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Conserved domains on  [gi|1676319720|ref|NP_001316363|]
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nuclear pore complex protein Nup205 isoform 2 [Homo sapiens]

Protein Classification

nuclear pore complex Nup192/Nup205 family protein( domain architecture ID 10571003)

nuclear pore complex Nup192/Nup205 family protein; similar to Homo sapiens Nup205 and Saccharomyces cerevisiae Nup192, which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC) that can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 3-1326 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


:

Pssm-ID: 463387  Cd Length: 1484  Bit Score: 993.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720    3 ELAIADNVFLFLM--------------------------------ESVVVSEYFyqEEFYIRRVHNLITDFLALMPMKVK 50
Cdd:pfam11894  179 DEALEDGAFEFLLsiaadtsnkdwedplrydfrsllqrhiprltpEKLLLSDYF--EEFLLRQLHTFITDFISNMADVLT 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720   51 QLRNRADEDARMIHMSMQMGneppislRRDLEHLMLLIGELYKKNPfhlELALEYWcpteplqtptimgsylgvahqrpP 130
Cdd:pfam11894  257 KLRDREEDSLLSQESLLQEG-------RADLERFLLIIAYLYEGRP---DLALEFW-----------------------S 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  131 QRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCAHYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLMLYHEH 210
Cdd:pfam11894  304 DRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENARAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDK 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  211 LRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKA 286
Cdd:pfam11894  380 LRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRLISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  287 ELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVRIPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES- 359
Cdd:pfam11894  460 AILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVPRTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPp 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  360 ----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLRfRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQF 429
Cdd:pfam11894  540 edssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK-STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPS 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  430 VE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELALSLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKEN 503
Cdd:pfam11894  619 GInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALFSIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQE 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  504 LFMDLLR----ESQLALIVCPL---------EQLLQGINprtkkadNVVNIARYLYHGNtnPELAFESAKILCCISCNSN 570
Cdd:pfam11894  696 TYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS-------LVLNLGLYVGYGH--PELALASLKILEKISSSPK 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  571 I----------QIKLVGDFTHDQSiSQKLMAGFVECLDCEDAEEfvrlEEGSElekklvAIRHETRIHILNLLITSLECN 640
Cdd:pfam11894  767 FsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEAPIDEE----EQGAE------SIGLQIKEAILDFLNSNLSAS 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  641 P--PNLALYLLGFELKKPVSTTNLQDPgVLGCPRTCLHAILNILEKGTEGRTGPVAVRE-SPQLAELCYQVIYQLCACSD 717
Cdd:pfam11894  836 PkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHSLLLLLLSSLDLISEGDYIDYaPARLAELILEILYKLCRNPL 914

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  718 TSGPTMRYLRtSQDFLFSQLQYLPFSNKEYE---------------------ISMLNQMSWLMKTASIELRVTSLNRQRS 776
Cdd:pfam11894  915 TSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfdgvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPS 993

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  777 HTQRLLHLLLDDMPVKpysdgeggiedenrsvsgflhfDTATKVRRKILNILDSIDFS-QEIPEPLQLDFFDRAQIEQVI 855
Cdd:pfam11894  994 KKKRYVDLLLGNNILD----------------------GGEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDL 1051

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  856 ANCEHKN-LRGQTVCNVKLLHRVLVAEV---NALQGMAAIGQRPLLMEEISTVLQYVVGRNKLLQCLHAKRHALESWRQL 931
Cdd:pfam11894 1052 DKCELDDaDSGNKLYDISKLHELLRLELkqlLLVQGESKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQL 1131

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  932 VEIILTACpqdLIQAEDRQLIIRDILQDVHDKI-----LDDEAAQELMPVVAGAVFTLTAHLSQAVLTEQKETSVLgpae 1006
Cdd:pfam11894 1132 VQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQKGNL---- 1204

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1007 ahyafmldscftspppeenplvgfasiGDSSLYIILKKLLDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaa 1086
Cdd:pfam11894 1205 ---------------------------SSDRLHQLFKTCIDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR-------- 1248

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1087 kktmwerltapeDVFSKLQRENIAIIESYGAALMEVVCRDACDGHEIGRMLALALLDRIVSVDKQQQ--WLLYLSNSGYL 1164
Cdd:pfam11894 1249 ------------SSEESLRKETLQIIKSYGEKLIEVICNDAIGGEGTCRITALLLLDSLVHLDSNKSnfILETLSKNNYL 1316

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1165 KVLVDSLVEDDRTLQSLLTPQPPLLKALY--TYESKMAFLTRVAKIQQGALELLRSGVIVRLAQCQVYDMRPEtdpqsmF 1242
Cdd:pfam11894 1317 LLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPD------L 1390

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1243 GM-RDPPMFIPTPVDRYRQILLPALQLCQVILTSSMAQHLQAAGQVLQFLISHSDTIQAILR---------CQDVSAGSL 1312
Cdd:pfam11894 1391 GLsLDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNKSAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGL 1470

                         1450
                   ....*....|....
gi 1676319720 1313 QELALLTGIISKAA 1326
Cdd:pfam11894 1471 QELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 3-1326 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 993.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720    3 ELAIADNVFLFLM--------------------------------ESVVVSEYFyqEEFYIRRVHNLITDFLALMPMKVK 50
Cdd:pfam11894  179 DEALEDGAFEFLLsiaadtsnkdwedplrydfrsllqrhiprltpEKLLLSDYF--EEFLLRQLHTFITDFISNMADVLT 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720   51 QLRNRADEDARMIHMSMQMGneppislRRDLEHLMLLIGELYKKNPfhlELALEYWcpteplqtptimgsylgvahqrpP 130
Cdd:pfam11894  257 KLRDREEDSLLSQESLLQEG-------RADLERFLLIIAYLYEGRP---DLALEFW-----------------------S 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  131 QRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCAHYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLMLYHEH 210
Cdd:pfam11894  304 DRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENARAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDK 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  211 LRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKA 286
Cdd:pfam11894  380 LRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRLISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  287 ELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVRIPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES- 359
Cdd:pfam11894  460 AILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVPRTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPp 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  360 ----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLRfRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQF 429
Cdd:pfam11894  540 edssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK-STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPS 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  430 VE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELALSLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKEN 503
Cdd:pfam11894  619 GInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALFSIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQE 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  504 LFMDLLR----ESQLALIVCPL---------EQLLQGINprtkkadNVVNIARYLYHGNtnPELAFESAKILCCISCNSN 570
Cdd:pfam11894  696 TYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS-------LVLNLGLYVGYGH--PELALASLKILEKISSSPK 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  571 I----------QIKLVGDFTHDQSiSQKLMAGFVECLDCEDAEEfvrlEEGSElekklvAIRHETRIHILNLLITSLECN 640
Cdd:pfam11894  767 FsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEAPIDEE----EQGAE------SIGLQIKEAILDFLNSNLSAS 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  641 P--PNLALYLLGFELKKPVSTTNLQDPgVLGCPRTCLHAILNILEKGTEGRTGPVAVRE-SPQLAELCYQVIYQLCACSD 717
Cdd:pfam11894  836 PkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHSLLLLLLSSLDLISEGDYIDYaPARLAELILEILYKLCRNPL 914

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  718 TSGPTMRYLRtSQDFLFSQLQYLPFSNKEYE---------------------ISMLNQMSWLMKTASIELRVTSLNRQRS 776
Cdd:pfam11894  915 TSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfdgvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPS 993

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  777 HTQRLLHLLLDDMPVKpysdgeggiedenrsvsgflhfDTATKVRRKILNILDSIDFS-QEIPEPLQLDFFDRAQIEQVI 855
Cdd:pfam11894  994 KKKRYVDLLLGNNILD----------------------GGEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDL 1051

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  856 ANCEHKN-LRGQTVCNVKLLHRVLVAEV---NALQGMAAIGQRPLLMEEISTVLQYVVGRNKLLQCLHAKRHALESWRQL 931
Cdd:pfam11894 1052 DKCELDDaDSGNKLYDISKLHELLRLELkqlLLVQGESKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQL 1131

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  932 VEIILTACpqdLIQAEDRQLIIRDILQDVHDKI-----LDDEAAQELMPVVAGAVFTLTAHLSQAVLTEQKETSVLgpae 1006
Cdd:pfam11894 1132 VQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQKGNL---- 1204

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1007 ahyafmldscftspppeenplvgfasiGDSSLYIILKKLLDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaa 1086
Cdd:pfam11894 1205 ---------------------------SSDRLHQLFKTCIDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR-------- 1248

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1087 kktmwerltapeDVFSKLQRENIAIIESYGAALMEVVCRDACDGHEIGRMLALALLDRIVSVDKQQQ--WLLYLSNSGYL 1164
Cdd:pfam11894 1249 ------------SSEESLRKETLQIIKSYGEKLIEVICNDAIGGEGTCRITALLLLDSLVHLDSNKSnfILETLSKNNYL 1316

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1165 KVLVDSLVEDDRTLQSLLTPQPPLLKALY--TYESKMAFLTRVAKIQQGALELLRSGVIVRLAQCQVYDMRPEtdpqsmF 1242
Cdd:pfam11894 1317 LLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPD------L 1390

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1243 GM-RDPPMFIPTPVDRYRQILLPALQLCQVILTSSMAQHLQAAGQVLQFLISHSDTIQAILR---------CQDVSAGSL 1312
Cdd:pfam11894 1391 GLsLDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNKSAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGL 1470

                         1450
                   ....*....|....
gi 1676319720 1313 QELALLTGIISKAA 1326
Cdd:pfam11894 1471 QELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 3-1326 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 993.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720    3 ELAIADNVFLFLM--------------------------------ESVVVSEYFyqEEFYIRRVHNLITDFLALMPMKVK 50
Cdd:pfam11894  179 DEALEDGAFEFLLsiaadtsnkdwedplrydfrsllqrhiprltpEKLLLSDYF--EEFLLRQLHTFITDFISNMADVLT 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720   51 QLRNRADEDARMIHMSMQMGneppislRRDLEHLMLLIGELYKKNPfhlELALEYWcpteplqtptimgsylgvahqrpP 130
Cdd:pfam11894  257 KLRDREEDSLLSQESLLQEG-------RADLERFLLIIAYLYEGRP---DLALEFW-----------------------S 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  131 QRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCAHYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLMLYHEH 210
Cdd:pfam11894  304 DRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENARAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDK 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  211 LRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQLTSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKA 286
Cdd:pfam11894  380 LRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRLISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  287 ELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVRIPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES- 359
Cdd:pfam11894  460 AILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVPRTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPp 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  360 ----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLRfRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQF 429
Cdd:pfam11894  540 edssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK-STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPS 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  430 VE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELALSLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKEN 503
Cdd:pfam11894  619 GInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALFSIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQE 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  504 LFMDLLR----ESQLALIVCPL---------EQLLQGINprtkkadNVVNIARYLYHGNtnPELAFESAKILCCISCNSN 570
Cdd:pfam11894  696 TYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS-------LVLNLGLYVGYGH--PELALASLKILEKISSSPK 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  571 I----------QIKLVGDFTHDQSiSQKLMAGFVECLDCEDAEEfvrlEEGSElekklvAIRHETRIHILNLLITSLECN 640
Cdd:pfam11894  767 FsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEAPIDEE----EQGAE------SIGLQIKEAILDFLNSNLSAS 835

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  641 P--PNLALYLLGFELKKPVSTTNLQDPgVLGCPRTCLHAILNILEKGTEGRTGPVAVRE-SPQLAELCYQVIYQLCACSD 717
Cdd:pfam11894  836 PkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHSLLLLLLSSLDLISEGDYIDYaPARLAELILEILYKLCRNPL 914

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  718 TSGPTMRYLRtSQDFLFSQLQYLPFSNKEYE---------------------ISMLNQMSWLMKTASIELRVTSLNRQRS 776
Cdd:pfam11894  915 TSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfdgvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPS 993

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  777 HTQRLLHLLLDDMPVKpysdgeggiedenrsvsgflhfDTATKVRRKILNILDSIDFS-QEIPEPLQLDFFDRAQIEQVI 855
Cdd:pfam11894  994 KKKRYVDLLLGNNILD----------------------GGEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDL 1051

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  856 ANCEHKN-LRGQTVCNVKLLHRVLVAEV---NALQGMAAIGQRPLLMEEISTVLQYVVGRNKLLQCLHAKRHALESWRQL 931
Cdd:pfam11894 1052 DKCELDDaDSGNKLYDISKLHELLRLELkqlLLVQGESKAGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQL 1131

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720  932 VEIILTACpqdLIQAEDRQLIIRDILQDVHDKI-----LDDEAAQELMPVVAGAVFTLTAHLSQAVLTEQKETSVLgpae 1006
Cdd:pfam11894 1132 VQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveLDIAFAEELASLASVLLFDLYAKLRQCINLDEEQKGNL---- 1204

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1007 ahyafmldscftspppeenplvgfasiGDSSLYIILKKLLDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaa 1086
Cdd:pfam11894 1205 ---------------------------SSDRLHQLFKTCIDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR-------- 1248

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1087 kktmwerltapeDVFSKLQRENIAIIESYGAALMEVVCRDACDGHEIGRMLALALLDRIVSVDKQQQ--WLLYLSNSGYL 1164
Cdd:pfam11894 1249 ------------SSEESLRKETLQIIKSYGEKLIEVICNDAIGGEGTCRITALLLLDSLVHLDSNKSnfILETLSKNNYL 1316

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1165 KVLVDSLVEDDRTLQSLLTPQPPLLKALY--TYESKMAFLTRVAKIQQGALELLRSGVIVRLAQCQVYDMRPEtdpqsmF 1242
Cdd:pfam11894 1317 LLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLALLIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPD------L 1390

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1676319720 1243 GM-RDPPMFIPTPVDRYRQILLPALQLCQVILTSSMAQHLQAAGQVLQFLISHSDTIQAILR---------CQDVSAGSL 1312
Cdd:pfam11894 1391 GLsLDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNKSAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGL 1470

                         1450
                   ....*....|....
gi 1676319720 1313 QELALLTGIISKAA 1326
Cdd:pfam11894 1471 QELAKLFVLLATLT 1484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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