLLDPILYYFM 325
Cdd:cd15365   236 -CDCRNAKWLYTLYKITVALTSLNCIADPFLYCFV 269
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
58-333 3.10e-24

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 100.17  E-value: 3.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVlCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15114     7 YAVVFLVGVPGNALVAWV-TGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAqDGHWPFGAAACKLLPSLILLNMYA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIWIVVGTACLPFPILRSTDLNNNKS---CFADLG--YKQMNAV 210
Cdd:cd15114    86 SVLLLTAISADRCLLVLRPVWCQNHRRARLAwIACGAAWLLALLLTVPSFIYRRIHQEHFPEktvCVVDYGgsTGVEWAV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 AlvgmiTVAELAGFVIPVIIIAWCTWK--TTISLRQPPMAfqgiserQKALRMVFMCAAVFFICFTPYHINFIFYTMVKe 288
Cdd:cd15114   166 A-----IIRFLLGFLGPLVVIASCHGVllVRTWSRRRQKS-------RRTLKVVTAVVVGFFLCWTPYHVVGLIIAASA- 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 289 tiiSSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15114   233 ---PNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
58-330 8.93e-24

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 98.83  E-value: 8.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15970     7 YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVG-ISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMI 216
Cdd:cd15970    87 IYCLTVLSIDRYIAVVHPIKAARYRRPTVAKmVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEPSQRWLAVFV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIAWCTWKTTISLRQPPMAfQGISERQKALR----MVFMCAAVFFICFTPYHINFIFYTMVKE--TI 290
Cdd:cd15970   167 VYTFLMGFLLPVIAICLCYILIIVKMRVVALK-AGWQQRKRSERkitlMVMMVVTVFVICWMPFYVVQLVSVFVGQhdAT 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISSCPVVrialyfhpfclcLASLCCLLDPILYYFMASEFR 330
Cdd:cd15970   246 VSQLSVI------------LGYANSCANPILYGFLSDNFK 273
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-330 1.55e-23

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 98.30  E-value: 1.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15093     7 YAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMI 216
Cdd:cd15093    87 IFCLTVMSVDRYLAVVHPIKSARWRRpRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQWPEPAAAWSAGFI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIAWC----TWKTTISLRQPPMAFQGISERqKALRMVFMCAAVFFICFTPyhinfiFYTMVKETIIS 292
Cdd:cd15093   167 IYTFVLGFLLPLLIICLCylliVIKVKSAGLRAGWQQRKRSER-KVTRMVVMVVVVFVICWLP------FYVLQLVNVFV 239
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15093   240 QLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFK 277
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
59-330 3.27e-23

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 97.47  E-value: 3.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRI-YYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15922     8 SLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIaYFSLGSHWPFGQFLCQLKVFLLSTHMYGS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYKQMNAVALVGM 215
Cdd:cd15922    88 IYFLMLISIHRYVTVVHYNWKSLWKKKSFMkKLCLGVWLLLFVQGLPfFFVLKTSVIDGKTKCLSIHQSELSLLYFVWNF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVaeLAGFVIPVIIIAWC-TWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSC 294
Cdd:cd15922   168 VLL--ILGFLLPFGVSLTCyALLGASIAKMNSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESC 245
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1023300921 295 PV---VRIALYfhpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15922   246 TLlhkVEVAYY---ISWVLTGVNCCLDPLLYCFASEKFR 281
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
53-328 3.34e-23

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 97.14  E-value: 3.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKY 131
Cdd:cd15367     2 LFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIV-VGTACLPFPILR-STDLNNNKSCFADLGYK--- 205
Cdd:cd15367    82 ENIYISIGFLCCISVDRYLAVVHPFRFHAFRTmKAATLVSTVIWLKeLMTCVFFFLHGEiSKDKENHSVCFEHYPIKawe 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 -QMNAVALvgmitvaeLAGFVIPVIIIAWCTWKTTISLRQPpmafQGISERQKAL--RMVFMCAAVFFICFTPYHInfif 282
Cdd:cd15367   162 hNINYYRF--------YAGFLFPIFLLSFSYCRILRAVRKS----HGTQKSQKIQikRLVLSTVVIFLVCFGPYHI---- 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 283 YTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFmASE 328
Cdd:cd15367   226 LLLVRSVFERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCF-ASE 270
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
58-333 1.85e-22

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 95.12  E-value: 1.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYiSHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15182     7 YYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYH-SSGWIFGEILCKAVTSIFYIGFYSS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPIL---RSTDLNN----NKSCFADLGYKQMNA 209
Cdd:cd15182    86 ILFLTLMTIDRYLAVVHPLSALRSRKlRYASLVSVAVWVISILASLPELILstvMKSDEDGslceYSSIKWKLGYYYQQN 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VAlvgmitvaelagFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHInFIFYTMVKET 289
Cdd:cd15182   166 LF------------FLIPLGIIVYCYVRILQTLMRTRT-----MRKHRTVKLIFVIVLVFFLSWAPYNI-VIFLRSLKDL 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 290 IISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15182   228 TIPICECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
58-333 2.06e-22

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 95.21  E-value: 2.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNkAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15924     7 YTVIFFAGILLNGLAMWIFFHIPSKSS-FIIYLKNTVVADLLMILTFPFKILSDAGLGpWQLRTFVCRVTSVLFYFTMYT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPIL--RSTDLNNNKSCFA---DLGYKQMNAV 210
Cdd:cd15924    86 SIVFLGLISIDRYLKIVRPFKTSFPKSvSFAKILSVVVWALMFLLSLPNMILtnQQPREKNVKKCSFlksELGLKWHEIV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGM-ITVAELAGFVIPVIIIAWCTWKTTISLRQppmafQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15924   166 NYICQvIFWIVFLLMIVCYTAITKKVYRSYRRVFR-----SSSSRRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQTR 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 290 IISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15924   241 DVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
53-330 2.55e-22

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 95.36  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd14993     2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLvSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDW--KRRYDVGIsAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGY----- 204
Cdd:cd14993    82 VSVSASVLTLVAISIDRYLAICYPLKARRVstKRRARIII-VAIWVIAIIIMLPLLVVYELEEIISSEPGTITIYicted 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 205 ------KQMNAVALVGMItvaelagFVIPVIIIAWCTWKTTISL--RQPP---------MAFQGISERQKALRMVFMCAA 267
Cdd:cd14993   161 wpspelRKAYNVALFVVL-------YVLPLLIISVAYSLIGRRLwrRKPPgdrgsanstSSRRILRSKKKVARMLIVVVV 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 268 VFFICFTPYHINFIFYTMvkeTIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14993   234 LFALSWLPYYVLSILLDF---GPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFR 293
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
58-330 3.40e-22

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 94.64  E-value: 3.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15091     7 YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVG-ISAAIWIVVGTACLPFPILRSTDLNNNKSC------FADLGYKQMNAV 210
Cdd:cd15091    87 IFTLTMMSVDRYIAVCHPVKALDFRTPLKAKiINICIWLLSSSVGISAIVLGGTKVREDVDStecslqFPDDDYSWWDTF 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAelagFVIPVIIIAWCTWKTTISLRQPPMaFQGISERQKAL----RMVFMCAAVFFICFTPYHInfifYTMV 286
Cdd:cd15091   167 MKICVFIFA----FVIPVLIIIVCYTLMILRLKSVRL-LSGSREKDRNLrritRLVLVVVAVFVVCWTPIHI----FILV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 287 KETIISSCPVVRIALYFhpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15091   238 EALGSVSHSTAAVSSYY--FCIALGYTNSSLNPILYAFLDENFK 279
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
59-333 3.48e-22

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 94.44  E-value: 3.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd14991     8 ILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGeHWIFGEAWCRVNLFMLSVNRSAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKP-FRARDWKRRYDVGISAAIWIVVgtACLPFPILRSTDLNNNKSCFADLGYKQMNAVAL-VGM 215
Cdd:cd14991    88 IAFLTAVALDRYFKVVHPhHRVNRMSVKAAAGVAGLLWALV--LLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLsIRW 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTWKTTISL--RQPPMAFQGIserQKALRMVFMCAAVFFICFTPyHINFIFYTMVKETIISS 293
Cdd:cd14991   166 HNALFLLEFFLPLGLIVFCSVRIACNLriRQSLGKQARV---QRAIRLVFLVVIVFVLCFLP-SIIAGLLALVFKNLGSC 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 294 CPVVRIALYFHpFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14991   242 RCLNSVAQLFH-ISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
52-330 5.43e-22

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 94.21  E-value: 5.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLlCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARdWKRRYDVGISAAIWIVVGTACLPFPILRST---DLNNNKSC--FADLGYK 205
Cdd:cd15203    81 GVSIFVSTLTLTAIAIDRYQLIVYPTRPR-MSKRHALLIIALIWILSLLLSLPLAIFQELsdvPIEILPYCgyFCTESWP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 QMNAVALVGMITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQG------------ISERQKALRMVFMCAAVFFICF 273
Cdd:cd15203   160 SSSSRLIYTISVL--VLQFVIPLLIISFCYFRISLKLRKRVKKKRGkrtlssrrrrseLRRKRRTNRLLIAMVVVFAVCW 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 274 TPYHINFIFYTMVKETIISSCPVVRIALYFHpfclCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15203   238 LPLNLFNLLRDFEPLPQIDGRHFYLIFLICH----LIAMSSACVNPLLYGWLNDNFR 290
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
55-330 6.70e-22

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 93.99  E-value: 6.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLN 133
Cdd:cd15148     4 AVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNqWTLGPLLCKVVGNLFYMN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 134 MYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPFpILRSTDLNNNKSCF-----ADLGYKQM 207
Cdd:cd15148    84 MYISIILLGFISLDRYLKINRSSRRQKFlTRKWSIVACGVLWAVALVGFVPM-IVLTEKNEESTKCFqykdrKNAKGKAI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELAgFVIPVIIIAwctwKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMvK 287
Cdd:cd15148   163 FNFLIVAMFWLVFLL-LILSYGKIA----KKLLRISRDKPDFPNAAKYNRTARKSFFVLFIFTVCFVPYHAFRIFYIT-S 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 288 ETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15148   237 QLQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIR 279
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
60-329 7.09e-22

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 93.73  E-value: 7.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALW-VLCRfISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd15121     9 LAFILGFPGNLFVVWsVLCR-MKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMIT 217
Cdd:cd15121    88 FLITLMSMDRCLAVAKPFLSQKMRTKRSVrALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPSVGHEAFQYLFE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 218 VaeLAGFVIPVIIIAWCTwkTTISLRQPPMAFQgisERQKALRMVFMCAAVFFICFTPYHI-NFIFYTMVKETIISSCPV 296
Cdd:cd15121   168 T--ITGFLLPFTAIVTCY--STIGRRLRSARFR---RKRRTNRLVVLIIATFALFWLPYHVvNLIQVAGALQNQAGNASV 240
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1023300921 297 VRIALYFHPFCLCLASLCCLLDPILYYFMASEF 329
Cdd:cd15121   241 LKAAKLARPNVTALAFLSSSVNPVLYAFAGGSL 273
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
60-278 7.82e-22

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 93.70  E-value: 7.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASIC 139
Cdd:cd14975     9 LAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 140 FLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIW---IVVGTACLPFPILRSTdlNNNKSCFadlgYKQMNAVALVGM 215
Cdd:cd14975    89 LITLMSLERFLAVSRPFVSQGWRAKALAhKVLAIIWllaVLLATPVIAFRHVEET--VENGMCK----YRHYSDGQLVFH 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTwkTTISLRQPPMAFqgiSERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd14975   163 LLLETVVGFAVPFTAVVLCY--SCLLRRLRRRRF---RRRRRTGRLIASVVVAFAACWLPYHV 220
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
58-333 8.08e-22

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 93.65  E-value: 8.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCrFISKKNKAIIFMINLSVADLAHVLSLPLRI-YYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15119     7 YIVAFVLGVPGNAIVIWVTG-FKWKKTVNTLWFLNLAIADFVFVLFLPLHItYVALDFHWPFGVWLCKINSFVAVLNMFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGI-SAAIWIVVGTACLPFPILRST-DLNNNKS-CFAD-LGYKQMNAVAL 212
Cdd:cd15119    86 SVLFLTVISLDRYISLAHPVWSHRYRTLKSALIlCGIVWLSAAAISGPALYFRDTmELSINVTiCFNNfHKHDGDLIVMR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVAELA-GFVIPVIIIAWCTWKTTISLRQppmafQGISERQKALRMVFMCAAVFFICFTPYHInfifYTMVKETII 291
Cdd:cd15119   166 HTILVWVRFFfGFLFPLLTMVVCYSLLAIKVKR-----RTLLISSKFFWTISAVIVAFFVCWTPYHI----FSILELSIH 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 292 SSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15119   237 HSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
58-333 1.05e-21

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 93.32  E-value: 1.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRfISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15969     7 YLIIFIGSILLNGLAVWIFFH-IRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGlGPWNFNFFLCRYTSVLFYASMYT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPF-RARDWKRRYDVGISAAIWIVVGTACLPFPIL--RSTDLNNNKSCF---ADLGYKQMNAV 210
Cdd:cd15969    86 SIVFLGLISLDRYLKVVKPFgDSRMYSITFTKVLSACVWLIMAFLSLPNIILtnGQPTEDNIHDCSklkSPLGVKWHTAV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITvaelagFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQ-KALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15969   166 SYINICI------FVAVLVILIVCYISISRYIYKSSKQFISSSSRTrKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQLD 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 290 IISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15969   240 KILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
57-333 2.03e-21

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 92.49  E-value: 2.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMiNLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15117     6 IYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFL-NLAVADFAFCLFLPFSVVYTALgFHWPFGWFLCKLYSTLVVFNLF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNK-SCFADLGYKQMNAVALV 213
Cdd:cd15117    85 ASVFLLTLISLDRCVSVLWPVWARNHRTpARAALVAVGAWLLALALSGPHLVFRDTRKENGCtHCYLNFDPWNETAEDPV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAE-----------LAGFVIPVIIIAWCTwkttiSLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIF 282
Cdd:cd15117   165 LWLETVVqrlsaqvitrfVLGFLVPLVIIGGCY-----GLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLL 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 283 YTMVKETIISScpVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15117   240 ELVVILNQKED--LNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
56-278 3.22e-21

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 91.78  E-value: 3.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNM 134
Cdd:cd15366     5 TLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRdNWIHGPESCKLFGFIFYTNI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIV-VGTACLP-FPILRSTDLNNNKSCFADlgYKQMNAVA 211
Cdd:cd15366    85 YISIAFLCCISVDRYLAVAHPLRfAKVRRVKTAVAVSAVVWAIeIGANSAPlFHDELFRDRYNHTFCFEK--YPMEDWVA 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 212 LVGMITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQgiSERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15366   163 WMNLYRV--FVGFLFPWVLMLFSYRGILRAVRGNVSTEQ--QEKAKIKRLALSLIAIVLLCFAPYHV 225
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
52-333 3.39e-21

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 91.88  E-value: 3.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd14969     1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLlMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIvVGTACLPFPIL---RSTDLNNNKSCFADLGYKQM 207
Cdd:cd14969    81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWL-YGLFWALPPLFgwsSYVPEGGGTSCSVDWYSKDP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVaelAGFVIPVIIIAWCTWKTTISLRQ-----------PPMAFQGISERqKALRMVFMCAAVFFICFTPY 276
Cdd:cd14969   160 NSLSYIVSLFV---FCFFLPLAIIIFCYYKIYRTLRKmskraarrknsAITKRTKKAEK-KVAKMVLVMIVAFLIAWTPY 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 277 HInFIFYTMVKETIISSCPVVRIALYFhpfclclASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14969   236 AV-VSLYVSFGGESTIPPLLATIPALF-------AKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
58-333 4.52e-21

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 91.37  E-value: 4.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd14988     7 YLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVwMLEVMLDYTWLWGSFLCKFTHYFYFANMYS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLK--PFRARDWKRRYDVgISAAIWIVvgTACLPFPILRSTDL--NNNKSCFADLGYKQMNAVAL 212
Cdd:cd14988    87 SIFFLTCLSVDRYLTLTSssPFWQQHQHRIRRA-LCAGIWVL--SAIIPLPEVVHMQLldGVEPMCLFLAPFETYDEWAL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 -VGMITVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAfqgisERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETII 291
Cdd:cd14988   164 aVSLLTL--IIGFLIPFSIIAVFNVLTARYIRTAGRP-----ESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHIS 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 292 SSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14988   237 LHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
58-330 4.68e-21

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 91.46  E-value: 4.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15973     7 YALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMI 216
Cdd:cd15973    87 VFCLTVLSVDRYIAVVHPLRAARYRRpTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAWSAAFVIY 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVaeLAGFVIPVIIIAWCTWKTTISLRQPPMAfQGISERQKA----LRMVFMCAAVFFICFTPYHIN---FIFYTMVKET 289
Cdd:cd15973   167 TF--LLGFLLPVLAIGLCYILIIGKMRAVALK-AGWQQRRKSekkiTRMVLMVVTVFVICWMPFYVVqllNLFLPRLDAT 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 290 IISSCPVVRIAlyfhpfclclaslCCLLDPILYYFMASEFR 330
Cdd:cd15973   244 VNHASLILSYA-------------NSCANPILYGFLSDNFR 271
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
58-278 5.01e-21

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 91.38  E-value: 5.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15364     7 YSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHkWPWGSLACKITGYIFFCNIYI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGM 215
Cdd:cd15364    87 SILLLCCISIDRFVAVVYALESRGRRRqRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHTCFETLQMDTQVAGFYYAR 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 216 ITVaelaGFVIPVIIIAWCTWKTTISLRQPpmafQGISERQKALRMVFMCA--AVFFICFTPYHI 278
Cdd:cd15364   167 FCI----GFAIPLAILIFTNYRIFRSIQTS----TSLTPHQKAKVKYLAIAviVIFLICFAPYHL 223
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
53-333 9.89e-21

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 90.64  E-value: 9.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVL--CRFISKKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYL 129
Cdd:cd14976     2 LVSVVYMVVFTVGLLGNLLVLYLLksNKKLRQQSESNKFVFNLALTDLIFVLTLPFwAVEYALDFVWPFGTAMCKVVRYV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 130 KYLNMYASICFLTCISLQRCFFLLKPFRA-RDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLN--NNKSC-------- 198
Cdd:cd14976    82 TKLNMYSSIFFLTALSVTRYIAVARALKHgWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSsvNHTLCllrfpkns 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 199 FADLGYKQMNAVALVGMITvaelaGFVIPVIIIAWCtwkTTISLRQPPMAFQGISERQ-KALRMVFMCAAVFFICFTPYH 277
Cdd:cd14976   162 SVTRWYNWLGMYQLQKVVL-----GFFLPLGIITLS---YLLLLRFLQRKRGGSKRRKsRVTKSVFIVVLSFFICWLPNQ 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 278 INFIFYTMVKETIIS-SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14976   234 ALSLWSALIKFDDVPfSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
56-330 1.14e-20

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 90.20  E-value: 1.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15193     5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFwAASTALGGQWLFGEGLCKLSSFIIAVNR 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRstDLNNNKSCFADlgykqMNAVALV 213
Cdd:cd15193    85 CSSILFLTGMSVDRYLAVVKLLDSRPLRtRRCALITCCIIWAVSLVLGIPSLVYR--NLINESVCVED-----SSSRFFQ 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISE-RQKALRMVFMCAAVFFICFTPYH-INFIFYTMVKETII 291
Cdd:cd15193   158 GISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRrRRNSLRIVFAIVTAFVLSWLPFNtLKAVRLLLELGGGV 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1023300921 292 SSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15193   238 LPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
59-330 1.24e-20

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 89.85  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIShhwpfqRALCLLCFYLK----YLNM 134
Cdd:cd15163     8 TLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYS------AGNCLTCSFVHifsyFVNM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTacLPFPILrSTDLNNNKSCFADLgykqmnavalv 213
Cdd:cd15163    82 YCSILFLTCICVDRYLAIVQVEASRRWRNpNYAKGICVFIWLFAIV--VTFSIL-TTAIKFASCCLSKL----------- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAElagFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFytmvkeTIISS 293
Cdd:cd15163   148 FALTVFE---FFLPLLIITFFTIRIMCALSRPGLMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVA------VAFNP 218
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1023300921 294 CPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15163   219 DIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
58-330 1.37e-20

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 90.39  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15089     7 YSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVG-ISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMI 216
Cdd:cd15089    87 IFTLTMMSVDRYIAVCHPVKALDFRTPAKAKlINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSWYWDTVTK 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIAWCTWKTTISLRQPPMaFQGISERQKAL----RMVFMCAAVFFICFTPYHINFIFYTMVKetIIS 292
Cdd:cd15089   167 ICVFIFAFVVPILVITVCYGLMILRLRSVRL-LSGSKEKDRNLrritRMVLVVVAAFIICWTPIHIFVIVWTLVD--IDR 243
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 293 SCPVVRIALYfhpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15089   244 RNPLVVAALH---LCIALGYANSSLNPVLYAFLDENFK 278
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
60-330 1.76e-20

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 89.83  E-value: 1.76e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd15381     9 IIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFA-DLGYKQMNAVALVGMI 216
Cdd:cd15381    89 YFLMMVSIDRYLALVKTMSsGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITAcVLDYPSEGWHVALNIL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TvaELAGFVIPVIIIAWCTWKTTISLRQPPM-AFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCP 295
Cdd:cd15381   169 L--NVVGFLIPLSIITFCSTQIIQVLRNNKMqKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISGCR 246
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1023300921 296 VVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15381   247 WEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
58-278 1.78e-20

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 89.76  E-value: 1.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVL-CRFISKKNKAIIFMINLSVADLAHVLSLP-LRIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15376     7 LGVEFLVAVLGNGLALWLFvTRERRPWHTGVVFSFNLAVSDLLYALSLPlLAAYYYPPKNWRFGEAACKLERFLFTCNLY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVgtACLPFPILRstdlnnnkscFADLGYKQMNAVALVG 214
Cdd:cd15376    87 GSIFFITCISLNRYLGIVHPFFTRSHVRpKHAKLVSLAVWLLV--AALSAPVLS----------FSHLEVERHNKTECLG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELAGF------------VIPVII-------IAWCTWKTtislrqppmafQGIS--ERQKALRMVFMCAAVFFICF 273
Cdd:cd15376   155 TAVDSRLPTYlpyslflavvgcGLPFLLtlasylaIVWAVLRS-----------PGITtlEKRKVAALVAVVVALYAVSF 223

                  ....*
gi 1023300921 274 TPYHI 278
Cdd:cd15376   224 VPYHI 228
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
59-329 2.65e-20

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 89.34  E-value: 2.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15201     8 ILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGkHWKFGDIPCRIVLFMLAMNRAGS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWkrrydVGISAAIWIVVG------------------------TACLPFPILRSTDLN 193
Cdd:cd15201    88 IFFLTAVAVDRYFRVVHPHHRINS-----ISVRKAAIIACGlwlltiamtvylltkkhlfprgnaTQCESFNICTGTDSS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 194 NNkscfadlgykQMNAVALVGmitvaelagFVIPVIIIAWCTWKTTISLRQPPMAFQGisERQKALRMVFMCAAVFFICF 273
Cdd:cd15201   163 SN----------WHEAMFLLE---------FFLPLAIILYCSVRIIWQLRGRQLDRHA--KIKRAVQFIMVVAIVFIICF 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 274 TPYHINFIFYTMVKETIISSCPVVR---IALYfhpFCLCLASLCCLLDPILYYFMASEF 329
Cdd:cd15201   222 LPSNVTRIAIWILKHTSNEDCQYYRsvdLAFY---ITISFTYFNSMLDPVVYYFSSPSF 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
60-330 5.99e-20

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 88.29  E-value: 5.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd14971     9 LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPI---LRSTDLNNNKSC---FADLGYKQMNAVA 211
Cdd:cd14971    89 FTLVAMSLDRFLAVVYPLRSLHIRtPRNALAASGCIWVVSLAVAAPVLAlhrLRNYTPGNRTVCseaWPSRAHRRAFALC 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVgmitvaeLAGFVIPVIIIAWCTWKTTISLRQ----PPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd14971   169 TF-------LFGYLLPLLLICVCYAAMLRHLWRvavrPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGP 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 288 EtiisscPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14971   242 F------PLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
53-330 6.28e-20

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 88.32  E-value: 6.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15974     2 LIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVvgTACLPFPILRSTDLNNN-KSCfaDLGYKQMNAV 210
Cdd:cd15974    82 NQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRpRVAKLINATVWTL--SFLVVLPVIIFSDVQPDlNTC--NISWPEPVSV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQ---KALRMVFMCAAVFFICFTPYHINFIFYTMVk 287
Cdd:cd15974   158 WSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKserKVTRMVVIIVVVFVFCWLPFYMLNIVNLIV- 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 288 etIISSCPVVrIALYFhpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15974   237 --ILPEEPAF-VGVYF--FVVVLSYANSCANPILYGFLSDNFK 274
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
58-333 1.19e-19

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 87.53  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAI-IFMINLSVADLAHVLSLPLRIYYyISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15188     7 YTLVFLLGLAGNLLLFVVLLLYVPKKKKMTeVYLLNLAVSDLLFLVTLPFWAMY-VAWHWVFGSFLCKFVSTLYTINFYS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGM 215
Cdd:cd15188    86 GIFFVSCMSLDKYLEIVHAQSPHRLRtRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHTIWKLVF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGiserqKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCP 295
Cdd:cd15188   166 QFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQG-----RALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIGNCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 296 VVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15188   241 RSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
58-277 1.28e-19

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 87.51  E-value: 1.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd14987     7 YIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHnQWPMGEFTCKITHLIFSINLFG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQR----CFFLLKPFRARDWKRRYdvgISAAIWIVVGTACLP---FPILRSTDLNNNKSCFADLGYKQMNA 209
Cdd:cd14987    87 SIFFLTCMSVDRylsvTLFGNTSSRRKKIVRRI---ICVLVWLLAFVASLPdtyFLKTVTSPSNNETYCRSFYPEESFKE 163
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 vALVGMITVAELAGFVIPVIIIA--WCTWKTTISLrqppmafQGISERQKALRMVFMCAAVFFICFTPYH 277
Cdd:cd14987   164 -WLIGMELVSIVLGFVIPFPIIAvfYFLLARAISA-------SSDQERKSSRKIIFSYVVVFLVCWLPYH 225
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
55-333 1.91e-19

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 87.11  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd14999     3 GTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-----CFADLGYKQMNA 209
Cdd:cd14999    83 HASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSggskrICLPTWSEESYK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALvgmiTVAELAGFVIPVIIIAWCTWK--TTISLRQPPMAFQGISE--RQKALRMVFMCAAVFFICFTPYHINFIFYTM 285
Cdd:cd14999   163 VYL----TLLFSTSIVIPGLVIGYLYIRlaRKYWLSQAAASNSSRKRlpKQKVLKMIFTIVLVFWACFLPFWIWQLLYLY 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1023300921 286 VKETIISScpvvRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14999   239 SPSLSLSP----RTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
52-278 1.91e-19

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 86.72  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFI-SKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd14983     1 QLSLMVYVLTILLGLPSNLLALYAFVNRArLRLTPNVIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILR--------STDLNNNKSCFAD 201
Cdd:cd14983    81 FSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKpLYSCLVCVAIWALVIFHVTLVFILEtsggtldiNTPVGNSSTCYEN 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 202 LGYKQMNAVALVGMitVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQgisERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd14983   161 FTPEQLALLAPVRL--ELSLVLFFLPLAITAFCYVRCIRILVRSRLHER---RKRRAVRVAVSTLLTFVVCFGPYNI 232
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
55-330 1.93e-19

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 86.84  E-value: 1.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15092     4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVG-ISAAIWIVVGTACLPFPILRSTDLNNNK-SCFADLGYKQMNAVAL 212
Cdd:cd15092    84 FTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKvVNVCIWALASVVGVPVMVMGSAQVEDEEiECLVEIPTPQDYWDPV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVaeLAGFVIPVIIIAWCtWKTTISLRQPPMAFQGISERQKAL----RMVFMCAAVFFICFTPYHInfifytMVKE 288
Cdd:cd15092   164 FGICVF--LFSFIIPVLIISVC-YSLMIRRLRGVRLLSGSKEKDRNLrritRLVLVVVAVFVGCWTPIQI------FVLA 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 289 TIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15092   235 QGLGVQPSSETAVAILRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
58-330 2.22e-19

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 86.82  E-value: 2.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15971     7 YFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKsCFADLGYKQMNAVALVGMI 216
Cdd:cd15971    87 IFCLTVMSIDRYLAVVHPIKSAKWRKpRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGR-SSCTIIWPGESSAWYTGFI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFqGISERQKA----LRMVFMCAAVFFICFTPYhinFIFYTMVKETIIS 292
Cdd:cd15971   166 IYTFILGFFVPLTIICLCYLFIIIKVKSSGIRV-GSSKRKKSekkvTRMVSIVVAVFVFCWLPF---YIFNVSSVSVSIS 241
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 293 SCPVVRIALyfhPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15971   242 PTPGLKGMF---DFVVVLSYANSCANPILYAFLSDNFK 276
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
58-278 2.25e-19

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 86.74  E-value: 2.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15088     7 FGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDgQWYFGEVMCKIITALDANNQFT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRY-DVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFAdlGYKQMNAVALVGM 215
Cdd:cd15088    87 STYILTAMSVDRYLAVVHPIRSTKYRTRFvAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFC--YVSLPSPDDLYWF 164
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAELAGFVIPVIIIAWC-------TWKTTISLRQPPmafqGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15088   165 TIYHFILGFAVPLVVITVCyililhrLARGVAPGNQSH----GSSRTKRVTKMVILIVVVFIVCWLPFHV 230
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
58-333 2.50e-19

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 86.73  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHhWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15181     7 YSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG-WVFGTFLCKLVGAIHKLNFYCS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVGISA-AIWIVVGTACLPFPILR--STDLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15181    86 SLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCgSIWLVCFLLSLPNLVFLevETSTNANRTSCSFHQYGIHESNWWLT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQgiseRQKALRMVFMCAAVFFICFTPYHINFIFYTMVK-ETIISS 293
Cdd:cd15181   166 SRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSRRLQ----KQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDlKAVVKN 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 294 CPV---VRIALYFHPFclcLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15181   242 CKLndlLDAAITVTES---LGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
58-333 2.59e-19

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 86.83  E-value: 2.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNkAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15149     7 YSLVFIVGILLNGVNFWIFFYVPSNKS-FIVYLKNIVFADLLMSLTFPFKILSDVElGPWQLNVIVCRYSAVIFYLNMYV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPIL--RSTDLNNNKSCF---ADLGYK--QMN 208
Cdd:cd15149    86 GIIFFGLIGFDRYYKIVKPLHTSFVQNvGYSKALSVVVWMLMAVLSVPNIILtnQSFHEANYTKCArlkSELGIQwhKAS 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVaelagfVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15149   166 NYICVSIFWV------VFLLLIIFYVAISRKIYKSNQKFRRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPYTLSQT 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 289 TIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15149   240 GADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
53-330 5.44e-19

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 85.77  E-value: 5.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAI-IFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLK 130
Cdd:cd15170     2 LVLAVYIITFLIGLPANLLAFYTFIRKVRRKPTPIdILLLNLTVSDLIFLLFLPFKMAEAASGmIWPLPYFLCPLSSFIF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTAC---------LPFPilrSTDLNNNKSCFA 200
Cdd:cd15170    82 FSTIYISTLFLTAISVERYLGVAFPIKYKLRRRpLYAVIASVFFWVLAFSHCsivyiveyhIDSE---NTSVTNNSRCYD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 201 DLGYKQMNAVALVGMITVAELagFVIPVIIIAWCTWK-TTISLRQPPMAFQgisERQKALRMVFMCAAVFFICFTPYHIN 279
Cdd:cd15170   159 NFTPEQLKILLPVRLELFLVL--FCIPFLITCFCYINfIRILSSLPHISRQ---RKQRAIGLAVATLLNFIVCFAPYNIS 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1023300921 280 FIFYTMVKETiisscPVVRI-ALYFHPFclclaslCCLLDPILYYFMASEFR 330
Cdd:cd15170   234 HVVGFIQRKS-----PEWRMyALLLSTL-------NACLDPIIFYFSSSAVR 273
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
54-333 6.46e-19

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 85.58  E-value: 6.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYL 132
Cdd:cd15167     3 FTYFYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGiAPWKLKIFHCQVTACLIYI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLP---FPIlRSTDLNNNKSCfADLGYK-QM 207
Cdd:cd15167    83 NMYLSIIFLGFVSIDRYLQLTHSSKlYRIQEPGFAKMISAVVWTLVLFIMVPnmaIPI-KTIEEKPGVGC-ADFKTEfGR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPpmafQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVK 287
Cdd:cd15167   161 HWHVLTNFICMAIFLNFSAIILISNFLVIRKLYRNKDS----EEYRNARQALVNILLVTAGYVICFVPYHIVRIPYTLSQ 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 288 ETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15167   237 SEVITDCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
53-278 3.39e-18

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 83.29  E-value: 3.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLcRFISKKNKAIIFMINLSVADLAHVLSLP-LRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15120     2 LIAVALFVTFLVGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPfMAVHVLMDNHWAFGTVLCKVLNSTLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGY------ 204
Cdd:cd15120    81 VGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTnRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYalstnw 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 205 --KQMNAVAL---VGMITVAELAGFVIPVIIIAWCTwkTTISLRqppMAFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15120   161 esAEVQASRQwihVAMFVFRFLLGFLLPFLIITFCY--VRMALK---MKERGLARSSKPFKVMFTAVVSFFVCWLPYHL 234
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
58-333 3.72e-18

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 83.20  E-value: 3.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIsHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15180     7 YSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAV-HGWIFGTGLCKLAGAVFKINFYCG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVGISA-AIWIVVGTACLP-FPILRST-DLNNNKS-C---FADLGYKQMNAV 210
Cdd:cd15180    86 IFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSClIVWLFCLLLSIPdFIFLEATkDPRQNKTeCvhnFPQSDTYWWLAL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMItvaelAGFVIPVIIIAWCTWKTTISLRQPPMAFQgiseRQKALRMVFMCAAVFFICFTPYHINFIFYTMVK-ET 289
Cdd:cd15180   166 RLLYHI-----VGFLLPLAVMVYCYTSILLRLLRSSQGFQ----KQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDlSV 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 290 IISSCPV---VRIAL-------YFHpfclclaslcCLLDPILYYFMASEFRDQL 333
Cdd:cd15180   237 LDRNCGTesrLDIALsvtsslgYFH----------CCLNPLLYAFVGVKFRRKL 280
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
53-333 4.68e-18

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 82.94  E-value: 4.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNkAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKY 131
Cdd:cd15150     2 IFPLLYTVLFIVGLTMNGLAMRVFFQIPSKSN-FIIFLKNTVISDLLMILTFPFKILSDAKlGSWPLRGFVCQVTSVIFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGI-SAAIWIVVGTACLPFPIL--RSTDLNNNKSCF---ADLGYK 205
Cdd:cd15150    81 FTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKIlSTVIWASMFALSLPNMILtnRQPTPKNVKKCSllkSEFGLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 QMNAVALVGMITvaelagFVIPVIIIAWCTWKTTISLRQP--PMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFY 283
Cdd:cd15150   161 WHEIVNYICQVI------FWVNFLIVIVCYTLITKELYKSykRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARIPY 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1023300921 284 TMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15150   235 TLSQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
58-330 5.95e-18

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 82.73  E-value: 5.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15090     7 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVGI-SAAIWIVVGTACLPFPILRSTDLNNNKS----CFADLGYKQMNAVAL 212
Cdd:cd15090    87 IFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIvNVCNWILSSAIGLPVMFMATTKYRQGSIdctlTFSHPSWYWENLLKI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITvaelaGFVIPVIIIAWCTWKTTISLRQPPMaFQGISERQKAL----RMVFMCAAVFFICFTPYHInfifYTMVKe 288
Cdd:cd15090   167 CVFIF-----AFIMPVLIITVCYGLMILRLKSVRM-LSGSKEKDRNLrritRMVLVVVAVFIVCWTPIHI----YVIIK- 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 289 TIISSCPVVRIALYFHpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15090   236 ALVTIPETTFQTVSWH-FCIALGYTNSCLNPVLYAFLDENFK 276
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
56-333 7.52e-18

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 82.51  E-value: 7.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15369     5 SVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSgNDWLFGEAMCRVVTAAFYCNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRST----DLNNNkSCFaDLGYKQMNA 209
Cdd:cd15369    85 YCSILLMTCISVDRFLAVVYPMQSLSWRTlRRASFTCAAIWLLSIAGVVPLLLSEQTiqipDLGIT-TCH-DVLNEQLLM 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITVAELAGFVIPVIIIAWCTWKTTISLRqppmAFQGISERQKALRMVFMCAAV---FFICFTP------YHINF 280
Cdd:cd15369   163 GYYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLS----SSSDVANSSKKTRALFMAVAVfcvFVICFGPtnvlllAHYVR 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 281 IFYTMVKEtiisscpvvriALYF-HPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15369   239 FAYTSTND-----------ASYFaYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
53-281 8.84e-18

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 82.15  E-value: 8.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIiFMINLSVADLAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKY 131
Cdd:cd15371     2 LIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTAI-FYANLAISDLLFCITLPFKIVYHLNgNNWVFGETMCRIITITFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPFPILRST---DLNNNKSCFADLGYKQM 207
Cdd:cd15371    81 GNMYCSILLLTCISINRYLAIVHPFIYRSLpKKTYAVLICALVWTIVFLYMLPFFILKQTyylKELNITTCHDVLPECEQ 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 208 NAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISerqKALRMVFMcaaVFFICFTPYHINFI 281
Cdd:cd15371   161 NSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTLNAYEHKWFWYV---KITALVLI---IFTICFAPSNVILI 228
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
56-330 9.71e-18

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 82.45  E-value: 9.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15195     5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFfNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAiWIVVGTACLP----FPILRSTDLNNNKSCFADLGY----KQ 206
Cdd:cd15195    85 YLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVA-WVLSALCSIPqsfiFSVLRKMPEQPGFHQCVDFGSaptkKQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 207 MNAVALVGMItvaelAGFVIPVIIIAWC----------TWKTTISLRQPPMAFQGISE----RQKALRMVFMCAAVFFIC 272
Cdd:cd15195   164 ERLYYFFTMI-----LSFVIPLIITVTCyllilfeiskMAKRARDTPISNRRRSRTNSleraRMRTLRMTALIVLTFIVC 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1023300921 273 FTPYHINFIFYTMVKETIISSCPVVRIAL----YFHPfclclaslccLLDPILYYFMASEFR 330
Cdd:cd15195   239 WGPYYVLGLWYWFDKESIKNLPPALSHIMfllgYLNP----------CLHPIIYGVFMKEIR 290
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
54-331 1.04e-17

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 81.94  E-value: 1.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15001     2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVfCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDW-----KRRydvgISAAIWIvvGTACLPFPILRSTDLNNNKSCFADLGYKQM 207
Cdd:cd15001    82 SFICSVLTLTAISIERYYVILHPMKAKSFctigrARK----VALLIWI--LSAILASPVLFGQGLVRYESENGVTVYHCQ 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELAGFV----IPVIIIAWCtwkttislrqppmafQGISERQKALRMVFMCAAVFFICFTPYHINFIFY 283
Cdd:cd15001   156 KAWPSTLYSRLYVVYLAIviffIPLIVMTFA---------------YARDTRKQVIKMLISVVVLFAVCWGPLLIDNLLV 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1023300921 284 TM--VKETIISSCPVVRIALYFHPFclclasLCCLLDPILYYFMASEFRD 331
Cdd:cd15001   221 SFdvISTLHTQALKYMRIAFHLLSY------ANSCINPIIYAFMSKNFRS 264
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-330 1.17e-17

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 82.13  E-value: 1.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLP---LRIYYYIShhWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15189     8 FSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPfwaMNILNQFN--WPFGELLCRVVNGVIKVNLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDL---NNNKSCFADLGYKQMNAVA 211
Cdd:cd15189    86 TSIYLLVMISQDRYLALVKTMAARRLRRrRYAKLICVLIWVVGLLLSIPTFLLRKIKAipdLNITACVLLYPHEAWHFAH 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVGMITVaelaGFVIPVIIIAWCTWKTTISLRQPPMA-FQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15189   166 IVLLNIV----GFLLPLLVITFCNYNILQALRTREEStRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGV 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15189   242 LDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
58-333 5.55e-17

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 79.80  E-value: 5.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPlriYYYI--SHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15174     7 YWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLP---FWATaaSSGWVFGTFLCKVVNSMYKINFY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRR---YDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSC---FADLGYKQMN 208
Cdd:cd15174    84 SCMLLLTCISVDRYIAIVQATKAHNSKNKrllYSKLVCFFVWLLSTILSLPeILFSQSKEEESVTTCtmvYPSNESNRFK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVaelaGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15174   164 VAVLALKVTV----GFFLPFVVMVICYTLIIHTLLQAKR-----FQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAY 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 289 TI-ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15174   235 NItITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
52-333 6.61e-17

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 79.84  E-value: 6.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIShHWPFQRALCLLCFYLKY 131
Cdd:cd15187     1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLD-QWVFGNAMCKIVSGAYY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPIL-RSTDLNNNKSCFADlgYKQMNA 209
Cdd:cd15187    80 IGFYSSMFFITLMSIDRYLAIVHAVYALKVRTaSHGTILSLALWLVAILASVPLLVFyQVASEDGRLQCIPF--YPGQGN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15187   158 SWKVFTNFEVNILGLLIPFSILIFCYHNILRNLRRCHN-----QNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLH 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 290 IISSCPVV-RIALYFHpFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15187   233 IIDGCQNSqRLTLALH-LTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
53-330 1.27e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 78.37  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd14967     1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIS-AAIWIVVGT-ACLPFPILRSTDLNNNKSCFADLGYKQmna 209
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMiAAVWVYSLLiSLPPLVGWRDETQPSVVDCECEFTPNK--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 valvGMITVAELAGFVIPVIIIAWCTWKTtislrqppmaFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMvket 289
Cdd:cd14967   158 ----IYVLVSSVISFFIPLLIMIVLYARI----------FRVARRELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF---- 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 290 iissCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14967   220 ----CPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFR 256
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
62-332 1.66e-16

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 78.66  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  62 FIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNMYASICF 140
Cdd:cd15200    11 FVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTASIVF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 141 LTCISLQRCFFLLKPFRARDwkrRYDVG----ISAAIWIVVgtACLPFPILRSTDLNNNKSCFA-DLGYKQMNAVALVGM 215
Cdd:cd15200    91 LTAIALNRYLKVVHPHHQLS---KASVGcaakVAAGLWILI--LLLNIHLLLLDHVQSNSTCLSyDHGTDPSASDRWHRI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAElagFVIPVIIIAWCTWKTTISLRQPPMAFQgiSERQKALRMVFMCAAVFFICFTPyHINFIFYTMVKETIISSCP 295
Cdd:cd15200   166 LFFLE---FFLPLGIILFCIFSIILTLKQRKLAKQ--AGPQRAVKVLAVIVLVYTVCFLP-SILFALASLVAFKVSQCRS 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1023300921 296 VVRIALYFHPfCLCLASLCCLLDPILYYFMASEFRDQ 332
Cdd:cd15200   240 LDLCTQLFHG-SLAFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
54-330 2.12e-16

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 78.30  E-value: 2.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYL 132
Cdd:cd15199     3 YASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNrWSLGGGTCKALLFMLSL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKP-FRARDWKRRYDVGISAAIWI-VVGTAClpfPILRSTDLNNNKSCFAdLGYKQMNAV 210
Cdd:cd15199    83 SRGVSIAFLTAVALDRYFRVVHPrGKKNSLSLQAAPYISFLVWLlLVGLTI---PTLLASQPKNFTECNS-FSPKDDEDF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAgFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKetI 290
Cdd:cd15199   159 SDTWQEAVFFLQ-FLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQRAMALVTSVVVVFGFCFLPCFLARVLMLIFQ--N 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15199   236 KESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
58-330 2.58e-16

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 78.24  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15087     7 YSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDVG---ISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15087    87 IYFLTVMSVDRYLVVLATVRSRRMPYRTYRAakiVSLCVWLLVTIIVLPFTVFAGVYSNELGRKSCVLSFPSPESLWFKA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELAGFVIPVIIIawCTWKTTISLRQPPMAFQGISE-----RQKALRMVFMCAAVFFICFTPYHINFIfytMVKET 289
Cdd:cd15087   167 SRIYTLVLGFAIPVSTI--CILYTMMLYKLRNMRLNSNAKaldkaKKKVTLMVLVVLAVCLFCWTPFHLSTV---VALTT 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 290 IISSCPVVRIALYfhpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15087   242 DLPQTPLVIGISY---FITSLSYANSCLNPFLYAFLDDSFR 279
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
58-330 4.75e-16

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 77.49  E-value: 4.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSaaLWVLCRFISKKNKAI--IFMINLSVADLAHVLSLPLRIYYYiSHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15172     7 YSLICVVGLIGNS--LVVITYAFYKRTKSMtdVYLLNMAIADILFVLTLPFWAVYE-AHQWIFGNFSCKLLRGIYAINFY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLL---KPFRARDWKRRYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYkQMNAVA 211
Cdd:cd15172    84 SGMLLLACISVDRYIAIVqatKSFRLRSRTLAYSKLICAAVWLLAILISLPtFIFSEVYDFGLEEQYVCEPKY-PKNSTA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVG---MITVAELAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKe 288
Cdd:cd15172   163 IMWkllVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQN-----SQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINL- 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 289 TIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15172   237 GEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
59-333 6.12e-16

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 76.79  E-value: 6.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKyLNMYASI 138
Cdd:cd14989     8 IFLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQ-INMYSSI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKRRYDVGISAA-IWIV-VGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALvgmi 216
Cdd:cd14989    87 FFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGlIWMAsISATLLPFTAVQAQHTGEVHFCFADVREIQWLEVTL---- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 tvaelaGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHInFIFYTMVKETIISSCPV 296
Cdd:cd14989   163 ------GFIIPFSIIGLCYSLIVRVLVRAQKHRRLRPRRQKALRMILVVVLVFFICWLPENV-FISIQLLQGTQEPSESY 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 297 VRIALYFHPFC----LCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14989   236 DESFRHNHPLTghivNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
58-333 1.12e-15

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 76.01  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15166     7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRST--DLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15166    87 LWLLAFISADRYMAIVQPKHAKELKNtPKAVLACVGVWIMTLASTFPLLFLYEDpdKASNFTTCLKMLDIIHLKEVNVLN 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELagFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFyTMVKETIISSC 294
Cdd:cd15166   167 FTRLIFF--FLIPLFIMIGCYLVIIHNLVHGRTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAF-LMLQNGDNSYN 243
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1023300921 295 PvvrialyFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15166   244 P-------WAAFTTFLMNLSTCLDVILYYIVSKQFQARV 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
53-330 1.31e-15

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 76.18  E-value: 1.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15390     2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLiSAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRyDVGISAAIWIVVGTACLPFPILRST------DLNNNKSCFADL--- 202
Cdd:cd15390    82 TTVAASVFTLMAISIDRYIAIVHPLRPRLSRRT-TKIAIAVIWLASFLLALPQLLYSTTetyyyyTGSERTVCFIAWpdg 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 203 GYKQMNAVALVGMITVAelagFVIPVIIIAWC-------TWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTP 275
Cdd:cd15390   161 PNSLQDFVYNIVLFVVT----YFLPLIIMAVAytrvgveLWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 276 YHINFIfYTMVKETIISSCPV--VRIALYFhpfclcLASLCCLLDPILYYFMASEFR 330
Cdd:cd15390   237 YHLYFI-LTYLYPDINSWKYIqqIYLAIYW------LAMSNSMYNPIIYCWMNKRFR 286
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
82-333 1.64e-15

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 75.70  E-value: 1.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  82 KKNKAIIFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARD 160
Cdd:cd15926    32 KKSSINLFVTSLAVTDFQFVLTLPFwAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 161 WKRRYDVG-ISAAIWIVVGTACLPFPILRST-DLNNNKSCFADLGYKQMNAVALVGMITVAE-LAGFVIPVIIIAWCTWK 237
Cdd:cd15926   112 RRGCCSAKwLCVLIWVLAILASLPNAIFSTTaTVSNEELCLVKFPDNRGNAQFWLGLYHAQKvLLGFLIPLGIISLCYLL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 238 TTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIIS-SCPVVRIALYFHPFCLCLASLCCL 316
Cdd:cd15926   192 LVRFITDKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPNQALTTWGILIKLNVVHfSYEYFTTQVYIFPITVCLAHSNSC 271
                         250
                  ....*....|....*..
gi 1023300921 317 LDPILYYFMASEFRDQL 333
Cdd:cd15926   272 LNPILYCLMRREFRKAL 288
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
56-302 2.64e-15

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 75.43  E-value: 2.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAI-IFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLN 133
Cdd:cd15382     5 IVYSVLFLIAAVGNLTVLLILLRNRRRKRSRVnILLMHLAIADLlVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 134 MYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAiWIVVGTACLPFPILRSTDLNNNKSCFADL-------GYKQ 206
Cdd:cd15382    85 LYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVA-WVISFLCSIPQSFIFHVESHPCVTWFSQCvtfnffpSHDH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 207 MNAVALVGMITVaelagFVIPVIIIAWC-------------TWKTTISLRQPPMAFQGIS------ERQKALRMVFMCAA 267
Cdd:cd15382   164 ELAYNIFNMITM-----YALPLIIIVFCyslilceisrkskEKKEDVSEKSSSVRLRRSSvgllerARSRTLKMTIVIVL 238
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1023300921 268 VFFICFTPYHINFIFYTMVKETIISSCPVVRIALY 302
Cdd:cd15382   239 VFIICWTPYFIMSLWYWFDRESASKVDPRIQKGLF 273
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
56-330 4.45e-15

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 74.45  E-value: 4.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIY-YYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15380     5 TFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAEnIRNQFNWPFGNFLCRVISGVIKANL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIWIVVGTACLPFPILRST----DLNNNkSCFADLGYKQMNA 209
Cdd:cd15380    85 FISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAqVICLLIWVFGGLLSIPTFLFRSVkhvpDLNIS-ACILLFPHEAWHF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITVaelaGFVIPVIIIAWCTWKTTISLRQPPMA----FQGISErQKALRMVFMCAAVFFICFTPYHINFIFYTM 285
Cdd:cd15380   164 ARRVELNIV----GFLLPLAAIVFFNFHIIASLRERTEEsrkrCGGLKD-TKATRLILTLVLMFLVCWTPYHFFAFLDFL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 286 VKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15380   239 FQVEVIQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
58-333 6.41e-15

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 74.10  E-value: 6.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIShHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15186     7 YSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLIN-EWGLHNAMCKLTTAFFFIGFFGG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCF-FLLKPFRARDWKRRYDVGISAAIW---IVVGTACLPFPILRSTDlnnnksCFADLGYKQMNAVALV 213
Cdd:cd15186    86 IFFITVISIDRYLaIVLAANSMNNRTVQHGVTISLGVWaaaILVAVPQFMFTKMKENE------CLGDYPEVLQEIWPVL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVaELAGFVIPVIIIAWCTW---KTTISLRQppmafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15186   160 RNVEL-NFLGFLLPLLIMSYCYFriiQTLFSCKN--------HKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDF 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 291 ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15186   231 FPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
53-333 6.51e-15

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 74.05  E-value: 6.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRfISKKNKAIIFMINLSVADLAHVLSLPLRIYYYiSHHWPFQ-RAL-CLLCFYLK 130
Cdd:cd15151     2 VFPVLYTVLFLVGLILNSVAAWIFFH-IPSTSTFIVYLKNTLVADLIMTLMLPFKILSD-SGLGPWQlRAFvCRFSAVVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRaRDWKRRYDVG--ISAAIWIVVGTACLPFPIL--RSTDLNNNKSCFADLGYKQ 206
Cdd:cd15151    80 YITMYISIILLGLISFDRYLKIVRPFG-KSWVQRVRFAkiLSGAVWLVMFLLSVPNMILsnKPATPISVKKCASLKSPLG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 207 MNAVALVGMI-TVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKAlrMVFMCAAVFFICFTPYHINFIFYTM 285
Cdd:cd15151   159 LKWHEVVNYIcQFIFWGVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKA--KVFIIVAVFFVCFAPFHFVRVPYTL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1023300921 286 VKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15151   237 SQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
58-333 7.17e-15

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 73.71  E-value: 7.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15185     7 YSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKP-FRARDWKRRYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYKQMNAVALVGM 215
Cdd:cd15185    87 IFFIILLTIDRYLAIVHAvFALRARTVTFGIITSIITWGLAVLAALPeFIFYETQELFEEFLCSPLYPEDTEDSWKRFHA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVaELAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCP 295
Cdd:cd15185   167 LRM-NIFGLALPLLIMVICYTGIIKTLLRCPS-----KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 296 VVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15185   241 RSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
53-333 7.37e-15

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 73.75  E-value: 7.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAI-IFMINLSVADLAHVLSLPL-RIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15925     2 LVALAYGLVCAIGLLGNLAVMYLLRNCARRAPPPIdVFVFNLALADFGFALTLPFwAVESALDFHWPFGGAMCKMVLTAT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQR-CFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRST-DLNNNKSCFADLGYKQMN 208
Cdd:cd15925    82 VLNVYASVFLLTAMSVTRyWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEgEVCGVELCLLKFPSNYWL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAelagFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15925   162 GAYHLQRVVVA----FVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKF 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 289 TIIS-SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15925   238 RAVPwNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
56-278 8.79e-15

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 73.91  E-value: 8.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15083     5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDfLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARdWK--RRYDVGISAAIWIVVGTACLPfPIL---RSTDLNNNKSCFADlgYKQMNA 209
Cdd:cd15083    85 IMSINTLAAIAVDRYLVITRPMKAS-VRisHRRALIVIAVVWLYSLLWVLP-PLFgwsRYVLEGLLTSCSFD--YLSRDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITVAeLAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQ----------------KALRMVFMCAAVFFICF 273
Cdd:cd15083   161 ANRSYVICLL-IFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFskselsspkarrqaevKTAKIALLLVLLFCLAW 239

                  ....*
gi 1023300921 274 TPYHI 278
Cdd:cd15083   240 TPYAV 244
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
57-330 1.16e-14

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 73.54  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNM 134
Cdd:cd14979     6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWWQYpWAFGDGGCKLYYFLFEACT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVG-ISAAIWIVVGTACLPFPILRSTDlNNNKSCFADLGYKQM-----N 208
Cdd:cd14979    86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKrFILAIWLVSILCAIPILFLMGIQ-YLNGPLPGPVPDSAVctlvvD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELAGFVIPVIIIAWC-------TWKTTISLRQPPMAFQG---ISERQKALRMV--FMCA--AVFFICFT 274
Cdd:cd14979   165 RSTFKYVFQVSTFIFFVLPMFVISILyfrigvkLRSMRNIKKGTRAQGTRnveLSLSQQARRQVvkMLGAvvIAFFVCWL 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1023300921 275 PYHINFIFYTMVKEtiiSSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14979   245 PFHAQRLMFSYASK---EDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
60-330 1.57e-14

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 72.84  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRfiSKKNKAI----IFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15098     9 LIFCLGVLGNSLVITVLAR--VKPGKRRsttnVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSM 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLP----FPILRSTDLNNNKSCFADLGYKQMNA 209
Cdd:cd15098    87 LVSIFTLVAMSVDRYIAVVHSRTSSSLrTRRNALLGVLVIWVLSLAMASPvavhQDLVHHWTASNQTFCWENWPEKQQKP 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITVaelaGFVIPVIIIAWCTWKTTISLRQPP--MAFQGISERQKALRMVFMCAAVFFICFTPYHInfifYTMVK 287
Cdd:cd15098   167 VYVVCTFVF----GYLLPLLLITFCYAKVLNHLHKKLknMSKKSERSKKKTAQTVLVVVVVFGISWLPHHI----IHLWV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 288 EtiISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15098   239 E--FGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
58-330 2.64e-14

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 72.08  E-value: 2.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIsHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15176     7 YTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAV-NGWVLGTAMCKITSALYTMNFSCG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRcFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-CFADlgYKQMNAVALVGMI 216
Cdd:cd15176    86 MQFLACISVDR-YVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYrCLPV--FPPSLVTSAKATI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAE-LAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHI-NFIFYTMVKETIISSC 294
Cdd:cd15176   163 QILEvLLGFVLPFLVMVFCYSRVARALSRTPN-----VKKSRALKVLLAVVGVFIVTQLPYNVvKFYRAIDVIYLLITDC 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 295 PVVR-----------IALyFHpfclclaslcCLLDPILYYFMASEFR 330
Cdd:cd15176   238 SMSKtldiaiqvtesIAL-FH----------SCLNPVLYVFMGASFK 273
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
57-330 2.92e-14

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 72.32  E-value: 2.92e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIY-YYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd14997     6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPVALVeTWAREPWLLGEFMCKLVPFVELTVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWIVVGTACLP---FPILRSTDLNNNKScfADLGYKQMNAV 210
Cdd:cd14997    86 HASVLTILAISFERYYAICHPLQAKYvCTKRRALVIIALIWLLALLTSSPvlfITEFKEEDFNDGTP--VAVCRTPADTF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRM------VFMCAAV---FFICFTPY---HI 278
Cdd:cd14997   164 WKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAANRHTLrsrrqvVYMLITVvvlFFVCLLPFrvvTL 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1023300921 279 NFIF------YTMVKETIISSCPVVRIALYFHpfclclaslcCLLDPILYYFMASEFR 330
Cdd:cd14997   244 WIIFapdedlQALGLEGYLNLLVFCRVMVYLN----------SALNPILYNLMSTKFR 291
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
57-330 3.06e-14

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 72.14  E-value: 3.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15972     6 VYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNkSCfaDLGYKQMNAVALVGM 215
Cdd:cd15972    86 SIFCLTVMSVDRYLAVVHPIRSSKWRKpPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG-TC--HIAWPEPAQVWRAGF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISER-----QKALRMVFMCAAVFFICFTPYHInfifYTMVKETI 290
Cdd:cd15972   163 IIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKrrgseRKVTRMVVIVVAAFVLCWLPFYA----LNIVNLVC 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISSCPVVRIALYFhpFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15972   239 PLPEEPSLFGLYF--FVVVLSYANSCANPIIYGFLSDNFK 276
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
58-333 3.67e-14

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 73.12  E-value: 3.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLcrfISKKNKAI--IFMINLSVADLAHVLSLPLRIYYYISHhWPFQRALCLLCFYLKYLNMY 135
Cdd:PHA02638  105 YIIIFILGLFGNAAIIMIL---FCKKIKTItdIYIFNLAISDLIFVIDFPFIIYNEFDQ-WIFGDFMCKVISASYYIGFF 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWkRRYDVGISAAI--WIVVGTACLP-----------FPILRSTDLNNNKSCFADL 202
Cdd:PHA02638  181 SNMFLITLMSIDRYFAILYPISFQKY-RTFNIGIILCIisWILSLIITSPayfifeasniiFSAQDSNETISNYQCTLIE 259
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 203 GYKQMNAVALVGMITVA-ELAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:PHA02638  260 DNEKNNISFLGRILQFEiNILGMFIPIIIFAFCYIKIILKLKQLKK-----SKKTKSIIIVSIIIICSLICWIPLNIVIL 334
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1023300921 282 FYTMVK----ETIISS--CPVVRIAlYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:PHA02638  335 FATMYSfkgfNSIISEhiCGFIKLG-YAMMLAEAISLTHCCINPLIYTLIGENFRMHL 391
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
52-330 4.23e-14

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 71.62  E-value: 4.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIY-YYISHHWPFQRALCLLCFYL 129
Cdd:cd15392     1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDiLMAVFCVPFSFIaLLILQYWPFGEFMCPVVNYL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 130 KYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPFPILRSTDLNNNKSC--------FAD 201
Cdd:cd15392    81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLI-AVIWIFALATALPIAITSRLFEDSNASCgqyictesWPS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 202 LGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWkttiSLRQPPMAF----QGISE-RQKALRMVFMCAAVFFICFTPY 276
Cdd:cd15392   160 DTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVW----AKRTPGEAEnnrdQRMAEsKRKLVKMMITVVAIFALCWLPL 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 277 HInFIFYTMVKETIISSCPVVRIALYFHpfclCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15392   236 NI-LNLVGDHDESIYSWPYIPYLWLAAH----WLAMSHCCYNPFIYCWMNAKFR 284
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
58-333 4.47e-14

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 71.44  E-value: 4.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15183     7 YSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKP-FRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLN-NNKSCFADLGYKQMNAVALVGM 215
Cdd:cd15183    87 IFFIILLTIDRYLAIVHAvFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEfTHHTCSAHFPRKSLIRWKRFQA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVaELAGFVIPVIIIAWC-TWKTTISLRQPPmafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSC 294
Cdd:cd15183   167 LKL-NLLGLILPLLVMIICyTGIINILLRRPN------EKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSC 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1023300921 295 PVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15183   240 EQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
55-330 4.56e-14

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 71.74  E-value: 4.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15094     4 AVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKSC---FADLGYKQMNA 209
Cdd:cd15094    84 FTSSFTLTVMSADRYLAVCHPIRSMRYRTpFIAKVVCATTWSISFLVMLPiILYASTVPDSGRYSCtivWPDSSAVNGQK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 ValvgMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISER---QKALRMVFMCAAVFFICFTPYHINFIFYTMV 286
Cdd:cd15094   164 A----FTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRrshRKVTRLVLTVISVYIICWLPYWAFQVHLIFL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 287 KETIISSCPVVRIALYFhpfcLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15094   240 PPGTDMPKWEILMFLLL----TVLSYANSMVNPLLYAFLSENFR 279
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
65-329 8.05e-14

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 70.99  E-value: 8.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  65 GLLANSAALWVLcRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYY-ISHHWPFQRALCLLCFYLKYLNMYASICFLTC 143
Cdd:cd15118    14 GIVENLLILWVV-GFRLRRTVISIWILNLALSDLLATLSLPFFTYYLaSGHTWELGTTFCRIHSSIFFLNMFVSGFLLAA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 144 ISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRST--DLNNNKSC---FADLGYKQMNAVALVGMIT 217
Cdd:cd15118    93 ISLDRCLLVVKPVWAQNHRNvAAAKKICGVIWAMALINTIPYFVFRDVieRKDGRKLCyynFALFSPSPDNNHPICKQRQ 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 218 VAE-----LAGFVIPVIIIAWCTWKTTISLRQppmafQGISERQKALRMVFMCAAVFFICFTPYHInFIFYTMVKETIIS 292
Cdd:cd15118   173 EGLaisklLLAFLIPLVIIAVSYAVVSLIIRH-----RCRRRPGRFVRLVVSVVVSFALCWAPYHI-FSIIEVMAHNQHS 246
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1023300921 293 SCPVVRIALyfhPFCLCLASLCCLLDPILYYFMASEF 329
Cdd:cd15118   247 LRPLVIQGL---PFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
57-333 1.06e-13

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 70.99  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLP-LRIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd14996     6 IYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPfQAAYFLKGFYWKYQSTQCRIANFFGTLVIH 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASIC----FLTCISLQR-------------------CFF--LLKPFRARDWKRRYDVGisaaIWIVVGTACLPFPIL--- 187
Cdd:cd14996    86 VSMCvsilILSWIAISRyatlmkhdsatqkqscyekIFYghFLKRFRQPKFARYLCIY----IWGVVLCIIIPVVVYysv 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 188 RSTDLNNNKSCF---ADLGYKQMNAVALVGMitvaELAGFVIPVIIIAWCTWKTTISLRQPPMAfqgISERQKALRMVF- 263
Cdd:cd14996   162 READEDGESLCYnrqVELGAKGSQIAGLIAT----TFFFLFFLVVLLSYYSFVNHLRRIQKNTC---ISEKDLIYRSVKr 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 264 ---MCAAVFFICFTPYHI-NFIFYTMVKEtiiSSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14996   235 nilIIQALLVVCFLPYHIfKPVFYVLHQR---EDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
59-330 1.31e-13

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 70.21  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIY-YYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15132     8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYrLWKSRPWIFGEFLCRLYHYISEGCTYAT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIWIVVGTACLPFPILRST--DLNNNKSCFADLGYKQMNAV--AL 212
Cdd:cd15132    88 ILHITALSIERYLAICFPLRAKVLVTRRRVkCVIAALWAFALLSAGPFLFLVGVeqDNNIHPDDFSRECKHTPYAVssGL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVAELAGFVIPVIIIAWC-------TWKTTISLRQPPMAFQGISERQkALRMVFMCAAVFFICFTPYHINFIFYTM 285
Cdd:cd15132   168 LGIMIWVTTTYFFLPMLCLSFLygfigrkLWKSKNDLRGPNAAARERSHRQ-TVRILAVVVLAFIICWLPFHIGRILFAN 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 286 VKETiisscPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15132   247 TEDY-----RTMMFSQYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
56-283 2.18e-13

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 69.60  E-value: 2.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15927     5 ILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLtCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLPFPILR------STDLNNNKSCFADlgYKQM 207
Cdd:cd15927    85 GVSVFTLTALSADRYFAIVNPMRkHRSQATRRTLVTAASIWIVSILLAIPEAIFShvvtftLTDNQTIQICYPY--PQEL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELAGFVIPVIII-------AWCTWKTT--ISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15927   163 GPNYPKIMVLLRFLVYYLIPLLIIgvfyvlmARHLIRSTrnIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHV 242

                  ....*
gi 1023300921 279 NFIFY 283
Cdd:cd15927   243 FMLWF 247
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
65-278 2.86e-13

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 69.07  E-value: 2.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  65 GLLANSAALWVLCRfISKKNKAIIFMINLSVADLAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYLNMYASICFLTC 143
Cdd:cd15339    14 GLVGNILVLFTIIR-SRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWArGGEWVFGSPLCTIITSLDTCNQFACSAIMTA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 144 ISLQRCFFLLKPFRARDWKRRY-----DVGISAAIWIVVGTACLPFPILRSTDlnNNKSCFADL-GYKQMNAVALVGMIT 217
Cdd:cd15339    93 MSLDRYIALVHPFRLTSLRTRSktiriNLLVWAASFILVLPVWVYAKVIKFRD--GLESCAFNLtSPDDVLWYTLYQTIT 170
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 218 vaelaGFVIPVIIIAWC-------TWKttiSLRQPPMAFQGIS--ERQKALR---MVFMCAAVFFICFTPYHI 278
Cdd:cd15339   171 -----TFFFPLPLILICyililcyTWE---MYRKNKKAGRYNTsiPRQRVMRltkMVLVLVGVFLVSAAPYHV 235
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
58-278 2.90e-13

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 69.11  E-value: 2.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15194     7 YCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGpWRSGSFLCKGSSYIISVNMYC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRR-YDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-CFADLGYKQMNAVALVG 214
Cdd:cd15194    87 SVFLLTCMSLDRYLAIVLPLVSRKFRTKhNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEyCNEDAGTPSKVIFSLVS 166
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1023300921 215 MITVaelagFVIPVIIIAWCTWKTTislRQPPMAFQGISERQKALR----MVFMCAAVFFICFTPYHI 278
Cdd:cd15194   167 LIVA-----FFLPLLSILTCYCTII---WKLCHHYQKSGKHQKKLRksikIVFIVVAAFVFSWMPFNL 226
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
65-329 3.28e-13

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 69.06  E-value: 3.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  65 GLLANSAALWVLCRFISKKNKAI--IFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLT 142
Cdd:cd15122    14 GLPGNGFIIWSILWKMKARGRSVtcILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIG 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 143 CISLQRCFFLLKPFRARDWKRRYDV-GISAAIWIVVGTACLPFPILRS--TDLNNNKS----CFADLGYKqmnavalVGM 215
Cdd:cd15122    94 LMSLDRCLAVTRPYLAQSLRKKALVrKILLAIWLLALLLALPAFVYRHvwKDEGMNDRicepCHASRGHA-------IFH 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTWKTTISLRqppmafqGISERQKAlRMVFMCAAV---FFICFTPYHINFIFYTM------- 285
Cdd:cd15122   167 YTFETLVAFVLPFGVILFSYSVILVRLK-------GARFRRRA-RVEKLIAAIvvaFALLWVPYHVVNLLQVVanlapge 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 286 VKETIISSCPVVRIALYFHPFCLCLAslccllDPILYYFMASEF 329
Cdd:cd15122   239 VLEKLGGAAKAARAGATALAFFSSSV------NPLLYVFAAGDL 276
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
57-330 3.81e-13

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 69.06  E-value: 3.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIY-YYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15928     6 VCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYrLWRYRPWRFGDLLCRLMYFFSETCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRRYDV-GISAAIWivVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15928    86 ASILHITALSVERYLAICHPLRAKVLVTRGRVkLLIAVIW--AVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSSG 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAEL---AGFVIPVII-------IAWCTWKTTISLRQPPMAFQGISERQkALRMVFMCAAVFFICFTPYHINFIFYT 284
Cdd:cd15928   164 LLSVMLWvstSFFFVPMVClsllyglIGRALWDRRQRSRTAGASRRDNNHRQ-TVRMLAVIVLAFVLCWLPFHVGRVIFN 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 285 MVKEtiiSSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15928   243 HSRA---STKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
58-330 6.85e-13

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 67.87  E-value: 6.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLrIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15173     7 YSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPF-WAYSAAHEWIFGTVMCKITNGLYTINLYSS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFRARDWK-RRYDVG--ISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVG 214
Cdd:cd15173    86 MLILTCITVDRFIVIVQATKAHNCHaKKMRWGkvVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPDAIEVVVNII 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVaelaGFVIPVIIIAWCtwkttISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI-------NFIFYTMVK 287
Cdd:cd15173   166 QMTV----GFFLPLLAMIIC-----YSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNImklirtlHIENTDSTN 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 288 ETiiSSCPVVRIALYFHpfclclaslcCLLDPILYYFMASEFR 330
Cdd:cd15173   237 FK--YAILITEAIAYLH----------ACLNPILYAFVGVKFR 267
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
60-330 8.42e-13

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 67.71  E-value: 8.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd15096     9 LIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVfCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKRRYDVGIS-AAIWIVVGTACLPFPILRSTDLNNNKSC-FADLGYKQMNAVALVGMI 216
Cdd:cd15096    89 YTLVLMSLDRYLAVVHPITSMSIRTERNTLIAiVGIWIVILVANIPVLFLHGVVSYGFSSEaYSYCTFLTEVGTAAQTFF 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVIPVIIIawCTWKTTISLR---QPPMAFQGISE----RQKALRMVFMCAAVFFICFTPYHINFI--FYTMVK 287
Cdd:cd15096   169 TSFFLFSYLIPLTLI--CVLYMLMLRRlrrQKSPGGRRSAEsqrgKRRVTRLVVVVVVVFAICWLPIHIILLlkYYGVLP 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 288 ETIISScpVVRIALYFHPFclclasLCCLLDPILYYFMASEFR 330
Cdd:cd15096   247 ETVLYV--VIQILSNCLAY------GNSCVNPILYAFLSQNFR 281
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
56-278 2.83e-12

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 66.34  E-value: 2.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLrIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15177     5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPF-AAAETLQGWIFGNAMCKLIQGLYAINFY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPF---RARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKScFADLGYKQMNAVAL 212
Cdd:cd15177    84 SGFLFLTCISVDRYVVIVRATsahRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELS-SCRMIFPEVVSRTV 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 213 VGMITVAEL-AGFVIPVIIIAWC---TWKTTISLRQPpmafqgisERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15177   163 KGATALTQVvLGFAIPLIVMAVCyaaIGRTLLAARGW--------ERHRALRVIAALVVAFVLFQLPYSV 224
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
56-333 3.01e-12

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 66.33  E-value: 3.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHhWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15175     5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK-WVFGEEMCKAVYCLYKMSFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRR---YDVGISAAIWIVvgTACLPFPILRSTDLNNNKS---CFADLGYKQMNA 209
Cdd:cd15175    84 SGMLLLMCISIDRYFAIVQAASAHRHRSRavfISKVSSLGVWVL--AFILSIPELLYSGVNNNDGngtCSIFTNNKQTLS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VAlvgmITVAELA-GFVIPVIIIAWCTWKTTISLRQPPMAfqgisERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15175   162 VK----IQISQMVlGFLVPLVVMSFCYSVIIKTLLQARNF-----EKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSF 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 289 TI-ISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15175   233 KGnTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
58-278 3.90e-12

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 66.00  E-value: 3.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRF-ISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15097     7 FSLIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRRYD-VGISAAIWIVVGTACLPF-PILRSTDLNNNKSCFAdlGYKQMNAVAlv 213
Cdd:cd15097    87 ASSFTLAAVSVDRYLAIRYPLRSRELRTPRNaVAAIALIWGLSLLFAGPYlSYYDLIDYANSTVCMP--GWEEARRKA-- 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 214 gMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALR----MVFMCAAVFFICFTPYHI 278
Cdd:cd15097   163 -MDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKRkvtkMIIIVTALFCLCWLPHHV 230
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
60-281 3.91e-12

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 65.86  E-value: 3.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd14986     9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVvAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAiWIVVGTACLP--FPILRSTDLNNNKSCFADlGY--KQMNAVALVG 214
Cdd:cd14986    89 YILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVA-WVLSFLFSIPqlVIFVERELGDGVHQCWSS-FYtpWQRKVYITWL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVaelagFVIPVIIIAWC-------TWKTTISLRQPPMAFQGISERQ----------------KALRMVFMCAAVFFI 271
Cdd:cd14986   167 ATYV-----FVIPLIILSYCygrilrtIWIRSRQKTDRPIAPTAMSCRSvscvssrvslisrakiKTIKMTLVIILAFIL 241
                         250
                  ....*....|
gi 1023300921 272 CFTPYHINFI 281
Cdd:cd14986   242 CWTPYFIVQL 251
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
53-330 4.62e-12

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 65.60  E-value: 4.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15202     2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADiMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPFPILRSTD-----LNNNKS-CFADLGYK 205
Cdd:cd15202    82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFII-AVIWTLALAFALPHAICSKLEtfkysEDIVRSlCLEDWPER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 QMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQG------ISERQKALRMVFMCAAVFFICFTPYHIN 279
Cdd:cd15202   161 ADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATTeryfalRRKKKKVIKMLMVVVVLFALCWLPFNIY 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 280 FIFYTMVKETIISSCPVVRIAlyFHPFclclASLCCLLDPILYYFMASEFR 330
Cdd:cd15202   241 VLLLSSKPDYLIKTINAVYFA--FHWL----AMSSTCYNPFIYCWLNERFR 285
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
60-278 5.00e-12

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 65.77  E-value: 5.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd15095     9 IIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFlVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATC 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS----CFADLGYKQMNAVALV 213
Cdd:cd15095    89 LTLTALSVDRYYAIVHPIRSLRFRTpRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGpqtyCREVWPSKAFQKAYMI 168
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 214 GMItvaeLAGFVIPVIIIAWCT-------WKTTI--SLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15095   169 YTV----LLTYVIPLAIIAVCYglilrrlWRRSVdgNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHV 238
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
53-294 5.33e-12

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 65.55  E-value: 5.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIyYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15184     2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWA-HYAANEWVFGNAMCKLLTGLYHI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKP-FRARDWKRRYDVGISAAIWIVVGTACLPFPIL-RSTDLNNNKSCFADL------GY 204
Cdd:cd15184    81 GFFSGIFFIILLTIDRYLAIVHAvFALKARTVTFGVVTSVVTWVVAVFASLPGIIFtKSQKEGSHYTCSPHFppsqyqFW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 205 KQMNAVALVgmitvaeLAGFVIPVIIIAWCTWKTTISLRQPPMAfqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYT 284
Cdd:cd15184   161 KNFQTLKMN-------ILGLVLPLLVMIICYSGILKTLLRCRNE----KKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNT 229
                         250
                  ....*....|
gi 1023300921 285 MVKETIISSC 294
Cdd:cd15184   230 FQEFFGLNNC 239
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
53-333 1.03e-11

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 64.77  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANsaaLWVLCRFISKKNKAII---FMINLSVADLAHVLSLPLR-IYYYISHHWPFQRALCLLCFY 128
Cdd:cd15012     1 IFIILYTLVFCCCFFGN---LLVILVVTSHRRMRTItnfFLANLAVADLCVGIFCVLQnLSIYLIPSWPFGEVLCRMYQF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 129 LKYLNMYASICFLTCISLQRCFFLLKPFRARD---WKRRYDVgiSAAIWIVVGTACLPFPILRSTDLNNNKSCfadlGYK 205
Cdd:cd15012    78 VHSLSYTASIGILVVISVERYIAILHPLRCKQlltAARLRVT--IVTVWLTSAVYNTPYFVFSQTVEILVTQD----GQE 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 QMNAVALVGMI------TVAELAGFVIPVIIIAWCTWKTTISLRQPpmafQGISERQKALRMVFMCAAVFFICFTPYHIN 279
Cdd:cd15012   152 EEICVLDREMFnsklydTINFIVWYLIPLLIMTVLYSKISIVLWKS----SSIEARRKVVRLLVAVVVSFALCNLPYHAR 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1023300921 280 FIFYTMVKETIISSCpvvrIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15012   228 KMWQYWSEPYRCDSN----WNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
52-281 1.22e-11

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 64.38  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd14992     1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLmALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVvgTACLPFP---------ILRSTDLNNNKSC-F 199
Cdd:cd14992    81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRqSYTTTVIIIITIWVV--SLLLAIPqlyyattevLFSVKNQEKIFCCqI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 200 ADLGYKQMNAVALVgMITVAElagFVIPVIIIAWC-------TW-KTTISLRQPPMAFQGISERQKALRMVFMCAAVFFI 271
Cdd:cd14992   159 PPVDNKTYEKVYFL-LIFVVI---FVLPLIVMTLAyarisreLWfRKVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVI 234
                         250
                  ....*....|
gi 1023300921 272 CFTPYHINFI 281
Cdd:cd14992   235 CWLPFHLFFL 244
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
56-283 3.50e-11

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 62.89  E-value: 3.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRfISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd14994     6 FLYSVVLIGGVIGVILMSFLLVK-MNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMH 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRcffLLKPFRARD----WKRRYDVGISAAIWIVVGTACLPFPILR--STDLNNNKSCFADLGYKQMNA 209
Cdd:cd14994    85 LTFLFYVIILVIR---YLIFFQRKDkmefYRKLHAVAASAVVWVLVLLIVVPVFVKEygSSSSYNSDQCFKFHKELEVHY 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 210 VALVGMITVAELAGFVIPVIII-AWCTWKTTISLRQPPMAFQGISERQKALrmVFMCaaVFFICFTPYHINFIFY 283
Cdd:cd14994   162 VKVLNYIIICIVLIVTLALLGFqVFILGHVYRKLRASLLSHQEFWAQMKSL--FFIV--VIIVCFVPYNLFRIYY 232
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
57-330 3.78e-11

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 63.12  E-value: 3.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNM 134
Cdd:cd15134     6 IYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLlLLILGLPFELYTIWQQYpWVFGEVFCKLRAFLSEMSS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRA-RDWKRRYDVGISAAIWIVVGTACLPFPILRST----DLNNNKSCFADLGYKQM-- 207
Cdd:cd15134    86 YASVLTITAFSVERYLAICHPLRShTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIvyleYPPTSGEALEESAFCAMln 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 NAVALVGMITVAELAGFVIPVIII-------AWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAV---FFICFTPYH 277
Cdd:cd15134   166 EIPPITPVFQLSTFLFFIIPMIAIivlyvliGLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVvvaFFICWAPFH 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 278 INFIFYTMVKETIISSCPVVRIALYFHPFclcLASLCCLLDPILYYFMASEFR 330
Cdd:cd15134   246 AQRLLTVYAKNMTPPYLFINRILFYISGV---LYYVSSTVNPILYNVMSAKYR 295
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-332 5.50e-11

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 62.79  E-value: 5.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15208     6 LYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIiCLPATLLVDVTETWFFGQVLCKIIPYLQTVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIV----------VGTACLPFPILRSTDLnnNKSCF---ADL 202
Cdd:cd15208    86 VSVLTLSCIALDRWYAICHPLMFKSTAKRARVSI-LIIWIVsllimipqaiVMECSRVVPLANKTIL--LTVCDerwSDS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 203 GYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISL------RQPPM--------AFQGISERQKALRMVFMCAAV 268
Cdd:cd15208   163 IYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGtssvvqRKWNKprksavaaEEKQLRSRRKTAKMLIVVVIM 242
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 269 FFICFTPYHI------NFIFYTMVKETIISSCPVVRIALYFHpfclclaslcCLLDPILYYFMASEFRDQ 332
Cdd:cd15208   243 FAICYLPVHLlnilryVFGLFTVDRETIYAWFLFSHWLVYAN----------SAINPIIYNFMSGKFREE 302
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
88-284 9.93e-11

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 61.94  E-value: 9.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  88 IFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKP--FRARDWKRR 164
Cdd:cd15048    37 FFLLNLAVADFlVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAvkYRAKQTKRR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 165 yDVGISAAIWIVV----GTACLPFPILRSTDLNNNKSCFADLGYkqmNAVALVGMITVAelagFVIPVIIIA-------W 233
Cdd:cd15048   117 -TVLLMALVWILAfllyGPAIIGWDLWTGYSIVPTGDCEVEFFD---HFYFTFITSVLE----FFIPFISVSffnlliyL 188
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 234 CTWKTTISLRQP--------PMAFQGISERQ--------KALRMVFMCAAVFFICFTPYHINFIFYT 284
Cdd:cd15048   189 NIRKRSRRRPLRsvpilpasQNPSRARSQREqvklrrdrKAAKSLAILVLVFLICWAPYTILTIIRS 255
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
52-282 1.88e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 60.91  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15073     1 NIVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGvSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWI-VVGTACLPFPILRSTDLN-NNKSCFADLgykQMN 208
Cdd:cd15073    81 IFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTnAFFWAAMPLVGWASYALDpTGATCTINW---RKN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQ------PPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIF 282
Cdd:cd15073   158 DSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKvlasdcLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCLW 237
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
89-281 2.21e-10

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 60.61  E-value: 2.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDV 167
Cdd:cd15391    38 YLINLAVSDLiMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKC 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 168 gISAAIWIV-VGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAG-FVIPV-------IIIAWCTWKT 238
Cdd:cd15391   118 -IIASIWAIsFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPDTSRSAYTVFVMLLtYIIPLliltstyGYVGFRLWNR 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1023300921 239 TIslrqPPMAFQG-----ISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd15391   197 TA----PGNADKGrddmqIKSKRKVIKMLVFVVLMFGICWLPLHLFNL 240
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
53-330 2.83e-10

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 60.35  E-value: 2.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCR---FISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHH--WPFQRALCLLC 126
Cdd:cd15130     2 LVTAIYLALFVVGTVGNSVTLFTLARkksLQSLQSTVRYHLGSLALSDLLILLlAMPVELYNFIWVHhpWAFGDAGCRGY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 127 FYLKYLNMYASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWIvvGTACLPFPILRSTDLNNNKSCFADLGYK 205
Cdd:cd15130    82 YFLRDACTYATALNVASLSVERYLAICHPFKAKTlMSRSRTKKFISAIWL--ASALLAIPMLFTMGLQNESDDGTHPGGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 Q----MNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLrqppmafqgISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd15130   160 VctpiVDTATLKVVIQVNTFMSFLFPMLVTSILNTVIANKL---------VQALRRGVLVLRAVVIAFVVCWLPYHVRRL 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1023300921 282 FYTMVKETIISScPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15130   231 MFCYISDEQWTT-FLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
55-295 5.24e-10

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 59.69  E-value: 5.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILiFIPGLLANSAALWVLCRFISKKNKAI-IFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15383     5 AVTFVL-FVLSACSNLAVLWSATRNRRRKLSHVrILILHLAAADLlVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAiWIVVGTACLP----FPILRSTDLNNNKSCFADLGYKQMN 208
Cdd:cd15383    84 AMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAA-WGLSALLALPqlflFHTVTATPPVNFTQCATHGSFPAHW 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELagFVIPVIIIAWC----TWKttISLRQPPMAFQGISE-------------RQKALRMVFMCAAVFFI 271
Cdd:cd15383   163 QETLYNMFTFFCL--FLLPLLIMIFCytriLLE--ISRRMKEKKDSAKNEvalrsssdnipkaRMRTLKMTIVIVSSFIV 238
                         250       260
                  ....*....|....*....|....
gi 1023300921 272 CFTPYHINFIFYTMVKETIISSCP 295
Cdd:cd15383   239 CWTPYYLLGLWYWFSPEMLEQTVP 262
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
58-331 8.69e-10

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 58.94  E-value: 8.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15206     7 YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLlLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTdLNNNKSC-------FADLGYKQMN 208
Cdd:cd15206    87 STFTLVAISLERYFAICHPLKSRVWQtLSHAYKVIAGIWLLSFLIMSPILVFSNL-IPMSRPGghkcrevWPNEIAEQAW 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMItvaelagFVIPVIIIAWCTWKTTISLRQppmafqgisERQKALRMVFMCAAVFFICFTPYHIN---FIFYTM 285
Cdd:cd15206   166 YVFLDLML-------LVIPGLVMSVAYGLISWTLLE---------AKKRVIRMLFVIVVEFFICWTPLYVIntwKAFDPP 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 286 VKETIISSCPVVRIALyfhpfclcLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15206   230 SAARYVSSTTISLIQL--------LAYISSCVNPITYCFMNKRFRQ 267
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
52-278 1.04e-09

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 58.50  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15389     1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDiLITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPFPI------LRSTDLNNNKSCFADLGY 204
Cdd:cd15389    81 YCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVI-AIIWIMASCLSLPHAIyqklveFEYSNERTRSRCLPSFPE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 205 KQMNAVALVGMITVAELagFVIPVIII--AWCTWKTTISLRQppmAFQGISERQ---------KALRMVFMCAAVFFICF 273
Cdd:cd15389   160 PSDLFWKYLDLATFILQ--YVLPLLIIgvAYTRVAKKLWLRN---AIGDVTTEQyvaqrrkkkKTIKMLMLVVLLFAICW 234

                  ....*...
gi 1023300921 274 TP---YHI 278
Cdd:cd15389   235 LPlncYHV 242
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
58-330 1.63e-09

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 57.96  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15978     7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRS----TDLNNNKSCFADLGYKqmNAVA 211
Cdd:cd15978    87 STFNLVAISLERYSAICKPLKSRVWQtKSHALKVIAATWCLSFTIMLPYPIYSNlvpfTRINNSTGNMCRLLWP--NDVT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVGMITVAELAGFVIPVIIIAWCTWKTTISLRQppmAFQGISERQKALRMVFMCAAVFFICFTP-YHINF--IFYTMVKE 288
Cdd:cd15978   165 QQSWYIFLLLILFLIPGIVMMTAYGLISLELYR---GIKFLMAKKRVIRMLIVIVILFFLCWTPiFSANAwrAFDTRSAD 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1023300921 289 TIISSCPVvrialyfhPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15978   242 RLLSGAPI--------SFIHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
56-330 1.68e-09

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 57.86  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYIShHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15179     5 TVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAA-NWYFGNFLCKAVHVIYTVNLY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRA-RDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKScFADLGYKQMNAVA-LV 213
Cdd:cd15179    84 SSVLILAFISLDRYLAIVHATNSqRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRY-ICDRIYPEDTFELwVV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYT-MVKETIIS 292
Cdd:cd15179   163 AFRFQHILVGLVLPGLVILTCYCIIISKLSHSKG-----HQKRKALKTTVILILAFFACWLPYYIGISIDTfMLLEIIKQ 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 293 SCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15179   238 SCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
54-303 1.75e-09

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 58.22  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYIL--IFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15384     1 LLKIVVLavMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLlVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAiWIVVGTACLP----FPILRSTDLNNNKSCFADLGYKQ 206
Cdd:cd15384    81 VFGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVA-WILSPIFSIPqaviFHVERGPFVEDFHQCVTYGFYTA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 207 MNAVALVGMITVAELagFVIPVIIIAWCTWKTTISLRQPPMAFQGISE----------------RQKALRMVFMCAAVFF 270
Cdd:cd15384   160 EWQEQLYNMLSLVFM--FPIPLVIMVTCYVLIFITLSKSSRDFQGLEIytrnrgpnrqrlfhkaKVKSLRMSAVIVTAFI 237
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1023300921 271 ICFTPYHINFIFYTMVKETIISscPVVRIALYF 303
Cdd:cd15384   238 LCWTPYYVIMIWFLFFNPYPLN--DILFDVIFF 268
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
53-276 1.99e-09

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 57.80  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15393     2 LLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIiIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISaAIWIVVGTACLPFPILRST-----DLNNNKSCFADLGYKQ 206
Cdd:cd15393    82 LSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIIL-IIWILALLVALPVALALRVeeltdKTNNGVKPFCLPVGPS 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 207 mNAVALVGMITVAELAGFVIPVII------IAWCTWKTTISLRQPPMAFQGISE-RQKALRMVFMCAAVFFICFTPY 276
Cdd:cd15393   161 -DDWWKIYNLYLVCVQYFVPLVIIcyaytrIAVKIWGTKAPGNAQDVRDDEILKnKKKVIKMLIIVVALFALCWLPL 236
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
53-333 7.39e-09

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 56.09  E-value: 7.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15207     2 LFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDlLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARdWKRRYDVGISAAIWIVVGTACLP-FPILRSTDLNNNKS-----C---FADL 202
Cdd:cd15207    82 VSVAASVFTLVAIAVDRYRAVVHPTEPK-LTNRQAFVIIVAIWVLALAIMIPqALVLEVKEYQFFRGqtvhiCvefWPSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 203 GYKQMNAVALVGMItvaelagFVIPVIIIA----------WCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFIC 272
Cdd:cd15207   161 EYRKAYTTSLFVLC-------YVAPLLIIAvlyvrigyrlWFKPVPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALS 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1023300921 273 FTPYHINFIFY-----TMVKETIISS--CPVVRIALYFHPFClclaslccllDPILYYFMASEFRDQL 333
Cdd:cd15207   234 WLPLHTVTMLDdfgnlSPNQREVLYVyiYPIAHWLAYFNSCV----------NPIVYGYFNRNFRKGF 291
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
89-278 9.25e-09

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 55.78  E-value: 9.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVAD-LAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYD 166
Cdd:cd15052    38 FLMSLAIADlLVGLLVMPLSILTELFGgVWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTT 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 167 VGISAAI-WIVVGTACLPFPILRSTDLNN---NKSCFADLGYkqmnavalvgMITVAELAGFVIPVIIIAWCTWKTTISL 242
Cdd:cd15052   118 VFLKIAIvWLISIGISSPIPVLGIIDTTNvlnNGTCVLFNPN----------FVIYGSIVAFFIPLLIMVVTYALTIRLL 187
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1023300921 243 RQppmafqgiseRQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15052   188 SN----------EQKASKVLGIVFAVFVICWCPFFI 213
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-278 9.63e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 55.75  E-value: 9.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHH--WPFQRALCLLCFYLKYLNM 134
Cdd:cd15204     7 YVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDfLVAVFCLPFEMDYYVVRQrsWTHGDVLCAVVNYLRTVSL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARdWKRRYDVGISAAIWIVVGTACLPFPIL-RSTDLNNNKSCFADLGY---KQMNAV 210
Cdd:cd15204    87 YVSTNALLVIAIDRYLVIVHPLKPR-MKRRTACVVIALVWVVSLLLAIPSAVYsKTTPYANQGKIFCGQIWpvdQQAYYK 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 211 ALVGMITVAElagFVIPVIIIAWC-------TWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15204   166 AYYLFLFVLE---FVLPVLIMTLCylrivrkVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYG 237
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
58-333 1.34e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 55.33  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRfISKKNKAIIFMINLSVAD----LAHVLSLPLRIYYYISHHWPFQRA--LCLLCFYLKY 131
Cdd:cd14978     7 LPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDilvlLSALPLFLLPYIADYSSSFLSYFYayFLPYIYPLAN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDW-KRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAV 210
Cdd:cd14978    86 TFQTASVWLTVALTVERYIAVCHPLKARTWcTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 A-----LVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKAL-----------RMVFMCAAVFFICFT 274
Cdd:cd14978   166 QnetylLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRLLsrsqrrerrttIMLIAVVIVFLICNL 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 275 PYHINFIFYTMVKETIISscpvvRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd14978   246 PAGILNILEAIFGESFLS-----PIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
58-278 1.70e-08

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 55.21  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15399     7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLmVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAiWIVVGTACLPFPILRSTDLNNNKSCF-----------ADLGYK 205
Cdd:cd15399    87 STVTLTVIALDRHRCIVYHLESKISKKISFLIIGLT-WAASALLASPLAIFREYSVIEISPDFkiqacsekwpnGTLNDG 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 206 QMNAVALVgmitvaeLAGFVIPVIIIAWCTWKTTISLRQ--PPMAF--QGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15399   166 TIYSVSML-------LIQYVLPLAIISYAYIRIWTKLKNhvSPGGGndHYHQRRRKTTKMLVCVVVVFAVSWLPFHA 235
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
58-276 2.12e-08

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 54.59  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15074     7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGiSVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWI-VVGTACLPF---------PILRSTDLNnnkscFADLGYKQ 206
Cdd:cd15074    87 SINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLyALFWAVAPLvgwgsygpePFGTSCSID-----WTGASASV 161
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1023300921 207 MNAVALVGMITVaelaGFVIPVIIIAWCTWK---TTISLRQPPMAFQGISERQ-----KALRMVFMCAAVFFICFTPY 276
Cdd:cd15074   162 GGMSYIISIFIF----CYLLPVLIIVFSYVKiirKVKSSRKRVAGFDSRSKRQhkierKVTKVAVLICAGFLIAWTPY 235
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
53-330 2.35e-08

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 54.49  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIF---MINLSVAD-LAHVLSLPLRIYYYISHHWP--FQRALCLLC 126
Cdd:cd15356     2 LFTAVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDlLILLISVPIELYNFVWFHYPwvFGDLVCRGY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 127 FYLKYLNMYASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWIVVGTACLPFPI-------LRSTDLNNNKSc 198
Cdd:cd15356    82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRlLSKRRTKWLLALIWASSLGFALPMAFimgqkyeLETADGEPEPS- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 199 fADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRqppmafqgISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15356   161 -SRVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLR--------IQSLQHSVQVLRAIVIAYVICWLPYHA 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1023300921 279 NFIFYTMVKETIISScPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15356   232 RRLMFCYVPDDAWTD-SLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFR 282
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
53-237 5.47e-08

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 53.35  E-value: 5.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15079     2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGT-ACLPFPIL--RSTDLNNNKSCFADLGYKQMNA 209
Cdd:cd15079    82 SGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILFIWLYALPwALLPLLFGwgRYVPEGFLTSCSFDYLTRDWNT 161
                         170       180
                  ....*....|....*....|....*...
gi 1023300921 210 VALVGMITVaelAGFVIPVIIIAWCTWK 237
Cdd:cd15079   162 RSFVATIFV---FAYVIPLIIIIYCYSF 186
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
58-281 5.54e-08

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 53.58  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd14977     7 SLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLlCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAA-IWIVVGTACLP---FPILRSTDLNNNKSCFADLGYKQMNAVAL 212
Cdd:cd14977    87 TVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAvIWVGSVLLAVPeavLSTVARESSLDNSSLTVCIMKPSTPFAET 166
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1023300921 213 VGMITVAELAG--FVIPVIIIAWCTWKTTISLRQPPMAFQ-----GISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd14977   167 YPKARSWWLFGcyFCLPLAFTAVCYLLMARTLIRAAKEYTrgtkkHMKQRRQLAKTVLCLVLVFAFCWLPEHISNI 242
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
83-289 5.93e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 53.37  E-value: 5.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  83 KNKAIIFMINLSVAD-LAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARD 160
Cdd:cd15305    32 QNATNFFLMSLAVADmLVGILVMPVSLIAILyDYAWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 161 WKRRYDVGIS-AAIWIVVGTACLPFPILrstDLNNNKSCFADlGYKQMNAVALVgmiTVAELAGFVIPVIIIAWcTWKTT 239
Cdd:cd15305   112 FNSRTKAMMKiAAVWTISIGISMPIPVI---GLQDDEKVFVN-GTCVLNDENFV---LIGSFVAFFIPLIIMVI-TYCLT 183
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1023300921 240 ISLRQPPMAFQGISERQKALRMVFMcaaVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15305   184 IQVLQRQQAINNERRASKVLGIVFF---LFLIMWCPFFITNILSVLCKEA 230
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
89-290 6.04e-08

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 53.09  E-value: 6.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPF--RARDWKRRY 165
Cdd:cd15049    38 FLLSLACADLIiGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLtyRAKRTPKRA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 166 DVGISAAiWIVvgTACLPFP-ILRSTDLNNNKSCFADLGYKQMNAVALVGMITVaeLAGFVIPVI---IIAWCTWKTTIS 241
Cdd:cd15049   118 ILMIALA-WVI--SFVLWAPaILGWQYFVGERTVPDGQCYIQFLDDPAITFGTA--IAAFYLPVLvmtILYWRIYRETAR 192
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1023300921 242 LRqppmafqgiserqKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15049   193 ER-------------KAARTLSAILLAFIITWTPYNILVLVSTFCAKCI 228
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-281 6.77e-08

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 53.31  E-value: 6.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLK 130
Cdd:cd16004     1 ALWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNdWYFGLEFCRFQNFFP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPFPILRSTDLNNNKS-CFA----DLGYK 205
Cdd:cd16004    81 ITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVI-AGIWLVALALAFPQCFYSTVTMDQGRTkCIVawpgDSGGK 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 206 QM--NAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAF-QGISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd16004   160 HQltYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYhRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFI 238
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
58-330 6.84e-08

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 53.31  E-value: 6.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKN---KAIIFMINLSVADL-AHVLSLPLRIYYYI--SHHWPFQRALCLLCFYLKY 131
Cdd:cd15355     7 YLALFVVGTVGNSITLYTLARKKSLQHlqsTVHYHLASLALSDLlILLLAMPVELYNFIwvHHPWAFGDAACRGYYFLRD 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARD-WKRRYDVGISAAIWivVGTACLPFPILRSTDLNNNKSCFAD--LGYKQMN 208
Cdd:cd15355    87 ACTYATALNVASLSVERYLAICHPFKAKSlMSRSRTKKFISAIW--LASALLAIPMLFTMGEQNRSGTHPGglICTPIVD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELAGFVIPVIIIA-------------------------WCTWKTTISLRQPPMAFQGISERQKALRMVF 263
Cdd:cd15355   165 TSTLKVVIQVNAFLSFLFPMLVISvlntlianqltvmvnqaeqenqvctIGGQRTVLSVSMEPGRVQSLRHGVLVLRAVV 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 264 McaaVFFICFTPYHINFIFYTMVKETiISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15355   245 I---AFVVCWLPYHVRRLMFCYVSDE-QWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFR 307
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
57-330 7.88e-08

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 52.97  E-value: 7.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYLNMY 135
Cdd:cd15131     6 TCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRpWNFGDLLCKLFQFVSESCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDW--KRRYDVGIsAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALV 213
Cdd:cd15131    86 STILNITALSVERYFAICFPLRAKVVvtKRRVKLVI-LVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVRS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAELAG---FVIPVI-------IIAWCTWKTTISLRQPPMAFQGISERQkALRMVFMCAAVFFICFTPYHINfiFY 283
Cdd:cd15131   165 GLLTIMVWVSsvfFFLPVFcltvlysLIGRKLWRRRRENIGPNASHRDKNNRQ-TVKMLAVVVFAFVLCWLPFHVG--RY 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 284 TMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15131   242 LFSKSFEAGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
56-333 8.92e-08

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 52.80  E-value: 8.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCrfiSKKNKAIIFMI-----NLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYL 129
Cdd:cd15002     4 ILLGVICLLGFAGNLMVIGILL---NNARKGKPSLIdslilNLSAADLLLLLfSVPFRAAAYSKGSWPLGWFVCKTADWF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 130 KYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS----CFADLGYK 205
Cdd:cd15002    81 GHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYlcilCIPPLAHE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 QMNAVALVgmitvAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGI--SERQKAL-RMVFMCAAVFFICFTPYHINFIF 282
Cdd:cd15002   161 FMSAFVKL-----YPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLrnQIRSRKLtHMLLSVVLAFTILWLPEWVAWLW 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 283 YTMVKETIISSCPVvrialyFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15002   236 LIHIKSSGSSPPQL------FNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
58-281 1.20e-07

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 52.43  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLS-LPLRIYYYISHH-WPFQRALCLLCFYLKYLNMY 135
Cdd:cd15394     7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRgWVFGRFMCYFVFLMQPVTVY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARdWKRRYDVGISAAIWIVVGTACLPFPI------LRSTDLNNNKSCFADLGYKQMNA 209
Cdd:cd15394    87 VSVFTLTAIAVDRYYVTVYPLRRR-ISRRTCAYIVAAIWLLSCGLALPAAAhtyyveFKGLDFSICEEFWFGQEKQRLAY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 210 VALVGMITvaelagFVIPVIIIAWCTWKTTISLRQ---PPMAFQGISE-----RQKALRMVFMCAAVFFICFTPYHI-NF 280
Cdd:cd15394   166 ACSTLLIT------YVLPLLAISLSYLRISVKLRNrvvPGSMTQSQAEwdrarRRKTFRLLVVVVVAFAICWLPLHIfNV 239

                  .
gi 1023300921 281 I 281
Cdd:cd15394   240 I 240
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
60-276 1.20e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 52.24  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA----HVL-SLPLRIYYYishhwpFQ--RALCLLCFYLKYL 132
Cdd:cd15196     9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLvalfNVLpQLIWDITYR------FYggDLLCRLVKYLQVV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNK--SCFADLGykqmNAV 210
Cdd:cd15196    83 GMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGvyDCWATFE----PPW 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWC-------TWKTTIslrqppmafqgiserqKALRMVFMCAAVFFICFTPY 276
Cdd:cd15196   159 GLRAYITWFTVAVFVVPLIILAFCygricyvVWRAKI----------------KTVKLTLVVVACYIVCWTPF 215
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
83-289 2.20e-07

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 51.47  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  83 KNKAIIFMINLSVAD-LAHVLSLPLRIYYYI-SHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARD 160
Cdd:cd15304    32 QNATNYFLMSLAIADmLLGFLVMPVSMLTILyGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 161 WKRRYDVGIS-AAIWIVVGTACLPFPILrstDLNNNKSCFADlgykQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTT 239
Cdd:cd15304   112 FNSRTKAFLKiIAVWTISVGISMPIPVF---GLQDDSKVFKE----GSCLLADENFVLIGSFVAFFIPLTIMVITYFLTI 184
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1023300921 240 ISLRqppmafQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKET 289
Cdd:cd15304   185 KSLQ------QSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKES 228
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-331 3.04e-07

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 51.38  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIY-YYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15133     6 TYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDlLVLLLGMPLELYeLWQNYPFLLGSGGCYFKTFLFETVC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCfADLGYKQMNAVALV 213
Cdd:cd15133    86 LASILNVTALSVERYIAVVHPLAARTCStRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVP-ASAQCTVRKPQAIY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMIT-VAELAGFVIPVIIIA--------WCTWKTTISLRQPPMA--------FQGISERQKALRMVFMCAAVFFICFTPY 276
Cdd:cd15133   165 NMIPqHTGHLFFVLPMAVISvlyllmalRLARERGLDATGAGSKigtrtgqlLQHPRTRAQVTKMLFILVVVFAICWAPF 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 277 HINFIFYTMVKETIISSCPVVRialYFHPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15133   245 HIDRLMWSFISDWTDNLHEVFQ---YVHIISGVFFYLSSAVNPILYNLMSTRFRE 296
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
57-333 4.51e-07

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 50.69  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLS-LPLRIYYYISHHWPFQRALCLLCFYLKYLNMY 135
Cdd:cd15123     6 TYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQLTSVG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAA-IWIVVGTACLPFPILRS----TDLNNNKSCFADLGYKQMNAV 210
Cdd:cd15123    86 VSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGcVWIVSMLFAIPEAVFSDlysfRDPEKNTTFEACAPYPVSEKI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIII-------AWCTWKTTISL--RQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd15123   166 LQEIHSLLCFLVFYIIPLSIIsvyyfliARTLYKSTFNMpaEEHSHARKQIESRKRVAKTVLVLVALFAFCWLPNHILYL 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1023300921 282 FYTMVKETIISSCPvvrIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15123   246 YRSFTYHTSVDSSA---FHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
55-206 4.74e-07

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 50.51  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLN 133
Cdd:cd15397     4 VVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDiLVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMS 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1023300921 134 MYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPF---PILRSTDLNNNKSCFADLGYKQ 206
Cdd:cd15397    84 VTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAV-VVIWMLACFISLPFlafHILTDEPYKNLSHFFAPLADKA 158
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
88-330 5.34e-07

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 50.05  E-value: 5.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  88 IFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWK-RRY 165
Cdd:cd15061    36 CYIVSLATADlLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRsRRL 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 166 DVGISAAIWIVVG-TACLPFPILRSTDLNNNKSCFadlgYKQMnavalVGMITVAELAGFVIPVIIIAWctwkttISLRq 244
Cdd:cd15061   116 AITMILAVWVISLlITSPPLVGPSWHGRRGLGSCY----YTYD-----KGYRIYSSMGSFFLPLLLMLF------VYLR- 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 245 ppmAFQGISERQKALRMVFMCAAVFFICFTPYhinFIFYTMvkeTIISSCPVVRIalyFHPFCLCLASLCCLLDPILYYF 324
Cdd:cd15061   180 ---IFRVIAKERKTAKTLAIVVGCFIVCWLPF---FIMYLI---EPFCDCQFSEA---LSTAFTWLGYFNSVINPFIYAF 247

                  ....*.
gi 1023300921 325 MASEFR 330
Cdd:cd15061   248 YNKDFR 253
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
59-336 5.60e-07

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 50.22  E-value: 5.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSaaLWVLCRFISKK--NKAIIFMINLSVADL-AHVLSLPLR-IYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15306     8 LMVIIPTIGGNI--LVILAVSLEKKlqYATNYFLMSLAVADLlVGLFVMPIAlLTILFEAMWPLPLVLCPIWLFLDVLFS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAI-WIVVGTACLPFPILRSTDLNNNKSCFADLgykqMNAVALV 213
Cdd:cd15306    86 TASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVvWLISIGIAIPVPIKGIETDVDNPNNITCV----LTKERFG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAELAGFVIPVIIIAWCTWKTTISLRQppmafQGISERQKALRMVFMCAAVFFICFTPYhinfiFYTMVKETIISS 293
Cdd:cd15306   162 DFILFGSLAAFFTPLAIMIVTYFLTIHALRK-----QTITNEQRASKVLGIVFFLFLLMWCPF-----FITNITSVLCDS 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 294 CPVVRIALYFHPFcLCLASLCCLLDPILYYFMASEFRDQLSRH 336
Cdd:cd15306   232 CNQTTLQMLMEIF-VWIGYVSSGVNPLVYTLFNKTFRDAFGRY 273
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
55-186 5.90e-07

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 50.58  E-value: 5.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLN 133
Cdd:cd15395     4 ALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLlMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCIS 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 134 MYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPFPI 186
Cdd:cd15395    84 ITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGI-AVIWVLAVLTSLPFLI 135
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
89-278 1.43e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 49.18  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFR-ARDWKRRYD 166
Cdd:cd15307    38 FLMSLAITDLmVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRfGRNKTRRRV 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 167 VGISAAIWIVVGTACLPFPILRSTD----LNNNKSCFADLGYKqmnavaLVGMITVaelagFVIPVIIIAwCTWKTTISL 242
Cdd:cd15307   118 TLKIVFVWLLSIAMSLPLSLMYSKDhasvLVNGTCQIPDPVYK------LVGSIVC-----FYIPLGVML-LTYCLTVRL 185
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1023300921 243 --RQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15307   186 laRQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFV 223
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
55-330 1.76e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 49.09  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHH-WPFQRALCLLCFYLKYL 132
Cdd:cd15357     4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLlVLLFGMPLEVYEMWSNYpFLFGPVGCYFKTALFET 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRAR-DWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVA 211
Cdd:cd15357    84 VCFASILSVTTVSVERYVAILHPFRAKlNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFPNGTLIPDSATCTVVK 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVGM----ITVAELAGFVIPVIIIAWCTWKTTISLR--------QPPMAFQGISeRQKALRMVFMCAAVFFICFTPYHIN 279
Cdd:cd15357   164 PLWIynliIQITSLLFYVLPMGVISVLYYLMGLKLRgdksleadEMNVNIQRPS-RKSVTKMLFVLVLVFAICWAPFHVD 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 280 FIFYTMVKETiisSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15357   243 RLFFSFVVEW---TEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
89-330 2.99e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 48.10  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDV 167
Cdd:cd15051    38 FIVSLAVTDlLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRV 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 168 GIS-AAIWIV-VGTACLPF------PILRSTDLNNNKSCFADLgykQMNAVALVGMITvaelagFVIPVIIIAWCTWK-- 237
Cdd:cd15051   118 AIAlAAIWVVsLAVSFLPIhlgwntPDGRVQNGDTPNQCRFEL---NPPYVLLVAIGT------FYLPLLIMCGVYLRif 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 238 -------------TTISLRQPPMAFQGISERQKALRM-VFMCAavFFICFTPYhinFIFYTMvkeTIISSCPvvrIALYF 303
Cdd:cd15051   189 riareqakrinalTPASTANSSKSAATAREHKATVTLaAVLGA--FIICWFPY---FTYFTY---RGLCGDN---INETA 257
                         250       260
                  ....*....|....*....|....*..
gi 1023300921 304 HPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15051   258 LSVVLWLGYANSALNPILYAFLNRDFR 284
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
89-278 3.41e-06

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 47.90  E-value: 3.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKP--FRARDWKRRY 165
Cdd:cd15301    38 FLFSLAVADFAiGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPltYRARRTTKKA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 166 DVGISAAiWIVVGTACLPFpILRSTDLNNNKSCFADLGYKQM---NAVALVGmitvAELAGFVIPV---IIIAWCTWKTT 239
Cdd:cd15301   118 AVMIASA-WIISLLLWPPW-IYSWPYIEGKRTVPAGTCYIQFletNPYVTFG----TALAAFYVPVtimCILYWRIWRET 191
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 240 islrqppmafQGISERQ--KALRMVFMCAAVFFICFTPYHI 278
Cdd:cd15301   192 ----------KKRQKKQesKAAKTLSAILLAFIVTWTPYNV 222
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-331 5.48e-06

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 47.54  E-value: 5.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYI--LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15976     1 YINTVVscLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHiIIDIPINVYKLLAEDWPFGVEMCKLVPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRcffllkpFRA-RDWKRRYDVGIS-------AAIWIVVGTACLPFPI-------------LRS 189
Cdd:cd15976    81 KASVGITVLSLCALSIDR-------YRAvASWSRIKGIGVPkwtaveiVLIWVVSIILAVPEAIgfdmitmdykgelLRI 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 190 TDLNNNKSCFADLGYKQMNAVALVGMItvaelagFVIPVIIIAWCTWKTTISLRQPPMAFQ-----GISERQKALRMVFM 264
Cdd:cd15976   154 CLLHPIQKTAFMQFYKTAKDWWLFSFY-------FCLPLACTAVFYTLMTCEMLRKKNGMQialndHLKQRREVAKTVFC 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1023300921 265 CAAVFFICFTPYHINFIF-YTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15976   227 LVLVFALCWLPLHLSRILkLTIYDEKDPNRCELLSFFLVLDYIGINMASLNSCINPIALYLVSKRFKN 294
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
59-285 8.95e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 46.86  E-value: 8.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRfISKKNKAIIF---MINLSVADLA-HVLSLPLRIYYYISHHWPFQRalCLLCFYLKYLNM 134
Cdd:cd14981     8 ALMFVFGVLGNLLALIVLAR-SSKSHKWSVFyrlVAGLAITDLLgILLTSPVVLAVYASNFEWDGG--QPLCDYFGFMMS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASIC---FLTCISLQRCFFLLKPF--RARDWKRRYDVgISAAIWIVVGT-ACLPFpilrsTDLNNNKS------CFADL 202
Cdd:cd14981    85 FFGLSsllIVCAMAVERFLAITHPFfyNSHVKKRRARL-MLGAVWAFALLiASLPL-----LGLGSYVLqypgtwCFLDF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 203 GYKQMNAVALVGMItvAELAGFVIPVIIIawCTWKTTISL-----RQPPMAFQGISERQKALR----MVFMCA--AVFFI 271
Cdd:cd14981   159 YSKNTGDAAYAYLY--SILGLLILLVTLL--CNLLVIITLlrmrrRKKRHRRSRRSARRQKRNeiqmVVLLLAitVVFSV 234
                         250
                  ....*....|....
gi 1023300921 272 CFTPYHINfIFYTM 285
Cdd:cd14981   235 CWLPLMIR-VLINA 247
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
89-290 1.03e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 46.50  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKP--FRARDWKRRY 165
Cdd:cd17790    38 FLLSLACADLIiGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPltYRAKRTPRRA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 166 DVGISAAiWIVVGTACLPfPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVaeLAGFVIPV---IIIAWCTWKTTIsl 242
Cdd:cd17790   118 AIMIGLA-WLISFVLWAP-AILFWQYLVGERTVLAGQCYIQFLSQPIITFGTA--IAAFYLPVtimIILYWRIYRETI-- 191
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1023300921 243 rqppmafqgisERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd17790   192 -----------KEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCV 228
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-281 1.11e-05

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 46.46  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISH-HWPFQRALCLLCFYLK 130
Cdd:cd16003     1 ALWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHsEWYFGEAYCRFHNFFP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARdWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKS-CFADL--GYKQ- 206
Cdd:cd16003    81 ITSVFASIYSMTAIAVDRYMAIIDPLKPR-LSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTlCFVAWpgGPDQh 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1023300921 207 -MNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd16003   160 fTYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFI 235
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
59-282 1.22e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 46.26  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIpgLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15197    10 LFVFI--VVGNSSVLFALWMRKAKKSRMNFFITQLAIADLcVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPFR-ARDWkRRYDVGISAAiWIVVGTACLPFPIL--RSTDLNNNKSCFADLGykqmNAVALVG 214
Cdd:cd15197    88 TYVLVALSIDRYDAICHPMNfSQSG-RQARVLICVA-WILSALFSIPMLIIfeKTGLSNGEVQCWILWP----EPWYWKV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 215 MITVAELAGFVIPVIIIAWC-------TWKTtiSLRQPPMAFQGISE---------------RQKALRMVFMCAAVFFIC 272
Cdd:cd15197   162 YMTIVAFLVFFIPATIISICyiiivrtIWKK--SKIQVTINKAGLHDgssrrsssrgiipraKIKTIKMTFVIVTVFIIC 239
                         250
                  ....*....|
gi 1023300921 273 FTPYhinFIF 282
Cdd:cd15197   240 WSPY---FVF 246
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
58-243 1.73e-05

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 46.05  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLC--RFISKKNkaiIFMINLSVADLAHVLSLPLRIYYYIShHWPFQRALCLLCFYLKYLNMY 135
Cdd:PHA02834   35 YILLFIFGLIGNVLVIAVLIvkRFMFVVD---VYLFNIAMSDLMLVFSFPFIIHNDLN-EWIFGEFMCKLVLGVYFVGFF 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 136 ASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTD-LNNNKSCFADLGYKQMNAVALVG 214
Cdd:PHA02834  111 SNMFFVTLISIDRYILVVNATKIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDnTDNLKQCIFNDYHENFSWSAFFN 190
                         170       180
                  ....*....|....*....|....*....
gi 1023300921 215 MitVAELAGFVIPVIIIAWCTWKTTISLR 243
Cdd:PHA02834  191 F--EINIFGIVIPLIILIYCYSKILYTLK 217
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
52-330 1.73e-05

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 46.03  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15980     1 AVFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDlLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARdWKRRYDVGISAAIWIVVGTACLPFPIL---------RSTDLNNNKS---- 197
Cdd:cd15980    81 GISVSASVFTLVAIAVDRFRCIVYPFKQK-LTISTAVVIIVIIWVLAIAIMCPSAVMlhvqeeknyRVVLGSQNKTspvy 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 198 -CFADLGYKQMNAV---ALVGMITVAELAGFVIPVIIIAWCTWKTTISL--RQPPMAFQGISER-QKALRMVFMCAAVFF 270
Cdd:cd15980   160 wCREDWPNQEMRKIyttVLFANIYLAPLSLIVIMYARIGITLFKTAMPHtgKHNQEQRHVVSRKkQKVIKMLLIVALLFI 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 271 ICFTPYHINFIFYTMVKetiISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15980   240 LSWLPLWTLMMLSDYAN---LSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFR 296
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
56-293 1.79e-05

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 46.02  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHH---WPFQRALCLLCFYLKY 131
Cdd:cd15006     4 TVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGIcASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRAR--DWKRRydvGISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYK--- 205
Cdd:cd15006    84 VFCSVTVLSFAAIALDRYYSVLYPLERKisDAKSR---DLVIYIWAHAVVASVPvFAVTNVTDIYAMSTCTESWGYSlgh 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 206 -----QMNAVALVGMITVAELAGFVI----------PVIIIAWCTWKTTISLrqpPMAFQGISERQKALRMVFMcaaVFF 270
Cdd:cd15006   161 lvyviIYNITTVILPVAVVFLFMILIrralsasqkkKVIIAALRTPQNTISI---PYVSQREAELHAMLLSMVL---VFI 234
                         250       260
                  ....*....|....*....|...
gi 1023300921 271 ICFTPYHINFIFYTMVKETIISS 293
Cdd:cd15006   235 LCSVPYATLVIYRTILNISDISV 257
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
58-281 1.80e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 45.88  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQR-ALCLLCFYLKYLNMYA 136
Cdd:cd14964     5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPqALCYLIYLLWYGANLA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVVGTACLPFPILRSTDLNNNkSCFADLGYKQMNAVALVGM 215
Cdd:cd14964    85 SIWTTLVLTYHRYFALCGPLKYTRLSSpGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYN-TLTGSCYLICTTIYLTWGF 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQ-KALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd14964   164 LLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNlKATKSLLILVITFLLCWLPFSIVFI 230
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
48-177 1.97e-05

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 45.77  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  48 KFQYSLYATTYILIFIPGLLANSAALwvlCRFISKKNKAIIFMINLSVADLAHVLSLPLR-IYYYISHHWPFQRALCLLC 126
Cdd:cd15169     1 QLSFGLYVAAFALGFPLNVLAIRGAT---AHARLRLTPSLVYALNLGCSDLLLTVSLPLKaVEALASGAWPLPASLCPVF 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1023300921 127 FYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAIWIVV 177
Cdd:cd15169    78 AVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRpCYSWGVCAAIWALV 129
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
56-331 2.01e-05

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 45.92  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIyYYISHHWPFQ--RALCLLCFYLKYL 132
Cdd:cd15358     5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDlLVLLLGMPLEL-YEMWSNYPFLlgAGGCYFKTLLFET 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVG-ISAAIWIVVGTACLPFPILRSTdlnNNKSCFADLGYKQMNAVA 211
Cdd:cd15358    84 VCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKrVIGAVWVVSILCSIPNTSLHGI---FQLTVPCRGPVPDSATCM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 212 LVG-------MITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAF-------------------QGISERQKALRMVFMC 265
Cdd:cd15358   161 LVKprwmynlIIQITTLLFFFLPMGTISVLYLLIGLQLKREKMLLvleakgskagdsyqhrriqQEKRRRRQVTKMLFVL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1023300921 266 AAVFFICFTPYHINFIFYTMVKEtiiSSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15358   241 VVVFGICWAPFHTDRLMWSFISQ---WTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFRE 303
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
52-333 2.14e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 45.58  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLcrFISKKNKAII--FMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFY 128
Cdd:cd15979     1 TVRILLYSVIFLLSVFGNMLIIVVL--GLNKRLRTVTnsFLLSLALSDLmLAVFCMPFTLIPNLMGTFIFGEVICKAVAY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 129 LKYLNMYASICFLTCISLQRCFFLLKPFRARDWK-RRYDVGISAAIWIVVGTACLPFPILRST------DLNNNKSCFAD 201
Cdd:cd15979    79 LMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQtRSHAYRVIAATWLLSGLIMIPYPVYSVTvpvpvgDRPRGHQCRHA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 202 LGYKQMNAVALVGMITVAelagFVIP--VIIIAWctwkTTISLRqppmAFQGISERQKALRMVFMCAAVFFICFTP-YHI 278
Cdd:cd15979   159 WPSAQVRQAWYVLLLLIL----FFIPgvVMIVAY----GLISRE----LYRGLLAKKRVIRMLVVIVAMFFLCWLPiFSA 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 279 NF--IFYTMVKETIISSCPVVRIALyfhpfclcLASLCCLLDPILYYFMASEFRDQL 333
Cdd:cd15979   227 NTwrAFDPLSAHRALSGAPISFIHL--------LSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
54-296 2.54e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 45.03  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKY 131
Cdd:cd15053     3 WALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLlVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLPFPI-LRSTDLNNNKSC-FADLGYkqmn 208
Cdd:cd15053    83 MCSTASIFNLCAISIDRYIAVTQPIKyARQKNSKRVLLTIAIVWVVSAAIACPLLFgLNNVPYRDPEECrFYNPDF---- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 avalvgmITVAELAGFVIPVIIIAWCTWKTTISLRQppmafqgisERqKALRMVFMCAAVFFICFTPYHINFIFYTMVKE 288
Cdd:cd15053   159 -------IIYSSISSFYIPCIVMLLLYYRIFRALRR---------EK-KATKTLAIVLGVFLFCWLPFFTLNILNAICPK 221

                  ....*...
gi 1023300921 289 TIISSCPV 296
Cdd:cd15053   222 LQNQSCHV 229
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
89-290 3.23e-05

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 44.96  E-value: 3.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDV 167
Cdd:cd15297    38 FLFSLACADLiIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 168 GIS-AAIWIVVGTACLPfPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVaeLAGFVIPVIIIAWCTWKTTislrqpp 246
Cdd:cd15297   118 GMMiAAAWVLSFILWAP-AILFWQFIVGGRTVPEGECYIQFFSNAAVTFGTA--IAAFYLPVIIMTVLYWQIS------- 187
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 247 mafQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15297   188 ---RASSREKKVTRTILAILLAFIITWTPYNVMVLINTFCASCI 228
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
53-285 3.38e-05

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 44.86  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd16002     2 LWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASmSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVvgTACLPFPILRSTD---LNNNKSCFAD------L 202
Cdd:cd16002    82 AAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVI-CVIWVL--AFLLAFPQGYYSDteeMPGRVVCYVEwpeheeR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 203 GYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIF 282
Cdd:cd16002   159 KYETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLL 238

                  ...
gi 1023300921 283 YTM 285
Cdd:cd16002   239 QYF 241
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
53-177 5.09e-05

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 44.44  E-value: 5.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15396     2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDvLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQS 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPfraRDWKRrydvGISAAIWIVV 177
Cdd:cd15396    82 VSVSVSIFSLVLIAIERYQLIVNP---RGWKP----SASHAYWGIV 120
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
55-282 5.12e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 44.51  E-value: 5.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLS-LPLRIYYYISHHWPFQRALCLLCFYLKYLN 133
Cdd:cd15124     4 PTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQLTS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 134 MYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAA-IWIVVGTACLPFPILRST----DLNNNKSCFADLGYKQMN 208
Cdd:cd15124    84 VGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAAlIWILSMLLAIPEAVFSDLhpfyDKSTNKTFVSCAPYPHSN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAF---------QGISERQKALRMVFMCAAVFFICFTPYHIN 279
Cdd:cd15124   164 ELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNLpvegnvhvrRQIESRKRLAKTVLVFVGLFAFCWLPNHII 243

                  ...
gi 1023300921 280 FIF 282
Cdd:cd15124   244 YLY 246
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-293 6.87e-05

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 44.17  E-value: 6.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLS-LPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15125     5 SLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLTSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISA-AIWIVVGTACLP---FPILRSTDLNNNKSCFADLGYKQMNAV 210
Cdd:cd15125    85 GVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAiAIWVVSVLLAVPeavFSEVAHIMPDDNTTFTACIPYPQTDEM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIA---WCTWKTTI-SLRQPPMAFQGISERQKALR-----MVFMCAAVFFICFTPYHINFI 281
Cdd:cd15125   165 HPKIHSVLIFLVYFLIPLAIISiyyYHIAKTLIkSAHNIPGEYSEHSKRQMETRkrlakIVLVFVGLFAFCWFPNHVLYM 244
                         250
                  ....*....|..
gi 1023300921 282 FYTMVKETIISS 293
Cdd:cd15125   245 YRSFNYNEIDSS 256
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
53-331 8.88e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 43.41  E-value: 8.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLansaaLWVLCRFISKK--NKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLCFYL 129
Cdd:cd15210     5 VWGIVFMVVGVPGNL-----LTVLALLRSKKlrTRTNAFIINLSISDLLFcAFNLPLAASTFLHQAWIHGETLCRVFPLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 130 KYLNMYASICFLTCISLQRCFFLLKPFR-ARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNK---SC-FADLGY 204
Cdd:cd15210    80 RYGLVAVSLLTLVLITLNRYILIAHPSLyPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPkvcSCsILRDKK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 205 KQMNAVALVgmitvaeLAGFVIPVIIIAWCTWKTtislrqppmafqgisERQKALRMVFMCAAVFFICFTPYHINFIFYT 284
Cdd:cd15210   160 GRSPKTFLF-------VFGFVLPCLVIIICYARR---------------EDRRLTRMMLVIFLCFLVCYLPITLVNVFDD 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1023300921 285 MVKETIIsscpvvrialyfHPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15210   218 EVAPPVL------------HIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
89-290 9.98e-05

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 43.40  E-value: 9.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKP--FRARDWKRRY 165
Cdd:cd15299    41 FLLSLACADLIiGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPltYRAKRTTKRA 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 166 DVGISAAiWIVVGTACLPfPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVaeLAGFVIPVIIIAWCTWKTtislrqp 245
Cdd:cd15299   121 GVMIGLA-WVISFVLWAP-AILFWQYFVGKRTVPPDECFIQFLSEPIITFGTA--IAAFYLPVTIMTILYWRI------- 189
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 246 pmaFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15299   190 ---YKETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI 231
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
59-282 1.06e-04

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 43.27  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAAL---WVLCRFISKKN---KAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15295     2 VLLFLMSLLALVIVLgnaLVIIAFVVDKNlrhRSNYFFLNLAISDfFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQR--CFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMna 209
Cdd:cd15295    82 LLCTASVYNIVLISYDRyqSVSNAVSYRNQQTATLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGECEPEFFSNWY-- 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1023300921 210 valvgMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAfqgiserQKALRMVFMCAAVFFICFTPYHINFIF 282
Cdd:cd15295   160 -----ILAITSVLEFLVPVILVAYFNTQIYWSLWKRLRD-------RKLAKSLAIILGTFAICWAPYSLFTII 220
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
59-156 1.14e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 43.25  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15056     8 SLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADlLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTAS 87
                          90
                  ....*....|....*....
gi 1023300921 138 ICFLTCISLQRCFFLLKPF 156
Cdd:cd15056    88 IMHLCCIALDRYYAICCQP 106
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
59-335 1.19e-04

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 43.01  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  59 ILIFIPGLLANSAALWVLCrFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd14973     8 VLLSLCGLVGNGLVLWLLG-FRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKP--FRARDWKRRYDVgISAAIWIVvgtaCLPFPILrstdlnnnKSCFADLGYKQMNAVALVGMI 216
Cdd:cd14973    87 SLLAAISTERCLSVLFPiwYRCHRPKHLSAV-VCALLWAL----SLLLSVL--------ESYFCGFLFWKFNESACRTFN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 217 TVAELAGFVI-------PVIIIAWCTWKttiSLRQPPMAFQGIserqkALRMVFMcaavFFICFTPYHINFIFYTMVKET 289
Cdd:cd14973   154 FLSALLFLLLflvmcvsSLTLLIRVQCS---SQRRPPTRLYVV-----ILLTVLV----FLLCGLPLGIYWFLLLWFSNY 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1023300921 290 IISscpvvrialYFHPFCLCLASLCCLLDPILYYFMASeFRDQLSR 335
Cdd:cd14973   222 LFH---------TFHPISDLLSCVNSSANPIIYFFVGS-LRGRRLR 257
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
88-281 1.19e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 43.19  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  88 IFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFR--ARDWKRR 164
Cdd:cd15050    37 LYIVSLSVADLiVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKylKYRTKTR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 165 YDVGISAAiWIVVGTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAelAGFVIPVIIIAWCTWKTtislrq 244
Cdd:cd15050   117 ASLMISGA-WLLSFLWVIPILGWHHFARGGERVVLEDKCETDFHDVTWFKVLTAI--LNFYIPSLLMLWFYAKI------ 187
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1023300921 245 ppmaFQGISERQKALRMVFMCAAVFFICFTPYHINFI 281
Cdd:cd15050   188 ----FKAVNRERKAAKQLGFIMAAFILCWIPYFILFM 220
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
61-234 1.48e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 43.25  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  61 IFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL--SLPlRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd15386    10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfqVLP-QLIWEITYRFQGPDLLCRAVKYLQVLSMFAST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLP----FPILRSTDLNNNKSCFADLGYKQmnavALVG 214
Cdd:cd15386    89 YMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCILSLPqvfiFSLREVDQGSGVLDCWADFGFPW----GAKA 164
                         170       180
                  ....*....|....*....|
gi 1023300921 215 MITVAELAGFVIPVIIIAWC 234
Cdd:cd15386   165 YITWTTLSIFVLPVAILIVC 184
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-234 2.02e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 42.50  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  56 TTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd15387     5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVvAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRArdWKRRYDVGISAAIWIVVGTACLP-FPILRSTDLNNN-KSCFADLgYKQMNAVAL 212
Cdd:cd15387    85 FASTYMLLLMSIDRCLAICQPLRS--LHRRSDRVYVLFSWLLSLVFSIPqVHIFSLREVGNGvYDCWADF-IQPWGPKAY 161
                         170       180
                  ....*....|....*....|..
gi 1023300921 213 VGMITvaeLAGFVIPVIIIAWC 234
Cdd:cd15387   162 ITWIT---LSVYIIPVLILSVC 180
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
61-278 2.54e-04

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 42.45  E-value: 2.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  61 IFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL--SLPlRIYYYISHHWPFQRALCLLCFYLKYLNMYASI 138
Cdd:cd15388    10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfqVLP-QLVWDITDRFRGPDVLCRLVKYLQVVGMFASS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 139 CFLTCISLQRCFFLLKPFRARDWKR-RYDVGISAAiWIVVGTACLP--FPILRSTDLNNNKSCFADLgykqMNAVALVGM 215
Cdd:cd15388    89 YMIVAMTFDRHQAICRPMVTFQKGRaRWNGPVCVA-WAISLILSLPqvFIFSKVEVAPGVYECWACF----IEPWGLKAY 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 216 ITVAELAGFVIPVIIIAWCTWK-------------------TTISLRQPPMAFQG---ISERQKALRMVFMCAAVFFICF 273
Cdd:cd15388   164 VTWITLVVFVLPTLIITVCQVLifkeihiniylksqiivavVKKKQLLSSRASSVaevSKAMIKTVKMTLVIVLVYVLCW 243

                  ....*
gi 1023300921 274 TPYHI 278
Cdd:cd15388   244 APFFL 248
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
58-330 4.64e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 41.22  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPL---RIYYYISHHWPFQRALCLLCFYLKYLNM 134
Cdd:cd14995     7 VLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLpneIESLLGPDSWIYGYAGCLLITYLQYLGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 135 YASICFLTCISLQRCFFLLKPFRAR---DWKRRYDvgISAAIWIVVGTACLP-FPILRSTDLNNNKSCFADLGYKqMNAV 210
Cdd:cd14995    87 NASSLSITAFTIERYIAICHPMKAQficTVSRAKK--IICFVWIFTSLYCSPwLFLLDLSIKHYGDDIVVRCGYK-VSRH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 211 ALVGMITVAELAGFVIPVIIIAWCTWKTTISLrqppmafqgISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd14995   164 YYLPIYLADFVLFYVIPLLLAIVLYGLIGRIL---------FSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPPY 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1023300921 291 ISScpvvrialYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd14995   235 LDL--------WFLLFCRTCIYLNSAINPILYNLMSQKFR 266
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
48-331 4.66e-04

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 41.43  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  48 KFQYSLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLC 126
Cdd:cd15081     9 RWVYNLTSVWMIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGEtVIASTISVVNQIFGYFILGHPMCVLE 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 127 FYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLP--FPILRSTDLNNNKSC----FA 200
Cdd:cd15081    89 GFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPpiFGWSRYWPHGLKTSCgpdvFS 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 201 DLGYKQMNAVALVGMITVAelagfVIPVIIIAWCTWKTTISLRQPPMAFQGISERQKA----LRMVFMCAAVFFICFTPY 276
Cdd:cd15081   169 GSSDPGVQSYMIVLMITCC-----IIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAekevSRMVVVMIFAYCFCWGPY 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 277 hinfifytmvkeTIISSCPVVRIALYFHPFCLCL----ASLCCLLDPILYYFMASEFRD 331
Cdd:cd15081   244 ------------TFFACFAAANPGYAFHPLAAALpayfAKSATIYNPIIYVFMNRQFRN 290
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
58-330 9.02e-04

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 40.58  E-value: 9.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFIPGLLANsaalwVLCRFISKKNKAI-----IFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15981     7 YLFIFLLCMVGN-----GLVCFIVLKNRQMrtvtnMFILNLAVSDLlVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGIsAAIWIVVGTACLPFPI----------LRSTDLNNNK---SC 198
Cdd:cd15981    82 MSVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTI-VIIWVLALIIMCPSAVtltvtreehhFMVDDYNNSYplySC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 199 FADLGYKQMNAV---ALVGMITVAELAGFVIPVIIIAWCTWKTTISLRQPPMAFQG---ISERQ-KALRMVFMCAAVFFI 271
Cdd:cd15981   161 WEAWPDTEMRKIyttVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEEEgrrVSKRKiKVINMLIIVALFFTL 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 272 CFTPYhinFIFYTMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15981   241 SWLPL---WTLMLLTDYGHLSEDQLNLVTVYVFPFAHWLAFFNSSVNPIIYGYFNENFR 296
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
57-187 9.13e-04

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 40.55  E-value: 9.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  57 TYILIFIPGLLANSA---ALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYI--SHHWPFQRALCLLCFYLK 130
Cdd:cd15135     6 LYSLILVAGILGNSAtikVTQVLQKKGYLQKSVTDHMVSLACSDlLVLLLGMPVELYSAIwdPFATPSGNIACKIYNFLF 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVvgTACLPFPIL 187
Cdd:cd15135    86 EACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLICFVWLT--SALVALPLL 140
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
52-184 1.14e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 40.15  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  52 SLYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15205     1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLlITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 131 YLNMYASICFLTCISLQRCFFLLKPFRAR-DWKRRYDVGISAAIWIVVGTACLPF 184
Cdd:cd15205    81 STAVVTSILTMTCIAVERHQGIVHPLKMKwQYTNRRAFTMLGLVWIVSVIVGSPM 135
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-331 1.60e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 39.81  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAH-VLSLPLRIYYYISHHWPF-----QRALCLLCFYLKYLN 133
Cdd:cd15128     9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYiVIDLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 134 MYASICFLTCISLQRcffllkpFRA-RDWKRRYDVGIS-------AAIWIVVGTACLP----FPILR--------STDLN 193
Cdd:cd15128    89 VGITVLNLCALSVDR-------YRAvASWSRIQGIGIPmwtaveiVMIWMLSAVLAVPeaigFDMVRfnykgvtlRTCLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 194 NNKSCFADLgYKQMNAVALVGMItvaelagFVIPVIIIA-WCTWKTTISLRQPPMAFQ-----GISERQKALRMVFMCAA 267
Cdd:cd15128   162 RPETSFMKF-YIDVKDWWLFGFY-------FCLPLVCTAiFYTLMTCEMLRKRNGMLRialneHLKQRREVAKTVFCLVV 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1023300921 268 VFFICFTPYHINFIFYTMV-KETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15128   234 IFALCWLPLHLSRILKLTVyDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFKN 298
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
89-330 1.80e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 39.34  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFR-ARDWKRRYD 166
Cdd:cd15060    38 FIVSLAVADLAvAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINyAQKRTLKRV 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 167 VGISAAIWIVVGTACLPfPILRSTDLNNNKScfadlGYKQMNAVALVGMITVAELAGFVIPVIIIAWCTWKTtislrqpp 246
Cdd:cd15060   118 LLMIVVVWALSALISVP-PLIGWNDWPENFT-----ETTPCTLTEEKGYVIYSSSGSFFIPLLIMTIVYVKI-------- 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 247 maFQGISERQKALRMVFMCAAVFFICFTPYhinFIFYtmvkeTIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMA 326
Cdd:cd15060   184 --FIATSKERRAARTLGIIMGVFVVCWLPF---FLMY-----VILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFN 253

                  ....
gi 1023300921 327 SEFR 330
Cdd:cd15060   254 LDFR 257
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
221-331 2.25e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 39.45  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 221 LAGFVIPVIIIAWCTWKTTISLRQ--PPMAFQG----ISERQKALRMVFMCAAVFFICFTPYhinfifytmvkeTIISSC 294
Cdd:cd15085   170 LMCFVIPVAIIGFSYGNVLRSLHKlnKKIEQQGgkncPEEEERAVIMVLAMVIAFLICWLPY------------TVFALI 237
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1023300921 295 PVVRIALYFHPFCLCLASLCC----LLDPILYYFMASEFRD 331
Cdd:cd15085   238 VVVNPELSISPLAATMPTYFAktspVYNPIIYIFLNKQFRE 278
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
55-175 2.29e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 39.32  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  55 ATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLN 133
Cdd:cd15336     4 GSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDfLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALF 83
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 134 MYASICFLTCISLQRCFFLLKPFRARDW--KRRYDVGIsAAIWI 175
Cdd:cd15336    84 GITSMITLLAISLDRYLVITKPLASIRWvsKKRAMIII-LLVWL 126
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
53-288 3.10e-03

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 39.04  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYyISHHWPFQRALCLLCFYLKYL 132
Cdd:cd15171     2 LVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHA-AWHGGSLGNPTCKVLVALSSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 133 NMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAI--WIVVGTACLPFPILRS--TDLNNNKSCFADLGYKQMN 208
Cdd:cd15171    81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVlaWLTAFLVTLPEFVFYKpqMDSQKSKCAFSRPHFLPAE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 209 AVALVGMITV-AELAGFVIPVIIIAWCTwkttISLRQPPMAfqgiSERQKAL-RMVFMCAAVFFICFTPYHINFiFYTMV 286
Cdd:cd15171   161 ETFWKYFLTLkMNIVVLVFPLLVFIICC----VQLRKTQRF----RERQRDLsKLVFAIMVVFLLMWAPYNIAL-FLSAF 231

                  ..
gi 1023300921 287 KE 288
Cdd:cd15171   232 KE 233
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
89-290 3.32e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 38.85  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKP--FRARDWKRRY 165
Cdd:cd15298    38 FLFSLACADLIiGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPltYPARRTTKMA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 166 DVGISAAiWIVVGTACLPfPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVaeLAGFVIPVIIIAwcTWKTTISLRQp 245
Cdd:cd15298   118 GLMIAAA-WVLSFVLWAP-AILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTA--IAAFYLPVVIMT--VLYIHISLAS- 190
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1023300921 246 pmafqgiSERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETI 290
Cdd:cd15298   191 -------ARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCI 228
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
88-201 3.53e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 38.97  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  88 IFMINLSVADLAH-VLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRAR----DWK 162
Cdd:cd15058    37 IFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQvlltKRR 116
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1023300921 163 RRYDVGIsaaIWIVVGTACLpFPIL----RSTDLNNNKsCFAD 201
Cdd:cd15058   117 ARVIVCV---VWIVSALVSF-VPIMnqwwRANDPEAND-CYQD 154
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
79-183 3.91e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 38.48  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  79 FISKKNKAI--IFMINLSVADLA-HVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKP 155
Cdd:cd15059    26 LTSRKLRAPqnWFLVSLAVADILvGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQA 105
                          90       100
                  ....*....|....*....|....*....
gi 1023300921 156 FR-ARDWKRRYDVGISAAIWIVVGTACLP 183
Cdd:cd15059   106 VEyNLKRTPRRAKAMIAAVWIISAVISLP 134
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
60-278 4.93e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 38.25  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  60 LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLR--IYYYISHHWPFQRALCLLCFYLKYLNMYAS 137
Cdd:cd15198     9 VILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSqiIWELLGDRWMAGDVACRLLKLLQASARGAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 138 ICFLTCISLQRCFFLLKPF--RARDWKrrydvgISAAIWIVVGTACLP--------FPILRSTDLNNNKSC---FADLGY 204
Cdd:cd15198    89 ANLVVLLALDRHQAIRAPLgqPLRAWK------LAALGWLLALLLALPqayvfrvdFPDDPASAWPGHTLCrgiFAPLPR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 205 KQMNAVALVGMItvaelAGFVIPVIIIAWCT----WKTTISLRQPP---MAFQGISE--------------RQKALRMVF 263
Cdd:cd15198   163 WHLQVYATYEAV-----VGFVAPVVILGVCYgrllLKWWERANQAPgakKPWKKPSKshlratapsalpraKVKTLKMTL 237
                         250
                  ....*....|....*
gi 1023300921 264 MCAAVFFICFTPYHI 278
Cdd:cd15198   238 VIALLFVGCSLPYFI 252
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
89-330 5.09e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 38.11  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  89 FMINLSVAD-LAHVLSLPLRIYYYIS-HHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPF--RARDWKRR 164
Cdd:cd15067    37 FIVSLAVADlLVGSIVMPFSILHEMTgGYWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPIsyPSRMTKRR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 165 YDVGIsAAIWIVvgTACLPFPIL------RSTDLNNNKSCFADLgykqmnavalVGMITVAELAGFVIPVIIIAWCTWKT 238
Cdd:cd15067   117 ALIMI-ALVWIC--SALISFPAIawwravDPGPSPPNQCLFTDD----------SGYLIFSSCVSFYIPLVVMLFTYYRI 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 239 TISlrqppmafqgISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCPVVrialyfHPFCLCLASLCCLLD 318
Cdd:cd15067   184 YRA----------AAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNPDIL------FPLVTWLGYINSGMN 247
                         250
                  ....*....|..
gi 1023300921 319 PILYYFMASEFR 330
Cdd:cd15067   248 PIIYACSSRDFR 259
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
91-330 5.13e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 38.02  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  91 INLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFR--ARDWKRRYDV 167
Cdd:cd15329    40 VSLAVSDLlVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTyaVKRTPKRMAL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 168 GIsAAIWIVVGTACLPFPILRSTDLNNNKSCF--ADLGYKqmnavalvgmiTVAELAGFVIPVIIIAWCTWKTtislrqp 245
Cdd:cd15329   120 MI-AIVWLLSALISIPPLFGWKNKVNDPGVCQvsQDFGYQ-----------IYATFGAFYIPLIVMLVLYYKI------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 246 pmaFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISSCP--VVRIAL---YFHPFclclaslcclLDPI 320
Cdd:cd15329   181 ---YRAAKSERKAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIKCSCIPlwLSRLFLwlgYANSF----------LNPI 247
                         250
                  ....*....|
gi 1023300921 321 LYYFMASEFR 330
Cdd:cd15329   248 IYAKFNREFR 257
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
88-303 7.33e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 37.92  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  88 IFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRardwkrrYD 166
Cdd:cd15055    37 LLLLSLAVADfLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLL-------YP 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 167 VGIS---AAIWIVVG---TACLPFPILRStDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIII--------- 231
Cdd:cd15055   110 TKITirrVKICICLCwfvSALYSSVLLYD-NLNQPGLIRYNSCYGECVVVVNFIWGVVDLVLTFILPCTVMivlymrifv 188
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1023300921 232 -------AWCTWKTTISLRQPPMAFQGISERqKALRMVFMCAAVFFICFTPYHINfifyTMVKETIISSCPVVRIALYF 303
Cdd:cd15055   189 varsqarAIRSHTAQVSLEGSSKKVSKKSER-KAAKTLGIVVGVFLLCWLPYYIV----SLVDPYISTPSSVFDVLIWL 262
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
53-330 7.80e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 37.69  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  53 LYATTYILIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADL-AHVLSLPLRIYYYISHHWPFQRALCLLCFYLKY 131
Cdd:cd15064     2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLlVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 132 LNMYASICFLTCISLQRCFFLLKP--FRARDWKRRYDVGISAAIWIVVGTACLPFPILRSTDLNNNKSCF--ADLGYkqm 207
Cdd:cd15064    82 TCCTASILHLCVIALDRYWAITDAveYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLisQDIGY--- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 208 navalvgmiTVAELAG-FVIPVIIIAWCTWKTtislrqppmaFQGISERQKALRMVFMCAAVFFICFTPYhinfifytMV 286
Cdd:cd15064   159 ---------TIFSTFGaFYIPLLLMLILYWKI----------YRAAARERKAAKTLGIILGAFIVCWLPF--------FL 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1023300921 287 KETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFR 330
Cdd:cd15064   212 VALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-331 7.94e-03

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 37.58  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  54 YATTYI--LIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVL-SLPLRIYYYISHHWPFQRALCLLCFYLK 130
Cdd:cd15977     1 YVNTILscVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILiAIPINVIKLIAEDWPFGVHVCKLYPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 131 YLNMYASICFLTCISLQRcffllkpFRA-RDWKRRYDVGIS-------AAIWIVVGTACLPFPI---LRSTDLNNNKSCF 199
Cdd:cd15977    81 KASVGITVLSLCALSIDR-------YRAvASWSRIRGIGIPvwkavevTLIWAVAIIVAVPEAIafdMVEIDYRGQTLLV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 200 ADLGYKQMNA-VALVGMITVAELAGFVIPVIIIAWCTWKTTISL----RQPPMAF---QGISERQKALRMVFMCAAVFFI 271
Cdd:cd15977   154 CMLPMEQTSSfMRFYQDVKDWWLFGFYFCLPLACTGVFYTLMSCemlsIKNGMRIalnDHMKQRREVAKTVFCLVVIFAL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1023300921 272 CFTPYHINFIFY-TMVKETIISSCPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRD 331
Cdd:cd15977   234 CWLPLHLSRILKkTIYDVKDPQRCELLSFLLVMDYTGINMASLNSCINPVALYFVSRKFKN 294
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
58-329 9.49e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 37.41  E-value: 9.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921  58 YILIFipGLLANSAALWVLCRFISKKNKAIIFMINLSVAD-LAHVLSLPLRIYYYISHHWPFQRALCLLCFYLKYLNMYA 136
Cdd:cd15086     9 FILTF--GFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDlLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 137 SICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVVGTACLPfPILRSTDLNNN---KSCFADLGYKQMNAVALV 213
Cdd:cd15086    87 SLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGSWLYSLLWTLP-PLLGWSSYGPEgpgTTCSVQWTSRSANSISYI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023300921 214 GMITVAELagfVIPVIIIAWCTWKTTISLRQPPMAFQGISER--QKALRMVFMCAAVFFICFTPYHINFIFYTMVKETII 291
Cdd:cd15086   166 ICLFIFCL---LLPFLVMVYCYGRLLYAIKQVGKINKSTARKreQHVLLMVVTMVICYLLCWLPYGVMALLATFGKPGLV 242
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1023300921 292 SscPVVRIalyfhpFCLCLASLCCLLDPILYYFMASEF 329
Cdd:cd15086   243 T--PVASI------VPSILAKSSTVVNPIIYVFMNKQF 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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