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Conserved domains on  [gi|1060099158|ref|NP_001317420|]
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BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BNIP3 super family cl05857
BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa ...
 17-178 3.53e-66

BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.


The actual alignment was detected with superfamily member pfam06553:

Pssm-ID: 461945  Cd Length: 181  Bit Score: 200.38  E-value: 3.53e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099158  17 LEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSP----SPQEDGqimfdvemhtSRDHSSQSEEEVVEGEKEVE 92
Cdd:pfam06553  27 DRHTPLPFSSHNGEYERILLEAQHESGRSSRVVSSASDSPprpkSPPNSP----------SEELASEEDELRGVYVEDEI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099158  93 ALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKgGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLS 172
Cdd:pfam06553  97 LMKKNADWVWDWSSRPENIPPKEFKFKHPKRSVTLSMRKTGVMKK-GLFSAEFLKVLLPSLLLSHLLGLGLGIYIGKRLT 175


                  ....*.
gi 1060099158 173 TPSAST 178
Cdd:pfam06553 176 TPTSST 181
 
Name Accession Description Interval E-value
BNIP3 pfam06553
BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa ...
 17-178 3.53e-66

BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.


Pssm-ID: 461945  Cd Length: 181  Bit Score: 200.38  E-value: 3.53e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099158  17 LEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSP----SPQEDGqimfdvemhtSRDHSSQSEEEVVEGEKEVE 92
Cdd:pfam06553  27 DRHTPLPFSSHNGEYERILLEAQHESGRSSRVVSSASDSPprpkSPPNSP----------SEELASEEDELRGVYVEDEI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099158  93 ALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKgGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLS 172
Cdd:pfam06553  97 LMKKNADWVWDWSSRPENIPPKEFKFKHPKRSVTLSMRKTGVMKK-GLFSAEFLKVLLPSLLLSHLLGLGLGIYIGKRLT 175


                  ....*.
gi 1060099158 173 TPSAST 178
Cdd:pfam06553 176 TPTSST 181
 
Name Accession Description Interval E-value
BNIP3 pfam06553
BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa ...
 17-178 3.53e-66

BNIP3; This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.


Pssm-ID: 461945  Cd Length: 181  Bit Score: 200.38  E-value: 3.53e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099158  17 LEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSP----SPQEDGqimfdvemhtSRDHSSQSEEEVVEGEKEVE 92
Cdd:pfam06553  27 DRHTPLPFSSHNGEYERILLEAQHESGRSSRVVSSASDSPprpkSPPNSP----------SEELASEEDELRGVYVEDEI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060099158  93 ALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKgGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLS 172
Cdd:pfam06553  97 LMKKNADWVWDWSSRPENIPPKEFKFKHPKRSVTLSMRKTGVMKK-GLFSAEFLKVLLPSLLLSHLLGLGLGIYIGKRLT 175


                  ....*.
gi 1060099158 173 TPSAST 178
Cdd:pfam06553 176 TPTSST 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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