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Conserved domains on  [gi|1057867292|ref|NP_001317234|]
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NGFI-A-binding protein 2 isoform 2 [Homo sapiens]

Protein Classification

NCD1 and NCD2 domain-containing protein( domain architecture ID 10522666)

NCD1 and NCD2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NCD2 pfam04905
NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with ...
 236-364 1.35e-68

NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.


:

Pssm-ID: 461474  Cd Length: 125  Bit Score: 214.53  E-value: 1.35e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867292 236 RLEPEMVRMVVESVERIFRSFPRGDAgevtSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSIIYGRFDSKRREGKQL 315
Cdd:pfam04905   1 VLSEAQVQRVAECAERLVRTLPRLDP----KLLKNKKKLAKDVEHIMEMSEDDPRRMEEIRKYSAIYGRFDSKRRPEKPL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1057867292 316 SLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSLKGSR 364
Cdd:pfam04905  77 TLHEVTVNEAAAQLCMRDPALLTRRDELFPLARQVVRDAGYHYSKSHSR 125
NCD1 pfam04904
NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with ...
 36-114 5.32e-50

NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.


:

Pssm-ID: 461473  Cd Length: 79  Bit Score: 164.56  E-value: 5.32e-50
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057867292  36 LPRTLGELQLYRVLQRANLLSYYETFIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFS 114
Cdd:pfam04904   1 TPSTLSELQLYRVLQRANLLQYYDTFISQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALQEWVTNPSAFQ 79
 
Name Accession Description Interval E-value
NCD2 pfam04905
NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with ...
 236-364 1.35e-68

NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.


Pssm-ID: 461474  Cd Length: 125  Bit Score: 214.53  E-value: 1.35e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867292 236 RLEPEMVRMVVESVERIFRSFPRGDAgevtSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSIIYGRFDSKRREGKQL 315
Cdd:pfam04905   1 VLSEAQVQRVAECAERLVRTLPRLDP----KLLKNKKKLAKDVEHIMEMSEDDPRRMEEIRKYSAIYGRFDSKRRPEKPL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1057867292 316 SLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSLKGSR 364
Cdd:pfam04905  77 TLHEVTVNEAAAQLCMRDPALLTRRDELFPLARQVVRDAGYHYSKSHSR 125
NCD1 pfam04904
NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with ...
 36-114 5.32e-50

NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.


Pssm-ID: 461473  Cd Length: 79  Bit Score: 164.56  E-value: 5.32e-50
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057867292  36 LPRTLGELQLYRVLQRANLLSYYETFIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFS 114
Cdd:pfam04904   1 TPSTLSELQLYRVLQRANLLQYYDTFISQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALQEWVTNPSAFQ 79
SAM_KIF24-like cd09541
SAM domain of KIF24-like subfamily; SAM (sterile alpha motif) domain of KIF24 subfamily is a ...
 44-72 3.34e-03

SAM domain of KIF24-like subfamily; SAM (sterile alpha motif) domain of KIF24 subfamily is a putative protein-protein interaction domain. This subfamily includes proteins related to human kinesin-like protein KIF24. SAM domain is located at the N-terminus followed by kinesin motor domain. Kinesins are proteins involved in a number of different cell processes including microtubule dynamics and axonal transport. Kinesins of this group belong to N-type; they drive microtubule plus end-directed transport. SAM apparently plays the role of adaptor or scaffold domain. In many cases SAM is known as a mediator of dimerization/oligomerization.


Pssm-ID: 188940  Cd Length: 60  Bit Score: 35.74  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*....
gi 1057867292  44 QLYRVLQRANLLSYYETFIQQGGDDVQQL 72
Cdd:cd09541     2 VLYEWLEEAGLQHYYPAFAAGGVTSIEAL 30
 
Name Accession Description Interval E-value
NCD2 pfam04905
NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with ...
 236-364 1.35e-68

NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.


Pssm-ID: 461474  Cd Length: 125  Bit Score: 214.53  E-value: 1.35e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057867292 236 RLEPEMVRMVVESVERIFRSFPRGDAgevtSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSIIYGRFDSKRREGKQL 315
Cdd:pfam04905   1 VLSEAQVQRVAECAERLVRTLPRLDP----KLLKNKKKLAKDVEHIMEMSEDDPRRMEEIRKYSAIYGRFDSKRRPEKPL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1057867292 316 SLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSLKGSR 364
Cdd:pfam04905  77 TLHEVTVNEAAAQLCMRDPALLTRRDELFPLARQVVRDAGYHYSKSHSR 125
NCD1 pfam04904
NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with ...
 36-114 5.32e-50

NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.


Pssm-ID: 461473  Cd Length: 79  Bit Score: 164.56  E-value: 5.32e-50
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057867292  36 LPRTLGELQLYRVLQRANLLSYYETFIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFS 114
Cdd:pfam04904   1 TPSTLSELQLYRVLQRANLLQYYDTFISQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALQEWVTNPSAFQ 79
SAM_KIF24-like cd09541
SAM domain of KIF24-like subfamily; SAM (sterile alpha motif) domain of KIF24 subfamily is a ...
 44-72 3.34e-03

SAM domain of KIF24-like subfamily; SAM (sterile alpha motif) domain of KIF24 subfamily is a putative protein-protein interaction domain. This subfamily includes proteins related to human kinesin-like protein KIF24. SAM domain is located at the N-terminus followed by kinesin motor domain. Kinesins are proteins involved in a number of different cell processes including microtubule dynamics and axonal transport. Kinesins of this group belong to N-type; they drive microtubule plus end-directed transport. SAM apparently plays the role of adaptor or scaffold domain. In many cases SAM is known as a mediator of dimerization/oligomerization.


Pssm-ID: 188940  Cd Length: 60  Bit Score: 35.74  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*....
gi 1057867292  44 QLYRVLQRANLLSYYETFIQQGGDDVQQL 72
Cdd:cd09541     2 VLYEWLEEAGLQHYYPAFAAGGVTSIEAL 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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