nudC domain-containing protein 2 isoform 2 [Homo sapiens]
Protein Classification
alpha-crystallin domain-containing protein( domain architecture ID 129)
alpha-crystallin domain-containing protein similar to alpha-crystallin-type small heat shock proteins
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| alpha-crystallin-Hsps_p23-like super family | cl00175 | alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a ... |
2-54 | 3.53e-24 | ||
alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.; The alpha-crystallin-Hsps_p23-like superfamily includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12-43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this superfamily is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). The actual alignment was detected with superfamily member cd06494: Pssm-ID: 469641 Cd Length: 93 Bit Score: 87.90 E-value: 3.53e-24
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| Name | Accession | Description | Interval | E-value | ||
| p23_NUDCD2_like | cd06494 | p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 ... |
2-54 | 3.53e-24 | ||
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup. Pssm-ID: 107243 Cd Length: 93 Bit Score: 87.90 E-value: 3.53e-24
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| CS | pfam04969 | CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ... |
13-41 | 3.45e-03 | ||
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2. Pssm-ID: 461503 Cd Length: 76 Bit Score: 33.77 E-value: 3.45e-03
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| Name | Accession | Description | Interval | E-value | ||
| p23_NUDCD2_like | cd06494 | p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 ... |
2-54 | 3.53e-24 | ||
p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup. Pssm-ID: 107243 Cd Length: 93 Bit Score: 87.90 E-value: 3.53e-24
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| p23_NUDC_like | cd06467 | p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ... |
14-54 | 4.13e-09 | ||
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart. Pssm-ID: 107224 Cd Length: 85 Bit Score: 49.08 E-value: 4.13e-09
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| p23_like | cd06463 | Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ... |
10-54 | 1.12e-04 | ||
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells. Pssm-ID: 107220 Cd Length: 84 Bit Score: 37.65 E-value: 1.12e-04
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| CS | pfam04969 | CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ... |
13-41 | 3.45e-03 | ||
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2. Pssm-ID: 461503 Cd Length: 76 Bit Score: 33.77 E-value: 3.45e-03
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| Blast search parameters | ||||
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