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Conserved domains on  [gi|1061385113|ref|NP_001317778|]
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Histone-lysine N-methyltransferase set-17 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 128-255 7.06e-66

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


:

Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 201.31  E-value: 7.06e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 128 QQTLPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKtDFYKDGYAWLIKSGDKR-FYIDGSDAERSNWLRY 206
Cdd:cd19193     1 RLTLPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDE-EAADSGYSWQIYKGGKLsHYIDAKDESKSNWMRY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1061385113 207 INSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSYGNEFVE 255
Cdd:cd19193    80 VNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELGI 128
PHD_SF super family cl22851
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 82-113 5.30e-04

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


The actual alignment was detected with superfamily member cd15617:

Pssm-ID: 473978  Cd Length: 47  Bit Score: 37.24  E-value: 5.30e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1061385113  82 GAYDENLDIHCDKCNKFYRPYCRLHPLFKIPD 113
Cdd:cd15617     7 GKQDAHMQLLCDECNMAYHIYCLNPPLDKIPE 38
 
Name Accession Description Interval E-value
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 128-255 7.06e-66

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 201.31  E-value: 7.06e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 128 QQTLPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKtDFYKDGYAWLIKSGDKR-FYIDGSDAERSNWLRY 206
Cdd:cd19193     1 RLTLPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDE-EAADSGYSWQIYKGGKLsHYIDAKDESKSNWMRY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1061385113 207 INSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSYGNEFVE 255
Cdd:cd19193    80 VNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELGI 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 135-252 4.73e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 78.15  E-value: 4.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113  135 FRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGR-----RCQKKTDFYKDGYAW--LIKSGDKRFYIDGSdaERSNWLRYI 207
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEiitseEAEERPKAYDTDGAKafYLFDIDSDLCIDAR--RKGNLARFI 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1061385113  208 NSPRFEDEQNMLAFQTNG-KIFYRVIKPIRINQELLVWYGSSYGNE 252
Cdd:smart00317  79 NHSCEPNCELLFVEVNGDdRIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 146-246 5.52e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 50.21  E-value: 5.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 146 GLGVIAEVFIPVGMVFGPYKGR-------------RCQKKTDFYKDGYAWLIKSGDKRFYIDGSDAERSNWLRYIN-Spr 211
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVllitkeeadkrelLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFINhS-- 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1061385113 212 feDEQNMLAF----QTNGKIFYRVIKPIRINQELLVWYG 246
Cdd:pfam00856  79 --CDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDYG 115
PHD_UHRF2 cd15617
PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2); ...
 82-113 5.30e-04

PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2); UHRF2 (also termed Np95/ICBP90-like RING finger protein (NIRF), Np95-like RING finger protein, nuclear protein 97, nuclear zinc finger protein Np97, RING finger protein 107, or E3 ubiquitin-protein ligase UHRF2) was originally identified as a ubiquitin ligase acting as a small ubiquitin-like modifier (SUMO) E3 ligase that enhances zinc finger protein 131 (ZNF131) SUMOylation but does not enhance ZNF131 ubiquitination. It also ubiquitinates PCNP, a PEST-containing nuclear protein. Moreover, UHRF2 functions as a nuclear protein involved in cell-cycle regulation and has been implicated in tumorigenesis. It interacts with cyclins, CDKs,p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA. It interacts with the cyclin E-CDK2 complex, ubiquitinates cyclins D1 and E1, induces G1 arrest, and is involved in the G1/S transition regulation. Furthermore, UHRF2 is a direct transcriptional target of the transcription factor E2F-1 in the induction of apoptosis. It recruits HDAC1 and binds to methyl-CpG. UHRF2 also participates in the maturation of Hepatitis B virus (HBV) by interacting with the HBV core protein and promoting its degradation. UHRF2 contains an N-terminal ubiquitin-like domain (UBL), a tandem Tudor domain (TTD), a plant homeodomain (PHD) finger, a SET- and RING-associated (SRA) domain, and a C-terminal RING finger.


Pssm-ID: 277089  Cd Length: 47  Bit Score: 37.24  E-value: 5.30e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1061385113  82 GAYDENLDIHCDKCNKFYRPYCRLHPLFKIPD 113
Cdd:cd15617     7 GKQDAHMQLLCDECNMAYHIYCLNPPLDKIPE 38
 
Name Accession Description Interval E-value
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 128-255 7.06e-66

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 201.31  E-value: 7.06e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 128 QQTLPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKtDFYKDGYAWLIKSGDKR-FYIDGSDAERSNWLRY 206
Cdd:cd19193     1 RLTLPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDE-EAADSGYSWQIYKGGKLsHYIDAKDESKSNWMRY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1061385113 207 INSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSYGNEFVE 255
Cdd:cd19193    80 VNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELGI 128
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 131-245 4.88e-31

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 112.15  E-value: 4.88e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRcQKKTDFYKDGYAWLIKSGDKRFY-IDGSDAERSNWLRYINS 209
Cdd:cd19188     4 LPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEK-KKRSQVKNNVYMWEIYGPKRGWMcVDASDPTKGNWLRYVNW 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1061385113 210 PRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWY 245
Cdd:cd19188    83 ARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 131-249 3.26e-28

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 104.75  E-value: 3.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCqKKTDFYKD---GYAW--LIKSGDKRFYIDGSDAERSNWLR 205
Cdd:cd19196     1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIV-SPEDVDPCknnNLMWevFNEDGTVSHFIDASQENHRSWMT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1061385113 206 YINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSY 249
Cdd:cd19196    80 FVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSY 123
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 130-249 5.91e-27

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 101.63  E-value: 5.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 130 TLPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKTDFYKDG--YAWLI-KSGDKRFYIDGSDAERSNWLRY 206
Cdd:cd19187     2 SLPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANrkYFWRIySNGEFYHYIDGFDPSKSNWMRY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1061385113 207 INSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSY 249
Cdd:cd19187    82 VNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREF 124
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 131-253 2.03e-26

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 100.24  E-value: 2.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKTDF---YKDGYAWLIKSGDKRF--YIDGSDAERSNWLR 205
Cdd:cd19191     1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIgavRNTQHLWEIYDQEGTLqhFIDGGDPSKSSWMR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1061385113 206 YINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSYGNEF 253
Cdd:cd19191    81 YIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 131-243 3.05e-26

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 100.13  E-value: 3.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGrrcQKKTDFYKDGYAWLI--KSGDKRFYIDGSDAERSNWLRYIN 208
Cdd:cd19200    10 IPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVG---VQRSSVKDPTYAWEIvdEFGKVKFWIDASEPGTGNWMKYIR 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1061385113 209 SPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLV 243
Cdd:cd19200    87 SAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 131-246 4.41e-25

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 95.34  E-value: 4.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRcqkktdfykdgyawliksgdkrfyidgsdaersNWLRYINSP 210
Cdd:cd10534     1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV---------------------------------NWMRFVRPA 47

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1061385113 211 RFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYG 246
Cdd:cd10534    48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 148-249 8.31e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 90.92  E-value: 8.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 148 GVIAEVFIPVGMVFGPYKGRRCQK---KTdfYKD-GYAWLI-KSGDKRFYIDGSdAERSNWLRYINSPRFEDEQNMLAFQ 222
Cdd:cd19198    21 GVFCKKTIPKGTRFGPFRGRVVNTseiKT--YDDnSFMWEIfEDGKLSHFIDGR-GSTGNWMSYVNCARYAEEQNLIAIQ 97

                          90       100
                  ....*....|....*....|....*..
gi 1061385113 223 TNGKIFYRVIKPIRINQELLVWYGSSY 249
Cdd:cd19198    98 CQGQIFYESCKEILQGQELLVWYGDCY 124
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 155-249 1.44e-22

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 89.92  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 155 IPVGMVFGPYKGRRCQkkTDFYKDGYAWLIKSGDKRF-YIDGSDAERSNWLRYINSPRFEDEQNMLAFQTNGKIFYRVIK 233
Cdd:cd19195    28 IPKGHIFGPYEGQICT--QDKSSGFFSWLIVDKNNRYkSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYFRACR 105

                          90
                  ....*....|....*.
gi 1061385113 234 PIRINQELLVWYGSSY 249
Cdd:cd19195   106 DIRPGEKLRVWYSEDY 121
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 131-244 1.19e-21

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 88.78  E-value: 1.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKG--RRCQKKTDFYKDGYAWLIKS--------------GDKRFYID 194
Cdd:cd19213    20 IPSDFELRESSIPGAGLGVWAKRKIEAGERFGPYTGvqRSTLKDTNFGWEQILNDVEVssqegcitkivddlGNEKFCVD 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1061385113 195 GSDAERSNWLRYINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVW 244
Cdd:cd19213   100 AGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 131-247 2.51e-20

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 84.99  E-value: 2.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKTD-FYkdGYAWLIKSGDKRFYIDGSDAERSNWLRYINS 209
Cdd:cd19214    30 IPSEFELRESNIPGTGLGIWTKRKIEVGEKFGPYVGEQRSNLKDpSY--GWEVLDEFGNVKFCIDASQPDVGSWLKYIRF 107

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1061385113 210 PRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGS 247
Cdd:cd19214   108 AGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFMKS 145
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 130-255 4.76e-19

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 80.86  E-value: 4.76e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 130 TLPI---LFRIEESKLpnaglGVIAEVFIPVGMVFGPYKGRRCqKKTDFYKDGYAWLIKSGDKR--FYIDGSDAERSNWL 204
Cdd:cd19194     5 SLPLilqIFRFGETLG-----GVFAKRRIPKRTQFGPLEGPLV-KKSELKDNKIHPLELEEDDGedLYFDLSDENKCNWM 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1061385113 205 RYINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSYGnEFVE 255
Cdd:cd19194    79 MFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYA-EFLG 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 135-252 4.73e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 78.15  E-value: 4.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113  135 FRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGR-----RCQKKTDFYKDGYAW--LIKSGDKRFYIDGSdaERSNWLRYI 207
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEiitseEAEERPKAYDTDGAKafYLFDIDSDLCIDAR--RKGNLARFI 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1061385113  208 NSPRFEDEQNMLAFQTNG-KIFYRVIKPIRINQELLVWYGSSYGNE 252
Cdd:smart00317  79 NHSCEPNCELLFVEVNGDdRIVIFALRDIKPGEELTIDYGSDYANE 124
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 130-249 2.48e-17

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 76.35  E-value: 2.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 130 TLPILFRIEESKLpNAGLGVIAEVFIPVGMVFGPYKGRRCQK-KTDFYKDGYA---WLIKSGD-KRFYIDGSDAERSNWL 204
Cdd:cd19189     5 SLPRQLYLRQSET-GAEVGVWTKETIPVRTCFGPLIGQQSHSaEVADWTDKAAphiWKIYHNDvLEFCIITTDENECNWM 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1061385113 205 RYINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSY 249
Cdd:cd19189    84 MFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDY 128
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 131-245 2.41e-16

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 73.15  E-value: 2.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LP-ILFRIEESKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKKTDfykDGYAWLIKSGDKRFYIDGSDA--ERSNWLRYI 207
Cdd:cd19201     3 LPgELELRKPSQDAGRSGGVWAKQPLPEGTRFGPYPGKLVKEPLD---PSYEWKVEAQGSKGGEGLLLLteDSGTWLKLV 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1061385113 208 NSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWY 245
Cdd:cd19201    80 RSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVL 117
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 155-246 8.43e-15

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 69.38  E-value: 8.43e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 155 IPVGMVFGPYKGrrcqkKTDFYKDGYAWLIKSGDKR--FYIDGSD-------AERSNWLRYINSPRFEDEQNMLAFQTN- 224
Cdd:cd19192    28 IPAGTIFGPCVL-----SFTLGYDIADIALKTTDKRvvPYIFRVDtgacngsSEPSDWLRLVQPARDRHEQNLEAFRKNe 102

                          90       100
                  ....*....|....*....|..
gi 1061385113 225 GKIFYRVIKPIRINQELLVWYG 246
Cdd:cd19192   103 GQVYFRTLRRIRKGEELLVWYS 124
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 155-248 1.05e-13

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 65.61  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 155 IPVGMVFGPYKGRrcQKKTDFYKDGYAWLIKSGDKR----FYIDGSDAERSNWLRYINSPRFEDEQNMLAFQT--NGKIF 228
Cdd:cd19197     1 IPAGLRLGPVPGI--FKLGKYLSDRKEPGNKKKVRRvrgdYLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGGQIF 78

                          90       100
                  ....*....|....*....|
gi 1061385113 229 YRVIKPIRINQELLVWYGSS 248
Cdd:cd19197    79 YRALRDIQPGEELTVWYSNS 98
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 129-249 1.57e-13

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 65.90  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 129 QTLPILFRIEesKLPNAGLGVIAEVFIPVGMVFGPYKGRRCQKkTDFYKDGYAWLIKSGDKRFYIDGSDAERSNWLRYIN 208
Cdd:cd19199     5 SSLPDNLEIR--QLEDGSEGVFALVPLVKRTQFGPFEAKRVAR-LDGFAVFPLKVFEKDGSVVYLDTSNEDDCNWMMFVR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1061385113 209 SPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSSY 249
Cdd:cd19199    82 PATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFY 122
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 131-248 1.61e-10

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 57.69  E-value: 1.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 131 LPILFRIEESKLPNaGLGVIAEVFIPVGMVFGPYKG-RRCQKKTDFYKDG-YAWLIK--SGDKRFYIDGSDAERSNWLRY 206
Cdd:cd19190     5 VPDRFSLKSSKVQD-GMGLYTARRVKKGEKFGPFAGeKRMPNELDESMDPrLMWEVRgsKGEVLYILDASNPRHSNWLRF 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1061385113 207 INSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVWYGSS 248
Cdd:cd19190    84 VHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDS 125
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 136-249 9.17e-10

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 55.43  E-value: 9.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 136 RIEESKLPNA---GLGVIAEVFIPVGMVFGPYKGR---RCQKKTD-FYKDGYAWLIKSGDKRFYIDGSDAErsNWLRYIN 208
Cdd:cd10522     1 KVDISMIPNLshnGLGLFAAETIAKGEFVGEYTGEvldRWEEDRDsVYHYDPLYPFDLNGDILVIDAGKKG--NLTRFIN 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1061385113 209 SPRF---EDEQNMLAFQTngKIFYRVIKPIRINQELLVWYGSSY 249
Cdd:cd10522    79 HSDQpnlELIVRTLKGEQ--HIGFVAIRDIKPGEELFISYGPKY 120
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 146-246 5.52e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 50.21  E-value: 5.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061385113 146 GLGVIAEVFIPVGMVFGPYKGR-------------RCQKKTDFYKDGYAWLIKSGDKRFYIDGSDAERSNWLRYIN-Spr 211
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVllitkeeadkrelLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFINhS-- 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1061385113 212 feDEQNMLAF----QTNGKIFYRVIKPIRINQELLVWYG 246
Cdd:pfam00856  79 --CDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDYG 115
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 191-244 9.96e-08

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 49.72  E-value: 9.96e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1061385113 191 FYIDGSDAER-SNWLRYINSPRFEDEQNMLAFQTNGKIFYRVIKPIRINQELLVW 244
Cdd:cd10520    61 QSGDVLACEQsSKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
PHD_UHRF2 cd15617
PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2); ...
 82-113 5.30e-04

PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2); UHRF2 (also termed Np95/ICBP90-like RING finger protein (NIRF), Np95-like RING finger protein, nuclear protein 97, nuclear zinc finger protein Np97, RING finger protein 107, or E3 ubiquitin-protein ligase UHRF2) was originally identified as a ubiquitin ligase acting as a small ubiquitin-like modifier (SUMO) E3 ligase that enhances zinc finger protein 131 (ZNF131) SUMOylation but does not enhance ZNF131 ubiquitination. It also ubiquitinates PCNP, a PEST-containing nuclear protein. Moreover, UHRF2 functions as a nuclear protein involved in cell-cycle regulation and has been implicated in tumorigenesis. It interacts with cyclins, CDKs,p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA. It interacts with the cyclin E-CDK2 complex, ubiquitinates cyclins D1 and E1, induces G1 arrest, and is involved in the G1/S transition regulation. Furthermore, UHRF2 is a direct transcriptional target of the transcription factor E2F-1 in the induction of apoptosis. It recruits HDAC1 and binds to methyl-CpG. UHRF2 also participates in the maturation of Hepatitis B virus (HBV) by interacting with the HBV core protein and promoting its degradation. UHRF2 contains an N-terminal ubiquitin-like domain (UBL), a tandem Tudor domain (TTD), a plant homeodomain (PHD) finger, a SET- and RING-associated (SRA) domain, and a C-terminal RING finger.


Pssm-ID: 277089  Cd Length: 47  Bit Score: 37.24  E-value: 5.30e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1061385113  82 GAYDENLDIHCDKCNKFYRPYCRLHPLFKIPD 113
Cdd:cd15617     7 GKQDAHMQLLCDECNMAYHIYCLNPPLDKIPE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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