|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
19-427 |
0e+00 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 671.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPlklkerkacnqelkemlppeagqenivcennndkqpskkklLDFSVLRDKGLIIYIIAKFI 258
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-----------------------------------------LDFSVFRDRGFVIYTIAKFI 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17430 200 MVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAAD 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd17430 280 YGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVL 359
|
....*....
gi 1027250549 419 AGIFLALAS 427
Cdd:cd17430 360 SALFLALGN 368
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
14-441 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 619.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 14 PDGGWGWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGG 93
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 94 LLASLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYG 173
Cdd:TIGR00892 92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 174 WRGGFLITGGLLLNCCTCGAVMRPLKLKERKAcNQELKEMLPPEAGQENIVCENNNDKqpsKKKLLDFSVLRDKGLIIYI 253
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVS-KSKSKEGLPPDGSTKKLSKKSTAEK---INRFLDFSLFTHRGFLVYL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 254 IAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCS 333
Cdd:TIGR00892 248 SGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLLC 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 334 ATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAG 413
Cdd:TIGR00892 328 ALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASG 407
|
410 420 430
....*....|....*....|....*....|
gi 1027250549 414 GELITAGIFLALASFCC--ISQKKRKDSPQ 441
Cdd:TIGR00892 408 SIVVSAGLFLAIGNYINyrLLAKEQKAALE 437
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
6.03e-135 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 393.02 E-value: 6.03e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPLKlkerkacnqelkemlppeagqenivcennndkqpskkklldfSVLRDKGLIIYIIAKFI 258
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLG------------------------------------------PLFKHRGFLIYLSGNVI 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17427 199 MFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAED 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd17427 279 YTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIV 358
|
....*
gi 1027250549 419 AGIFL 423
Cdd:cd17427 359 ASIWL 363
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
8.06e-128 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 374.98 E-value: 8.06e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPLklkerkacnqelkemlppeagqenivcennndkqpSKKKLLDFSVLRDKGLIIYIIAKFI 258
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPI-----------------------------------GPKPFLDLTLFTHRGFLLYLSGNVI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17426 206 MFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTS 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd17426 286 YVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLII 365
|
....*
gi 1027250549 419 AGIFL 423
Cdd:cd17426 366 SSIYL 370
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
19-427 |
1.30e-114 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 340.98 E-value: 1.30e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPLklkerkacnqelkemlppeagqenivCENnndkqpskkklldfsvlrdKGLIIYIIAKFI 258
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRPF--------------------------CSN-------------------TRYQIYTLGVTW 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17425 196 MVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISAS 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd17425 276 FPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVS 355
|
....*....
gi 1027250549 419 AGIFLALAS 427
Cdd:cd17425 356 AALFMGLSF 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-427 |
4.39e-114 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 339.53 E-value: 4.39e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRplklkerkacnqelkemlppeagqenivcennndkqpskkklldfsVLRDKGLIIYIIAKFI 258
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR----------------------------------------------LLKDPTFVLLALGVSF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKmsYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17352 195 AMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRL--YLYIFTLLILGLSLLAFPLATT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd17352 273 YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLL 352
|
....*....
gi 1027250549 419 AGIFLALAS 427
Cdd:cd17352 353 SGVLLFLLP 361
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-425 |
2.34e-83 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 261.56 E-value: 2.34e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPLKLKERKACnqelkemlPPEAGQEnivcennndkqpskkkLLDFSVLRDKGLIIYIIAKFI 258
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPA--------PPRSLSA----------------AFGLSLLTHRAFLRYALATTL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPkmSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17423 217 INTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKV 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGG-ELI 417
Cdd:cd17423 295 YGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSfLLL 374
|
....*...
gi 1027250549 418 TAGIFLAL 425
Cdd:cd17423 375 GSLILLTL 382
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-425 |
8.61e-78 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 246.20 E-value: 8.61e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRplklkerkacnqelkemlppeagqenivcennndkqpskkklldfsVLRDKGLIIYIIAKFI 258
Cdd:cd17422 161 LVVGALQLNIVVCGALLR----------------------------------------------VLKEPGFICYALFGLF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPkmSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17422 195 ATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRK--IYIELICVILLCVVLLLFPFAYG 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLM--GIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGEL 416
Cdd:cd17422 273 FWSLLVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGM 352
|
....*....
gi 1027250549 417 ITAGIFLAL 425
Cdd:cd17422 353 ALGAVFLAL 361
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
19-426 |
2.13e-65 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 214.29 E-value: 2.13e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPLklkerkacnqelkemLPPeagqenivcennndkqpskkklldfsvlrdkGLIIYIIAKFI 258
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFL---------------LMP-------------------------------DFLVLAVSVLF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17424 195 LAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKT 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd17424 275 FPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIF 354
|
....*...
gi 1027250549 419 AGIFLALA 426
Cdd:cd17424 355 SSLLLGSA 362
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
19-414 |
4.57e-51 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 176.94 E-value: 4.57e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLsALSPLGQLLLDQYGWRGGF 178
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTF-ALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPlklkerkacnqelkemlppeagqenivcennndkqpskkklLDFSVLRDKGLIIYIIAKFI 258
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRP-----------------------------------------IDFSLLKDPFFCIYTWSFVF 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVrpKMSYFFSLALLFNGLTDVCSATSTD 338
Cdd:cd17421 199 SQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWI--KKYHYHKAYLILCGVTNLLAPLATT 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGG 414
Cdd:cd17421 277 YPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGG 352
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
19-425 |
2.06e-48 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 170.79 E-value: 2.06e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKD-----TAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGG 93
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGDPeasfkAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 94 LLASLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYG 173
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 174 WRGGFLITGGLLLNCCTCGAVMRPLklkerkacnqeLKEMLPPEAGQENIVCENNNDKQPskKKLLDFSVLRDKGLIIYI 253
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPL-----------HPSPEDPKSKPGRRTLHSRINLFL--RKIFNVEIFKRKRYVIWA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 254 IAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMsYFFSLALLFNGLTDVCS 333
Cdd:cd17420 228 LGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 334 ATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAG 413
Cdd:cd17420 307 PLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAG 386
|
410
....*....|..
gi 1027250549 414 GELITAGIFLAL 425
Cdd:cd17420 387 VPPLIGSSLLFF 398
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
19-425 |
2.38e-43 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 156.88 E-value: 2.38e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKD-----TAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGG 93
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 94 LLASLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYG 173
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 174 WRGGFLITGGLLLNCCTCGAVMRPLKLKERKACNqelkemlppeagqenivcENNNDKQPSKKKLLDFSVLRDKGLIIYI 253
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEG------------------KKRKFKCPPLKKIFNFNIWKSTGYRIWA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 254 IAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVA----GLKWVRPKMSYFFslallFNGLT 329
Cdd:cd17464 223 FGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVAdyipGVKKVYLQVSSFF-----FIGLM 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 330 DVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIF 409
Cdd:cd17464 298 SMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAF 377
|
410
....*....|....*.
gi 1027250549 410 YMAGGELITAGIFLAL 425
Cdd:cd17464 378 YLAGVPPIIGGIILCF 393
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
19-427 |
8.06e-39 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 143.80 E-value: 8.06e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRplklkerkacnqelkemlppeagqenivcennndkqpskkklldfsVLRDKGLIIYIIAKFI 258
Cdd:cd17428 161 LIVGALALNLLACGSLMR----------------------------------------------LFKNRVFSALFIAILL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAF-LLSIIGFIDIFARPTCGVVAGLKWVrpKMSYFFSLALLFNGLTDVCSATST 337
Cdd:cd17428 195 FDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV--NSLYLYVLTLIGMGAALLAIPFAK 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 338 DYKGLIIFCVFFGLSYGMVGALQFeVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELI 417
Cdd:cd17428 273 SYLTLAVLSAILGFLSGNWSIFPY-VTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVL 351
|
410
....*....|
gi 1027250549 418 TAGIFLALAS 427
Cdd:cd17428 352 LGGFLLLLAA 361
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
19-425 |
9.83e-37 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 138.04 E-value: 9.83e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRplklkerkacnqelkemlppeagqenivcennndkqpskkklldfsVLRDKGLIIYIIAKFI 258
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR----------------------------------------------LFTNKVFVAFIFWALF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKDQGVPDKEAAF-LLSIIGFIDIFARPTCGVVAGLkwvrPKMSYF--FSLALLFNGLTDVCSAT 335
Cdd:cd17429 195 AYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDL----PCISVWnvFILANFTLGVCILILPL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 336 STDYKGLIIFCVFFGLSYGMVgALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGE 415
Cdd:cd17429 271 MHTYTGLAIVCALIGFSSGYF-SLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLL 349
|
410
....*....|
gi 1027250549 416 LITAGIFLAL 425
Cdd:cd17429 350 YMVGIICLLL 359
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-425 |
1.01e-34 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 133.17 E-value: 1.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCgykDTAWISSIILAMLYGSG---PISSIMVNKFGCRPVMLVGGLL 95
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGW---SRAVISLAFTVGLLAFGlaqPFVGRLLDRFGPRRVMLLGLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 96 ASLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAY-FDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGW 174
Cdd:cd17355 78 LAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 175 RGGFLITGGLLLNCCT-CGAVMRPLKLKERKACNQELKEMLPPEAGQEnivcennndkqpskkklldfsVLRDKGLIIYI 253
Cdd:cd17355 158 RTALLVLALLALLVLVpVLLLLRRRPADLALRAYDDASPASPGSTLKE---------------------ALRSASFWLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 254 IAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNGLTdvcS 333
Cdd:cd17355 217 LAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALL---L 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 334 ATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAG 413
Cdd:cd17355 294 LLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAV 373
|
410
....*....|...
gi 1027250549 414 G-ELITAGIFLAL 425
Cdd:cd17355 374 AlGLIAALLVLPI 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-428 |
7.45e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 130.77 E-value: 7.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLG 99
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 100 MISASFATSIIHLyITAGVITGLGLALNFQPSLIMLGAYFDK-RRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:COG2223 84 LLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLncctCGAVMRPLKLKERKAcnqelkemlppeagqenivcennNDKQPSKKKLLDF-SVLRDKGLIIYIIAKF 257
Cdd:COG2223 163 LILGILLL----VVAVLAWLFLRDPPA-----------------------GAAAAAKASLRDQlEALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 258 IVVLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVAglKWVRPKMSYFFSLALLFNGLTdVCSATS 336
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLS--DRIGGRRVLLIVFALMALGLL-LLALAL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 337 TDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGeL 416
Cdd:COG2223 293 GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAV-L 371
|
410
....*....|..
gi 1027250549 417 ITAGIFLALASF 428
Cdd:COG2223 372 ALVALVLTLLLY 383
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
19-423 |
1.06e-31 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 124.52 E-value: 1.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGcGYKD------TAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVG 92
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQE-DQKDqavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 93 GLLASLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQY 172
Cdd:cd17465 80 AAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 173 GWRGGFLITGGLLLncctcgavmrplklkerkacnqeLKEMLPpeagqenivcennndkqpskkklLDFSVLRDKGLIIY 252
Cdd:cd17465 160 GLAHTFQVLSLFMF-----------------------IQIFLS-----------------------LTYKVFRRKTYRIW 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 253 IIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCG----VVAGLKWVRPKMSYFFSLallfnGL 328
Cdd:cd17465 194 AFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGkigdLIPGLKKIYLQVASFLLL-----GI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 329 TDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELI 408
Cdd:cd17465 269 MSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVA 348
|
410
....*....|....*
gi 1027250549 409 FYMAGGELITAGIFL 423
Cdd:cd17465 349 FYLAGVPPIIGGTVL 363
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-425 |
5.71e-30 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 119.59 E-value: 5.71e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 16 GGWGWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLL 95
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 96 ASLGMISASFATSIIHLYITAgVITGLGLALNFQPSLIMLGAYF-DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGW 174
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 175 RGGFLITGGLLLncctCGAVMRplklkerkacnqelkemlppeagqenivcennndkqpskkklldfsvlrdkgLIIYII 254
Cdd:COG2271 164 RAAFLILGLPGL----LLALLR----------------------------------------------------FWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 255 AKFIVVLGLFVPTILLVNYAKD-QGVPDKEAAFLLSIIGFIDIFARPTCGVVAGlkWVRPKMSYFFSLALLFNGLTDVCS 333
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD--RLGRRRKLVLAIGLLLAALALLLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 334 ATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYkNYELIFYMAG 413
Cdd:COG2271 266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLA 344
|
410
....*....|..
gi 1027250549 414 GELITAGIFLAL 425
Cdd:COG2271 345 ALALLAALLALL 356
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-428 |
1.30e-29 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 119.05 E-value: 1.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASL 98
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 99 GMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLLLNCCTCGAVMRPlklkerkacNQELKEMLPPEAgqenivcenNNDKQPSKKKLldfsvLRDKGLIIYIIAKFI 258
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF---------KEPPDNQARLHV---------QKKKTQTMGEI-----FRDKVFWILFIAIFL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLFVPTILLVNYAKD-QGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRpkmSYFFSLALLFNGLTDVC---SA 334
Cdd:cd17314 218 VLIGGFLFIANMASLVRSlQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGR---LSTLSILLTILGLGLCAflfLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 335 TSTDYkGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGg 414
Cdd:cd17314 295 KMTPV-GLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYA- 372
|
410
....*....|....
gi 1027250549 415 elITAGIFLALASF 428
Cdd:cd17314 373 --VIVFLASAILLA 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-423 |
9.05e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.12 E-value: 9.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 23 LLGGFVITGFSYAfpkAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMIS 102
Cdd:cd06174 1 LLLGFFLTGLARG---LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 103 ASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYFDKR-RPLANGLAAAGSPVFLSALSPLGQLLLDQ--YGWRGGFL 179
Cdd:cd06174 78 FAFAPSFWLLLL-GRFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 180 ITGGLLLNCCTCGAVMRPLKLKERKACNQELkemlppeagqenivcennndKQPSKKKLLdFSVLRDKGLIIYIIAKFIV 259
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEA--------------------SSKSVLKLL-KRVLKNPGLWLLLLAIFLV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 260 VLGLFVPTILLVNYAKDQGV-PDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFslaLLFNGLTDVCSATSTD 338
Cdd:cd06174 216 NLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLLLAPS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELIT 418
Cdd:cd06174 293 LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLL 372
|
....*
gi 1027250549 419 AGIFL 423
Cdd:cd06174 373 AAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-392 |
2.34e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 2.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 22 VLLGGFVITGFSYAFPKAISVYfkeLMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMI 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLL---LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 102 SASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYF-DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLI 180
Cdd:pfam07690 78 LLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 181 TGGLLLNCCTCGAVMRPLKLKERKacnqelkemlppeagqenivcenNNDKQPSKKKLLDFSVLRDKGLIIYIIAKFIVV 260
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRP-----------------------KPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 261 LGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGlKWVRPKMSYFFSLALLFNGLTDVCSATSTDYK 340
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-RLGRRRRLLLALLLLILAALGLLLLSLTLSSL 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1027250549 341 GLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGP 392
Cdd:pfam07690 293 WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-426 |
4.07e-23 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 100.38 E-value: 4.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVI---TGFSYAFpkaiSVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLA 96
Cdd:cd17353 3 WLVLLGAVLMhliLGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 97 SLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGspVFLSAL--SPLGQLLLDQYGW 174
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAG--FGLGSLifSPLIAYLINTVGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 175 RGGFLITG-GLLLNCCTCGAVMRplklkerkacnqelkemLPPEAGQENIVCENNNDKQPSKKKLLDFSVLRDK-GLIIY 252
Cdd:cd17353 157 PTTFLILGiIFLIIIVIGAFLIR-----------------DPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPtFWLLW 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 253 IIAKFIVVLGLFVpTILLVNYAKDQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVAGlKWVRPKMsyfFSLALLFNGLTDV 331
Cdd:cd17353 220 LMFFLNATAGLML-IGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSD-KIGRKNT---LSIAFLIQGVAMF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 332 CSATSTDYKGLIIFCVF-FGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYkNYELIFY 410
Cdd:cd17353 295 LLPFIGSVAVLFVLGVAlIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG-GYNAAFI 373
|
410
....*....|....*.
gi 1027250549 411 MAGGeLITAGIFLALA 426
Cdd:cd17353 374 IAAA-LSLVALALALL 388
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-383 |
1.19e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.81 E-value: 1.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 21 VVLLGGFVITGFSYAfpkAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGM 100
Cdd:COG2814 13 LALALGAFLSGLGIG---IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 101 ISASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYFD-KRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFL 179
Cdd:COG2814 90 LLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 180 ITGGLLLncctCGAVMRPLKLKERKAcnqelkemlppeagqenivcennndKQPSKKKLLDFSVLRDKGLIIYIIAKFIV 259
Cdd:COG2814 169 VNAVLAL----LALLLLLRLLPESRP-------------------------AARARLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 260 VLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVAglKWVRPKMSYFFSLALLFNGLtdVCSATSTD 338
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLA--DRFGRRRLLLIGLLLLALGL--LLLALAGS 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1027250549 339 YKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLF 383
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-427 |
2.16e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 92.63 E-value: 2.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 8 RETAGAPDGGWGWVVLLGGFVITGFSYAFP-KAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCR 86
Cdd:COG2807 4 TSSSARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 87 PVMLVGGLLASLGMISASFATSIIHLYITAGVItGLGLALNFQPSLIMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQ 166
Cdd:COG2807 84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 167 LLLDQYGWRGGFLITGGLLLncctCGAVMRPLKLKERKAcnqelkemlppeagqenivcennnDKQPSKKKLLDFSVLRD 246
Cdd:COG2807 163 PLAAALGWRGALAVWALLAL----LALLLWLPLLRRRPA------------------------AAAAAPAAASLRSLWRS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 247 KGLIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGlKWVRPKMSYFFSLALLFN 326
Cdd:COG2807 215 PLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDRRPLLLLLGLLGLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 327 GLTDVCSATSTdykGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSAL-GLVLLFEAVAVLIGPPSAGYLVDKYKNY 405
Cdd:COG2807 294 GLLGLLLAPGS---LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSW 370
|
410 420
....*....|....*....|..
gi 1027250549 406 ELIFYMAGGELITAGIFLALAS 427
Cdd:COG2807 371 TAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-425 |
2.70e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 2.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 39 AISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYITAgV 118
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-F 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 119 ITGLGLALNFQPSLIMLGAYF-DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLLNCCTCGAVMRP 197
Cdd:cd17325 93 LQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 198 LKLKERKAcnqelkemlppeagqenivcennNDKQPSKKKLLDFSVLRDKGLIIYIIAKFI--VVLGLFVPTILLvnYAK 275
Cdd:cd17325 173 EPRPPPNK-----------------------RAVSAARLRSGLRLLLRDRRLLALFLAIFVlaFAFGALEPFLPL--YAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 276 DQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVAgLKWVRPKMsyfFSLALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYG 354
Cdd:cd17325 228 ELgGLSPAQIGLLFGAQGLASALSQPPAGKLS-DRIGRKPL---ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLG 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1027250549 355 MVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYkNYELIFYMAGGELITAGIFLAL 425
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-180 |
1.20e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 18 WGWVVLLGGFVITGFSYAfpkAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLAS 97
Cdd:COG0477 14 RALLALALGTFLEGLDFT---IVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 98 LGMISASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYF-DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRG 176
Cdd:COG0477 91 LASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
....
gi 1027250549 177 GFLI 180
Cdd:COG0477 170 IFLI 173
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-425 |
1.54e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.51 E-value: 1.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLG 99
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 100 MISASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYFDKR-RPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGF 178
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 179 LITGGLllncctcGAVMRPLKLkerkacnqelkemlppeagqenivcennndkqpskkklldfsvLRDKGLIIYIIAKFI 258
Cdd:cd17319 161 IIEGLL-------GLLLAVLWW-------------------------------------------FYLRQVWGLALGYFG 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 259 VVLGLF-----VPTILlvnyAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAG--LKWVRPKMSyFFSLALLFNGLtdV 331
Cdd:cd17319 191 INYALYglltwLPTYL----KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrlLRGARRLVI-IIGLLLAAVGL--L 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 332 CSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYM 411
Cdd:cd17319 264 LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLF 343
|
410
....*....|....
gi 1027250549 412 AGGELITAGIFLAL 425
Cdd:cd17319 344 LAAVALLAALLVLL 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-402 |
1.68e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.48 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 21 VVLLGGFVITGFSYAfpkAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGM 100
Cdd:COG0738 11 IAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 101 ISASFATSIIhLYITAGVITGLGLALnFQPSLIMLGA--YFDKRRPL------ANGLAAAGSPVFLSALSPLGQLLldqy 172
Cdd:COG0738 88 LLFALAPSYP-LLLLALFLLGLGLGL-LDVAANPYVAalGPETAASRlnllhaFFSLGALLGPLLGGLLILLGLSL---- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 173 GWRGGFLITGGLLLnccTCGAVMRPLKLKERKAcnqelkemlppeagqenivcennNDKQPSKKKLLDFSVLRDKGLIIY 252
Cdd:COG0738 162 SWHLPYLILAVLLL---LLALLFLRSKLPEIEE-----------------------EEEEAAGSAASLKSLLKNPRLLLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 253 IIAKFIVVLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVagLKWVRPKMSYFFSLALLFNGLtdV 331
Cdd:COG0738 216 GLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFL--LKRFGPVRLLRLSALLAAVGL--L 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1027250549 332 CSATSTDYKGLIIFCVFFGLSYGMVgalqFEVLMGIVGTS---KFSSALGLVLLFEAVAVLIGPPSAGYLVDKY 402
Cdd:COG0738 292 LALLAPGPWLALIGLALVGLGLSLM----FPTIFSLALDGlgkRTAAAVSAVLIMGIVGGAIGPPLIGFLADAF 361
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
74-428 |
2.11e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 2.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 74 PISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIhLYITAGVITGLGLALNFQPSLIMLGAYFDKRRpLANGLAAAG 153
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 154 SPVFLSAL--SPLGQLLLDQYGWRGGFLITGGLLLnccTCGAVMRPLKLKERKAcnqelkemlppeagqenivcennndK 231
Cdd:cd17489 127 LATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLAL---LALLLVFLVKDPPPVA-------------------------A 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 232 QPSKKKLLDFSVLRDKGLIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFidIFARPTCGVVAglKWV 311
Cdd:cd17489 179 EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIAL--LLSRPFSGKLS--DRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 312 RPKMSYFFSLALLFNGLtdVCSATSTDYKGLIIFCVFFGLSYGMV-GALQFEVLMgIVGTSKFSSALGLVLLFEAVAVLI 390
Cdd:cd17489 255 GPKTVIIPGLLLLALGL--LLLSFAGSPWMLLLAAVLYGLGFGLLfPALQALAVD-LVPPHRRGAANGTFFIFFDLGIGL 331
|
330 340 350
....*....|....*....|....*....|....*...
gi 1027250549 391 GPPSAGYLVDKYkNYELIFYMAGGeLITAGIFLALASF 428
Cdd:cd17489 332 GGLLLGLVAELF-GYRAMFLLAAV-VVLLALVLYIFLL 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
72-431 |
3.54e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.33 E-value: 3.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 72 SGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYFDK-RRPLANGLA 150
Cdd:cd17324 50 GALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL-ARALAGLAHGGFWAIAAAYAADLVPPeKRGRAIGLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 151 AAGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLLnccTCGAVMRPLklkerkacnqelkemLPPEAGQEnivcennnd 230
Cdd:cd17324 129 FSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL---LAALLLWRL---------------LPSLPPKK--------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 231 KQPSKKKLLDFSVLRDKGLIIYIIAKFIVVLGLFVP-TILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLK 309
Cdd:cd17324 182 PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 310 WVRPKMSYFFSLALLFNGLTdvcsATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKfSSALGLVLLFEAVAVL 389
Cdd:cd17324 262 GRRALLIALLLLAAALLLLT----LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGA 336
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1027250549 390 IGPPSAGYLVDKYKnyelifymAGGELITAGIFLALASFCCI 431
Cdd:cd17324 337 LGAALGGLVLDHGG--------WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
78-424 |
1.78e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 56.09 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 78 IMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLyITAGVITGLGLAlNFQPS---LIMlGAYFDKRRPLANGLAAAGS 154
Cdd:cd17475 53 WLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL-LVLLFLVGAGYG-SVQPGggrAIM-RWFPPRERGLAMGIRQTGV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 155 PV--FLSALspLGQLLLDQYGWRGGFLITGGLllncCTCGAVMRPLKLKERKAcnqelkEMLPPEAGQEnivcennndKQ 232
Cdd:cd17475 130 PLggALAAA--LLPPLALHYGWRAAFVVAGLV----SILAAVLFWLFYREPPA------ASAATESAST---------LL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 233 PSKKklldfSVLRDKGLIIYIIAKFIVVLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWV 311
Cdd:cd17475 189 RSLK-----EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 312 RPKMSYFFSLALLFNGLTDVCS--ATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVL 389
Cdd:cd17475 264 GRRRPVLVITAAIAAAALLVLSllSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIA 343
|
330 340 350
....*....|....*....|....*....|....*
gi 1027250549 390 IGPPSAGYLVDKYKNYELIFYMAGGELITAGIFLA 424
Cdd:cd17475 344 IGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-427 |
2.65e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.66 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 72 SGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYITAGVItGLGLALNFQPSLIMLGAYFD-KRRPLANGLA 150
Cdd:cd17473 51 FAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDYFEgEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 151 AAGSPVFLSALSPLGQLLLDqYGWRGGFLITG-GLLLncctcgAVMRPLKLKERKacnqelkemlpPEAGQENIVCENNN 229
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPV------LILVLLFLPEPA-----------RKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 230 DKQPSKKKLLdfsvlrdkgliIYIIAkFIVVLGLFVPTILLVNYAKD-QGVPDKEAAFLLSIIGFIdifarptcGVVAGL 308
Cdd:cd17473 192 AALPWKRVLP-----------IYFLA-FLAMLLFYVIPIQLPFLLQErGGGSAALIGLALAIASLA--------GAIGAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 309 --KWVRPKMS--YFFSLALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFE 384
Cdd:cd17473 252 lfGRLKRRLGkrRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1027250549 385 AVAVLIGPPSAGYLVDKYKNYELIFYMAGGELITAGIFLALAS 427
Cdd:cd17473 332 FLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
19-359 |
1.30e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.51 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 19 GWVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSI-ILAMLYGsGPISSIMVNKFGCRPVMLVGGLLAS 97
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAgLIGMAFG-ALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 98 LGMISASFATSIIHLYItAGVITGLGLALNFqPSLIMLGAYF--DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWR 175
Cdd:TIGR00895 94 VFTLLCALATNVTQLLI-LRFLAGLGLGGLM-PNLNALVSEYapKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 176 GGFLITG--GLLLNCCTCGAVMRPLK---LKERKACNQELKEMLPPEAGQENIVCENNNDKQPSKKKLLD--FSVLRDKG 248
Cdd:TIGR00895 172 SLFYVGGiaPLLLLLLLMRFLPESIDflvSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKalFQGKTARI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 249 LIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFArptcGVVAGLKWVRPKMSYFFSLALLFNGL 328
Cdd:TIGR00895 252 TVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIG----SIIFGWLADRLGPRVTALLLLLGAVF 327
|
330 340 350
....*....|....*....|....*....|..
gi 1027250549 329 TDVCSATSTDYKGLIIFCVFFGLSY-GMVGAL 359
Cdd:TIGR00895 328 AVLVGSTLFSPTLLLLLGAIAGFFVnGGQSGL 359
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-425 |
2.11e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELMHDfgcgykdTAWISSIILAML----YGSGPISSIMVNKFGCRPVMLVGGLL 95
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGL-------SASIVGLVLALSavagIVASLIGGRLADRFGRKPVMLAGLLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 96 ASLGMISASFATSIIhLYITAGVITGLGLALNFQPSLIMLGA-YFDKRRPLA---NGLAAAGSPvflsALSPLGQLLLDQ 171
Cdd:cd17329 75 RALGFALLGFAHSPW-LFAIALVLTGFGGGLFEPASEAMIADvTTPENRTRAfslLYWAINLGV----AIGPLLGGLLLL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 172 YGWRGGFLITGGLLLncctCGAVMRPLKLKERKACNQELKEMLPPEAGQenivcennndkqpskkklldfSVLRDKGLII 251
Cdd:cd17329 150 YSFRLLFLAAAVLFL----LAALVLLFLLPETRPKRRAAEKTEILRGYK---------------------IVLRDRAFLL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 252 YIIAKFIVVLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFIdifarptcgVVAG----LKWV-RPKMSYFFSLALLF 325
Cdd:cd17329 205 FLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGLLLALNALL---------IVLLqfpvARLVeRFRLRKILMIGILL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 326 NGLTDVCSATSTDYKGLIIFCVFFGLSyGMVGALQFEVLM------GIVGTSKFSSALGLvllfeAVAVLIGPPSAGYLV 399
Cdd:cd17329 276 FAIGFAVLAFANTLAVLILAMIVLTLG-EMLVFPAVQTLVaalappDKRGSYMGFYALAW-----GLGRAIGPLVGGLLL 349
|
410 420
....*....|....*....|....*.
gi 1027250549 400 DKYKNYELIFYMAGGELITAGIFLAL 425
Cdd:cd17329 350 DLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-186 |
2.18e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.59 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 21 VVLLGGFVITGFSYAFPKaisvyfkeLMHDFGCGYKDTAWISSI-ILAMLYGS---GPISsimvNKFGCRPVMLVGGLLA 96
Cdd:cd17365 7 IIVLDGFDLAVMGFVAPA--------LAQDWGLSPAQLGPVGSAaLFGMAIGAllaGPLA----DRFGRKRVLLVSVALF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 97 SLGMISASFATSIIHLYItAGVITGLGL--ALnfqPSLIMLGAYF--DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQY 172
Cdd:cd17365 75 GLFTLLTAFAQSVLQLAL-LRFLTGLGLgaAM---PNAITLVSEYapARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF 150
|
170
....*....|....
gi 1027250549 173 GWRGGFLITGGLLL 186
Cdd:cd17365 151 GWRSVFLLGGVPPL 164
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
86-400 |
2.48e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 86 RPVMLVGGLLASLGMI------SASFATSIIHLYITAgVITGLGLALNFQPSLIMLGAYFD--KRRPLANGLAAAGSPVF 157
Cdd:COG2211 81 RPWILIGAIPLALSFVllftapDLSPTGKLIYALVTY-LLLGLAYTLVNIPYSALGAELTPdyEERTRLSSWRFAFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 158 LSALSPLGQLLLDQYG--WRGGFLITGGLLLNCCTCGAVMRPLKLKERKAcnqelkemlppeagqenivcennndKQPSK 235
Cdd:COG2211 160 GLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKERPV-------------------------PEEEK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 236 KKLLDF--SVLRDKGLIIYIIAKFIVVLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFIDIFARPTCGVVAglKWVR 312
Cdd:COG2211 215 VSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 313 PKMSYFFSLALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIV-------GTSKFSSALGLVLLFEA 385
Cdd:COG2211 293 KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIK 372
|
330
....*....|....*
gi 1027250549 386 VAVLIGPPSAGYLVD 400
Cdd:COG2211 373 LGQALAGALAGLLLA 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
245-425 |
3.36e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 245 RDKGLIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVA---GLKWVrpkmsyfFSL 321
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAdrfGRRRV-------LLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 322 ALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDK 401
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....
gi 1027250549 402 YkNYELIFYMAGGELITAGIFLAL 425
Cdd:COG2814 161 F-GWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
39-180 |
3.46e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 52.63 E-value: 3.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 39 AISVYFKELMHDFGcGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLyITAGV 118
Cdd:cd06179 16 LPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNML-IGGQA 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1027250549 119 ITGLGLALNfQPSLIMLGAYF-DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQY--GWRGGFLI 180
Cdd:cd06179 94 LIGIGAGTQ-GLGAAVASELVpNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYI 157
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-186 |
4.45e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.42 E-value: 4.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLG 99
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 100 MISASFATSIIhLYITAGVITGLGLALNFQPSLIMLGAYFDKRRP------LANGLAAAGSPVFLSALSplgqlLLDQYG 173
Cdd:cd17312 82 NIFMGFSTSLW-FFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERgtvygiWSTSHNFGGILAPILAAS-----LASYYG 155
|
170
....*....|...
gi 1027250549 174 WRGGFLITGGLLL 186
Cdd:cd17312 156 WRAAFLVPGIVGL 168
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
39-356 |
6.06e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 6.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 39 AISVYFKELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLyITAGV 118
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 119 ITGLGLALNFQPSLIMLGAYFDKRRpLANGLAAAGSPVFLS-ALSP-LGQLLLDQYGWRGGFLItgglLLNCCTCGAVMR 196
Cdd:cd17503 93 LQGFGGGVLIPLAQTILLRIYPPEK-RGAAMGLVGLVILLApAIGPtLGGWLTDNLSWRWIFYI----NLPIGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 197 PlklkerkacnqelkemlppeagqenivcennndkqpskkkLLDFSVLRDKGLIIYIIAKFIVVLGLFVPTILLVNYAKD 276
Cdd:cd17503 168 P----------------------------------------LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 277 -QGVPDKEAAFLLSIIGFIDIFARPTCGVVagLKWVRPKMSYFFSLALLFNGLTDVCSAT-STDYKGLIIFCVFFGLSYG 354
Cdd:cd17503 208 vLGYSAFESGLVLAPGGLASAILSPLVGRL--LDKFGPRLLLLAGLLLLALGTLLLAFLTpDTSLWLIILPLFIRGLGMG 285
|
..
gi 1027250549 355 MV 356
Cdd:cd17503 286 LV 287
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-197 |
1.10e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELmhdFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFG--CRPVMLVGGLLAS 97
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEV---RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 98 LGMISASFATSIIhLYITAGVITGLGLALNFQPSLIMLGAYFDKR-RPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRG 176
Cdd:COG2271 260 LALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 1027250549 177 GFLITGGLLLNCCTCGAVMRP 197
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
73-195 |
2.14e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 44.18 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 73 GPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYItAGVITGLGLALNFQPSLIMLG-AYFDKRRPLANGLAA 151
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIAdIYPPEERGVALGLMS 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1027250549 152 AGSPVFLSALSPLGQLLLDQYGWRGGFLItgglllNCCTCGAVM 195
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLF------LAILALAAF 131
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
253-425 |
3.91e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 253 IIAKFIVVLGLFVPTILLVNY-AKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPkmsyFFSLALLFNGLTDV 331
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR----VLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 332 CSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYkNYELIFYM 411
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAFLI 156
|
170
....*....|....
gi 1027250549 412 AGGELITAGIFLAL 425
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-152 |
5.05e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 5.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELmhdFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLG 99
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEV---LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1027250549 100 MISASFATSIIHLYItAGVITGLGLALNFQPSLIMLGAYF-DKRRPLANGLAAA 152
Cdd:COG2814 287 LLLLALAGSLWLLLL-ALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNS 339
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-186 |
9.59e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.51 E-value: 9.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 40 ISVYFKELmhdfgcGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYItAGVI 119
Cdd:cd17489 217 LPLYAAER------GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVL 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1027250549 120 TGLGLALnFQPSL--IMLGAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLL 186
Cdd:cd17489 290 YGLGFGL-LFPALqaLAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-195 |
9.64e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.47 E-value: 9.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 46 ELMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLyITAGVITGLGLA 125
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 126 LNFQPSLIMLGAYFD-KRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLI---------------TGGLLLNCC 189
Cdd:cd17321 100 AIMPASLALIAATFPgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLInvpiglvalllartfSGAVLAAFL 179
|
....*.
gi 1027250549 190 TCGAVM 195
Cdd:cd17321 180 LGAALG 185
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-205 |
1.07e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELmhdFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLG 99
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQ---FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 100 MISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFD-KRRPLANGLAAAGSPVFLSALSPLGQLLLDQYG-WRGG 177
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAA 364
|
170 180
....*....|....*....|....*...
gi 1027250549 178 FLITGGLLLnccTCGAVMRPLKLKERKA 205
Cdd:COG2223 365 FLVFAVLAL---VALVLTLLLYRRPRRA 389
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
61-186 |
1.18e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 61 ISSIILAMLYGsgpissIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYITAGVITGLGLAlNFQPSLIMLGAYFD 140
Cdd:cd17341 45 LAGALLRLPYG------FLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFP 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1027250549 141 KRRP-LANGLAA-------AGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLL 186
Cdd:cd17341 118 KEKIgGAAGGIAgagnmgvAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLA 171
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
47-430 |
1.40e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.72 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 47 LMHDFGCGYKDTAWISSIILAMLYGSGPISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLYItAGVITGLGLAL 126
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA-GRALQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 127 nFQPSLIMLGAYF-DKRRPLANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLLncctCGAVMRPlklkerka 205
Cdd:cd17504 101 -FPLAFALVREEFpPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV----LLAALVP-------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 206 cnqelkemlppeagqenivcennndkqpskkkLLDFSVLRDKGLIIYIIAKFIVVLGLF-----VPTILLVNYAKDQGVP 280
Cdd:cd17504 168 --------------------------------LIDLRLLRRRNVLLANITALLAGFGMFmvfqlLPQLLQLPTPTGFGLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 281 DKEAAFLLSIIGFIDIFARPTCGVVA---GLKWVRPKMSYFFSLALLFNGLTDVCSATstdykgLIIFCVFFGLSYGMVG 357
Cdd:cd17504 216 ITEAGLLLLPGALVMLIAGPLAGRLIarvGPRRVLLIGLVISAVGLLLLALLHSSLWA------LVVALLLIGIGLGLAF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1027250549 358 ALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGE----LITAGIFLALASFCC 430
Cdd:cd17504 290 ASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGayvlAFLIGAALALAALLL 366
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
246-423 |
1.53e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 246 DKGLIIYIIAKFIVVLGLFvPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFArptcGVVAGLKWVRPKMSYFFSLALLF 325
Cdd:cd17370 199 PKAFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALA----AYPAGRLSDRIGRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 326 NGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYkNY 405
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SP 352
|
170
....*....|....*...
gi 1027250549 406 ELIFYMAGGELITAGIFL 423
Cdd:cd17370 353 SAAFLFSAVLALIALLLL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
73-425 |
2.73e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 73 GPISSIMVNKFGCRPVMLV-----GGLLASLGMISASFATSIIHLYITAgVITGLGLALnFQPSLI-MLGAYFDKRR-PL 145
Cdd:cd06173 51 SPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAF-FGPARQaLLPELVPKEQlVR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 146 ANGLAAAGSPVFLSALSPLGQLLLDQYGWRGGFLITGGLLLnccTCGAVMRPLKLKERKACNQElkemlppeagqenivc 225
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFL---LSALLLLFIRRPPPAAPGES---------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 226 enNNDKQPSKKKLLDFsVLRDKGLIIYIIAKFIVVLGLFVPTILLVNYAKDQ-GVPDKEAAFLLSIIGFidifarptcGV 304
Cdd:cd06173 190 --SSLLLRDLREGLRY-LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGV---------GA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 305 VAG---LKWVRPKMSY--FFSLALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGL 379
Cdd:cd06173 258 LLGallLGRLSKRRRRgrLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1027250549 380 VLLFEAVAVLIGPPSAGYLVDKYKNYELIFYMAGGELITAGIFLAL 425
Cdd:cd06173 338 YNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
253-451 |
3.59e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 253 IIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGvvAGLKWVRPKMSYFFSLALLfnGLTDVC 332
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAG--RLLDRFGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 333 SATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDKYkNYELIFyma 412
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLF--- 153
|
170 180 190
....*....|....*....|....*....|....*....
gi 1027250549 413 ggelITAGIFLALASFCCISQKKRKDSPQTQQTDVEVNP 451
Cdd:cd17489 154 ----IVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAF 188
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
249-426 |
5.16e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.15 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 249 LIIYIIAKFIVVLGLFVPTILLVNYAKDQGVPDKEAAFLLSIIGFIDIFARPTCGVVAGLKWVRPKMSYFFSLALLFNgl 328
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 329 tdVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGTSKFSSALGLVLLFEAVAVLIGPPSAGYLVDkYKNYELI 408
Cdd:cd17324 79 --LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAA 155
|
170
....*....|....*...
gi 1027250549 409 FYMAGgeLITAGIFLALA 426
Cdd:cd17324 156 FLAIA--VLALLAALLLW 171
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-186 |
6.77e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 6.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 17 GWGWVVLLGGFVITGFSYAFPKAI--SVYFKELMHDFGCGYKDTAWISSII-LAMLYGSGPISSIMVNKFGCRPVMLVGG 93
Cdd:cd17330 169 VLFFLPPLRRLLLVYFLIALAFAGleSVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 94 LLASLGMISASFATSIIHLYItAGVITGLGLALNFQPSLIML-GAYFDKRRPLANGLAAAGSPVFLSALSPLGQLLLDQY 172
Cdd:cd17330 249 LLAIIGLLLLPFASSVPLLVL-AAAILAFGTGIVFPALSALLsKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
|
170
....*....|....
gi 1027250549 173 GWRGGFLITGGLLL 186
Cdd:cd17330 328 GPGVPFLLAAGLLL 341
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
74-425 |
1.32e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 74 PISSIMVNKFGCRPVMLVGGLLASLGMISASFATSIIHLyITAGVITGLGLALNFQPSLIMLGAYFDKRRP--------L 145
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPLALTLIGDLFEGGERakamglyeA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 146 ANGLAAAGSPVflsalspLGQLLLDqYGWRGGFLITGGLLLnccTCGAVMRplklkerkacnqelkeMLPPEagqenivc 225
Cdd:cd17474 131 ALGLGIAVGPL-------LGGLLAA-ISWRYPFFLLAALIP---VAFLAIL----------------FLLPE-------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 226 ENNNDKQPSKKKLLDFS-VLRDKGLIIYIIAKFIVVLGLFVptilLVNYAKDqgVPDKEAAFLLSIIGFIdiFARPTCGV 304
Cdd:cd17474 176 PKEKAKSSSATKLRDLKkALRGRGLLTFLVSAFLYFFLYFA----FLTYLPF--LLELLYGISPIIIGLL--FAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 305 VAGLKWVRPKMSYFFS------LALLFNGLTDVCSATSTDYKGLIIFCVFFGLSYGMVGALQFEVLMGIVGT---SKFSS 375
Cdd:cd17474 248 ALGSLFVGRLLKKRFGarrilvIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEeerGTASS 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1027250549 376 ALGLVLLfeaVAVLIGPPSAGYLVDKYkNYELIFYMAGGELITAGIFLAL 425
Cdd:cd17474 328 LYNFVRF---LGQAVGPLLFGLLLEIF-GLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
20-133 |
1.37e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 40.62 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFKELMHDfgcgykdTAWISSIILAMLYGSGPISSIM----VNKFGC-RPVMLVGGL 94
Cdd:cd17502 170 LLSSIFGFLFGGALFGLIYYLPLYFQLVLGD-------SATKSGVRLLPLIIGLVIGSIIsgalISKTGRyKPLIVIGTI 242
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1027250549 95 LASLGMISASF--ATSIIHLYITAGVITGLGLALNFQPSLI 133
Cdd:cd17502 243 LMSVGAGLLTTltLDTSKWLLIGYLILLGLGLGIGFQQPLV 283
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
20-149 |
3.06e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027250549 20 WVVLLGGFVITGFSYAFPKAISVYFkELMHDFGCGYKDTA---WISSIILAMLYGsGPISSIMVNKFGCRPVMLVGGLLA 96
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLL-QLPTPTGFGLGITEaglLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVIS 257
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1027250549 97 SLGMISASFATSIIHLYITAGVITGLGLALNFQPSLIMLGAYFDKRRP-LANGL 149
Cdd:cd17504 258 AVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTgIATGM 311
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
72-135 |
7.13e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 38.31 E-value: 7.13e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1027250549 72 SGPISSIMVNKFGCRPVMLVGGLLASLGMISASF--ATSIIHLYITAGVITGLGLALNFQPSLIML 135
Cdd:cd17321 220 AAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgADSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
|
|
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