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Conserved domains on  [gi|1024389571|ref|NP_001311318|]
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homeobox-containing protein 1 isoform 6 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11153336)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 25-227 1.19e-58

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461440  Cd Length: 178  Bit Score: 189.26  E-value: 1.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024389571  25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLDPEFGVKlESLPLSPGSSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024389571  99 PSPSNSYDTSPQPcttnqNGRENNERLSTsngkmsptryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNSYDTPPIL-----DLGGELGDLDP-------------------------EEAAEQRAEVEELLREDPWRVAEMIK 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1024389571 179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 268-340 1.12e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.79  E-value: 1.12e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1024389571 268 RGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkklsdlerVTSLKVYNWFANRRKEIKRR 340
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------LTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 25-227 1.19e-58

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 189.26  E-value: 1.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024389571  25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLDPEFGVKlESLPLSPGSSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024389571  99 PSPSNSYDTSPQPcttnqNGRENNERLSTsngkmsptryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNSYDTPPIL-----DLGGELGDLDP-------------------------EEAAEQRAEVEELLREDPWRVAEMIK 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1024389571 179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 268-340 1.12e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.79  E-value: 1.12e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1024389571 268 RGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkklsdlerVTSLKVYNWFANRRKEIKRR 340
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------LTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 267-338 6.75e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.79  E-value: 6.75e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1024389571  267 RRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRRKEIK 338
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------LS--ERQ----VKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
267-339 2.14e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 2.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1024389571 267 RRGSRFTwrKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRRKEIKR 339
Cdd:pfam00046   2 RKRTTFT--PEQLEELEKEFQENPYPSAEEREELAAQLG---------LT--ERQ----VKVWFQNRRAKWKR 57
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 162-206 1.03e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.08  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1024389571 162 VEELMRRD------SSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWL 206
Cdd:COG3620     1 VRDLMSRDvvtvspDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIE 51
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 25-227 1.19e-58

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 189.26  E-value: 1.19e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024389571  25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLDPEFGVKlESLPLSPGSSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024389571  99 PSPSNSYDTSPQPcttnqNGRENNERLSTsngkmsptryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNSYDTPPIL-----DLGGELGDLDP-------------------------EEAAEQRAEVEELLREDPWRVAEMIK 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1024389571 179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 268-340 1.12e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.79  E-value: 1.12e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1024389571 268 RGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkklsdlerVTSLKVYNWFANRRKEIKRR 340
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------LTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 267-338 6.75e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.79  E-value: 6.75e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1024389571  267 RRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRRKEIK 338
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------LS--ERQ----VKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
267-339 2.14e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 2.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1024389571 267 RRGSRFTwrKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRRKEIKR 339
Cdd:pfam00046   2 RKRTTFT--PEQLEELEKEFQENPYPSAEEREELAAQLG---------LT--ERQ----VKVWFQNRRAKWKR 57
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 162-206 1.03e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.08  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1024389571 162 VEELMRRD------SSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWL 206
Cdd:COG3620     1 VRDLMSRDvvtvspDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIE 51
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 164-217 2.58e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 36.43  E-value: 2.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1024389571 164 ELMRRdssvIKEEIKAflanRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQK 217
Cdd:pfam13744  18 QLARA----IARLIEG----RGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDK 63
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
166-205 2.91e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.51  E-value: 2.91e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1024389571 166 MRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHW 205
Cdd:COG1396     1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRI 40
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
164-204 7.89e-03

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 35.63  E-value: 7.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1024389571 164 ELMRrdssvikeEIKAFLANRRISQAVVAQVTGISQSRISH 204
Cdd:COG5606    32 QLMA--------AIRKLIKERGLTQAEAAELLGITQPRVSD 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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