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Conserved domains on  [gi|1060604675|ref|NP_001317545|]
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adenylate kinase 4, mitochondrial isoform b [Homo sapiens]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11995178)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
1-136 4.57e-70

Adenylate kinase;


:

Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 209.86  E-value: 4.57e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELE-NRRGQHWLLDGFPRTLGQAEALDK----ICEVDLVISLNIPFETLKDRLSRRW 75
Cdd:pfam00406  44 EAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRR 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  76 IHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSR 136
Cdd:pfam00406 124 IHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
1-136 4.57e-70

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 209.86  E-value: 4.57e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELE-NRRGQHWLLDGFPRTLGQAEALDK----ICEVDLVISLNIPFETLKDRLSRRW 75
Cdd:pfam00406  44 EAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRR 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  76 IHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSR 136
Cdd:pfam00406 124 IHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-159 1.75e-68

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 206.70  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELENRRGQH--WLLDGFPRTLGQAEALDKICE--VDLVISLNIPFETLKDRLSRRWI 76
Cdd:TIGR01351  47 KAKEYMEKGELVPDEIVNQLVKERLTQNDDNEngFILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRI 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  77 HPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT-ETNKIWPYVY 155
Cdd:TIGR01351 127 CPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRIL 206


                  ....
gi 1060604675 156 TLFS 159
Cdd:TIGR01351 207 EALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 2-145 1.86e-56

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 176.09  E-value: 1.86e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLM---MSELENRRGqhWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSR 73
Cdd:COG0563    49 AKEYMDAGELVPDEIVIGLVkerLAQPDCANG--FILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERLSG 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  74 RWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 145
Cdd:COG0563   127 RRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 2-145 4.05e-52

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 165.32  E-value: 4.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELEN---RRGqhWLLDGFPRTLGQAEALDKIC-----EVDLVISLNIPFETLKDRLSR 73
Cdd:PRK00279   49 AKSYMDAGELVPDEIVIGLVKERLAQpdcKNG--FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSG 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  74 RWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 145
Cdd:PRK00279  127 RRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-147 2.62e-51

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 162.79  E-value: 2.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELENR-RGQHWLLDGFPRTLGQAEALDKICE----VDLVISLNIPFETLKDRLSRRW 75
Cdd:cd01428    47 KAKEYIDSGKLVPDEIVIKLLKERLKKPdCKKGFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRR 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  76 IHPPSGRVYNLdfnpphvhGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 147
Cdd:cd01428   127 ICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
1-136 4.57e-70

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 209.86  E-value: 4.57e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELE-NRRGQHWLLDGFPRTLGQAEALDK----ICEVDLVISLNIPFETLKDRLSRRW 75
Cdd:pfam00406  44 EAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLDGFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRR 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  76 IHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSR 136
Cdd:pfam00406 124 IHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-159 1.75e-68

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 206.70  E-value: 1.75e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELENRRGQH--WLLDGFPRTLGQAEALDKICE--VDLVISLNIPFETLKDRLSRRWI 76
Cdd:TIGR01351  47 KAKEYMEKGELVPDEIVNQLVKERLTQNDDNEngFILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRI 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  77 HPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT-ETNKIWPYVY 155
Cdd:TIGR01351 127 CPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRIL 206


                  ....
gi 1060604675 156 TLFS 159
Cdd:TIGR01351 207 EALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 2-145 1.86e-56

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 176.09  E-value: 1.86e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLM---MSELENRRGqhWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSR 73
Cdd:COG0563    49 AKEYMDAGELVPDEIVIGLVkerLAQPDCANG--FILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERLSG 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  74 RWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 145
Cdd:COG0563   127 RRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk PRK00279
adenylate kinase; Reviewed
 2-145 4.05e-52

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 165.32  E-value: 4.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELEN---RRGqhWLLDGFPRTLGQAEALDKIC-----EVDLVISLNIPFETLKDRLSR 73
Cdd:PRK00279   49 AKSYMDAGELVPDEIVIGLVKERLAQpdcKNG--FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSG 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  74 RWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 145
Cdd:PRK00279  127 RRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-147 2.62e-51

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 162.79  E-value: 2.62e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELENR-RGQHWLLDGFPRTLGQAEALDKICE----VDLVISLNIPFETLKDRLSRRW 75
Cdd:cd01428    47 KAKEYIDSGKLVPDEIVIKLLKERLKKPdCKKGFILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRR 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  76 IHPPSGRVYNLdfnpphvhGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 147
Cdd:cd01428   127 ICPVSGRVYHL--------GKDDVTGEPLSQRSDDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
PLN02674 PLN02674
adenylate kinase
 2-141 2.90e-37

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 128.46  E-value: 2.90e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELENRRGQH-WLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRW 75
Cdd:PLN02674   80 AKEAMDKGELVSDDLVVGIIDEAMKKPSCQKgFILDGFPRTVVQAQKLDEMLAkqgakIDKVLNFAIDDAILEERITGRW 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1060604675  76 IHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQ 141
Cdd:PLN02674  160 IHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVAN 225
PRK14530 PRK14530
adenylate kinase; Provisional
 3-151 2.57e-33

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 117.20  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   3 KQYIEKSLLVPDHVITRLMMSELENRRGqhWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGR 82
Cdd:PRK14530   57 GEYMDAGELVPDAVVNEIVEEALSDADG--FVLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGA 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  83 VYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET-NKIW 151
Cdd:PRK14530  135 NYHVEFNQPEEEGVCDECGGELIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVW 204
PLN02842 PLN02842
nucleotide kinase
 2-135 2.40e-23

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 95.31  E-value: 2.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSEL--ENRRGQHWLLDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLKDRLSRRWIHP 78
Cdd:PLN02842   46 AKEFMNSGRLVPDEIVIAMVTGRLsrEDAKEKGWLLDGYPRSFAQAQSLEKLkIRPDIFILLDVPDEILIDRCVGRRLDP 125

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1060604675  79 PSGRVYNLDFNPPHvhgiDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKS 135
Cdd:PLN02842  126 VTGKIYHIKNFPPE----SEEIKARLITRPDDTEEKVKARLQIYKKNAEAILSTYSD 178
PRK14526 PRK14526
adenylate kinase; Provisional
 3-133 4.20e-21

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 85.67  E-value: 4.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   3 KQYIEKSLLVPDHVITRLM---MSELENRRgqHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPP 79
Cdd:PRK14526   50 KQIVENGQLVPDSITIKIVedkINTIKNND--NFILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKS 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1060604675  80 SGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELY 133
Cdd:PRK14526  128 CNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKEESLKTRLQEYKLQTKPLIEFY 181
PLN02459 PLN02459
probable adenylate kinase
 11-142 1.18e-20

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 85.28  E-value: 1.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  11 LVPDHVITRLMMSELEN--RRGQH-WLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDR-LSRRwIHPPSGRVYNL 86
Cdd:PLN02459   87 LVPDEIIFSLLSKRLEAgeEEGESgFILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKcLGRR-ICSECGKNFNV 165

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1060604675  87 -DFNPPHVHGIDDVTGEPL----------VQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQF 142
Cdd:PLN02459  166 aDIDLKGEDGRPGIVMPPLlpppecasklITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 74-109 5.33e-16

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 67.49  E-value: 5.33e-16
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1060604675  74 RWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQED 109
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
adk PRK02496
adenylate kinase; Provisional
 2-147 1.37e-15

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 70.55  E-value: 1.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELENRRGQH-WLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRw 75
Cdd:PRK02496   50 AQGYMDKGELVPDQLVLDLVQERLQQPDAANgWILDGFPRKVTQAAFLDELLQeigqsGERVVNLDVPDDVVVERLLAR- 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060604675  76 ihppsGRvynldfnpphvhgiddvtgeplvqqEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 147
Cdd:PRK02496  129 -----GR-------------------------KDDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQS 170
PRK14527 PRK14527
adenylate kinase; Provisional
 2-147 1.77e-15

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 70.20  E-value: 1.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRwi 76
Cdd:PRK14527   55 AKPIMEAGDLVPDELILALIRDELAGMEPVRVIFDGFPRTLAQAEALDRLLEelgarLLAVVLLEVPDEELIRRIVER-- 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  77 hppsGRvynldfnpphvhgiddvtgepLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 147
Cdd:PRK14527  133 ----AR---------------------QEGRSDDNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGT 178
PRK14528 PRK14528
adenylate kinase; Provisional
 2-147 4.81e-15

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 69.27  E-value: 4.81e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHV---ITRLMMSELENRRGqhWLLDGFPRTLGQAEALDKIC-----EVDLVISLNIPFETLKDRLSR 73
Cdd:PRK14528   50 AKRYMDAGDLVPDSVvigIIKDRIREADCKNG--FLLDGFPRTVEQADALDALLknegkSIDKAINLEVPDGELLKRLLG 127

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1060604675  74 RWIHppSGRvynldfnpphvhgiddvtgeplvqqEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 147
Cdd:PRK14528  128 RAEI--EGR-------------------------ADDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGS 174
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 11-138 4.86e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 67.13  E-value: 4.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  11 LVPDHVITRLMMSELENRRGQH---WLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNL- 86
Cdd:PTZ00088   64 LVPDNLVIAIVKDEIAKVTDDCfkgFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIa 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  87 -----DFNPPHV---HGIDDVTGEP-LVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGV 138
Cdd:PTZ00088  144 hirsdPYDMPPIlppADCEGCKGNPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14531 PRK14531
adenylate kinase; Provisional
 11-139 7.99e-14

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 65.60  E-value: 7.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  11 LVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKicevdLVISLNIPFETlkdrlsrrwihppsgrVYNLDFNp 90
Cdd:PRK14531   60 LVSDALVLAIVESQLKALNSGGWLLDGFPRTVAQAEALEP-----LLEELKQPIEA----------------VVLLELD- 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  91 phvhgiDDVTGEPLVQ--QEDDKPEAVAARLRQYKDVAKPVIELYKSRGVL 139
Cdd:PRK14531  118 ------DAVLIERLLArgRADDNEAVIRNRLEVYREKTAPLIDHYRQRGLL 162
PRK14532 PRK14532
adenylate kinase; Provisional
 3-144 1.16e-13

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 65.61  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   3 KQYIEKSLLVPDHVITRLMMSEL-ENRRGQHWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRWi 76
Cdd:PRK14532   50 KGIMDRGELVSDEIVIALIEERLpEAEAAGGAIFDGFPRTVAQAEALDKMLAsrgqkIDVVIRLKVDDEALIERIVKRF- 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1060604675  77 hPPSGRvynldfnpphvhgiddvtgeplvqqEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSG 144
Cdd:PRK14532  129 -EEQGR-------------------------PDDNPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDG 170
PRK14529 PRK14529
adenylate kinase; Provisional
 2-74 3.03e-13

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 64.74  E-value: 3.03e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRR 74
Cdd:PRK14529   49 AKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLDGFPRNKVQAEKLWEALQkegmkLDYVIEILLPREVAKNRIMGR 126
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-141 1.89e-12

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 62.14  E-value: 1.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   6 IEKSLLVPDHVITRL----MMSELENRRGqhWLLDGFPRTLGQAEALD-KICEVDLVISLNIPFETLKDRLSRRwiHPPS 80
Cdd:TIGR01360  56 MESGDLVPLDTVLDLlkdaMVAALGTSKG--FLIDGYPREVKQGEEFErRIGPPTLVLYFDCSEDTMVKRLLKR--AETS 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  81 GRVynldfnpphvhgiddvtgeplvqqeDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQ 141
Cdd:TIGR01360 132 GRV-------------------------DDNEKTIKKRLETYYKATEPVIAYYETKGKLRK 167
PRK13808 PRK13808
adenylate kinase; Provisional
 2-136 2.24e-11

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 60.67  E-value: 2.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   2 AKQYIEKSLLVPDHVITRLMMSELENRRG-QHWLLDGFPRTLGQAEALD-----KICEVDLVISLNIPFETLKDRLSRRw 75
Cdd:PRK13808   49 AKDIMASGGLVPDEVVVGIISDRIEQPDAaNGFILDGFPRTVPQAEALDallkdKQLKLDAVVELRVNEGALLARVETR- 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1060604675  76 IHPPSGRvynldfnpphvhgiddvtGEPLvqQEDDKPEAVAARLRQYKDVAKPVIELYKSR 136
Cdd:PRK13808  128 VAEMRAR------------------GEEV--RADDTPEVLAKRLASYRAQTEPLVHYYSEK 168
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1-159 1.62e-10

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 57.00  E-value: 1.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSEL-ENRRGQHWLLDGFPRTLGQAEALDKI----CEVDLVISLNIPFETLKDRLSRRw 75
Cdd:TIGR01359  48 LIESYIKEGKIVPSEVTVELLKKAIqEDGSSKKFLIDGFPRNEENLEAWEKLmdnkVNFKFVLFFDCPEETMIKRLLKR- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675  76 iHPPSGRVynldfnpphvhgiddvtgeplvqqeDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET-NKIWPYV 154
Cdd:TIGR01359 127 -GQTSGRV-------------------------DDNIETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSvEEVFEDV 180


                  ....*
gi 1060604675 155 YTLFS 159
Cdd:TIGR01359 181 EKIFA 185
PLN02200 PLN02200
adenylate kinase family protein
 6-159 8.85e-09

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 52.97  E-value: 8.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   6 IEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEALDKI--CEVDLVISLNIPFETLKDRLSRRwihpPSGRV 83
Cdd:PLN02200   96 IKEGKIVPSEVTVKLIQKEMESSDNNKFLIDGFPRTEENRIAFERIigAEPNVVLFFDCPEEEMVKRVLNR----NQGRV 171

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1060604675  84 ynldfnpphvhgiddvtgeplvqqeDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET-NKIWPYVYTLFS 159
Cdd:PLN02200  172 -------------------------DDNIDTIKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTvDEIFEQVRPIFA 223
AAA_17 pfam13207
AAA domain;
1-74 3.83e-07

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 46.85  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060604675   1 MAKQYIEKSLLVPDHVITRLMMSELENRRGQH-WLLDGFPRTLGQAEALD-------KICEVDLVISLNIPFETLKDRLS 72
Cdd:pfam13207  41 EDRDEMRKLPLEPQKELQKLAAERIAEEAGEGgVIVDGHPRIKTPAGYLPglpvevlRELKPDAIILLEADPEEILERRL 120


                  ..
gi 1060604675  73 RR 74
Cdd:pfam13207 121 KD 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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