EKC/KEOPS complex subunit TPRKB isoform c [Homo sapiens]
EKC/KEOPS complex subunit CGI121/TPRKB( domain architecture ID 10554361)
EKC/KEOPS complex subunit CGI121/TPRKB, such as CGI21 from fungi and its homolog, TPRKB (TP53RK-binding protein) from mammals, acts as an allosteric effector that regulates the t(6)A activity of the EKC/KEOPS complex, which is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine
List of domain hits
Name | Accession | Description | Interval | E-value | |||
CGI-121 | pfam08617 | Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein ... |
30-155 | 2.68e-48 | |||
Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics. : Pssm-ID: 462537 Cd Length: 160 Bit Score: 153.08 E-value: 2.68e-48
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Name | Accession | Description | Interval | E-value | |||
CGI-121 | pfam08617 | Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein ... |
30-155 | 2.68e-48 | |||
Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics. Pssm-ID: 462537 Cd Length: 160 Bit Score: 153.08 E-value: 2.68e-48
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PRK14886 | PRK14886 | KEOPS complex subunit Cgi121; |
30-94 | 3.73e-03 | |||
KEOPS complex subunit Cgi121; Pssm-ID: 237848 Cd Length: 167 Bit Score: 36.13 E-value: 3.73e-03
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Name | Accession | Description | Interval | E-value | |||
CGI-121 | pfam08617 | Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein ... |
30-155 | 2.68e-48 | |||
Kinase binding protein CGI-121; CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics. Pssm-ID: 462537 Cd Length: 160 Bit Score: 153.08 E-value: 2.68e-48
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PRK14886 | PRK14886 | KEOPS complex subunit Cgi121; |
30-94 | 3.73e-03 | |||
KEOPS complex subunit Cgi121; Pssm-ID: 237848 Cd Length: 167 Bit Score: 36.13 E-value: 3.73e-03
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Blast search parameters | ||||
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