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Conserved domains on  [gi|1060628736|ref|NP_001317580|]
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rho GTPase-activating protein 36 isoform 3 [Homo sapiens]

Protein Classification

rho GTPase-activating 6 family protein( domain architecture ID 10138145)

rho GTPase-activating 6 family protein (RhoGAP6-like) such as RhoGAP6, also known as ArhGAP6, which is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actin remodelling, and RhoGAP36 (ArhGAP36) which is a potent antagonist of PKA signaling

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 91-296 5.04e-123

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239841  Cd Length: 206  Bit Score: 354.82  E-value: 5.04e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  91 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 170
Cdd:cd04376     1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 171 PDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSA 250
Cdd:cd04376    81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1060628736 251 LLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 296
Cdd:cd04376   161 LLHKQKSGEREFVQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 91-296 5.04e-123

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 354.82  E-value: 5.04e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  91 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 170
Cdd:cd04376     1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 171 PDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSA 250
Cdd:cd04376    81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1060628736 251 LLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 296
Cdd:cd04376   161 LLHKQKSGEREFVQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 100-252 2.14e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 148.46  E-value: 2.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 100 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLD-DNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060628736 179 LLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLL 144
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 97-286 2.76e-43

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 148.95  E-value: 2.76e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736   97 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQ-NVHDVAALLKEFFRDMKDSLLPDDLY 175
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  176 MSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEdsigidgqlvpGNRMTSTNLALVFGSALLkk 254
Cdd:smart00324  81 EEFIEAAKLEDETErLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLL-- 147

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1060628736  255 gkfgkRESRKTKLGIDHYVASVNVVRAMIDNW 286
Cdd:smart00324 148 -----RPPDGEVASLKDIRHQNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 91-296 5.04e-123

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 354.82  E-value: 5.04e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  91 SLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 170
Cdd:cd04376     1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 171 PDDLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGIDGQLVPGNRMTSTNLALVFGSA 250
Cdd:cd04376    81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1060628736 251 LLKKGKFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 296
Cdd:cd04376   161 LLHKQKSGEREFVQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 100-252 2.14e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 148.46  E-value: 2.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 100 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLD-DNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1060628736 179 LLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLL 144
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 97-286 2.76e-43

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 148.95  E-value: 2.76e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736   97 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQ-NVHDVAALLKEFFRDMKDSLLPDDLY 175
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  176 MSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEdsigidgqlvpGNRMTSTNLALVFGSALLkk 254
Cdd:smart00324  81 EEFIEAAKLEDETErLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLL-- 147

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1060628736  255 gkfgkRESRKTKLGIDHYVASVNVVRAMIDNW 286
Cdd:smart00324 148 -----RPPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 100-285 1.82e-40

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 141.67  E-value: 1.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 100 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFL 179
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 180 LTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLKKGKFG 258
Cdd:cd00159    81 ELAKIEdEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV-----------NKMTASNLAIVFAPTLLRPPDSD 149

                         170       180
                  ....*....|....*....|....*..
gi 1060628736 259 KRESRKTKLGIdhyvasvNVVRAMIDN 285
Cdd:cd00159   150 DELLEDIKKLN-------EIVEFLIEN 169
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 99-286 3.79e-27

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 106.62  E-value: 3.79e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ-GLDVVLDDN-QNVHDVAALLKEFFRDMKDSLLPDDLYM 176
Cdd:cd04385    15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdARSVQLREGeYTVHDVADVLKRFLRDLPDPLLTSELHA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 177 SFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKItENCEDSigidgqlvpgNRMTSTNLALVFGSALLKKG 255
Cdd:cd04385    95 EWIEAAELENKDErIARYKELIRRLPPINRATLKVLIGHLYRV-QKHSDE----------NQMSVHNLALVFGPTLFQTD 163

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1060628736 256 KFGKRESRKtklgidhyvaSVNVVRAMIDNW 286
Cdd:cd04385   164 EHSVGQTSH----------EVKVIEDLIDNY 184
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 97-253 2.16e-26

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 104.79  E-value: 2.16e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  97 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGL-DVVLDDN--QNVHDVAALLKEFFRDMKDSLLPDD 173
Cdd:cd04395    16 PYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGfDIDLQDPrwRDVNVVSSLLKSFFRKLPEPLFTNE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 174 LYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:cd04395    96 LYPDFIEANRIEdPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTLV 164


                  .
gi 1060628736 253 K 253
Cdd:cd04395   165 R 165
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 99-296 4.17e-26

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 104.48  E-value: 4.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHgLSAVGIFTLEYSVQRVRQLREEFDQGLDVvlDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04394    20 VPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEAC--LSSALPCDVAGLLKQFFRELPEPLLPYDLHEAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 179 LLTATL-KPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLKKGKF 257
Cdd:cd04394    97 LKAQELpTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSE-----------NKMDSSNLAVIFAPNLFQSEEG 165

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1060628736 258 GKRESRKTKLGIDHYVAsvnVVRAMIDNWDVLFQVPPHI 296
Cdd:cd04394   166 GEKMSSSTEKRLRLQAA---VVQTLIDNASNIGIVPDFI 201
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 99-253 2.42e-25

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 101.71  E-value: 2.42e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVL----DDNQN-VHDVAALLKEFFRDMKDSLLPDD 173
Cdd:cd04398    16 VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLlispEDYESdIHSVASLLKLFFRELPEPLLTKA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 174 LYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENceDSIgidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:cd04398    96 LSREFIEAAKIEdESRRRDALHGLINDLPDANYATLRALMFHLARIKEH--ESV---------NRMSVNNLAIIWGPTLM 164


                  .
gi 1060628736 253 K 253
Cdd:cd04398   165 N 165
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 99-300 9.30e-25

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 100.88  E-value: 9.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ--GLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYM 176
Cdd:cd04391    22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 177 SFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSALLKKG 255
Cdd:cd04391   102 AFYSVQGLPsKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDH-EEK----------NKMNLWNVAMIMAPNLFPPR 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1060628736 256 KFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHIQRQV 300
Cdd:cd04391   171 GKHSKDNESLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQV 215
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 99-253 8.07e-23

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 94.81  E-value: 8.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04377    15 VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYENF 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1060628736 179 LLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSALLK 253
Cdd:cd04377    95 LRAMELEeKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQ-EEV----------NRMSANALAIVFAPCILR 159
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 90-293 9.68e-23

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 95.56  E-value: 9.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  90 MSLNPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSL 169
Cdd:cd04375    11 VNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQYFRDLPEPL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 170 LPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENcedsigidgqlVPGNRMTSTNLALVFG 248
Cdd:cd04375    91 LTNKLSETFIAIFQYVPKEQrLEAVQCAILLLPDENREVLQTLLYFLSDVAAN-----------SQENQMTATNLAVCLA 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1060628736 249 SAL-----LKKGKFGKRESRKTK--LGIDHY------VASVNVVRAMIDNWDVLFQVP 293
Cdd:cd04375   160 PSLfhlntSRRENSSPARRMQRKksLGKPDQkelsenKAAHQCLAYMIEECNTLFMVP 217
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 97-290 8.53e-22

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 92.52  E-value: 8.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  97 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG-LDVVLDD-NQNVHDVAALLKEFFRDMKDSLLPDDL 174
Cdd:cd04386    18 REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEfYSDPHAVASALKSYLRELPDPLLTYNL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 175 YMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLk 253
Cdd:cd04386    98 YEDWVQAANKPDEDErLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE-----------NKMSPSNIAIVLAPNLL- 165

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1060628736 254 kgkFGKRESRKTKLGIDHYVASVNVVRAMIDNWDVLF 290
Cdd:cd04386   166 ---WAKNEGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 93-252 3.54e-21

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 90.47  E-value: 3.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  93 NPIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPD 172
Cdd:cd04404    17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTFLRELPEPLLTF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 173 DLYMSFLLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:cd04404    97 DLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLL 165
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 96-253 2.36e-20

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 88.27  E-value: 2.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  96 AKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLY 175
Cdd:cd04390    19 PRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQY 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 176 MSFLLTATLKPQDQLSALQLL---VYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:cd04390    99 EDFLSCAQLLSKDEEKGLGELmkqVSILPKVNYNLLSYICRFLDEVQSNSSV-----------NKMSVQNLATVFGPNIL 167


                  .
gi 1060628736 253 K 253
Cdd:cd04390   168 R 168
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 100-290 3.00e-20

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 87.74  E-value: 3.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 100 PQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDdNQNVHDVAALLKEFFRDMKDSLLPDDLYMSFL 179
Cdd:cd04402    16 PKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLK-AEPVLLLASVLKDFLRNIPGSLLSSDLYEEWM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 180 LTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLKKGKFG 258
Cdd:cd04402    95 SALDQENEEEkIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSET-----------NKMDAFNLAVCIAPSLLWPPASS 163

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1060628736 259 KRESRKTKlgidhyvASVNVVRAMIDNWDVLF 290
Cdd:cd04402   164 ELQNEDLK-------KVTSLVQFLIENCQEIF 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 99-256 4.68e-20

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 87.06  E-value: 4.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDD--NQNVHDVAALLKEFFRDMKDSLLPDDLYM 176
Cdd:cd04403    16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDskWEDIHVITGALKLFFRELPEPLFPYSLFN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 177 SFllTATLKPQDQ---LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLK 253
Cdd:cd04403    96 DF--VAAIKLSDYeqrVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK-----------NRMTTQNLAIVFGPTLLR 162


                  ...
gi 1060628736 254 KGK 256
Cdd:cd04403   163 PEQ 165
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 94-296 8.97e-20

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 87.04  E-value: 8.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  94 PIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLD-DNQNVHDVAALLKEFFRDMKDSLLPD 172
Cdd:cd04397    22 PGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDlSKENPVQLAALLKKFLRELPDPLLTF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 173 DLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEdsigIDGQLvpGNRMTSTNLALVFGSAL 251
Cdd:cd04397   102 KLYRLWISSQKIEDEEErKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSH----IDEET--GSKMDIHNLATVITPNI 175

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1060628736 252 LkkgkfgkRESRKTKLGIDHYVASVNVVRAMIDNWDVLFQVPPHI 296
Cdd:cd04397   176 L-------YSKTDNPNTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 97-253 3.20e-19

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 84.86  E-value: 3.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  97 KQIPQVVEACCQFIEKHGLsAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDN---QNVHDVAALLKEFFRDMKDSLLPDD 173
Cdd:cd04384    16 QDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyiQDIHSVSSLCKLYFRELPNPLLTYQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 174 LYMSFLLTATLKPQD-QLSALQLLVYLMPPCHSDTLERLLKALHKITENCedsiGIDGqlvpgnrMTSTNLALVFGSALL 252
Cdd:cd04384    95 LYEKFSEAVSAASDEeRLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYC----SITN-------MHAKNLAIVWAPNLL 163


                  .
gi 1060628736 253 K 253
Cdd:cd04384   164 R 164
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 99-251 1.08e-18

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 83.56  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHG-LSAVGIFTLEYSVQRVRQLREEFDQGLDV-VLDDNQ--NVHDVAALLKEFFRDMKDSLLPDDL 174
Cdd:cd04400    22 LPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNTEYDVdLFSSSLypDVHTVAGLLKLYLRELPTLILGGEL 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1060628736 175 YMSFLLTATLKPQDQLSALQLLVYL--MPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSAL 251
Cdd:cd04400   102 HNDFKRLVEENHDRSQRALELKDLVsqLPQANYDLLYVLFSFLRKIIEH-SDV----------NKMNLRNVCIVFSPTL 169
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 99-251 1.68e-17

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 80.03  E-value: 1.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04382    17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1060628736 179 LLTAT-LKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcedsigidgqlvPGNRMTSTNLALVFGSAL 251
Cdd:cd04382    97 MEAAEiLDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQS------------PECKMDINNLARVFGPTI 158
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 99-248 2.06e-17

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 79.81  E-value: 2.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04393    20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLFLQELPEGLIPASLQIRL 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1060628736 179 L-LTATLKPQD-QLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFG 248
Cdd:cd04393   100 MqLYQDYNGEDeFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHE-----------NRMTAENLAAVFG 160
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 99-252 2.59e-17

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 79.39  E-value: 2.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDnQNVHD---VAALLKEFFRDMKDSLLPDDLY 175
Cdd:cd04383    18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPLADD-QNDHDinsVAGVLKLYFRGLENPLFPKERF 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1060628736 176 MSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALL 252
Cdd:cd04383    97 EDLMSCVKLEnPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDE-----------NMMDPYNLAICFGPTLM 163
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 99-253 4.06e-17

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 78.88  E-value: 4.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04407    15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDF 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1060628736 179 LLTATL-KPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENcEDSigidgqlvpgNRMTSTNLALVFGSALLK 253
Cdd:cd04407    95 LRAVELpEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALE-EDV----------NRMSPNALAIVFAPCLLR 159
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 98-290 4.15e-17

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 79.10  E-value: 4.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  98 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQG---LDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDL 174
Cdd:cd04372    15 QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDgekADISATVYPDINVITGALKLYFRDLPIPVITYDT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 175 YMSFLLTATLKPQD-QLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLK 253
Cdd:cd04372    95 YPKFIDAAKISNPDeRLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD-----------NKMNAENLGIVFGPTLMR 163

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1060628736 254 KgkfgKRESRKTKLGIDHYvaSVNVVRAMIDNWDVLF 290
Cdd:cd04372   164 P----PEDSALTTLNDMRY--QILIVQLLITNEDVLF 194
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 98-255 2.12e-16

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 77.16  E-value: 2.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  98 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMS 177
Cdd:cd04408    15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 178 FLLTA-------------TLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLA 244
Cdd:cd04408    95 FIALAkelqrdsekaaesPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFED-----------NKMSPNNLG 163

                         170
                  ....*....|.
gi 1060628736 245 LVFGSALLKKG 255
Cdd:cd04408   164 IVFGPTLLRPL 174
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 99-253 5.29e-16

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 75.92  E-value: 5.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04378    16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 179 LLTA---------------TLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNL 243
Cdd:cd04378    96 IALAkeiqrdteedkapntPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------NKMSPNNL 164

                         170
                  ....*....|
gi 1060628736 244 ALVFGSALLK 253
Cdd:cd04378   165 GIVFGPTLIR 174
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 97-253 5.09e-15

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 72.73  E-value: 5.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  97 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYM 176
Cdd:cd04406    13 RSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYE 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1060628736 177 SFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLALVFGSALLK 253
Cdd:cd04406    93 EFLRAMGLQERREtVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEET-----------NRMSANALAIVFAPCILR 159
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 97-253 8.58e-15

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 72.10  E-value: 8.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  97 KQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ--GLDVVLDDNqNVHDVAALLKEFFRDMKDSLLPDDL 174
Cdd:cd04373    13 KPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQdhNLDLVSKDF-TVNAVAGALKSFFSELPDPLIPYSM 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 175 YMSfLLTATLKPQD--QLSALQLLVYLMPPCHSDTLERLLKALHKITENCedsigidgqlvPGNRMTSTNLALVFGSALL 252
Cdd:cd04373    92 HLE-LVEAAKINDReqRLHALKELLKKFPPENFDVFKYVITHLNKVSQNS-----------KVNLMTSENLSICFWPTLM 159


                  .
gi 1060628736 253 K 253
Cdd:cd04373   160 R 160
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 98-296 6.27e-13

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 67.49  E-value: 6.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  98 QIPQVVEaccqFIEKHgLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQ-NVHDVAALLKEFFRDMKDSLLPDDLYM 176
Cdd:cd04392    12 QIYQLIE----YLEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLTHAHYP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 177 SFLLTATL-------------KPQDQLSALQLLVYLMPPCHSDTLERLLKALHKiTENCEDSigidgqlvpgNRMTSTNL 243
Cdd:cd04392    87 AHLQIADLcqfdekgnktsapDKERLLEALQLLLLLLPEENRNLLKLILDLLYQ-TAKHEDK----------NKMSADNL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1060628736 244 ALVFGSALL--KKGKFGKRESRKTKLGidhyvasvNVVRAMIDNWDVLFQVPPHI 296
Cdd:cd04392   156 ALLFTPHLIcpRNLTPEDLHENAQKLN--------SIVTFMIKHSQKLFKAPAYL 202
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 99-289 1.43e-12

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 66.66  E-value: 1.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDV---VLDDNQNVHDVAALLKEFFRDMKDSLLPDDLY 175
Cdd:cd04396    32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYgksFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLY 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 176 MSFLLtATLKPQDQLSAL-------------------QLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgN 236
Cdd:cd04396   112 EEFRN-PLRKRPRILQYMkgrineplntdidqaikeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDK-----------N 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1060628736 237 RMTSTNLALVFGSALLKKgkfgkresRKTKLGIDHYVASVNVVRAMIDNWDVL 289
Cdd:cd04396   180 LMTASNLAAIFQPGILSH--------PDHEMDPKEYKLSRLVVEFLIEHQDKF 224
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 83-253 3.84e-12

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 64.95  E-value: 3.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  83 LLGSKRKMSLnpiakqIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLD--VVLDDNQNVHDVAALLKE 160
Cdd:cd04387     6 STVTKRERSK------VPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKdvSVMLSEMDVNAIAGTLKL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 161 FFRDMKDSLLPDDLYMSFLLTATLK-PQDQLSALQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMT 239
Cdd:cd04387    80 YFRELPEPLFTDELYPNFAEGIALSdPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEV-----------NKMS 148

                         170
                  ....*....|....
gi 1060628736 240 STNLALVFGSALLK 253
Cdd:cd04387   149 LHNLATVFGPTLLR 162
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 94-256 7.74e-12

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 64.02  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  94 PIAKQIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQ---GLDVVLDDNQNVHDVAALLKEFFRDMKDSLL 170
Cdd:cd04379    13 GESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVLKDYLRELPEPLI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 171 PDDLYMSFLLTATLKPQDQLS-----ALQLLVYLmPPCHSDTLERLLKALHKITENCEDsigidgqlvpgNRMTSTNLAL 245
Cdd:cd04379    93 TPQLYEMVLEALAVALPNDVQtnthlTLSIIDCL-PLSAKATLLLLLDHLSLVLSNSER-----------NKMTPQNLAV 160

                         170
                  ....*....|.
gi 1060628736 246 VFGSALLKKGK 256
Cdd:cd04379   161 CFGPVLMFCSQ 171
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 98-220 1.14e-11

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 63.22  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  98 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDnQNVHDVAALLKEFFRDMKDSLLPDDLYMS 177
Cdd:cd04381    19 DLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEE-YEPPTVASLLKQYLRELPEPLLTKELMPR 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1060628736 178 F-LLTATLKPQDQLSALQLLVYLMPPCHSDTLERLLKALHKITE 220
Cdd:cd04381    98 FeEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIA 141
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 99-253 2.92e-10

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 59.82  E-value: 2.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  99 IPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEFDQGLDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSF 178
Cdd:cd04409    16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 179 L-----------------LTATLKPQDQLSALQLLVYL------MPPCHSDTLERLLKALHKITENCEDsigidgqlvpg 235
Cdd:cd04409    96 IglakesqhvnetqeakkNSDKKWPNMCTELNRILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEE----------- 164

                         170
                  ....*....|....*...
gi 1060628736 236 NRMTSTNLALVFGSALLK 253
Cdd:cd04409   165 NKMSASNLGIIFGPTLIR 182
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 84-253 8.62e-08

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 52.40  E-value: 8.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  84 LGSKRKMSLNPIAKQIPQVVEA------------CCQFIEKHGLSAVGIFTLEYSVQRVRQL------REEFDQGlDVVL 145
Cdd:cd04374     1 MDGKEPVYHSPGRLQSEVEGEAqlddigfkfvrkCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldPKTSTPG-DVDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 146 DDNQ-NVHDVAALLKEFFRDMKDSLLPDDLYMSFLLTATLKPQDQ-LSALQLLVYLMPPCHSDTLERLLKALHKITENCE 223
Cdd:cd04374    80 DNSEwEIKTITSALKTYLRNLPEPLMTYELHNDFINAAKSENLESrVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSK 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 1060628736 224 DsigidgqlvpgNRMTSTNLALVFGSALLK 253
Cdd:cd04374   160 K-----------NLMTVSNLGVVFGPTLLR 178
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 80-252 1.18e-05

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 46.18  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736  80 GQRLLGSKRKMSLNP----IAKQIPQVVEACCQFIEKHGLSAVGIF----TLEYSVQRVRQLREEFDQGldVVLDDNQNV 151
Cdd:cd04380    27 GIRNLIDQLELGDNPdyseVPLSIPKEIWRLVDYLYTRGLAQEGLFeepgLPSEPGELLAEIRDALDTG--SPFNSPGSA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 152 HDVAALLKEFFRDMKDSLLPDDLYMSfLLTATLKPQDQLSalQLLVYLMPPCHSDTLERLLKALHKITENCEDsigidgq 231
Cdd:cd04380   105 ESVAEALLLFLESLPDPIIPYSLYER-LLEAVANNEEDKR--QVIRISLPPVHRNVFVYLCSFLRELLSESAD------- 174

                         170       180
                  ....*....|....*....|.
gi 1060628736 232 lvpgNRMTSTNLALVFGSALL 252
Cdd:cd04380   175 ----RGLDENTLATIFGRVLL 191
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 119-253 4.93e-05

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 43.92  E-value: 4.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 119 GIFTLEYSVQRVRQLREEFDQGlDVVLDDNQNVHDVAALLKEFFRDMKDSLLPDDLYMSfLLTATLKPQDQLSALQLLvy 198
Cdd:cd04389    42 GIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASLLKLWLRELEEPLIPDALYQQ-CISASEDPDKAVEIVQKL-- 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1060628736 199 lmPPCHSDTLERLLKALHKITENcedsigidgQLVPGNRMTSTNLALVFGSALLK 253
Cdd:cd04389   118 --PIINRLVLCYLINFLQVFAQP---------ENVAHTKMDVSNLAMVFAPNILR 161
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 119-220 9.75e-04

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 40.39  E-value: 9.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1060628736 119 GIFTLEYSVQRVRQLREEFDQGLDVVLDD----NQNVHDVAALLKEFFRDMKDSLLPDD-------LYMSFLLTATLKPQ 187
Cdd:cd04399    42 NVWTDPVSLKETHQLRNLLNKPKKPDKEViilkKFEPSTVASVLKLYLLELPDSLIPHDiydlirsLYSAYPPSQEDSDT 121

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1060628736 188 DQLSALQLLVYLMPPCHSDTLERLLKALHKITE 220
Cdd:cd04399   122 ARIQGLQSTLSQLPKSHIATLDAIITHFYRLIE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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