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Conserved domains on  [gi|1045560225|ref|NP_001316583|]
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zinc finger protein 25 isoform b [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-68 1.27e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.38  E-value: 1.27e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045560225    8 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-453 3.45e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 144 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCE-KSFYQKPHLTEH 220
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 221 QKTHT---GEKPFECTECGKFFYVKAYlMVHQKTHTGEKPYE-CKECGKAFSQKSHL-------------------TVHQ 277
Cdd:COG5048   112 SSSSNsndNNLLSSHSLPPSSRDPQLP-DLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 278 RMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTF 351
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 352 YYKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEK 424
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1045560225 425 PYECQECGETFIQKSQLTA--HQKTHTKKRN 453
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-68 1.27e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.38  E-value: 1.27e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045560225    8 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.89e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 4.89e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1045560225   7 PVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVG 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 3.13e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1045560225   8 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVS 46
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-453 3.45e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 144 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCE-KSFYQKPHLTEH 220
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 221 QKTHT---GEKPFECTECGKFFYVKAYlMVHQKTHTGEKPYE-CKECGKAFSQKSHL-------------------TVHQ 277
Cdd:COG5048   112 SSSSNsndNNLLSSHSLPPSSRDPQLP-DLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 278 RMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTF 351
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 352 YYKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEK 424
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1045560225 425 PYECQECGETFIQKSQLTA--HQKTHTKKRN 453
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-269 7.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1045560225 244 YLMVHQKTHTGEKPYECKECGKAFSQ 269
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-68 1.27e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.38  E-value: 1.27e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045560225    8 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWI 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.89e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 4.89e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1045560225   7 PVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVG 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 3.13e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1045560225   8 VTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVS 46
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-453 3.45e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 3.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 144 KSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYEC--KECKKIFYHLSSLSRHLRTHAGEKPYECNQCE-KSFYQKPHLTEH 220
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLpLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 221 QKTHT---GEKPFECTECGKFFYVKAYlMVHQKTHTGEKPYE-CKECGKAFSQKSHL-------------------TVHQ 277
Cdd:COG5048   112 SSSSNsndNNLLSSHSLPPSSRDPQLP-DLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 278 RMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYEC------KECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTF 351
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 352 YYKSDLTKHQRKHTG-EKPYECTECGKSFAVNSVLRLHQRT--HTGE--KPYACKE--CGKSFSQKSHFIIHQRKHTGEK 424
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1045560225 425 PYECQECGETFIQKSQLTA--HQKTHTKKRN 453
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNepPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-432 1.57e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 180 KKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFF--------YVKAYLMvHQKT 251
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqsPSSLSSS-DSSS 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 252 HTGEKPYECKeCGKAFSQKSHLTVHQRMHTG-EKPYKCKECGKFFSRNSHLKTHQRS--HTGE--KPYECKE--CRKCFY 324
Cdd:COG5048   256 SASESPRSSL-PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFS 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 325 QKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTK-------HQRKHTGEKPYECT--ECGKSFAVNSVLRLHQRTHTGE 395
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSF 414

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1045560225 396 KPYACK--ECGKSFSQKSHFIIHQRKHTGEKPYECQECG 432
Cdd:COG5048   415 RPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-456 2.45e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 171 DKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQ--CEKSFYQKPHLTEHQKTHTGEKPFECT-ECGKFFYVKAYLMV 247
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 248 HQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKEC-GKFFSRNSHLKTHQRSHTgekpyecKECRKCFYQK 326
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 327 SALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECG-----------KSFAVNSVLRLHQRTH--- 392
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqsPSSLSSSDSSSSASESprs 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 393 ---------------------TGEKPYACKECGKSFSQKSHFIIHQRK--HTGE--KPYEC--QECGETFIQKSQLTAHQ 445
Cdd:COG5048   264 slptassqssspnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330
                  ....*....|.
gi 1045560225 446 KTHTKKRNAEK 456
Cdd:COG5048   344 LLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-411 4.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 256 KPYECKECGKAFSQKSHLTVHQRM--HTGE--KPYKCKE--CGKFFSRNSHLKTHQRSHTGEKPYECKECRKCFYQKSAL 329
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 330 T-------VHQRTHTGEKPFEC--NKCGKTFYYKSDLTKHQRKHTGEKPYEC--TECGKSFAVNSVLRLHQRTHTGEKPY 398
Cdd:COG5048   368 NneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|...
gi 1045560225 399 ACKECGKSFSQKS 411
Cdd:COG5048   448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-412 2.13e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225  95 SQAGNSRNGELTKHQKTHttekacECKECGKFFCQKSALIVHQHTHSKGKSYDC--DKCGKSFSKNEDLIRHQKIHTRDK 172
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPD------SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 173 TYECkeCKKIFYHLSSLSRHLRTHAGEKPYECNQCE-------------KSFYQKPHLTEHQKTHTGEKPFECTEC---- 235
Cdd:COG5048    91 SDLN--SKSLPLSNSKASSSSLSSSSSNSNDNNLLSshslppssrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSnslh 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 236 --------GKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRnsHLKTHQRS 307
Cdd:COG5048   169 pplpanslSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 308 HTGeKPYECKECRKC---------FYQKSALTVHQRTHTG-EKPFECNKCGKTFYYKSDLTKHQRK--HTGE--KPYECT 373
Cdd:COG5048   247 SLS-SSDSSSSASESprsslptasSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCP 325

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1045560225 374 E--CGKSFAVNSVLRLHQRTHTGEKPYACK--ECGKSFSQKSH 412
Cdd:COG5048   326 YslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-304 9.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 9.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 107 KHQKTHTTEKACECKECGKFFCQKSALIVHQHTHS-------KGKSYDCDKCGKSFSKNEDLIRHQ--KIHTR--DKTYE 175
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045560225 176 CKE--CKKIFYHLSSLSRHLRTHAGEKPYEC--NQCEKSFYQKPH-----LTEHQKTHTGEKPFECT--ECGKFFYVKAY 244
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSN 403

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1045560225 245 LMVHQKTHTGEKPYECK--ECGKAFSQKSHLTVHQRMHTGEKPYKCkECGKFFSRNSHLKTH 304
Cdd:COG5048   404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-269 7.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1045560225 244 YLMVHQKTHTGEKPYECKECGKAFSQ 269
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-409 9.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.85e-04
                          10        20
                  ....*....|....*....|....*
gi 1045560225 385 LRLHQRTHTGEKPYACKECGKSFSQ 409
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560225 272 HLTVHQRMHTGEKPYKCKECGKFFSR 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....*
gi 1045560225 356 DLTKHQRKHTGEKPYECTECGKSFA 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-325 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560225 300 HLKTHQRSHTGEKPYECKECRKCFYQ 325
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 286-308 2.38e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.38e-03
                          10        20
                  ....*....|....*....|...
gi 1045560225 286 YKCKECGKFFSRNSHLKTHQRSH 308
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 258-280 3.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.22e-03
                          10        20
                  ....*....|....*....|...
gi 1045560225 258 YECKECGKAFSQKSHLTVHQRMH 280
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-213 6.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560225 188 SLSRHLRTHAGEKPYECNQCEKSFYQ 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-239 6.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.96e-03
                          10        20
                  ....*....|....*....|....
gi 1045560225 216 HLTEHQKTHTGEKPFECTECGKFF 239
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 9.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 1045560225 328 ALTVHQRTHTGEKPFECNKCGKTFYY 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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